LOCUS       HUMTYRA                 2384 bp    mRNA    linear   HUM 02-DEC-1996
DEFINITION  Human tyrosinase (TYR) mRNA, complete cds.
ACCESSION   M27160
VERSION     M27160.1
KEYWORDS    tyrosinase.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 601 to 2384)
  AUTHORS   Shibahara,S., Tomita,Y., Tagami,H., Muller,R.M. and Cohen,T.
  TITLE     Molecular basis for the heterogeneity of human tyrosinase
  JOURNAL   Tohoku J. Exp. Med. 156 (4), 403-414 (1988)
   PUBMED   2854305
REFERENCE   2  (bases 1 to 600)
  AUTHORS   Takeda,A., Tomita,Y., Okinaga,S., Tagami,H. and Shibahara,S.
  TITLE     Functional analysis of the cDNA encoding human tyrosinase precursor
  JOURNAL   Biochem. Biophys. Res. Commun. 162 (3), 984-990 (1989)
   PUBMED   2504160
COMMENT     On Dec 2, 1996 this sequence version replaced gi:340036.
            Draft entry and computer-readable copy of sequence [1] kindly
            provided by S.Shibahara, 15-AUG-1989.
FEATURES             Location/Qualifiers
     source          1..2384
                     /db_xref="H-InvDB:HIT000195113"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q14-q21"
                     /cell_line="MeWo melanoma DNA, and cDNA to mRNA"
                     /tissue_type="placenta"
     gene            1..2384
                     /gene="TYR"
     regulatory      392..399
                     /regulatory_class="TATA_box"
                     /gene="TYR"
     mRNA            421..2384
                     /gene="TYR"
                     /product="tyrosinase mRNA"
     CDS             503..2092
                     /gene="TYR"
                     /EC_number="1.14.18.1"
                     /codon_start=1
                     /product="tyrosinase precursor"
                     /protein_id="AAB37227.1"
                     /db_xref="GI:340037"
                     /db_xref="GDB:G00-120-476"
                     /translation="MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRS
                     PCGQLSGRGSCQNILLSNAPLGPQFPFTGVDDRESWPSVFYNRTCQCSGNFMGFNCGN
                     CKFGFWGPNCTERRLLVRRNIFDLSAPEKDKFFAYLTLAKHTISSDYVIPIGTYGQMK
                     NGSTPMFNDINIYDLFVWMHYYVSMDALLGGSEIWRDIDFAHEAPAFLPWHRLFLLRW
                     EQEIQKLTGDENFTIPYWDWRDAEKCDICTDEYMGGQHPTNPNLLSPASFFSSWQIVC
                     SRLEEYNSHQSLCNGTPEGPLRRNPGNHDKSRTPRLPSSADVEFCLSLTQYESGSMDK
                     AANFSFRNTLEGFASPLTGIADASQSSMHNALHIYMNGTMSQVQGSANDPIFLLHHAF
                     VDSIFEQWLRRHRPLQEVYPEANAPIGHNRESYMVPFIPLYRNGDFFISSKDLGYDYS
                     YLQDSDPDSFQDYIKSYLEQASRIWSWLLGAAMVGAVLTALLAGLVSLLCRHKRKQLP
                     EEKQPLLMEKEDYHSLYQSHL"
     sig_peptide     503..556
                     /gene="TYR"
     mat_peptide     557..2089
                     /gene="TYR"
                     /product="tyrosinase"
BASE COUNT          652 a          533 c          520 g          679 t
ORIGIN      
        1 tattgagttc ttcaaacatt gtagcctctt tatggtctct gagaaataac taccttaaac
