LOCUS       HUMBGAL                 2379 bp    mRNA    linear   HUM 31-OCT-1994
DEFINITION  Human beta-galactosidase (GLB1) mRNA, complete cds.
ACCESSION   M22590
VERSION     M22590.1
KEYWORDS    beta-galactosidase.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2379)
  AUTHORS   Oshima,A., Tsuji,A., Nagao,Y., Sakuraba,H. and Suzuki,Y.
  TITLE     Cloning, sequencing, and expression of cDNA for human
            beta-galactosidase
  JOURNAL   Biochem. Biophys. Res. Commun. 157 (1), 238-244 (1988)
   PUBMED   3143362
COMMENT     Original source text: Human placenta (library of J.E.Saddler), cDNA
            to mRNA, clone GP8.
            Draft entry and sequence for [1] kindly submitted by A.Oshima,
            16-FEB-1989.
FEATURES             Location/Qualifiers
     source          1..2379
                     /db_xref="H-InvDB:HIT000194850"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /map="3p23-p22"
     gene            1..2379
                     /gene="GLB1"
     CDS             35..2068
                     /gene="GLB1"
                     /note="beta-galactosidase precursor (EC 3.2.1.23)"
                     /codon_start=1
                     /protein_id="AAA51822.1"
                     /db_xref="GI:179419"
                     /db_xref="GDB:G00-119-987"
                     /translation="MPGFLVRILPLLLVLLLLGPTRGLRNATQRMFEIDYSRDSFLKD
                     GQPFRYISGSIHYSRVPRFYWKDRLLKMKMAGLNAIQTYVPWNFHEPWPGQYQFSEDH
                     DVEYFLRLAHELGLLVILRPGPYICAEWEMGGLPAWLLEKESILLRSSDPDYLAAVDK
                     WLGVLLPKMKPLLYQNGGPVITVQVENEYGSYFACDFDYLAFLQKRFRHHLGDDVVLF
                     TTDGAHKTFLKCGALQGLYTTVDFGTGSNITDAFLSQRKCEPKGPLINSEFYTGWLDH
                     WGQPHSTIKTEAVASSLYDILARGASVNLYMFIGGTNFAYWNGANSPYAAQPTSYDYD
                     APLSEAGDLTEKYFALRNIIQKFEKVPEGPIPPSTPKFAYGKVTLEKLKTVGAALDIL
                     CPSGPIKSLYPLTFIQVKQHYGFVLYRTTLPQDCSNPAPLSSPLNGVHDRAYVAVDGI
                     PQGVLERNNVITLNITGKAGATLDLLVENMGRVNYGAYINDFKGLVSNLTLSSNILTD
                     WTIFPLDTEDAVRSHLGGWGHRDSGHHDEAWAHNSSNYTLPAFYMGNFSIPSGIPDLP
                     QDTFIQFPGWTKGQVWINGFNLGRYWPARGPQLTLFVPQHILMTSAPNTITVLELEWA
                     PCSSDDPELCAVTFVDRPVIGSSVTYDHPSKPVEKRLMPPPPQKNKDSWLDHV"
     sig_peptide     35..103
                     /gene="GLB1"
                     /note="beta-galactosidase signal peptide"
     mat_peptide     104..2065
                     /gene="GLB1"
                     /product="beta-galactosidase"
BASE COUNT          561 a          625 c          601 g          592 t
ORIGIN      Unreported.
