LOCUS HUMCHEB 2416 bp mRNA linear HUM 24-APR-1996
DEFINITION Human butyrylcholinesterase, mRNA, complete cds.
ACCESSION M16541 J02964
VERSION M16541.1
KEYWORDS butyrylcholinesterase; cholinesterase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2416)
AUTHORS McTiernan,C., Adkins,S., Chatonnet,A., Vaughan,T.A., Bartels,C.F.,
Kott,M., Rosenberry,T.L., La Du,B.N. and Lockridge,O.
TITLE Brain cDNA clone for human cholinesterase
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 84 (19), 6682-6686 (1987)
PUBMED 3477799
COMMENT On Apr 25, 1996 this sequence version replaced gi:180483.
Original source text: Human 1-day old female basal gangaglia, cDNA
to mRNA, clones Oh57,z35, z3, z2 and z13.
Draft entry and computer-readable copy of sequence in [1] kindly
provided by S.Adkins, 29-JUL-1987. ATG codons were found at
nucleotides 7-9, 73-75, 130-132 and 190-192 but the triplet at
bases 130-132 was confirmed as the initiation codon.
FEATURES Location/Qualifiers
source 1..2416
/db_xref="H-InvDB:HIT000194458"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="3q26"
gene 1..2416
/gene="BCHE"
mRNA 1..2416
/gene="BCHE"
/product="BCHE mRNA"
CDS 130..1938
/gene="BCHE"
/note="cholinesterase (EC 3.1.1.8)"
/codon_start=1
/protein_id="AAA98113.1"
/db_xref="GDB:G00-120-558"
/translation="MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGM
NLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFP
GFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKF
LARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPK
SVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAK
LTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDIL
LELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPGVSEF
GKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYYFE
HRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNP
NETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFPKVLEMTGNIDE
AEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCVGL"
sig_peptide 130..213
/gene="BCHE"
/note="cholinesterase signal peptide"
mat_peptide 214..1935
/gene="BCHE"
/product="cholinesterase mature peptide"
BASE COUNT 774 a 431 c 478 g 733 t
ORIGIN 303 bp upstream of EcoRI site; HGML map location 3q21-qter.
1 tactgaatgt cagtgcagtc caatttacag gctggagcag cagctgcatc ctgcatttcc
61 ccgaagtatt acatgatttt cactccttgc aaactttacc atctttgttg cagagaatcg
121 gaaatcaata tgcatagcaa agtcacaatc atatgcatca gatttctctt ttggtttctt
181 ttgctctgca tgcttattgg gaagtcacat actgaagatg acatcataat tgcaacaaag
241 aatggaaaag tcagagggat gaacttgaca gtttttggtg gcacggtaac agcctttctt
301 ggaattccct atgcacagcc acctcttggt agacttcgat tcaaaaagcc acagtctctg
361 accaagtggt ctgatatttg gaatgccaca aaatatgcaa attcttgctg tcagaacata
421 gatcaaagtt ttccaggctt ccatggatca gagatgtgga acccaaacac tgacctcagt
481 gaagactgtt tatatctaaa tgtatggatt ccagcaccta aaccaaaaaa tgccactgta
541 ttgatatgga tttatggtgg tggttttcaa actggaacat catctttaca tgtttatgat
601 ggcaagtttc tggctcgggt tgaaagagtt attgtagtgt caatgaacta tagggtgggt
661 gccctaggat tcttagcttt gccaggaaat cctgaggctc cagggaacat gggtttattt
721 gatcaacagt tggctcttca gtgggttcaa aaaaatatag cagcctttgg tggaaatcct
781 aaaagtgtaa ctctctttgg agaaagtgca ggagcagctt cagttagcct gcatttgctt
841 tctcctggaa gccattcatt gttcaccaga gccattctgc aaagtggatc ctttaatgct
901 ccttgggcgg taacatctct ttatgaagct aggaacagaa cgttgaactt agctaaattg
961 actggttgct ctagagagaa tgagactgaa ataatcaagt gtcttagaaa taaagatccc
1021 caagaaattc ttctgaatga agcatttgtt gtcccctatg ggactccttt gtcagtaaac
1081 tttggtccga ccgtggatgg tgattttctc actgacatgc cagacatatt acttgaactt
1141 ggacaattta aaaaaaccca gattttggtg ggtgttaata aagatgaagg gacagctttt
1201 ttagtctatg gtgctcctgg cttcagcaaa gataacaata gtatcataac tagaaaagaa
1261 tttcaggaag gtttaaaaat attttttcca ggagtgagtg agtttggaaa ggaatccatc
1321 ctttttcatt acacagactg ggtagatgat cagagacctg aaaactaccg tgaggccttg
1381 ggtgatgttg ttggggatta taatttcata tgccctgcct tggagttcac caagaagttc
1441 tcagaatggg gaaataatgc ctttttctac tattttgaac accgatcctc caaacttccg
1501 tggccagaat ggatgggagt gatgcatggc tatgaaattg aatttgtctt tggtttacct
1561 ctggaaagaa gagataatta cacaaaagcc gaggaaattt tgagtagatc catagtgaaa
1621 cggtgggcaa attttgcaaa atatgggaat ccaaatgaga ctcagaacaa tagcacaagc
1681 tggcctgtct tcaaaagcac tgaacaaaaa tatctaacct tgaatacaga gtcaacaaga
1741 ataatgacga aactacgtgc tcaacaatgt cgattctgga catcattttt tccaaaagtc
1801 ttggaaatga caggaaatat tgatgaagca gaatgggagt ggaaagcagg attccatcgc
1861 tggaacaatt acatgatgga ctggaaaaat caatttaacg attacactag caagaaagaa
1921 agttgtgtgg gtctctaatt aatagattta ccctttatag aacatatttt cctttagatc
1981 aaggcaaaaa tatcaggagc ttttttacac acctactaaa aaagttatta tgtagctgaa
2041 acaaaaatgc cagaaggata atattgattc ctcacatctt taacttagta ttttacctag
2101 catttcaaaa cccaaatggc tagaacatgt ttaattaaat ttcacaatat aaagttctac
2161 agttaattat gtgcatatta aaacaatggc ctggttcaat ttctttcttt ccttaataaa
2221 tttaagtttt ttccccccaa aattatcagt gctctgcttt tagtcacgtg tattttcatt
2281 accactcgta aaaaggtatc ttttttaaat gaattaaata ttgaaacact gtacaccata
2341 gtttacaata ttatgtttcc taattaaaat aagaattgaa tgtcaatatg agatattaaa
2401 ataagcacag aaaatc
//