LOCUS HUMTNFAB 7112 bp DNA linear HUM 14-JAN-1995 DEFINITION Human tumor necrosis factor and lymphotoxin genes, complete cds. ACCESSION M16441 VERSION M16441.1 KEYWORDS lymphotoxin; tumor necrosis factor. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 7112) AUTHORS Nedospasov,S.A., Shakhov,A.N., Turetskaya,R.L., Mett,V.A., Azizov,M.M., Georgiev,G.P., Korobko,V.G., Dobrynin,V.N., Filippov,S.A., Bystrov,N.S., Boldyreva,E.F., Chuvpilo,S.A., Chumakov,A.M., Shingarova,L.N. and Ovchinnikov,Y.A. TITLE Tandem arrangement of genes coding for tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) in the human genome JOURNAL Cold Spring Harb. Symp. Quant. Biol. 51 (Pt 1), 611-624 (1986) PUBMED 3555974 COMMENT Original source text: Human placenta DNA, clone pTNF186. Draft entry and computer-readable sequence for [1] kindly submitted by C.V.Jongeneel, 02-OCT-1988. FEATURES Location/Qualifiers source 1..7112 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /map="6p21.3" prim_transcript 819..2855 /note="lymphotoxin mRNA and introns" intron 980..1266 /note="lymphotoxin intron A" CDS join(1276..1374,1461..1566,1814..2226) /note="lymphotoxin" /codon_start=1 /protein_id="AAA61199.1" /translation="MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSA AQTARQHPKMHLAHSTLKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVP TSGIYFVYSQVVFSGKAYSPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQ EPWLHSMYHGAAFQLTQGDQLSTHTDGIPHLVLSPSTVFFGAFAL" gene 1276..1374 /gene="TNFB" exon <1276..1374 /gene="TNFB" /note="lymphotoxin, (first expressed exon); G00-120-442" /number=2 intron 1375..1460 /note="lymphotoxin intron B" exon 1461..1566 /number=3 intron 1567..1813 /note="lymphotoxin intron C" exon 1814..>2226 /note="lymphotoxin" /number=4 prim_transcript 4095..6859 /note="TNF mRNA and introns" CDS join(4275..4460,5067..5112,5300..5347,5649..6070) /note="tumor necrosis factor" /codon_start=1 /protein_id="AAA61200.1" /translation="MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGA TTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQL QWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIA VSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYL DFAESGQVYFGIIAL" gene 4275..4460 /gene="TNFA" exon <4275..4460 /gene="TNFA" /note="tumor necrosis factor; G00-120-441" /number=1 intron 4461..5066 /note="TNF intron A" exon 5067..5112 intron 5113..5299 /note="TNF intron B" exon 5300..5347 /number=3 intron 5348..5648 /note="TNF intron C" BASE COUNT 1676 a 2005 c 1865 g 1566 t ORIGIN 1 bp upstream of EcoRI site; chromosome 6p21.3. 