LOCUS HUMAGPRO 7137 bp mRNA linear HUM 06-MAR-1995
DEFINITION Human large aggregating cartilage proteoglycan core protein mRNA,
complete cds.
ACCESSION M55172
VERSION M55172.1
KEYWORDS aggrecan; large aggregating cartilage proteoglycan core protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7137)
AUTHORS Doege,K.J., Sasaki,M., Kimura,T. and Yamada,Y.
TITLE Complete coding sequence and deduced primary structure of the human
cartilage large aggregating proteoglycan, aggrecan. Human-specific
repeats, and additional alternatively spliced forms
JOURNAL J. Biol. Chem. 266 (2), 894-902 (1991)
PUBMED 1985970
COMMENT Original source text: Human juvenile cartilage chondrocyte, cDNA to
mRNA, clone PSA003-5.
FEATURES Location/Qualifiers
source 1..7137
/db_xref="H-InvDB:HIT000195772"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="PSA003-5"
/cell_type="chondrocyte"
/tissue_type="cartilage"
/dev_stage="juvenile"
CDS 61..7011
/codon_start=1
/product="large aggregating cartilage proteoglycan core
protein"
/protein_id="AAA62824.1"
/translation="MTTLLWVFVTLRVITAAVTVETSDHDNSLSVSIPQPSPLRVLLG
TSLTIPCYFIDPMHPVTTAPSTAPLAPRIKWSRVSKEKEVVLLVATEGRVRVNSAYQD
KVSLPNYPAIPSDATLEVQSLRSNDSGVYRCEVMHGIEDSEATLEVVVKGIVFHYRAI
STRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPRE
GCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRL
GARLATTGHVYLAWQAGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYVHANQ
TGYPDPSSRYDAICYTGEDFVDIPENFFGVGGEEDITVQTVTWPDMELPLPRNITEGE
ARGSVILTVKPIFEVSPSPLEPEEPFTFAPEIGATAFAEVENETGEATRPWGFPTPGL
GPATAFTSEDLVVQVTAVPGQPHLPGGVVFHYRPGPTRYSLTFEEAQQACPGTGAVIA
SPEQLQAAYEAGYEQCDAGWLRDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPSTET
YDVYCFVDRLEGEVFFATRLEQFTFQEALEFCESHNATATTGQLYAAWSRGLDKCYAG
WLADGSLRYPIVTPRPACGGDKPGVRTVYLYPNQTGLPDPLSRHHAFCFRGISAVPSP
GEEEGGTPTSPSGVEEWIVTQVVPGVAAVPVEEETTAVPSGETTAILEFTTEPENQTE
WEPAYTPVGTSPLPGILPTWPPTGAETEESTEGPSATEVPSASEEPSPSEVPFPSEEP
SPSEEPFPSVRPFPSVELFPSEEPFPSKEPSPSEEPSASEEPYTPSPPEPSWTELPSS
GEESGAPDVSGDFTGSGDVSGHLDFSGQLSGDRASGLPSGDLDSSGLTSTVGSGLTVE
SGLPSGDEERIEWPSTPTVGELPSGAEILEGSASGVGDLSGLPSGEVLETSASGVGDL
SGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDIS
GLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETAAPGVEDISG
LPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGL
PSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLP
SGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPS
GEVLETAAPGVEDISGLPSGEVLETTAPGVEEISGLPSGEVLETTAPGVDEISGLPSG
EVLETTAPGVEEISGLPSGEVLETSTSAVGDLSGLPSGGEVLEISVSGVEDISGLPSG
EVVETSASGIEDVSELPSGEGLETSASGVEDLSRLPSGEEVLEISASGFGDLSGVPSG
GEGLETSASEVGTDLSGLPSGREGLETSASGAEDLSGLPSGKEDLVGSASGDLDLGKL
PSGTLGSGQAPETSGLPSGFSGEYSGVDLGSGPPSGLPDFSGLPSGFPTVSLVDSTLV
EVVTASTASELEGRGTIGISGAGEISGLPSSELDISGRASGLPSGTELSGQASGSPDV
SGEIPGLFGVSGQPSGFPDTSGETSGVTELSGLSSGQPGVSGEASGVLYGTSQPFGIT
DLSGETSGVPDLSGQPSGLPGFSGATSGVPDLVSGTTSGSGESSGITFVDTSLVEVAP
TTFKEEEGLGSVELSGLPSGEADLSGKSGMVDVSGQFSGTVDSSGFTSQTPEFSGLPS
GIAEVSGESSRAEIGSSLPSGAYYGSGTPSSFPTVSLVDRTLVESVTQAPTAQEAGEG
