LOCUS       HUMPDGFR                5427 bp    mRNA    linear   HUM 27-APR-1993
DEFINITION  Human platelet-derived growth factor (PDGF) receptor mRNA, complete
            cds.
ACCESSION   M21616
VERSION     M21616.1
KEYWORDS    platelet-derived growth factor.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5427)
  AUTHORS   Claesson-Welsh,L., Eriksson,A., Moren,A., Severinsson,L., Ek,B.,
            Ostman,A., Betsholtz,C. and Heldin,C.H.
  TITLE     cDNA cloning and expression of a human platelet-derived growth
            factor (PDGF) receptor specific for B-chain-containing PDGF
            molecules
  JOURNAL   Mol. Cell. Biol. 8 (8), 3476-3486 (1988)
   PUBMED   2850496
COMMENT     Original source text: Human foreskin fibroblast mRNA, clone
            lambda-HPDGFR-8.
FEATURES             Location/Qualifiers
     source          1..5427
                     /db_xref="H-InvDB:HIT000194798"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /cell_type="fibroblast"
                     /tissue_type="foreskin"
     CDS             187..3507
                     /codon_start=1
                     /product="platelet-derived growth factor receptor"
                     /protein_id="AAA36427.1"
                     /db_xref="GI:189730"
                     /translation="MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVL
                     NVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTH
                     NDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTL
                     HEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSV
                     NAVQTVVRQGENITLMCIVIGNDVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSIL
                     HIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSR
                     TLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAG
                     HYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSA
                     CRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRC
                     TLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRW
                     KVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSH
                     SQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITE
                     YCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGY
                     MDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVL
                     SYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSN
                     YISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFY
                     NAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQ
                     VDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKP
                     EVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQ
                     LPDSGCPAPRAEAEDSFL"
     sig_peptide     187..282
     mat_peptide     283..3504
                     /product="platelet-derived growth factor receptor"
BASE COUNT         1178 a         1605 c         1492 g         1152 t
ORIGIN      
        1 tgttctcctg agccttcagg agcctgcacc agtcctgcct gtccttctac tcagctgtta
       61 cccactctgg gaccagcagt ctttctgata actgggagag ggcagtaagg aggacttcct
      121 ggagggggtg actgtccaga gcctggaact gtgcccacac cagaagccat cagcagcaag
