LOCUS HUMTNFX 3103 bp DNA linear HUM 03-AUG-1993 DEFINITION Human tumor necrosis factor gene, complete cds. ACCESSION M26331 VERSION M26331.1 KEYWORDS tumor necrosis factor. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3103) AUTHORS Marmenout,A., Fransen,L., Tavernier,J., Van Der Heyden,J., Tizard,R., Kawashima,E., Shaw,A., Johnson,M.-J., Semon,D., Mueller,R., Ruysschaert,M.-R., Van Vliet,A. and Fiers,W. TITLE Molecular cloning and expression of human tumor necrosis factor and comparison with mouse tumor necrosis factor JOURNAL Eur. J. Biochem. 152 (3), 515-522 (1985) PUBMED 3932069 COMMENT Original source text: Human histiocytic lymphoma cell line U-937 DNA. FEATURES Location/Qualifiers source 1..3103 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" sig_peptide 362..1403 /note="tumor necrosis factor signal peptide" CDS join(570..755,1362..1407,1595..1642,1944..2365) /note="tumor necrosis factor precursor" /codon_start=1 /protein_id="AAA36758.1" /translation="MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGA TTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQL QWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIA VSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYL DFAESGQVYFGIIAL" sig_peptide 570..755 /note="tumor necrosis factor signal peptide" mat_peptide join(1404..1407,1595..1596) /product="tumor necrosis factor protein" mat_peptide join(1407,1595..1642,1944..1945) /product="tumor necrosis factor protein" mat_peptide join(1642,1944..2362) /product="tumor necrosis factor protein" prim_transcript 570..2365 /note="tumor necrosis factor mRNA and introns" exon <570..755 /note="tumor necrosis factor precursor" /number=1 intron 756..1361 /note="TNF intron A" exon 1362..1407 /number=2 intron 1408..1594 /note="TNF intron B" exon 1595..1642 /number=3 intron 1643..1943 /note="TNF intron C" exon 1944..>2365 /note="tumor necrosis factor precursor" /number=4 BASE COUNT 784 a 781 c 880 g 658 t ORIGIN 263 bp upstream of ApaI site; chromosome 6p21.3. 1 atcctgtctg gaagttagaa ggaaacagac cacagacctg gtccccaaaa gaaatggagg 61 caataggttt tgaggggcat ggggacgggg ttcagcctcc agggtcctac acacaaatca 121 gtcagtggcc cagaagaccc ccctcggaat cggagcaggg aggatgggga gtgtgagggg 181 tatccttgat gcttgtgtgt ccccaacttt ccaaatcccc gcccccgcga tggagaagaa 241 accgagacag aaggtgcagg gcccactacc gcttcctcca gatgagctca tgggtttctc 301 caccaaggaa gttttccgct ggttgaatga ttctttcccc gccctcctct cgccccaggg 361 acatataaag gcagttgttg gcacacccag ccagcagacg ctccctcagc aaggacagca 421 gaggaccagc taagagggag agaagcaact acagaccccc cctgaaaaca accctcagac 481 gccacatccc ctgacaagct gccaggcagg ttctcttcct ctcacatact gacccacggc 541 tccaccctct ctcccctgga aaggacacca tgagcactga aagcatgatc cgggacgtgg 601 agctggccga ggaggcgctc cccaagaaga caggggggcc ccagggctcc aggcggtgct 661 tgttcctcag cctcttctcc ttcctgatcg tggcaggcgc caccacgctc