PSGILELSGAHSGAPDMSGEHSGFLDLSGLQSGLIEPSGEPPGTPYFSGDFASTTNVS
GESSVAMGTSGEASGLPEVTLITSEFVEGVTEPTISQELGQRPPVTHTPQLFESSGKV
STAGDISGATPVLPGSGVEVSSVPESSSETSAYPEAGFGASAAPEASREDSGSPDLSE
TTSAFHEANLERSSGLGVSGSTLTFQEGEASAAPEVSGESTTTSDVGTEAPGLPSATP
TASGDRTEISGDLSGHTSQLGVVISTSIPESEWTQQTQRPAETHLEIESSSLLYSGEE
THTVETATSPTDASIPASPEWKRESESTAADQEVCEEGWNKYQGHCYRHFPDRETWVD
AERRCREQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDRTIEGDFRWSDGHPMQFENW
RPNQPDNFFAAGEDCVVMIWHEKGEWNDVPCNYHLPFTCKKGTATTYKRRLQKRSSRH
PRRSRPSTAH"
BASE COUNT 1567 a 2010 c 2078 g 1482 t
ORIGIN
1 cggccaggtg tgtgggactg aagttcttgg agaagggagt ccaactcttc aaggtgaact
61 atgaccactt tactctgggt tttcgtgact ctgagggtca tcactgcagc tgtcactgta
121 gaaacttcag accatgacaa ctcgctgagt gtcagcatcc cccaaccgtc cccgctgagg
181 gtcctcctgg ggacctccct caccatcccc tgctatttca tcgaccccat gcaccctgtg
241 accaccgccc cttctaccgc cccactggcc ccaagaatca agtggagccg tgtgtccaag
301 gagaaggagg tagtgctgct ggtggccact gaagggcgcg tgcgggtcaa cagtgcctat
361 caggacaagg tctcactgcc caactacccg gccatcccca gtgacgccac cttggaagtc
421 cagagcctgc gctccaatga ctctggggtc taccgctgcg aggtgatgca tggcatcgag
481 gacagcgagg ccaccctgga agtcgtggtg aaaggcatcg tgttccatta cagagccatc
541 tctacacgct acaccctcga ctttgacagg gcgcagcggg cctgcctgca gaacagtgcc
601 atcattgcca cgcctgagca gctgcaggcc gcctacgaag acggcttcca ccagtgtgac
661 gccggctggc tggctgacca gactgtcaga taccccatcc acactccccg ggaaggctgc
721 tatggagaca aggatgagtt tcctggtgtg aggacgtatg gcatccgaga caccaacgag
781 acctatgatg tgtactgctt cgccgaggag atggagggtg aggtctttta tgcaacatct
841 ccagagaagt tcaccttcca ggaagcagcc aatgagtgcc ggcggctggg tgcccggctg
901 gccaccacgg gccacgtcta cctggcctgg caggctggca tggacatgtg cagcgccggc
961 tggctggccg accgcagcgt gcgctacccc atctccaagg cccggcccaa ctgcggtggc
1021 aacctcctgg gcgtgaggac cgtctacgtg catgccaacc agacgggcta ccccgacccc
1081 tcatcccgct acgacgccat ctgctacaca ggtgaagact ttgtggacat cccagaaaac
1141 ttctttggag tggggggtga ggaggacatc accgtccaga cagtgacctg gcctgacatg
1201 gagctgccac tgcctcgaaa catcactgag ggtgaagccc gaggcagcgt gatccttacc
1261 gtaaagccca tcttcgaggt ctcccccagt cccctggaac ccgaggagcc cttcacgttt
1321 gcccctgaaa taggggccac tgccttcgct gaggttgaga atgagactgg agaggccacc
1381 aggccctggg gctttcccac acctggcctg ggccctgcca cggcattcac cagtgaggac
1441 ctcgtcgtgc aggtgaccgc tgtccctggg cagccgcatt tgccaggggg ggtcgtcttc
1501 cactaccgcc cgggacccac ccgctactcg ctgacctttg aggaggcaca gcaggcctgc
1561 cctggcacgg gggcggtcat tgcctcgccg gagcagctcc aggccgccta cgaagcaggc
1621 tatgagcagt gtgacgccgg ctggctgcgg gaccagaccg tcagataccc cattgtgagc
1681 ccacggaccc catgcgtggg tgacaaggac agcagcccag gggtcaggac ctatggcgtg
1741 cgcccatcaa cagagaccta cgatgtctac tgctttgtag acagacttga gggggaggtg
1801 ttcttcgcca cacgccttga gcagttcacc ttccaggaag cactggagtt ctgtgaatct
1861 cacaatgcca ctgccaccac gggccagctc tacgccgcct ggagccgcgg cctggacaag
1921 tgctatgccg gctggctggc cgacggcagc ctccgctacc ccatcgtcac cccaaggcct
1981 gcctgcggtg gggacaagcc aggcgtgaga acggtctacc tctaccctaa ccagacgggc
2041 ctcccagacc cactgtcccg gcaccatgcc ttctgcttcc gaggcatttc agcggttcct