       61 ccataatctt taatacttcc taaactttct taataagaga agctctattc ctgacactac
      121 ctctcatttg caaggtcaaa tcatcattag ttttgtagtc tattaactgg gtttgcttag
      181 gtcaggcatt attattacta accttattgt taatattcta accataagaa ttaaactatt
      241 aatggtgaat agagtttttc actttaacat aggcctatcc cactggtggg atacgagcca
      301 attcgaaaga aaagtcagtc atgtgctttt cagaggatga aagcttaaga taaagactaa
      361 aagtgtttga tgctggaggt gggagtggta ttatataggt ctcagccaag acatgtgata
      421 atcactgtag tagtagctgg aaagagaaat ctgtgactcc aattagccag ttcctgcaga
      481 ccttgtgagg actagaggaa gaatgctcct ggctgttttg tactgcctgc tgtggagttt
      541 ccagacctcc gctggccatt tccctagagc ctgtgtctcc tctaagaacc tgatggagaa
      601 ggaatgctgt ccaccgtgga gcggggacag gagtccctgt ggccagcttt caggcagagg
      661 ttcctgtcag aatatccttc tgtccaatgc accacttggg cctcaatttc ccttcacagg
      721 ggtggatgac cgggagtcgt ggccttccgt cttttataat aggacctgcc agtgctctgg
      781 caacttcatg ggattcaact gtggaaactg caagtttggc ttttggggac caaactgcac
      841 agagagacga ctcttggtga gaagaaacat cttcgatttg agtgccccag agaaggacaa
      901 attttttgcc tacctcactt tagcaaagca taccatcagc tcagactatg tcatccccat
      961 agggacctat ggccaaatga aaaatggatc aacacccatg tttaacgaca tcaatattta
     1021 tgacctcttt gtctggatgc attattatgt gtcaatggat gcactgcttg ggggatctga
     1081 aatctggaga gacattgatt ttgcccatga agcaccagct tttctgcctt ggcatagact
     1141 cttcttgttg cggtgggaac aagaaatcca gaagctgaca ggagatgaaa acttcactat
     1201 tccatattgg gactggcggg atgcagaaaa gtgtgacatt tgcacagatg agtacatggg
     1261 aggtcagcac cccacaaatc ctaacttact cagcccagca tcattcttct cctcttggca
     1321 gattgtctgt agccgattgg aggagtacaa cagccatcag tctttatgca atggaacgcc
     1381 cgagggacct ttacggcgta atcctggaaa ccatgacaaa tccagaaccc caaggctccc
     1441 ctcttcagct gatgtagaat tttgcctgag tttgacccaa tatgaatctg gttccatgga
     1501 taaagctgcc aatttcagct ttagaaatac actggaagga tttgctagtc cacttactgg
     1561 gatagcggat gcctctcaaa gcagcatgca caatgccttg cacatctata tgaatggaac
     1621 aatgtcccag gtacagggat ctgccaacga tcctatcttc cttcttcacc atgcatttgt
     1681 tgacagtatt tttgagcagt ggctccgaag gcaccgtcct cttcaagaag tttatccaga
     1741 agccaatgca cccattggac ataaccggga atcctacatg gttcctttta taccactgta
     1801 cagaaatggt gatttcttta tttcatccaa agatctgggc tatgactata gctatctaca
     1861 agattcagac ccagactctt ttcaagacta cattaagtcc tatttggaac aagcgagtcg
     1921 gatctggtca tggctccttg gggcggcgat ggtaggggcc gtcctcactg ccctgctggc
     1981 agggcttgtg agcttgctgt gtcgtcacaa gagaaagcag cttcctgaag aaaagcagcc
     2041 actcctcatg gagaaagagg attaccacag cttgtatcag agccatttat aaaaggctta
     2101 ggcaatagag tagggccaaa aagcctgacc tcactctaac tcaaagtaat gtccaggttc
     2161 ccagagaata tctgctggta tttttctgta aagaccattt gcaaaattgt aacctaatac
     2221 aaagtgtagc cttcttccaa ctcaggtaga acacacctgt ctttgtcttg ctgttttcac
     2281 tcagcccttt taacattttc ccctaagccc atatgtctaa ggaaaggatg ctatttggta
     2341 atgaggaact gttatttgta tgtgaattaa agtgctctta tttt
//