LOCUS AH002888 5755 bp DNA linear HUM 26-AUG-2016 DEFINITION Homo sapiens MHC class II protein (HLA-DRB4) gene, exons 1 through 6. ACCESSION AH002888 M19556 M20548 M20549 M20550 VERSION AH002888.2 KEYWORDS cell surface glycoprotein; class II gene; complement system protein; integral membrane protein; major histocompatibility complex. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 747; 852 to 2206; 2307 to 5755) AUTHORS Andersson,G., Larhammar,D., Widmark,E., Servenius,B., Peterson,P.A. and Rask,L. TITLE Class II genes of the human major histocompatibility complex. Organization and evolutionary relationship of the DR beta genes JOURNAL J. Biol. Chem. 262 (18), 8748-8758 (1987) PUBMED 3036826 REMARK Erratum:[J Biol Chem 1988 Jun 15;263(17):8551] REFERENCE 2 (bases 1 to 751) AUTHORS Andersson,G., Larhammar,D.G., Widmark,E., Servenius,B., Peterson,P.A. and Rask,L. TITLE Revision: Class II genes of the human major histocompatibility complex: Organization and evolutionary relationship of the DR-beta genes JOURNAL J. Biol. Chem. 263, 8551-8551 (1988) COMMENT On or before Aug 26, 2016 this sequence version replaced M20548.1, M20549.1, M20550.1, AH002888.1. FEATURES Location/Qualifiers source 1..5755 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /map="6p21.3" misc_feature 1..5755 /note="Original segmented set titles: Human MHC class II HLA-DR4-beta (DR4,w4) gene; Human MHC class II HLA-DR4-beta (DR4,w4) gene, exon 1.; Human MHC class II HLA-DR4-beta (DR4,w4) gene, exon 2.; Human MHC class II HLA-DR4-beta (DR4,w4) gene, exon 3,4,5,6." gene 515..5347 /gene="HLA-DRB4" mRNA join(<515..614,1226..1495,3130..3412,4110..4220, 4690..4713,5334..5347) /gene="HLA-DRB4" /product="MHC class II protein" /note="G00-120-645" exon <515..614 /gene="HLA-DRB4" /note="G00-120-645" /number=1 sig_peptide 515..601 /gene="HLA-DRB4" /note="MHC DR-beta signal peptide" mat_peptide 602..613 /gene="HLA-DRB4" /note="MHC DR-beta" intron order(615..751,852..1225) /gene="HLA-DRB4" /note="G00-120-645" /number=1 gap 752..851 /estimated_length=unknown prim_transcript <852..>2206 /gene="HLA-DRB4" /note="MHC DR-beta mRNA and introns" exon 1226..1495 /gene="HLA-DRB4" /note="G00-120-645" /number=2 intron order(1496..2206,2307..3129) /gene="HLA-DRB4" /note="G00-120-645" /number=2 gap 2207..2306 /estimated_length=unknown prim_transcript <2307..5343 /gene="HLA-DRB4" /note="MHC DR-beta mRNA and introns" exon 3130..3412 /gene="HLA-DRB4" /note="G00-120-645" /number=3 intron 3413..4109 /gene="HLA-DRB4" /note="G00-120-645" /number=3 exon 4110..4220 /gene="HLA-DRB4" /note="G00-120-645" /number=4 intron 4221..4689 /gene="HLA-DRB4" /note="G00-120-645" /number=4 exon 4690..4713 /gene="HLA-DRB4" /note="G00-120-645" /number=5 intron 4714..5333 /gene="HLA-DRB4" /note="G00-120-645" /number=5 repeat_region 4739..5067 /gene="HLA-DRB4" /note="Alu repeat" repeat_region 4739..4750 /gene="HLA-DRB4" /note="Alu 5' direct repeat" repeat_region 5055..5067 /gene="HLA-DRB4" /note="Alu 3' direct repeat" exon 5334..5347 /gene="HLA-DRB4" /note="G00-120-645" /number=6 BASE COUNT 1391 a 1258 c 1422 g 1479 t ORIGIN 747 bp upstream of BamHI site; chromosome 6p21.3. 