2101 tctccaggag aagaagaggg tggcacaccc acatcaccct ctggtgtgga ggagtggatc
2161 gtgacccaag tggttcctgg tgtggctgct gtccccgtag aagaggagac aactgctgta
2221 ccctcagggg agactactgc catcctagag ttcaccaccg agccagaaaa ccagacagaa
2281 tgggaaccag cctatacccc agtgggcaca tccccgctgc cagggatcct tcctacttgg
2341 cctcctactg gcgccgaaac agaggaaagt acagaaggcc cttctgcaac tgaagtgccc
2401 tctgcctcag aggaaccatc cccctcagag gtgccattcc cctcagagga gccatccccc
2461 tcagaggaac cattcccctc agtgaggcca ttcccctcag tggagctgtt cccctcagag
2521 gagccattcc cctccaagga gccatccccc tcagaggaac catcagcctc agaagagccg
2581 tatacacctt caccccccga gcccagctgg actgagctgc ccagctctgg ggaggaatct
2641 ggggcccctg atgtcagtgg tgacttcaca ggcagtggag atgtttcagg acaccttgac
2701 ttcagtgggc agctgtcagg ggacagggca agtggactgc cctctggaga cctggactcc
2761 agtggtctta cttccacagt gggctcaggc ctgactgtgg aaagtggact accctcaggg
2821 gatgaagaga gaattgagtg gcccagcact cctacggttg gtgaactgcc ctctggagct
2881 gagatcctag agggctctgc ctctggagtt ggggatctca gtggacttcc ttctggagaa
2941 gttctagaga cctctgcctc tggagtagga gacctcagtg ggcttccttc tggagaagtt
3001 ctagagacca ctgcccctgg agtagaggac atcagcgggc ttccttctgg agaagttcta
3061 gagaccactg cccctggagt agaggacatc agcgggcttc cttctggaga agttctagag
3121 accactgccc ctggagtaga ggacatcagc gggcttcctt ctggagaagt tctagagacc
3181 actgcccctg gagtagagga catcagcggg cttccttctg gagaagttct agagaccact
3241 gcccctggag tagaggacat cagcgggctt ccttctggag aagttctaga gaccgctgcc
3301 cctggagtag aggacatcag cgggcttcct tctggagaag ttctagagac cgctgcccct
3361 ggagtagagg acatcagcgg gcttccttct ggagaagttc tagagaccgc tgcccctgga
3421 gtagaggaca tcagcgggct tccttctgga gaagttctag agaccgctgc ccctggagta
3481 gaggacatca gcgggcttcc ttctggagaa gttctagaga ccgctgcccc tggagtagag
3541 gacatcagcg ggcttccttc tggagaagtt ctagagaccg ctgcccctgg agtagaggac
3601 atcagcgggc ttccttctgg agaagttcta gagaccgctg cccctggagt agaggacatc
3661 agcgggcttc cttctggaga agttctagag actgctgccc ctggagtaga ggacatcagc
3721 gggcttcctt ctggagaagt tctagagact gctgcccctg gagtagagga catcagcggg
3781 cttccttctg gagaagttct agagactgct gcccctggag tagaggacat cagcgggctt
3841 ccttctggag aagttctaga gactgctgcc cctggagtag aggacatcag cgggcttcct
3901 tctggagaag ttctagagac tactgcccct ggagtagagg agatcagcgg gcttccttct
3961 ggagaagttc tagagactac tgcccctgga gtagatgaga tcagtgggct tccttctgga
4021 gaagttctag agactactgc ccctggagta gaggagatca gcgggcttcc ttctggagaa
4081 gttctagaga cttctacctc tgcggtaggg gacctcagtg gacttccttc tggaggagaa
4141 gttctagaga tttctgtctc tggagtagag gacatcagtg ggcttccttc tggagaggtt
4201 gtagagactt ctgcctctgg aatagaggat gtcagtgaac ttccttcagg agaaggtcta
4261 gagacctctg cttctggagt agaggacctc agcaggctcc cttctggaga agaagttcta
4321 gagatttctg cctctggatt tggggacctc agtggagttc cttctggagg agaaggtcta
4381 gagacctctg cttctgaagt agggactgac ctcagtgggc ttccttctgg aagggagggt
4441 ctagagactt cagcttctgg agctgaggac ctcagtgggt tgccttctgg aaaagaagac
4501 ttggtggggt cagcttctgg agacttggac ttgggcaaac tgccttctgg aactctagga
4561 agtgggcaag ctccagaaac aagtggtctt ccctctggat ttagtggtga gtattctggg
