LOCUS       HUMNFR                  3683 bp    mRNA    linear   HUM 07-JAN-1995
DEFINITION  Human tumor necrosis factor receptor mRNA, complete cds.
ACCESSION   M32315
VERSION     M32315.1
KEYWORDS    c-myc proto-oncogene; necrosis factor receptor.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3683)
  AUTHORS   Smith,C.A., Davis,T., Anderson,D., Solam,L., Beckmann,M.P.,
            Jerzy,R., Dower,S.K., Cosman,D. and Goodwin,R.G.
  TITLE     A receptor for tumor necrosis factor defines an unusual family of
            cellular and viral proteins
  JOURNAL   Science 248 (4958), 1019-1023 (1990)
   PUBMED   2160731
COMMENT     Original source text: Homo sapiens lung cDNA to mRNA.
            Draft entry and computer-readable sequence for [1] kindly submitted
            by C.A.Smith, 30-MAR-1990, for release after publication.
FEATURES             Location/Qualifiers
     source          1..3683
                     /db_xref="H-InvDB:HIT000195467"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /cell_line="WI26-VA4"
                     /cell_type="fibroblast"
                     /tissue_type="lung"
     gene            1..3683
                     /gene="tnfr"
     CDS             90..1475
                     /gene="tnfr"
                     /codon_start=1
                     /product="tumor necrosis factor receptor"
                     /protein_id="AAA59929.1"
                     /db_xref="GI:189186"
                     /translation="MAPVAVWAALAVGLELWAAAHALPAQVAFTPYAPEPGSTCRLRE
                     YYDQTAQMCCSKCSPGQHAKVFCTKTSDTVCDSCEDSTYTQLWNWVPECLSCGSRCSS
                     DQVETQACTREQNRICTCRPGWYCALSKQEGCRLCAPLRKCRPGFGVARPGTETSDVV
                     CKPCAPGTFSNTTSSTDICRPHQICNVVAIPGNASMDAVCTSTSPTRSMAPGAVHLPQ
                     PVSTRSQHTQPTPEPSTAPSTSFLLPMGPSPPAEGSTGDFALPVGLIVGVTALGLLII
                     GVVNCVIMTQVKKKPLCLQREAKVPHLPADKARGTQGPEQQHLLITAPSSSSSSLESS
                     ASALDRRAPTRNQPQAPGVEASGAGEARASTGSSDSSPGGHGTQVNVTCIVNVCSSSD
                     HSSQCSSQASSTMGDTDSSPSESPKDEQVPFSKEECAFRSQLETPETLLGSTEEKPLP
                     LGVPDAGMKPS"
     sig_peptide     90..155
                     /gene="tnfr"
     mat_peptide     156..1472
                     /gene="tnfr"
                     /product="tumor necrosis factor receptor"
BASE COUNT          781 a         1098 c         1086 g          718 t
ORIGIN      
        1 gcgagcgcag cggagcctgg agagaaggcg ctgggctgcg agggcgcgag ggcgcgaggg
       61 cagggggcaa ccggaccccg cccgcaccca tggcgcccgt cgccgtctgg gccgcgctgg
      121 ccgtcggact ggagctctgg gctgcggcgc acgccttgcc cgcccaggtg gcatttacac
      181 cctacgcccc ggagcccggg agcacatgcc ggctcagaga atactatgac cagacagctc
      241 agatgtgctg cagcaaatgc tcgccgggcc aacatgcaaa agtcttctgt accaagacct
      301 cggacaccgt gtgtgactcc tgtgaggaca gcacatacac ccagctctgg aactgggttc
      361 ccgagtgctt gagctgtggc tcccgctgta gctctgacca ggtggaaact caagcctgca
      421 ctcgggaaca gaaccgcatc tgcacctgca ggcccggctg gtactgcgcg ctgagcaagc
      481 aggaggggtg ccggctgtgc gcgccgctgc gcaagtgccg cccgggcttc ggcgtggcca
      541 gaccaggaac tgaaacatca gacgtggtgt gcaagccctg tgccccgggg acgttctcca
      601 acacgacttc atccacggat atttgcaggc cccaccagat ctgtaacgtg gtggccatcc
      661 ctgggaatgc aagcatggat gcagtctgca cgtccacgtc ccccacccgg agtatggccc
      721 caggggcagt acacttaccc cagccagtgt ccacacgatc ccaacacacg cagccaactc
      781 cagaacccag cactgctcca agcacctcct tcctgctccc aatgggcccc agccccccag
      841 ctgaagggag cactggcgac ttcgctcttc cagttggact gattgtgggt gtgacagcct