1 cccaagtcta caacagtaag atatggtgca ataaggacca gattaaaagt ctcctgattt 61 gcaaccatgt tccctccatc tcctttactc ctaagcacac tcacacactc actcctgcaa 121 acaattctct tgtcaagtgg gaaatgaatg ctcttacaag gctcaaattt gtgaacacat 181 cactgaccag cacagagctg gctaacaata gggacacaat taaggtgttt tacacgcaac 241 tggttgaacc cttcgagtac taaattaaaa caatccttta aagaaggaaa ttgtttcaga 301 aaaggacctt catacagcat ctctgaccag cgactgatga tgctattgta ctcagatgct 361 gattcgttct ccaacactag attacccaat ccacgagcaa ggaaatcagt aacttcttcc 421 ctataatttg gaatgtgggt ggagaggggt catagttctc cctgagtgag actcacctgc 481 tcctctggcc cctagtcctg tcctgttctc cagcatggtg tgtctgaagt tccctggagg 541 ctcctgcatg gcagctctga cagtgacact gatggtgctg agctccccac tggctttggc 601 tggggacacc cgacgtaagt gcacattgtg ggtgctgacc tactatgggg tggggaaaaa 661 agggagttgt gttaacattg tgcccaggcc atgtccctta agaaagtgtg acattttctt 721 cagggattgc ccatctttat catatggatc cnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 781 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 841 nnnnnnnnnn ngtgttcaca ggatgaaagc ggtgcgtgct gtttaaaggc aaagggtaaa 901 gcctttaaat ggtaaagggt tgagagaagg agcaaagtgc ctttggggtg gaggctccca 961 ngaggaggcg gcgcgggctg cggtgctgga cggatcctcc tccagctcct gcctggaggt 1021 ctccagaaca ggctggaggc agggaggggg tcccaaaagc cttgggatca gaggtagttt 1081 ttccacctng tcccccagac ccccgtccgc ctcagaaaga cagaggatga gcccctgggc 1141 tgcgtgttgt cggggttgcg ggtggggcca gatagtgtct tccccggagg ccgcttctgt 1201 aaccggatcg ttcttgtccc cccagcacgt ttcttggagc aggttaaaca tgagtgtcat 1261 ttcttcaacg ggacggagcg ggtgcggttc ctggacagat acttctatca ccaagaggag 1321 tacgtgcgct tcgacagcga cgtgggggag taccgggcgg tgacggagct ggggcggcct 1381 gatgccgagt actggaacag ccagaaggac ctcctggagc agaagcgggc cgcggtggac 1441 acctactgca gacacaacta cggggttggt gagagcttca cagtgcagcg gcgaggtgag 1501 cacggcgccg gggcgggccg agccctgtga gcggcgaccg agtgtgtgtg tgtgtgtgtg 1561 tgtgtgtgtg tgtgtgtgtg tgtgagagag agagagagag agagagagag agagagagcg 1621 ccatctgtga gcatttagaa tcctctctat ccttggctgc gtagtattcc ctggtgtata 1681 ggagcaagga gttctgcggg cacaggtgtg tgtgtggagt gtggatttgt ccgtgtctgt 1741 gaggctgttg tgggagggga ggcaggaggg ggctgcttct tattcttgga gacttctgtg 1801 gggaggtgac aagggaggtg ggtgctgggg gctggagaga gaggcgacct tgattgtctc 1861 gggtccttag agatgcaagg aagggaaatg tatggggtgt gtggttgggg tgaaggttta 1921 ggggaggaga gctgaggggt aaggaaggtt tgggataatg tgaagaggcc agtttcagac 1981 tgtccctggc acacaccctt catgtaatct ctgaaataaa agtgtgtgct gtttgtttgt 2041 aaaagcatta gattaacttc taggggaatt gagtagacct ctgaggcacc tctgaagctt 2101 ctttaggtat aaatttcttg ctagtttttt gttttcatta gtgttatatt tttacatagt 2161 tgaaatgatc gtgaaactaa ctttttgaat taaagtttga aaacacnnnn nnnnnnnnnn 2221 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2281 nnnnnnnnnn nnnnnnnnnn nnnnnnaaat gacgttcctt aatctttctc tctgctttag 2341 gaatcatgct ttcttaggaa cttaaagatt tggagaatca tttctgtctg tcccaccttc 2401 ccaggagcat aaccatttct gtggtgttct aaggtgtgag tgcatggcag tagtattcct 2461 aaaaatccat attcagtttc ctcatgtgcc ctactccgtc cctttctcta tccacattgc 2521 tttaaatcat atttttctct caaggtgtac aaggatgata aataggtgcc aagtggagaa 2581 cccaagtgtg acgagccctc tcacagtaga atggagtgag aagctttctg acctcataaa 2641 ttgaaggcta tcgtaattca ttcttttata tattttactt gcattaatcc tcatataacc 2701 tcaagaggta aattaatata attatcctcc attattggag agaaagttga gacacaaaag 2761 aatcaaaaac tcttccaggg tcaaccagta aaaggcagac cttggatttg aaccaggcaa 2821 cctggctcag aagtcagttt taattaccac actctgtact ttcaaagatt tgtaaacgct 2881 ttgacaatgc atgtcaattt caagctatga agagccaaac ataatttttc acaatatctc 2941 tcaaatctaa