LOCUS       HUMHUGBR1               2351 bp    mRNA    linear   HUM 07-MAR-1995
DEFINITION  Human bilirubin UDP-glucuronosyltransferase isozyme 1 mRNA,
            complete cds.
ACCESSION   M57899
VERSION     M57899.1
KEYWORDS    UDP-glucuronosyltransferase; bilirubin UDP-glucuronosyltransferase.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2351)
  AUTHORS   Ritter,J.K., Crawford,J.M. and Owens,I.S.
  TITLE     Cloning of two human liver bilirubin UDP-glucuronosyltransferase
            cDNAs with expression in COS-1 cells
  JOURNAL   J. Biol. Chem. 266 (2), 1043-1047 (1991)
   PUBMED   1898728
COMMENT     Original source text: Human adult female liver, cDNA to mRNA,
            clones Z6, Z11 and Z6MB2.
FEATURES             Location/Qualifiers
     source          1..2351
                     /db_xref="H-InvDB:HIT000195845"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /isolate="AK"
                     /db_xref="taxon:9606"
                     /map="2"
                     /clone="Z6"
                     /sex="female"
                     /tissue_type="liver"
                     /dev_stage="adult"
                     /tissue_lib="lambda-ZAP"
     gene            1..2351
                     /gene="UGT1"
     CDS             16..1617
                     /gene="UGT1"
                     /EC_number="2.4.1.17"
                     /standard_name="bilirubin UDP-glucuronosyltransferase
                     isozyme 1"
                     /codon_start=1
                     /product="UDP-glucuronosyltransferase 1"
                     /protein_id="AAA63195.1"
                     /db_xref="GI:184473"
                     /db_xref="GDB:G00-120-007"
                     /translation="MAVESQGGRPLVLGLLLCVLGPVVSHAGKILLIPVDGSHWLSML
                     GAIQQLQQRGHEIVVLAPDASLYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFEN
                     DSFLQRVIKTYKKIKKDSAMLLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCSPIV
                     AQYLSLPTVFFLHALPCSLEFEATQCPNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFS
                     QNFLCDVVYSPYATLASEFLQREVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVG
                     GINCLHQNPLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVL
                     WRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMP
                     LFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDR
                     PVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFK
                     CCAYGYRKCLGKKGRVKKAHKSKTH"
     sig_peptide     43..75
                     /gene="UGT1"
                     /note="G00-120-007"
     mat_peptide     76..1614
                     /gene="UGT1"
                     /product="UDP-glucuronosyltransferase 1"
                     /EC_number="2.4.1.17"
                     /standard_name="bilirubin UDP-glucuronosyltransferase
                     isozyme 1"
                     /note="G00-120-007"
BASE COUNT          601 a          540 c          557 g          653 t
ORIGIN      
        1 aggagcaaag gcgccatggc tgtggagtcc cagggcggac gcccacttgt cctgggcctg
       61 ctgctgtgtg tgctgggccc agtggtgtcc catgctggga agatactgtt gatcccagtg
      121 gatggcagcc actggctgag catgcttggg gccatccagc agctgcagca gaggggacat
      181 gaaatagttg tcctagcacc tgacgcctcg ttgtacatca gagacggagc attttacacc
      241 ttgaagacgt accctgtgcc attccaaagg gaggatgtga aagagtcttt tgttagtctc
      301 gggcataatg tttttgagaa tgattctttc ctgcagcgtg tgatcaaaac atacaagaaa
      361 ataaaaaagg actctgctat gcttttgtct ggctgttccc acttactgca caacaaggag
      421 ctcatggcct ccctggcaga aagcagcttt gatgtcatgc tgacggaccc tttccttcct
      481 tgcagcccca tcgtggccca gtacctgtct ctgcccactg tattcttctt gcatgcactg
      541 ccatgcagcc tggaatttga ggctacccag tgccccaacc cattctccta cgtgcccagg
      601 cctctctcct ctcattcaga tcacatgacc ttcctgcagc gggtgaagaa catgctcatt
      661 gccttttcac agaactttct gtgcgacgtg gtttattccc cgtatgcaac ccttgcctca
      721 gaattccttc agagagaggt gactgtccag gacctattga gctctgcatc tgtctggctg
      781 tttagaagtg actttgtgaa ggattaccct aggcccatca tgcccaatat ggtttttgtt
      841 ggtggaatca actgccttca ccaaaatcca ctatcccagg aatttgaagc ctacattaat
      901 gcttctggag aacatggaat tgtggttttc tctttgggat caatggtctc agaaattcca
      961 gagaagaaag ctatggcaat tgctgatgct ttgggcaaaa tccctcagac agtcctgtgg
     1021 cggtacactg gaacccgacc atcgaatctt gcgaacaaca cgatacttgt taagtggcta
     1081 ccccaaaacg atctgcttgg tcacccgatg acccgtgcct ttatcaccca tgctggttcc
     1141 catggtgttt atgaaagcat atgcaatggc gttcccatgg tgatgatgcc cttgtttggt
     1201 gatcagatgg acaatgcaaa gcgcatggag actaagggag ctggagtgac cctgaatgtt
     1261 ctggaaatga cttctgaaga tttagaaaat gctctaaaag cagtcatcaa tgacaaaagt
     1321 tacaaggaga acatcatgcg cctctccagc cttcacaagg accgcccggt ggagccgctg
     1381 gacctggccg tgttctgggt ggagtttgtg atgaggcaca agggcgcgcc acacctgcgc
     1441 cccgcagccc acgacctcac ctggtaccag taccattcct tggacgtgat tggtttcctc
     1501 ttggccgtcg tgctgacagt ggccttcatc acctttaaat gttgtgctta tggctaccgg
     1561 aaatgcttgg ggaaaaaagg gcgagttaag aaagcccaca aatccaagac ccattgagaa
     1621 gtgggtggga aataaggtaa aattttgaac cattccctag tcatttccaa acttgaaaac
     1681 agaatcagtg ttaaattcat tttattctta ttaaggaaat actttgcata aattaatcag
     1741 ccccagagtg ctttaaaaaa ttctcttaaa taaaaataat agactcgcta gtcagtaaag
     1801 atatttgaat atgtatcgtg ccccctccgg tgtctttgat caggatgaca tgtgccattt
     1861 ttcagaggac gtgcagacag gctggcattc tagattactt ttcttactct gaaacatggc
     1921 ctgtttggga gtgcgggatt caaaggtggt cccaccgctg cccctactgc aaatggcagt
     1981 tttaatctta tcttttggct tctgcagatg gttgcaattg atccttaacc aataatggtc
     2041 agtcctcatc tctgtcctgc ttcataggtg ccaccttgtg tgtttaaaga agggaagctt
     2101 tgtaccttta gagtgtaggt gaaatgaatg aatggcttgg agtgcactga gaacagcata
     2161 tgatttcttg ctttggggaa aaagaatgat gctatgaaat tggtgggtgg tgtatttgag
     2221 aagataatca ttgcttatgt caaatggagc tgaatttgat aaaaacccaa aatacagcta
     2281 tgaagtgctg ggcaagttta ctttttttct gatgtttcct acaactaaaa ataaattaat
     2341 aaatttataa a
//