LOCUS HUMERCC3A 2751 bp mRNA linear HUM 07-NOV-1994
DEFINITION Human DNA repair helicase (ERCC3) mRNA, complete cds.
ACCESSION M31899
VERSION M31899.1
KEYWORDS Cockayne's syndrome; DNA repair protein; excision repair protein;
helicase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2751)
AUTHORS Weeda,G., van Ham,R.C., Vermeulen,W., Bootsma,D., van der Eb,A.J.
and Hoeijmakers,J.H.
TITLE A presumed DNA helicase encoded by ERCC-3 is involved in the human
repair disorders xeroderma pigmentosum and Cockayne's syndrome
JOURNAL Cell 62 (4), 777-791 (1990)
PUBMED 2167179
REFERENCE 2 (sites)
AUTHORS Weeda,G., van Ham,R.C., Masurel,R., Westerveld,A., Odijk,H., de
Wit,J., Bootsma,D., van der Eb,A.J. and Hoeijmakers,J.H.
TITLE Molecular cloning and biological characterization of the human
excision repair gene ERCC-3
JOURNAL Mol. Cell. Biol. 10 (6), 2570-2581 (1990)
PUBMED 2111438
COMMENT Original source text: Human lymphoid cell line K562 cDNA to mRNA.
[2] sites.
Draft entry and computer-readable sequence for [2] kindly submitted
by G. Weeda, 07-FEB-1990, for release after publication.
FEATURES Location/Qualifiers
source 1..2751
/db_xref="H-InvDB:HIT000195445"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="2q21"
gene 1..2751
/gene="ERCC3"
CDS 96..2444
/gene="ERCC3"
/note="DNA repair helicase"
/codon_start=1
/protein_id="AAA52396.1"
/db_xref="GDB:G00-119-881"
/translation="MGKRDRADRDKKKSRKRHYEDEEDDEEDAPGNDPQEAVPSAAGK
QVDESGTKVDEYGAKDYRLQMPLKDDHTSRPLWVAPDGHIFLEAFSPVYKYAQDFLVA
IAEPVCRPTHVHEYKLTAYSLYAAVSVGLQTSDITEYLRKLSKTGVPDGIMQFIKLCT
VSYGKVKLVLKHNRYFVESCHPDVIQHLLQDPVIRECRLRNSEGEATELITETFTSKS
AISKTAESSGGPSTSRVTDPQGKSDIPMDLFDFYEQMDKDEEEEEETQTVSFEVKQEM
IEELQKRCIHLEYPLLAEYDFRNDSVNPDINIDLKPTAVLRPYQEKSLRKMFGNGRAR
SGVIVLPCGAGKSLVGVTAACTVRKRCLVLGNSAVSVEQWKAQFKMWSTIDDSQICRF
TSDAKDKPIGCSVAISTYSMLGHTTKRSWEAERVMEWLKTQEWGLMILDEVHTIPAKM
FRRVLTIVQAHCKLGLTATLVREDDKIVDLNFLIGPKLYEANWMELQNNGYIAKVQCA
EVWCPMSPEFYREYVAIKTKKRILLYTMNPNKFRACQFLIKFHERRNDKIIVFADNVF
ALKEYAIRLNKPYIYGPTSQGERMQILQNFKHNPKINTIFISKVGDTSFDLPEANVLI
QISSHGGSRRQEAQRLGRVLRAKKGMVAEEYNAFFYSLVSQDTQEMAYSTKRQRFLVD
QGYSFKVITKLAGMEEEDLAFSTKEEQQQLLQKVLAATDLDAEEEVVAGEFGSRSSQA
SRRFGTMSSMSGADDTVYMEYHSSRSKAPSKHVHPLFKRFRK"
BASE COUNT 727 a 668 c 726 g 630 t
ORIGIN
1 gggagcttcc ggattgagcc ggaagtcccc ccagagcgga tgccgcggcg ggcctgtggg
61 agcggggtca tcttctctct gctgctgtag ctgccatggg caaaagagac cgagcggacc
121 gcgacaagaa gaaatccagg aagcggcact atgaggatga agaggatgat gaagaggacg
181 ccccggggaa cgaccctcag gaagcggttc cctcggcggc ggggaagcag gtggatgagt
241 caggcaccaa agtggatgaa tatggagcca aggactacag gctgcaaatg ccgctgaagg
301 acgaccacac ctccaggccc ctctgggtgg ctcccgatgg ccatatcttc ttggaagcct
361 tctctccagt ttacaaatat gcccaagact tcttggtggc tattgcagag ccagtgtgcc