tgggtcccca ctataaggat taaattccag gctgatgaca ctgtgagggc 3001 cacatggcca gctgtgctgg aggcctgctc aaggccagag cctaggttta cagagaagca 3061 gacaaaaagc taaacaagga gacttactct gtctgcatga cttattccct ctaccttgtt 3121 ttctcctagt ctatcctgag gtgactgtgt atcctgcaaa gacccagccc ctgcagcacc 3181 acaacctcct ggtctgctct gtgaatggtt tctatccagg cagcattgaa gtcaggtggt 3241 tccggaacgg ccaggaagag aagactgggg tggtgtccac aggcctgatc cagaatggag 3301 actggacctt ccagaccctg gtgatgctgg aaacagttcc tcggagtgga gaggtttaca 3361 cctgccaagt ggagcaccca agcctgacga gccctctcac agtggaatgg aggtagcagc 3421 tttctgactt cgtaaatttc tcacccacca agacgcgaac tttactaatc cctgagtatc 3481 aggcttctcc tatcccacat cctattttca tttgctccac gttctcatct ccatcagcac 3541 aggtcactgg ggggtagccc tgtaatactt tctagaaaca cctgtacccc ctggggaagc 3601 agtcatgcct gccaggcagg agaggctgtc cctcttttga acctccccat gatgtcacaa 3661 gtcggggtca cctgctgtct gtgggctcca ggccctgcct ctgggtctga gactgagttt 3721 ctggtactgt tgctctgagt cgtttgttgt aatctgagaa gaggagaagt atagggacct 3781 ttcctgacat gaggggagtc caatctcagc tccgcctttt attagatctg tcactctagg 3841 caactactta acctcattgg gtctcaggct ttctgttcat cagatgttga agtcctgtct 3901 tacatcaagg ctgtaatatt tgaatgagtt tgatgactga accttgtaac tgttcagtgt 3961 gatttgaaaa cctttctcaa gaaatggtca gttattttag ttcttgcaga gcagccttct 4021 ttctcatttt caaagctctg aatctcaagg tgtcaattaa agaggttcca tttgggataa 4081 aaatcactaa acctggcttc ctctctcagg agcacggtct gaatctgcac agagcaagat 4141 gctgagtgga gtcgggggct tcgtgctggg cctgctcttc cttggggccg ggctgttcat 4201 ctacttcagg aatcagaaag gtgaggagcc tttggtagct ggctgtctcc atacgctttt 4261 ctggaggagg aactatggct ttgctgaagt tggttctcag catatgaatg gccctggata 4321 aagcctctct actcccaaat gacctccaat gttctgcaaa tccagaaatc atcagtgcat 4381 ggttgctatg tcaaagcata atagcttgtg gcctacagag ataacagaaa gattaacagg 4441 tataggtgct ttggttgaga tcgtggagca aattaaggaa gagcaactaa agctaataca 4501 attacactgg atcctgtgac agcacttcac acttcatggg tcacatggtc tgtttcgctc 4561 ctctctgccc tggctggtgt gggttgtggt gtcagagaca ctctcaggtg ggagatctgg 4621 agctgggaca ttgtgttgga ggacagattt gcttccatat cttttaagtg tatatcttct 4681 cttttctagg acactctgga cttcagccaa caggtaatac cttttcatcc tctttaagaa 4741 acagatttgg aggctaggcg cagtggctca cgtcctgtaa tcccagcact ttgggaggcc 4801 gaggcgggcg aatcatgagg tcaggagttc gagaccagcc tgaccaacgt ggtgaaaccc 4861 cgtctctact aaaaatacaa aaaaaaatca gtcgggcgtg gtggtgtgcg cctgtaatcc 4921 cagtctactc aggaggccaa ggcaggagat cgccggaacc taggaggcag aggttgcagc 4981 cgagattggg ccaccgcact ccggacctag gtgacggagt gagaccccat ctcaaaaaac 5041 aaaaaaagaa aagaaaacgg aatttccttt ccctngaatg atgtgaggta taggcacgag 5101 acggaagtaa tagcaaggac attggatcca aatttctgat caggcaattt acaccagaac 5161 tcctcctctc cacttagaaa aggcctgtgc ttctgcagga gtattgactc atggagactt 5221 cagaacttgt ttttcttctt cctgcagtgc tctcatctga gtccttgaaa gagggcaaaa 5281 taaactgtta gtagagcnag gtctgaaaac aacactttcc tgcgtctccg caggattcct 5341 gagctgaagt gaagatgacc acattcaagg aagaaccttc tgccccagct ttgcaggatg 5401 aaacacttcc ccgcttggct ctcattcttc cacaagagag acctttctcc ggacntggtt 5461 gctactggtt cagcagctct gcagaaaatg tcctcccttg tggctgcctc agctcgtacc 5521 tttggcctga agtcccagca ttaatggcag cccctcatct tccaagtttt gtgctcccct 5581 ttacctaatg cttcctgcct cccatgcatc tgtactcctg ctgtgccaca aacacattac 5641 attattaaat gtttctcaaa catggagtta aaaatcgtct ggtcatttgg ccccaaggac 5701 aaaaaataaa aagaaaagaa aaagtgaaga ttatttcccg atagaataat ggttt //