      181 gacaccatgc ggcttccggg tgcgatgcca gctctggccc tcaaaggcga gctgctgttg
      241 ctgtctctcc tgttacttct ggaaccacag atctctcagg gcctggtcgt cacacccccg
      301 gggccagagc ttgtcctcaa tgtctccagc accttcgttc tgacctgctc gggttcagct
      361 ccggtggtgt gggaacggat gtcccaggag cccccacagg aaatggccaa ggcccaggat
      421 ggcaccttct ccagcgtgct cacactgacc aacctcactg ggctagacac gggagaatac
      481 ttttgcaccc acaatgactc ccgtggactg gagaccgatg agcggaaacg gctctacatc
      541 tttgtgccag atcccaccgt gggcttcctc cctaatgatg ccgaggaact attcatcttt
      601 ctcacggaaa taactgagat caccattcca tgccgagtaa cagacccaca gctggtggtg
      661 acactgcacg agaagaaagg ggacgttgca ctgcctgtcc cctatgatca ccaacgtggc
      721 ttttctggta tctttgagga cagaagctac atctgcaaaa ccaccattgg ggacagggag
      781 gtggattctg atgcctacta tgtctacaga ctccaggtgt catccatcaa cgtctctgtg
      841 aacgcagtgc agactgtggt ccgccagggt gagaacatca ccctcatgtg cattgtgatc
      901 gggaatgatg tggtcaactt cgagtggaca tacccccgca aagaaagtgg gcggctggtg
      961 gagccggtga ctgacttcct cttggatatg ccttaccaca tccgctccat cctgcacatc
     1021 cccagtgccg agttagaaga ctcggggacc tacacctgca atgtgacgga gagtgtgaat
     1081 gaccatcagg atgaaaaggc catcaacatc accgtggttg agagcggcta cgtgcggctc
     1141 ctgggagagg tgggcacact acaatttgct gagctgcatc ggagccggac actgcaggta
     1201 gtgttcgagg cctacccacc gcccactgtc ctgtggttca aagacaaccg caccctgggc
     1261 gactccagcg ctggcgaaat cgccctgtcc acgcgcaacg tgtcggagac ccggtatgtg
     1321 tcagagctga cactggttcg cgtgaaggtg gcagaggctg gccactacac catgcgggcc
     1381 ttccatgagg atgctgaggt ccagctctcc ttccagctac agatcaatgt ccctgtccga
     1441 gtgctggagc taagtgagag ccaccctgac agtggggaac agacagtccg ctgtcgtggc
     1501 cggggcatgc cgcagccgaa catcatctgg tctgcctgca gagacctcaa aaggtgtcca
     1561 cgtgagctgc cgcccacgct gctggggaac agttccgaag aggagagcca gctggagact
     1621 aacgtgacgt actgggagga ggagcaggag tttgaggtgg tgagcacact gcgtctgcag
     1681 cacgtggatc ggccactgtc ggtgcgctgc acgctgcgca acgctgtggg ccaggacacg
     1741 caggaggtca tcgtggtgcc acactccttg ccctttaagg tggtggtgat ctcagccatc
     1801 ctggccctgg tggtgctcac catcatctcc cttatcatcc tcatcatgct ttggcagaag
     1861 aagccacgtt acgagatccg atggaaggtg attgagtctg tgagctctga cggccatgag
     1921 tacatctacg tggaccccat gcagctgccc tatgactcca cgtgggagct gccgcgggac
     1981 cagcttgtgc tgggacgcac cctcggctct ggggcctttg ggcaggtggt ggaggccaca
     2041 gctcatggtc tgagccattc tcaggccacg atgaaagtgg ccgtcaagat gcttaaatcc
     2101 acagcccgca gcagtgagaa gcaagccctt atgtcggagc tgaagatcat gagtcacctt
     2161 gggccccacc tgaacgtggt caacctgttg ggggcctgca ccaaaggagg acccatctat
     2221 atcatcactg agtactgccg ctacggagac ctggtggact acctgcaccg caacaaacac
     2281 accttcctgc agcaccactc cgacaagcgc cgcccgccca gcgcggagct ctacagcaat
     2341 gctctgcccg ttgggctccc cctgcccagc catgtgtcct tgaccgggga gagcgacggt
     2401 ggctacatgg acatgagcaa ggacgagtcg gtggactatg tgcccatgct ggacatgaaa
     2461 ggagacgtca aatatgcaga catcgagtcc tccaactaca tggcccctta cgataactac
     2521 gttccctctg cccctgagag gacctgccga gcaactttga tcaacgagtc tccagtgcta
     2581 agctacatgg acctcgtggg cttcagctac caggtggcca atggcatgga gtttctggcc
     2641 tccaagaact gcgtccacag agacctggcg gctaggaacg tgctcatctg tgaaggcaag
     2701 ctggtcaaga tctgtgactt tggcctggct cgagacatca tgcgggactc gaattacatc
     2761 tccaaaggca gcaccttttt gcctttaaag tggatggctc cggagagcat cttcaacagc
