LOCUS       HUMPLASM                2497 bp    mRNA    linear   HUM 27-APR-1993
DEFINITION  Human plasminogen mRNA, complete cds.
ACCESSION   M74220
VERSION     M74220.1
KEYWORDS    plasminogen; zymogen.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2497)
  AUTHORS   Browne,M.J., Chapman,C.G., Dodd,I., Carey,J.E., Lawrence,G.M.P.,
            Mitchell,D. and Robinson,J.H.
  TITLE     Expression of recombinant human plasminogen and aglycoplasminogen
            in HeLa cells
  JOURNAL   Fibrinolysis (1991) In press
COMMENT     Original source text: Homo sapiens female adult liver cDNA to mRNA.
FEATURES             Location/Qualifiers
     source          1..2497
                     /db_xref="H-InvDB:HIT000196309"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /haplotype="diploid"
                     /sex="female"
                     /tissue_type="liver"
                     /dev_stage="adult"
     CDS             50..2482
                     /codon_start=1
                     /product="plasminogen"
                     /protein_id="AAA36451.1"
                     /db_xref="GI:190026"
                     /translation="MEHKEVVLLLLLFLKSGQGEPLDDYVNTQGASLFSVTKKQLGAG
                     SIEECAAKCEEDEEFTCRAFQYHSKEQQCVIMAENRKSSIIIRMRDVVLFEKKVYLSE
                     CKTGNGKNYRGTMSKTKNGITCQKWSSTSPHRPRFSPATHPSEGLEENYCRNPDNDPQ
                     GPWCYTTDPEKRYDYCDILECEEECMHCSGENYDGKISKTMSGLECQAWDSQSPHAHG
                     YIPSKFPNKNLKKNYCRNPDRELRPWCFTTDPNKRWELCDIPRCTTPPPSSGPTYQCL
                     KGTGENYRGNVAVTVSGHTCQHWSAQTPHTHNRTPENFPCKNLDENYCRNPDGKRAPW
                     CHTTNSQVRWEYCKIPSCDSSPVSTEQLAPTAPPELTPVVQDCYHGDGQSYRGTSSTT
                     TTGKKCQSWSSMTPHRHQKTPENYPNAGLTMNYCRNPDADKGPWCFTTDPSVRWEYCN
                     LKKCSGTEASVVAPPPVVLLPDVETPSEEDCMFGNGKGYRGKRATTVTGTPCQDWAAQ
                     EPHRHSIFTPETNPRAGLEKNYCRNPDGDVGGPWCYTTNPRKLYDYCDVPQCAAPSFD
                     CGKPQVEPKKCPGRVVGGCVAHPHSWPWQVSLRTRFGMHFCGGTLISPEWVLTAAHCL
                     EKSPRPSSYKVILGAHQEVNLEPHVQEIEVSRLFLEPTRKDIALLKLSSPAVITDKVI
                     PACLPSPNYVVADRTECFVTGWGETQGTFGAGLLKEAQLPVIENKVCNRYEFLNGRVQ
                     STELCAGHLAGGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSR
                     FVTWIEGVMRNN"
     sig_peptide     50..106
     mat_peptide     107..2479
                     /product="plasminogen"
BASE COUNT          691 a          624 c          637 g          545 t
ORIGIN      
        1 catcctggga ttgggaccca ctttctgggc actgctggcc agtcccaaaa tggaacataa
       61 ggaagtggtt cttctacttc ttttatttct gaaatcaggt caaggagagc ctctggatga
      121 ctatgtgaat acccaggggg cttcactgtt cagtgtcact aagaagcagc tgggagcagg
      181 aagtatagaa gaatgtgcag caaaatgtga ggaggacgaa gaattcacct gcagggcatt
      241 ccaatatcac agtaaagagc aacaatgtgt gataatggct gaaaacagga agtcctccat