        1 gggcgccgac tgcagagccg ggaggctggt ggtcatgccg gggttcctgg ttcgcatcct
       61 ccctctgttg ctggttctgc tgcttctggg ccctacgcgc ggcttgcgca atgccaccca
      121 gaggatgttt gaaattgact atagccggga ctccttcctc aaggatggcc agccatttcg
      181 ctacatctca ggaagcattc actactcccg tgtgccccgc ttctactgga aggaccggct
      241 gctgaagatg aagatggctg ggctgaacgc catccagacg tatgtgccct ggaactttca
      301 tgagccctgg ccaggacagt accagttttc tgaggaccat gatgtggaat attttcttcg
      361 gctggctcat gagctgggac tgctggttat cctgaggccc gggccctaca tctgtgcaga
      421 gtgggaaatg ggaggattac ctgcttggct gctagagaaa gagtctattc ttctccgctc
      481 ctccgaccca gattacctgg cagctgtgga caagtggttg ggagtccttc tgcccaagat
      541 gaagcctctc ctctatcaga atggagggcc agttataaca gtgcaggttg aaaatgaata
      601 tggcagctac tttgcctgtg attttgacta cctcgcgttc ctgcagaagc gctttcgcca
      661 ccatctgggg gatgatgtgg ttctgtttac cactgatgga gcacataaaa cattcctgaa
      721 atgtggggcc ctgcagggcc tctacaccac ggtggacttt ggaacaggca gcaacatcac
      781 agatgctttc ctaagccaga ggaagtgtga gcccaaagga cccttgatca attctgaatt
      841 ctatactggc tggctagatc actggggcca acctcactcc acaatcaaga ccgaagcagt
      901 ggcttcctcc ctctatgata tacttgcccg tggggcgagt gtgaacttgt acatgtttat
      961 aggtgggacc aattttgcct attggaatgg ggccaactca ccctatgcag cacagcccac
     1021 cagctacgac tatgatgccc cactgagtga ggctggggac ctcactgaga agtattttgc
     1081 tctgcgaaac atcatccaga agtttgaaaa agtaccagaa ggtcctatcc ctccatctac
     1141 accaaagttt gcatatggaa aggtcacttt ggaaaagtta aagacagtgg gagcagctct
     1201 ggacattctg tgtccctctg ggcccatcaa aagcctttat cccttgacat ttatccaggt
     1261 gaaacagcat tatgggtttg tgctgtaccg gacaacactt cctcaagatt gcagcaaccc
     1321 agcacctctc tcttcacccc tcaatggagt ccacgatcga gcatatgttg ctgtggatgg
     1381 gatcccccag ggagtccttg agcgaaacaa tgtgatcact ctgaacataa cagggaaagc
     1441 tggagccact ctggaccttc tggtagagaa catgggacgt gtgaactatg gtgcatatat
     1501 caacgatttt aagggtttgg tttctaacct gactctcagt tccaatatcc tcacggactg
     1561 gacgatcttt ccactggaca ctgaggatgc agtgcgcagc cacctggggg gctggggaca
     1621 ccgtgacagt ggccaccatg atgaagcctg ggcccacaac tcatccaact acacgctccc
     1681 ggccttttat atggggaact tctccattcc cagtgggatc ccagacttgc cccaggacac
     1741 ctttatccag tttcctggat ggaccaaggg ccaggtctgg attaatggct ttaaccttgg
     1801 ccgctattgg ccagcccggg gccctcagtt gaccttgttt gtgccccagc acatcctgat
     1861 gacctcggcc ccaaacacca tcaccgtgct ggaactggag tgggcaccct gcagcagtga
     1921 tgatccagaa ctatgtgctg tgacgttcgt ggacaggcca gttattggct catctgtgac
     1981 ctacgatcat ccctccaaac ctgttgaaaa aagactcatg cccccacccc cgcaaaaaaa
     2041 caaagattca tggctggacc atgtatgatg atgaaagcct gtgtctttga gggattctac
     2101 cctgaactaa cctcacagat cctccctgtc atgccacatt tcactgattg gaatgtggaa
     2161 atggaaaagg aatttaggat gtgcattttc acctgaggtt tccctgcatc cctgcagtgc
     2221 caaagcccca ccttcaggga ccacctggaa tgtgtgaggg gctgacagca cagtaacgtg
     2281 catacatatc tgcagggctg gaatggaagc tttaaaggtg gtagtgattt ttattttgga
     2341 agaatcatgt tacctttttg ttaaataaaa tttgtactc
//