LOCUS HUMTYRA 2384 bp mRNA linear HUM 02-DEC-1996 DEFINITION Human tyrosinase (TYR) mRNA, complete cds. ACCESSION M27160 VERSION M27160.1 KEYWORDS tyrosinase. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 601 to 2384) AUTHORS Shibahara,S., Tomita,Y., Tagami,H., Muller,R.M. and Cohen,T. TITLE Molecular basis for the heterogeneity of human tyrosinase JOURNAL Tohoku J. Exp. Med. 156 (4), 403-414 (1988) PUBMED 2854305 REFERENCE 2 (bases 1 to 600) AUTHORS Takeda,A., Tomita,Y., Okinaga,S., Tagami,H. and Shibahara,S. TITLE Functional analysis of the cDNA encoding human tyrosinase precursor JOURNAL Biochem. Biophys. Res. Commun. 162 (3), 984-990 (1989) PUBMED 2504160 COMMENT On Dec 2, 1996 this sequence version replaced gi:340036. Draft entry and computer-readable copy of sequence [1] kindly provided by S.Shibahara, 15-AUG-1989. FEATURES Location/Qualifiers source 1..2384 /db_xref="H-InvDB:HIT000195113" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="11" /map="11q14-q21" /cell_line="MeWo melanoma DNA, and cDNA to mRNA" /tissue_type="placenta" gene 1..2384 /gene="TYR" regulatory 392..399 /regulatory_class="TATA_box" /gene="TYR" mRNA 421..2384 /gene="TYR" /product="tyrosinase mRNA" CDS 503..2092 /gene="TYR" /EC_number="1.14.18.1" /codon_start=1 /product="tyrosinase precursor" /protein_id="AAB37227.1" /db_xref="GDB:G00-120-476" /translation="MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRS PCGQLSGRGSCQNILLSNAPLGPQFPFTGVDDRESWPSVFYNRTCQCSGNFMGFNCGN CKFGFWGPNCTERRLLVRRNIFDLSAPEKDKFFAYLTLAKHTISSDYVIPIGTYGQMK NGSTPMFNDINIYDLFVWMHYYVSMDALLGGSEIWRDIDFAHEAPAFLPWHRLFLLRW EQEIQKLTGDENFTIPYWDWRDAEKCDICTDEYMGGQHPTNPNLLSPASFFSSWQIVC SRLEEYNSHQSLCNGTPEGPLRRNPGNHDKSRTPRLPSSADVEFCLSLTQYESGSMDK AANFSFRNTLEGFASPLTGIADASQSSMHNALHIYMNGTMSQVQGSANDPIFLLHHAF VDSIFEQWLRRHRPLQEVYPEANAPIGHNRESYMVPFIPLYRNGDFFISSKDLGYDYS YLQDSDPDSFQDYIKSYLEQASRIWSWLLGAAMVGAVLTALLAGLVSLLCRHKRKQLP EEKQPLLMEKEDYHSLYQSHL" sig_peptide 503..556 /gene="TYR" mat_peptide 557..2089 /gene="TYR" /product="tyrosinase" BASE COUNT 652 a 533 c 520 g 679 t ORIGIN 1 tattgagttc ttcaaacatt gtagcctctt tatggtctct gagaaataac taccttaaac 61 ccataatctt taatacttcc taaactttct taataagaga agctctattc ctgacactac 121 ctctcatttg caaggtcaaa tcatcattag ttttgtagtc tattaactgg gtttgcttag 181 gtcaggcatt attattacta accttattgt taatattcta accataagaa ttaaactatt 241 aatggtgaat agagtttttc actttaacat aggcctatcc cactggtggg atacgagcca 301 attcgaaaga aaagtcagtc atgtgctttt cagaggatga aagcttaaga taaagactaa 361 aagtgtttga tgctggaggt gggagtggta ttatataggt ctcagccaag acatgtgata 421 atcactgtag tagtagctgg aaagagaaat ctgtgactcc aattagccag ttcctgcaga 481 ccttgtgagg actagaggaa gaatgctcct ggctgttttg tactgcctgc tgtggagttt 541 ccagacctcc gctggccatt tccctagagc ctgtgtctcc tctaagaacc tgatggagaa 601 ggaatgctgt ccaccgtgga gcggggacag gagtccctgt ggccagcttt caggcagagg 661 ttcctgtcag aatatccttc tgtccaatgc accacttggg cctcaatttc ccttcacagg 721 ggtggatgac cgggagtcgt ggccttccgt cttttataat aggacctgcc agtgctctgg 781 caacttcatg ggattcaact gtggaaactg caagtttggc ttttggggac caaactgcac 841 agagagacga ctcttggtga gaagaaacat cttcgatttg agtgccccag agaaggacaa 901 attttttgcc tacctcactt tagcaaagca taccatcagc tcagactatg tcatccccat 961 agggacctat ggccaaatga aaaatggatc aacacccatg tttaacgaca tcaatattta 1021 tgacctcttt gtctggatgc attattatgt gtcaatggat gcactgcttg ggggatctga 1081 aatctggaga gacattgatt ttgcccatga agcaccagct tttctgcctt ggcatagact 1141 cttcttgttg cggtgggaac aagaaatcca gaagctgaca ggagatgaaa acttcactat 1201 tccatattgg gactggcggg atgcagaaaa gtgtgacatt tgcacagatg agtacatggg 1261 aggtcagcac cccacaaatc ctaacttact cagcccagca tcattcttct cctcttggca 1321 gattgtctgt agccgattgg aggagtacaa cagccatcag tctttatgca atggaacgcc 1381 cgagggacct ttacggcgta atcctggaaa ccatgacaaa tccagaaccc caaggctccc 1441 ctcttcagct gatgtagaat tttgcctgag tttgacccaa tatgaatctg gttccatgga 1501 taaagctgcc aatttcagct ttagaaatac actggaagga tttgctagtc cacttactgg 1561 gatagcggat gcctctcaaa gcagcatgca caatgccttg cacatctata tgaatggaac 1621 aatgtcccag gtacagggat ctgccaacga tcctatcttc cttcttcacc atgcatttgt 1681 tgacagtatt tttgagcagt ggctccgaag gcaccgtcct cttcaagaag tttatccaga 1741 agccaatgca cccattggac ataaccggga atcctacatg gttcctttta taccactgta 1801 cagaaatggt gatttcttta tttcatccaa agatctgggc tatgactata gctatctaca 1861 agattcagac ccagactctt ttcaagacta cattaagtcc tatttggaac aagcgagtcg 1921 gatctggtca tggctccttg gggcggcgat ggtaggggcc gtcctcactg ccctgctggc 1981 agggcttgtg agcttgctgt gtcgtcacaa gagaaagcag cttcctgaag aaaagcagcc 2041 actcctcatg gagaaagagg attaccacag cttgtatcag agccatttat aaaaggctta 2101 ggcaatagag tagggccaaa aagcctgacc tcactctaac tcaaagtaat gtccaggttc 2161 ccagagaata tctgctggta tttttctgta aagaccattt gcaaaattgt aacctaatac 2221 aaagtgtagc cttcttccaa ctcaggtaga acacacctgt ctttgtcttg ctgttttcac 2281 tcagcccttt taacattttc ccctaagccc atatgtctaa ggaaaggatg ctatttggta 2341 atgaggaact gttatttgta tgtgaattaa agtgctctta tttt //