421 gaccaaccca tgtgcatgag tacaaactaa ctgcctactc cttgtatgca gctgtcagcg
481 ttgggctgca aaccagtgac atcaccgagt acctcaggaa gctcagcaag actggagtcc
541 ctgatggaat tatgcagttt attaagttgt gtactgtcag ctatggaaaa gtcaagctgg
601 tcttgaagca caacagatac ttcgttgaaa gttgccaccc tgatgtaatc cagcatcttc
661 tccaggaccc cgtgatccga gaatgccgct taagaaactc tgaaggggag gccactgagc
721 tcatcacaga gactttcaca agcaaatctg ccatttctaa gactgctgaa agcagtggtg
781 ggccctccac ttcccgagtg acagatccac agggtaaatc tgacatcccc atggacctgt
841 ttgacttcta tgagcaaatg gacaaggatg aagaagaaga agaagagaca cagacagtgt
901 cttttgaagt caagcaggaa atgattgagg aactccagaa acgttgcatc cacctggagt
961 accctctgtt ggcagaatat gacttccgga atgattctgt caaccctgat atcaacattg
1021 acctaaagcc cacagctgtc ctcagaccct atcaggagaa gagcttgcga aagatgtttg
1081 gaaacgggcg tgcacgttcg ggggtcattg ttcttccctg cggtgctgga aagtccctgg
1141 ttggtgtgac tgctgcatgc actgtcagaa aacgctgtct ggtgctgggc aactcagctg
1201 tttctgtgga gcagtggaaa gcccagttca agatgtggtc caccattgac gacagccaga
1261 tctgccggtt cacctccgat gccaaggaca agcccatcgg ctgctccgtt gccattagca
1321 cctactccat gctgggccac accaccaaaa ggtcctggga ggccgagcga gtcatggagt
1381 ggctcaagac ccaggagtgg ggcctcatga tcctggatga agtgcacacc ataccagcca
1441 agatgttccg aagggtgctc accatcgtgc aggcccactg taagctgggt ttgactgcga
1501 ccctcgtccg cgaagatgac aaaattgtgg atttaaattt tctgattggg cctaagctct
1561 acgaagccaa ctggatggag ctgcagaata atggctacat cgccaaagtc cagtgtgctg
1621 aggtctggtg ccctatgtct cctgaatttt accgggaata tgtggcaatc aaaaccaaga
1681 aacgaatctt gctgtacacc atgaacccca acaaatttag agcttgccag tttctgatca
1741 agtttcatga aaggaggaat gacaagatta ttgtctttgc tgacaatgtg tttgccctaa
1801 aggaatatgc cattcgactg aacaaaccct atatctacgg acctacgtct cagggggaaa
1861 ggatgcaaat tctccagaat ttcaagcaca accccaaaat taacaccatc ttcatatcca
1921 aggtaggtga cacttcgttt gatctgccgg aagcaaatgt cctcattcag atctcatccc
1981 atggtggctc caggcgtcag gaagcccaaa ggctagggcg ggtgcttcga gctaaaaaag
2041 ggatggttgc agaagagtac aatgcctttt tctactcact ggtatcccag gacacacagg
2101 aaatggctta ctcaaccaag cggcagagat tcttggtaga tcaaggttat agcttcaagg
2161 tgatcacgaa actcgctggc atggaggagg aagacttggc gttttcgaca aaagaagagc
2221 aacagcagct cttacagaaa gtcctggcag ccactgacct ggatgccgag gaggaggtgg
2281 tggctgggga atttggctcc agatccagcc aggcatctcg gcgctttggc accatgagtt
2341 ctatgtctgg ggccgacgac actgtgtaca tggagtacca ctcatcgcgg agcaaggcgc
2401 ccagcaaaca tgtacacccg ctcttcaagc gctttaggaa atgatgctta ggcagggtac
2461 ttcgttcaag accggcgctt ggcacccttg ttggaaaggg attttcagca taacattttc
2521 cttccacctc tttgaccttc cctccagcgt tggccaaatt gtgctgagga agatgcatca
2581 agggcttggc tgtgccttca taggtcatct agggttttat aaaggaggag gagacaatat
2641 tttttcaaac tttttgggga gtggggtcat ttctgtatat aaaaaatgtt aatatttaag
2701 gtgtatttat gttaccgttc tgaataaaca gaatggacca ttgaaccagt a
//