1 gaattctcga aacttccttt gtagaaaact ttggaaggtg tctgccacat tgatcctgga 61 atgtgtgttt atttggggtt atataaatct gttctgtgga agccacctga agtcaggaag 121 agatggaggg catccttcag gagtgagatg agacctcatc atacttgact gtccagcatc 181 atctctgagt gaggggacca aaaaatttat cttccaaact aggacacttt caagagtgga 241 agggggatcc attaatattt tcacctggac aagaggcaaa caccagaatg tccccgatga 301 aggggatata taatggacct tcttgatgtg aaacctgcca gatgggctgg aaagtccgta 361 tactgggaca agtatgattt gagttgtttg ggacaaggac aggggtacaa gagaaggaaa 421 tgggcaaaga gagaagcctg tactcagcca agggtgcaga gatgttatat atgattgctc 481 ttcagggaac cgggcctcca gctcacaccc cagctgctca accacctcct ctctgaattg 541 actgtccctt ctttggaact ctaggcctga ccccactccc tggccctccc agcccacgat 601 tcccctgacc cgactccctt tcccagaact cagtcgcctg aacccccagc ctgtggttct 661 ctcctaggcc tcagcctttc ctgcctttga ctgaaacagc agtatcttct aagccctggg 721 ggcttccccg ggccccagcc ccgacctaga acccgcccgc tgcctgccac gctgccactg 781 ccgcttcctc tataaaggga cctgagcgtc cgggcccagg ggctccgcac agcaggtgag 841 gctctcctgc cccatctcct tgggctgccc gtgcttcgtg ctttggacta ccgcccagca 901 gtgtcctgcc ctctgcctgg gcctcggtcc ctcctgcacc tgctgcctgg atccccggcc 961 tgcctgggcc tgggccttgg tgggtttggt tttggtttcc ttctctgtct ctgactctcc 1021 atctgtcagt ctcattgtct ctgtcacaca ttctctgttt ctgccatgat tcctctctgt 1081 tcccttcctg tctctctctg tctccctctg ctcaccttgg ggtttctctg actgcatctt 1141 gtccccttct ctgtcgatct ctctctcggg ggtcgggggg tgctgtctcc cagggcggga 1201 ggtctgtctt ccgccgcgtg ccccgccccg ctcactgtct ctctctctct ctctctttct 1261 ctgcaggttc tccccatgac accacctgaa cgtctcttcc tcccaagggt gtgtggcacc 1321 accctacacc tcctccttct ggggctgctg ctggttctgc tgcctggggc ccaggtgagg 1381 cagcaggaga atgggggctg ctggggtggc tcagccaaac cttgagccct agagcccccc 1441 tcaactctgt tctcccctag gggctccctg gtgttggcct cacaccttca gctgcccaga 1501 ctgcccgtca gcaccccaag atgcatcttg cccacagcac cctcaaacct gctgctcacc 1561 tcattggtaa acatccacct gacctcccag acatgtcccc accagctctc ctcctacccc 1621 tgcctcagga acccaagcat ccacccctct cccccaactt cccccacgct aaaaaaaaca 1681 gagggagccc actcctatgc ctccccctgc catcccccag gaactcagtt gttcagtgcc 1741 cacttcctca gggattgaga cctctgatcc agacccctga tctcccaccc ccatccccta 1801 tggctcttcc taggagaccc cagcaagcag aactcactgc tctggagagc aaacacggac 1861 cgtgccttcc tccaggatgg tttctccttg agcaacaatt ctctcctggt ccccaccagt 1921 ggcatctact tcgtctactc ccaggtggtc ttctctggga aagcctactc tcccaaggcc 1981 acctcctccc cactctacct ggcccatgag gtccagctct tctcctccca gtaccccttc 2041 catgtgcctc tcctcagctc ccagaagatg gtgtatccag ggctgcagga accctggctg 2101 cactcgatgt accacggggc tgcgttccag ctcacccagg gagaccagct atccacccac 2161 acagatggca tcccccacct agtcctcagc cctagtactg tcttctttgg agccttcgct 2221 ctgtagaact tggaaaaatc cagaaagaaa aaataattga tttcaagacc ttctccccat 2281 tctgcctcca ttctgaccat ttcaggggtc gtcaccacct ctcctttggc cattccaaca 2341 gctcaagtct tccctgatca agtcaccgga gctttcaaag aaggaattct aggcatccca 2401 ggggaccaca cctccctgaa ccatccctga tgtctgtctg gctgaggatt tcaagcctgc 2461 ctaggaattc ccagcccaaa gctgttggtc ttgtccacca gctaggtggg gcctagatcc 2521 acacacagag gaagagcagg cacatggagg agcttggggg atgactagag gcagggaggg 2581 gactatttat gaaggcaaaa aaattaaatt atttatttat ggaggatgga gagaggggaa 2641 taatagaaga acatccaagg agaaacagag acaggcccaa gagatgaaga gtgagagggc 2701 atgcgcacaa ggctgaccaa gagagaaaga agtaggcatg agggatcaca