     2821 ctctacacca ccctgagcga cgtgtggtcc ttcgggatcc tgctctggga gatcttcacc
     2881 ttgggtggca ccccttaccc agagctgccc atgaacgagc agttctacaa tgccatcaaa
     2941 cggggttacc gcatggccca gcctgcccat gcctccgacg agatctatga gatcatgcag
     3001 aagtgctggg aagagaagtt tgagattcgg ccccccttct cccagctggt gctgcttctc
     3061 gagagactgt tgggcgaagg ttacaaaaag aagtaccagc aggtggatga ggagtttctg
     3121 aggagtgacc acccagccat ccttcggtcc caggcccgct tgcctgggtt ccatggcctc
     3181 cgatctcccc tggacaccag ctccgtcctc tatactgccg tgcagcccaa tgagggtgac
     3241 aacgactata tcatccccct gcctgacccc aaacctgagg ttgctgacga gggcccactg
     3301 gagggttccc ccagcctagc cagctccacc ctgaatgaag tcaacacctc ctcaaccatc
     3361 tcctgtgaca gccccctgga gccccaggac gaaccagagc cagagcccca gcttgagctc
     3421 caggtggagc cggagccgga gctggaacag ttgccggatt cggggtgccc tgcgcctcgg
     3481 gcggaagcag aggatagctt cctgtagggg gctggcccct accctgccct gcctgaagct
     3541 cccccgctgc cagcacccag catctcctgg cctggcctgg ccgggcttcc tgtcagccag
     3601 gctgccctta tcagctgtcc ccttctggaa gctttctgct cctgacgtgt tgtgccccaa
     3661 accctggggc tggcttagga ggcaagaaaa ctgcaggggc cgtgaccagc cctctgcctc
     3721 cagggaggcc aactgactct gagccagggt tcccccaggg aactcagttt tcccatatgt
     3781 aagatgggaa agttaggctt gatgacccag aatctaggat tctctccctg gctgacaggt
     3841 ggggagaccg aatccctccc tgggaagatt cttggagtta ctgaggtggt aaattaactt
     3901 ttttctgttc agccagctac ccctcaagga atcatagctc tctcctcgca cttttatcca
     3961 cccaggagct agggaagaga ccctagcctc cctggctgct ggctgagcta gggcctagcc
     4021 ttgagcagtg ttgcctcatc cagaagaaag ccagtctcct ccctatgatg ccagtccctg
     4081 cgttccctgg cccgagctgg tctggggcca ttaggcagcc taattaatgc tggaggctga
     4141 gccaagtaca ggacaccccc agcctgcagc ccttgcccag ggcacttgga gcacacgcag
     4201 ccatagcaag tgcctgtgtc cctgtccttc aggcccatca gtcctggggc tttttcttta
     4261 tcaccctcag tcttaatcca tccaccagag tctagaaggc cagacgggcc ccgcatctgt
     4321 gatgagaatg taaatgtgcc agtgtggagt ggccacgtgt gtgtgccaga tatggccctg
     4381 gctctgcatt ggacctgcta tgaggctttg gaggaatccc tcaccctctc tgggcctcag
     4441 tttccccttc aaaaaatgaa taagtcggac ttattaactc tgagtgcctt gccagcacta
     4501 acattctaga gtatccaggt ggttgcacat ttgtccagat gaagcaaggc catataccct
     4561 aaacttccat cctgggggtc agctgggctc ctgggagatt ccagatcaca catcacactc
     4621 tggggactca ggaaccatgc cccttcccca ggcccccagc aagtctcaag aacacagctg
     4681 cacaggcctt gacttagagt gacagccggt gtcctggaaa gcccccagca gctgccccag
     4741 ggacatggga agaccacggg acctctttca ctacccacga tgacctccgg gggtatcctg
     4801 ggcaaaaggg acaaagaggg caaatgagat cacctcctgc agcccaccac tccagcacct
     4861 gtgccgaggt ctgcgtcgaa gacagaatgg acagtgagga cagttatgtc ttgtaaaaga
     4921 caagaagctt cagatgggta ccccaagaag gatgtgagag gtgggcgctt tggaggtttg
     4981 cccctcaccc accagctgcc ccatccctga ggcagcgctc catgggggta tggttttgtc
     5041 actgcccaga cctagcagtg acatctcatt gtccccagcc cagtgggcat tggaggtgcc
     5101 aggggagtca gggttgtagc caagacgccc ccgcacgggg agggttggga agggggtgca
     5161 ggaagctcaa cccctctggg caccaaccct gcattgcagg ttggcacctt acttccctgg
     5221 gatcccagag ttggtccaag gagggagagt gggttctcaa tacggtacca aagatataat
     5281 cacctaggtt tacaaatatt tttaggactc acgttaactc acatttatac agcagaaatg
     5341 ctattttgta tgctgttaag tttttctatc tgtgtacttt tttttaaggg aaagatttta
     5401 atattaaacc tggtgcttct cactcac
//