      901 tgggtctact aataatagga gtggtgaact gtgtcatcat gacccaggtg aaaaagaagc
      961 ccttgtgcct gcagagagaa gccaaggtgc ctcacttgcc tgccgataag gcccggggta
     1021 cacagggccc cgagcagcag cacctgctga tcacagcgcc gagctccagc agcagctccc
     1081 tggagagctc ggccagtgcg ttggacagaa gggcgcccac tcggaaccag ccacaggcac
     1141 caggcgtgga ggccagtggg gccggggagg cccgggccag caccgggagc tcagattctt
     1201 cccctggtgg ccatgggacc caggtcaatg tcacctgcat cgtgaacgtc tgtagcagct
     1261 ctgaccacag ctcacagtgc tcctcccaag ccagctccac aatgggagac acagattcca
     1321 gcccctcgga gtccccgaag gacgagcagg tccccttctc caaggaggaa tgtgcctttc
     1381 ggtcacagct ggagacgcca gagaccctgc tggggagcac cgaagagaag cccctgcccc
     1441 ttggagtgcc tgatgctggg atgaagccca gttaaccagg ccggtgtggg ctgtgtcgta
     1501 gccaaggtgg gctgagccct ggcaggatga ccctgcgaag gggccctggt ccttccaggc
     1561 ccccaccact aggactctga ggctctttct gggccaagtt cctctagtgc cctccacagc
     1621 cgcagcctcc ctctgacctg caggccaaga gcagaggcag cgagttgggg aaagcctctg
     1681 ctgccatggt gtgtccctct cggaaggctg gctgggcatg gacgttcggg gcatgctggg
     1741 gcaagtccct gactctctgt gacctgcccc gcccagctgc acctgccagc ctggcttctg
     1801 gagcccttgg gttttttgtt tgtttgtttg tttgtttgtt tgtttctccc cctgggctct
     1861 gcccagctct ggcttccaga aaaccccagc atccttttct gcagaggggc tttctggaga
     1921 ggagggatgc tgcctgagtc acccatgaag acaggacagt gcttcagcct gaggctgaga
     1981 ctgcgggatg gtcctggggc tctgtgtagg gaggaggtgg cagccctgta gggaacgggg
     2041 tccttcaagt tagctcagga ggcttggaaa gcatcacctc aggccaggtg cagtggctca
     2101 cgcctatgat cccagcactt tgggaggctg aggcgggtgg atcacctgag gttaggagtt
     2161 cgagaccagc ctggccaaca tggtaaaacc ccatctctac taaaaataca gaaattagcc
     2221 gggcgtggtg gcgggcacct atagtcccag ctactcagaa gcctgaggct gggaaatcgt
     2281 ttgaacccgg gaagcggagg ttgcagggag ccgagatcac gccactgcac tccagcctgg
     2341 gcgacagagc gagagtctgt ctcaaaagaa aaaaaaaaaa gcaccgcctc caaatgctaa
     2401 cttgtccttt tgtaccatgg tgtgaaagtc agatgcccag agggcccagg caggccacca
     2461 tattcagtgc tgtggcctgg gcaagataac gcacttctaa ctagaaatct gccaattttt
     2521 taaaaaagta agtaccactc aggccaacaa gccaacgaca aagccaaact ctgccagcca
     2581 catccaaccc cccacctgcc atttgcaccc tccgccttca ctccggtgtg cctgcagccc
     2641 cgcgcctcct tccttgctgt cctaggccac accatctcct ttcagggaat ttcaggaact
     2701 agagatgact gagtcctcgt agccatctct ctactcctac ctcagcctag accctcctcc
     2761 tcccccagag gggtgggttc ctcttcccca ctccccacct tcaattcctg ggccccaaac
     2821 gggctgccct gccactttgg tacatggcca gtgtgatccc aagtgccagt cttgtgtctg
     2881 cgtctgtgtt gcgtgtcgtg ggtgtgtgta gccaaggtcg gtaagttgaa tggcctgcct
     2941 tgaagccact gaagctggga ttcctcccca ttagagtcag ccttccccct cccagggcca
     3001 gggccctgca gaggggaaac cagtgtagcc ttgcccggat tctgggagga agcaggttga
     3061 ggggctcctg gaaaggctca gtctcaggag catggggata aaggagaagg catgaaattg
     3121 tctagcagag caggggcagg gtgataaatt gttgataaat tccactggac ttgagcttgg
     3181 cagctgaact attggagggt gggagagccc agccattacc atggagacaa gaagggtttt
     3241 ccaccctgga atcaagatgt cagactggct ggctgcagtg acgtgcacct gtactcagga
     3301 ggctgagggg aggatcactg gagcccagga gtttgaggct gcagcgagct atgatcgcgc
     3361 cactacactc cagcctgagc aacagagtga gaccctgtct cttaaagaaa aaaaaagtca
     3421 gactgctggg actggccagg tttctgccca cattggaccc acatgaggac atgatggagc
     3481 gcacctgccc cctggtggac agtcctggga gaacctcagg cttccttggc atcacagggc
     3541 agagccggga agcgatgaat ttggagactc tgtggggcct tggttccctt gtgtgtgtgt
     3601 gttgatccca agacaatgaa agtttgcact gtatgctgga cggcattcct gcttatcaat
     3661 aaacctgttt gttttaaaaa aaa
//