      301 aatcattagg atgagagatg tagttttatt tgaaaagaaa gtgtatctct cagagtgcaa
      361 gactgggaat ggaaagaact acagagggac gatgtccaaa acaaaaaatg gcatcacctg
      421 tcaaaaatgg agttccactt ctccccacag acctagattc tcacctgcta cacacccctc
      481 agagggactg gaggagaact actgcaggaa tccagacaac gatccgcagg ggccctggtg
      541 ctatactact gatccagaaa agagatatga ctactgcgac attcttgagt gtgaagagga
      601 atgtatgcat tgcagtggag aaaactatga cggcaaaatt tccaagacca tgtctggact
      661 ggaatgccag gcctgggact ctcagagccc acacgctcat ggatacattc cttccaaatt
      721 tccaaacaag aacctgaaga agaattactg tcgtaacccc gatagggagc tgcggccttg
      781 gtgtttcacc accgacccca acaagcgctg ggaactttgt gacatccccc gctgcacaac
      841 acctccacca tcttctggtc ccacctacca gtgtctgaag ggaacaggtg aaaactatcg
      901 cgggaatgtg gctgttaccg tgtccgggca cacctgtcag cactggagtg cacagacccc
      961 tcacacacat aacaggacac cagaaaactt cccctgcaaa aatttggatg aaaactactg
     1021 ccgcaatcct gacggaaaaa gggccccatg gtgccataca accaacagcc aagtgcggtg
     1081 ggagtactgt aagataccgt cctgtgactc ctccccagta tccacggaac aattggctcc
     1141 cacagcacca cctgagctaa cccctgtggt ccaggactgc taccatggtg atggacagag
     1201 ctaccgaggc acatcctcca ccaccaccac aggaaagaag tgtcagtctt ggtcatctat
     1261 gacaccacac cggcaccaga agaccccaga aaactaccca aatgctggcc tgacaatgaa
     1321 ctactgcagg aatccagatg ccgataaagg cccctggtgt tttaccacag accccagcgt
     1381 caggtgggag tactgcaacc tgaaaaaatg ctcaggaaca gaagcgagtg ttgtagcacc
     1441 tccgcctgtt gtcctgcttc cagatgtaga gactccttcc gaagaagact gtatgtttgg
     1501 gaatgggaaa ggataccgag gcaagagggc gaccactgtt actgggacgc catgccagga
     1561 ctgggctgcc caggagcccc atagacacag cattttcact ccagagacaa atccacgggc
     1621 gggtctggaa aaaaattact gccgtaaccc tgatggtgat gtaggtggtc cctggtgcta
     1681 cacgacaaat ccaagaaaac tttacgacta ctgtgatgtc cctcagtgtg cggccccttc
     1741 atttgattgt gggaagcctc aagtggagcc gaagaaatgt cctggaaggg ttgtaggggg
     1801 gtgtgtggcc cacccacatt cctggccctg gcaagtcagt cttagaacaa ggtttggaat
     1861 gcacttctgt ggaggcacct tgatatcccc agagtgggtg ttgactgctg cccactgctt
     1921 ggagaagtcc ccaaggcctt catcctacaa ggtcatcctg ggtgcacacc aagaagtgaa
     1981 tctcgaaccg catgttcagg aaatagaagt gtctaggctg ttcttggagc ccacacgaaa
     2041 agatattgcc ttgctaaagc taagcagtcc tgccgtcatc actgacaaag taatcccagc
     2101 ttgtctgcca tccccaaatt atgtggtcgc tgaccggacc gaatgtttcg tcactggctg
     2161 gggagaaacc caaggtactt ttggagctgg ccttctcaag gaagcccagc tccctgtgat
     2221 tgagaataaa gtgtgcaatc gctatgagtt tctgaatgga agagtccaat ccaccgaact
     2281 ctgtgctggg catttggccg gaggcactga cagttgccag ggtgacagtg gaggtcctct
     2341 ggtttgcttc gagaaggaca aatacatttt acaaggagtc acttcttggg gtcttggctg
     2401 tgcacgcccc aataagcctg gtgtctatgt tcgtgtttca aggtttgtta cttggattga
     2461 gggagtgatg agaaataatt aattggacgg gagacag
//