ttctgcctgc 721 tgcactttgg agtgatcggc ccccagaggg aagaggtgag tgcctggcca gccttcatcc 781 actctcccac ccaaggggaa atggagacgc aagagaggga gagagatggg atgggtgaaa 841 gatgtgcgct gatagggagg gatggagaga aaaaaacgtg gagaaagacg gggatgcaga 901 aagagatgtg gcaagagatg gggaagagag agagagaaag atggagagac aggatgtctg 961 gcacatggaa ggtgctcact aagtgtgtat ggagtgaatg aatgaatgaa tgaatgaaca 1021 agcagatata taaataagat atggagacag atgtggggtg tgagaagaga gatgggggaa 1081 gaaacaagtg atatgaataa agatggtgag acagaaagag cgggaaatat gacagctaag 1141 gagagagatg ggggagataa ggagagaaga agatagggtg tctggcacac agaagacact 1201 cagggaaaga gctgttgaat gcctggaagg tgaatacaca gatgaatgga gagagaaaac 1261 cagacacctc agggctaaga gcgcaggcca gacaggcagc cagctgttcc tcctttaagg 1321 gtgactccct cgatgttaac cattctcctt ctccccaaca gttccccagg gacctctctc 1381 taatcagccc tctggcccag gcagtcagta agtgtctcca aacctctttc ctaattctgg 1441 gtttgggttt gggggtaggg ttagtaccgg tatggaagca gtgggggaaa tttaaagttt 1501 tggtcttggg ggaggatgga tggaggtgaa agtagggggg tattttctag gaagtttaag 1561 ggtctcagct ttttcttttc tctctcctct tcaggatcat cttctcgaac cccgagtgac 1621 aagcctgtag cccatgttgt aggtaagagc tctgaggatg tgtcttggaa cttggagggc 1681 taggatttgg ggattgaagc ccggctgatg gtaggcagaa cttggagaca atgtgagaag 1741 gactcgctga gctcaaggga agggtggagg aacagcacag gccttagtgg gatactcaga 1801 acgtcatggc caggtgggat gtgggatgac agacagagag gacaggaacc ggatgtgggg 1861 tgggcagagc tcgagggcca ggatgtggag agtgaaccga catggccaca ctgactctcc 1921 tctccctctc tccctccctc cagcaaaccc tcaagctgag gggcagctcc agtggctgaa 1981 ccgccgggcc aatgccctcc tggccaatgg cgtggagctg agagataacc agctggtggt 2041 gccatcagag ggcctgtacc tcatctactc ccaggtcctc ttcaagggcc aaggctgccc 2101 ctccacccat gtgctcctca cccacaccat cagccgcatc gccgtctcct accagaccaa 2161 ggtcaacctc ctctctgcca tcaagagccc ctgccagagg gagaccccag agggggctga 2221 ggccaagccc tggtatgagc ccatctatct gggaggggtc ttccagctgg agaagggtga 2281 ccgactcagc gctgagatca atcggcccga ctatctcgac tttgccgagt ctgggcaggt 2341 ctactttggg atcattgccc tgtgaggagg acgaacatcc aaccttccca aacgcctccc 2401 ctgccccaat ccctttatta ccccctcctt cagacaccct caacctcttc tggctcaaaa 2461 agagaattgg gggcttaggg tcggaaccca agcttagaac tttaagcaac aagaccacca 2521 cttcgaaacc tgggattcag gaatgtgtgg cctgcacagt gaagtgctgg caaccactaa 2581 gaattcaaac tggggcctcc agaactcact ggggcctaca gctttgatcc ctgacatctg 2641 gaatctggag accagggagc ctttggttct ggccagaatg ctgcaggact tgagaagacc 2701 tcacctagaa attgacacaa gtggacctta ggccttcctc tctccagatg tttccagact 2761 tccttgagac acggagccca gccctcccca tggagccagc tccctctatt tatgtttgca 2821 cttgtgatta tttattattt atttattatt tatttattta cagatgaatg tatttatttg 2881 ggagaccggg gtatcctggg ggacccaatg taggagctgc cttggctcag acatgttttc 2941 cgtgaaaacg gagctgaaca ataggctgtt cccatgtagc cccctggcct ctgtgccttc 3001 ttttgattat gttttttaaa atatttatct gattaagttg tctaaacaat gctgatttgg 3061 tgaccaactg tcactcattg ctgagcctct gctccccagg gga //