4621 gtggaccttg gaagtggccc accctctggc ctgcctgact ttagtggact tccatctgga
4681 ttcccaactg tttccctagt ggattctaca ttggtggaag tggtcacagc ctccactgca
4741 agtgaactgg aagggagggg aaccattggc atcagtggtg caggagaaat atctggactg
4801 ccctccagtg agctggacat tagtgggaga gctagtggac tcccttcagg aactgaactc
4861 agtggccaag catctgggtc tcctgatgtc agtggggaaa tacctggact ctttggtgtc
4921 agtggacagc catcagggtt tcctgacact agtggggaaa catctggagt gactgagctt
4981 agcgggctgt cctctggaca accaggtgtt agtggagaag catctggagt tctttatggc
5041 actagtcaac cctttggcat aactgatctg agtggagaaa catctggggt ccctgatctc
5101 agtgggcagc cttcagggtt accagggttc agtggggcaa catcaggagt ccctgacctg
5161 gtttctggta ccacgagtgg cagcggtgaa tcttctggga ttacatttgt ggacaccagt
5221 ttggttgaag tggcccctac tacatttaaa gaagaagaag gcttagggtc tgtggaactc
5281 agtggcctcc cttccggaga ggcagatctg tcaggcaaat ctgggatggt ggatgtcagt
5341 ggacagtttt ctggaacagt cgattccagt gggtttacat cccagactcc ggaattcagt
5401 ggcctaccaa gtggcatagc tgaggtcagt ggagaatcct ccagagctga gattgggagc
5461 agcctgccct cgggagcata ttatggcagt ggaactccat ctagtttccc cacggtctct
5521 cttgtagaca gaactttggt ggaatctgta acccaggctc caacagccca agaggcagga
5581 gaagggcctt ctggcatttt agaactcagt ggtgctcatt ctggagcacc agacatgtct
5641 ggggagcatt ctggatttct ggacctaagt gggctgcagt ccgggctgat agagcccagc
5701 ggagagccac caggtactcc atattttagt ggggattttg ccagcaccac caatgtaagt
5761 ggagaatcct ctgtagccat gggcaccagt ggagaggcct caggacttcc agaagttact
5821 ttaatcactt ctgagttcgt ggagggtgtt actgaaccaa ctatttctca ggaactaggc
5881 caaaggcccc ctgtgacaca cacaccccag ctttttgagt ccagtggaaa agtctccaca
5941 gctggggaca ttagtggagc taccccagtg ctccctgggt ctggagtaga agtatcatca
6001 gtcccagaat ctagcagtga gacgtccgcc tatcctgaag ctgggttcgg ggcatctgcc
6061 gcccctgagg ccagcagaga agattctggg tcccctgatc tgagtgaaac cacctctgca
6121 ttccacgaag ctaaccttga gagatcctct ggcctaggag tgagcggcag cactttgaca
6181 tttcaagaag gcgaggcgtc cgctgcccca gaagtgagtg gagaatccac caccaccagt
6241 gatgtgggga cagaggcacc aggcttgcct tcagccactc ccacggcttc tggagacagg
6301 actgaaatca gcggagacct gtctggtcac acctcgcagc tgggcgttgt catcagcacc
6361 agcatcccag agtctgagtg gacccagcag acccagcgcc ctgcagagac gcatctagaa
6421 attgagtcct caagcctcct gtactcagga gaagagactc acacagtcga aacagccacc
6481 tccccaacag atgcttccat cccagcttct ccggaatgga aacgtgaatc agaatcaact
6541 gctgcagacc aggaggtatg tgaggagggc tggaacaagt accagggcca ctgttaccgc
6601 cacttcccgg accgcgagac ctgggtggat gctgagcgcc ggtgtcggga gcagcagtca
6661 cacctgagca gcatcgtcac ccccgaggag caggagtttg tcaacaacaa tgcccaagac
6721 taccagtgga tcggcctgaa cgacaggacc atcgaagggg acttccgctg gtcagatgga
6781 caccccatgc aatttgagaa ctggcgcccc aaccagcctg acaacttttt tgccgctgga
6841 gaggactgtg tggtgatgat ctggcacgag aagggcgagt ggaatgatgt tccctgcaat
6901 taccacctcc ccttcacgtg taaaaagggc acagccacca cctacaaacg cagactacag
6961 aagcggagct cacggcaccc tcggaggagc cgccccagca cagcccactg agaagagctt
7021 ccaggacgca cccaggacgc tgagcccagg agcctgccag gctgacgtgc atcccaccca
7081 gacggtgtcc tcttcttgtc gctttttgtc atataaggaa tcccattaaa aaaaaaa
//