LOCUS HUMCYPDB1 1567 bp mRNA linear HUM 02-NOV-1994
DEFINITION Human cytochrome P450 db1 mRNA, complete cds.
ACCESSION M20403 M19697
VERSION M20403.1
KEYWORDS cytochrome P450; debrisoquine 4-hydroxylase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1567)
AUTHORS Gonzalez,F.J., Vilbois,F., Hardwick,J.P., McBride,O.W.,
Nebert,D.W., Gelboin,H.V. and Meyer,U.A.
TITLE Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino
acid sequence and assignment of the CYP2D locus to chromosome 22
JOURNAL Genomics 2 (2), 174-179 (1988)
PUBMED 3410476
COMMENT Original source text: Human hepatocyte, cDNA to mRNA.
Draft entry and printed copy of sequence for [1] kindly provided by
D.W.Nebert, 15-JUL-1988.
FEATURES Location/Qualifiers
source 1..1567
/db_xref="H-InvDB:HIT000194724"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="22q11.2-qter"
gene 1..1567
/gene="CYP2D"
mRNA <1..1567
/gene="CYP2D"
/product="CY P450 db1 mRNA"
CDS 1..1494
/gene="CYP2D"
/note="debrisoquine 4-hydroxylase"
/codon_start=1
/protein_id="AAA52153.1"
/db_xref="GDB:G00-119-832"
/translation="MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLG
NLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRP
PVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACL
CAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESG
FLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFL
AEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQE
IDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKG
TTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLAR
MELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR"
BASE COUNT 267 a 527 c 465 g 308 t
ORIGIN Chromosome 22.
1 atggggctag aagcactggt gcccctggcc gtgatagtgg ccatcttcct gctcctggtg
61 gacctgatgc accggcgcca acgctgggct gcacgctacc caccaggccc cctgccactg
121 cccgggctgg gcaacctgct gcatgtggac ttccagaaca caccatactg cttcgaccag
181 ttgcggcgcc gcttcgggga cgtgttcagc ctgcagctgg cctggacgcc ggtggtcgtg
241 ctcaatgggc tggcggccgt gcgcgaggcg ctggtgaccc acggcgagga caccgccgac
301 cgcccgcctg tgcccatcac ccagatcctg ggtttcgggc cgcgttccca aggggtgttc
361 ctggcgcgct atgggcccgc gtggcgcgag cagaggcgct tctccgtgtc caccttgcgc
421 aacttgggcc tgggcaagaa gtcgctggag cagtgggtga ccgaggaggc cgcctgcctt
481 tgtgccgcct tcgccaacca ctccggacgc ccctttcgcc ccaacggtct cttggacaaa
541 gccgtgagca acgtgatcgc ctccctcacc tgcgggcgcc gcttcgagta cgacgaccct
601 cgcttcctca ggctgctgga cctagctcag gagggactga aggaggagtc gggctttctg
661 cgcgaggtgc tgaatgctgt ccccgtcctc ctgcatatcc cagcgctggc tggcaaggtc
721 ctacgcttcc aaaaggcttt cctgacccag ctggatgagc tgctaactga gcacaggatg
781 acctgggacc cagcccagcc cccccgagac ctgactgagg ccttcctggc agagatggag
841 aaggccaagg ggaaccctga gagcagcttc aatgatgaga acctgcgcat agtggtggct
901 gacctgttct ctgccgggat ggtgaccacc tcgaccacgc tggcctgggg cctcctgctc
961 atgatcctac atccggatgt gcagcgccgt gtccaacagg agatcgacga cgtgataggg
1021 caggtgcggc gaccagagat gggtgaccag gctcacatgc cctacaccac tgccgtgatt
1081 catgaggtgc agcgctttgg ggacatcgtc cccctgggta tgacccatat gacatcccgt
1141 gacatcgaag tacagggctt ccgcatccct aagggaacga cactcatcac caacctgtca
1201 tcggtgctga aggatgaggc cgtctgggag aagcccttcc gcttccaccc cgaacacttc
1261 ctggatgccc agggccactt tgtgaagccg gaggccttcc tgcctttctc agcaggccgc
1321 cgtgcatgcc tcggggagcc cctggcccgc atggagctct tcctcttctt cacctccctg
1381 ctgcagcact tcagcttctc ggtgcccact ggacagcccc ggcccagcca ccatggtgtc
1441 tttgctttcc tggtgagccc atccccctat gagctttgtg ctgtgccccg ctagaatggg
1501 gtacctagtc cccagcctgc tcctagccca gaggctctaa tgtacaataa agcaatgtgg
1561 tagttcc
//