gggccccaga 2761 aggcagggaa aggctctgaa agccagctgc cgaccagagc cccacacgga ggcatctgca 2821 ccctcgatga agcccaataa acctcttttc tctgaaatgc tgtctgcttg tgtgtgtgtg 2881 tctgggagtg agaacttccc agtctatcta aggaatggag ggagggacag agggctcaaa 2941 gggagcaaga gctgtgggga gaacaaaagg ataagggctc agagagcttc agggatatgt 3001 gatggactca ccaggtgagg ccgccagact gctgcagggg aagcaaagga gaagctgaga 3061 agatgaagga aaagtcaggg tctggagggg cgggggtcag ggagctcctg ggagatatgg 3121 ccacatgtag cggctctgag gaatgggtta caggagacct ctggggagat gtgaccacag 3181 caatgggtag gagaatgtcc agggctatga aagtcgagta tggggacccc cccttaacga 3241 agacagggcc atgtagaggg ccccagggag tgaaagagcc tccaggacct ccaggtatgg 3301 aatacagggg acgtttaaga agatatggcc acacactggg gccctgagaa gtgagagctt 3361 catgaaaaaa atcagggacc ccagagttcc ttggaagcca agactgaaac cagcattatg 3421 agtctccggg tcagaatgaa agaagagggc ctgccccagt ggggtctgtg aattcccggg 3481 ggtgatttca ctccccgggg ctgtcccagg cttgtccctg ctacccgcac ccagcctttc 3541 ctgaggcctc aagcctgcca ccaagccccc agctccttct ccccgcaggg cccaaacaca 3601 ggcctcagga ctcaacacag cttttccctc caaccccgtt ttctctccct caacggactc 3661 agctttctga agcccctccc agttctagtt ctatcttttt cctgcatcct gtctggaagt 3721 tagaaggaaa cagaccacag acctggtccc caaaagaaat ggaggcaata ggttttgagg 3781 ggcatgggga cggggttcag cctccagggt cctacacaca aatcagtcag tggcccagaa 3841 gacccccctc ggaatcggag cagggaggat ggggagtgtg aggggtatcc ttgatgcttg 3901 tgtgtcccca actttccaaa tccccgcccc cgcgatggag aagaaaccga gacagaaggt 3961 gcagggccca ctaccgcttc ctccagatga gctcatgggt ttctccacca aggaagtttt 4021 ccgctggttg aatgattctt tccccgccct cctctcgccc cagggacata taaaggcagt 4081 tgttggcaca cccagccagc agacgctccc tcagcaagga cagcagagga ccagctaaga 4141 gggagagaag caactacaga ccccccctga aaacaaccct cagacgccac atcccctgac 4201 aagctgccag gcaggttctc ttcctctcac atactgaccc acggcttcac cctctctccc 4261 ctggaaagga caccatgagc actgaaagca tgatccggga cgtggagctg gccgaggagg 4321 cgctccccaa gaagacaggg gggccccagg gctccaggcg gtgcttgttc ctcagcctct 4381 tctccttcct gatcgtggca ggcgccacca cgctcttctg cctgctgcac tttggagtga 4441 tcggccccca gagggaagag gtgagtgcct ggccagcctt catccactct cccacccaag 4501 gggaaatgga gacgcaagag agggagagag atgggatggg tgaaagatgt gcgctgatag 4561 ggagggatgg agagaaaaaa acgtggagaa agacggggat gcagaaagag atgtggcaag 4621 agatggggaa gagagagaga gaaagatgga gagacaggat gtctggcaca tggaaggtgc 4681 tcactaagtg tgtatggagt gaatgaatga atgaatgaat gaacaagcag atatataaat 4741 aagatatgga gacagatgtg gggtgtgaga agagagatgg gggaagaaac aagtgatatg 4801 aataaagatg gtgagacaga aagagcggga aatatgacag ctaaggagag agatggggga 4861 gataaggaga gaagaagata gggtgtctgg cacacagaag acactcaggg aaagagctgt 4921 tgaatgcctg gaaggtgaat acacagatga atggagagag aaaaccagac acctcagggc 4981 taagagcgca ggccagacag gcagccagct gttcctcctt taagggtgac tccctcgatg 5041 ttaaccattc tccttctccc caacagttcc ccagggacct ctctctaatc agccctctgg 5101 cccaggcagt cagtaagtgt ctccaaacct ctttcctaat tctgggtttg ggtttggggg 5161 tagggttagt accggtatgg aagcagtggg ggaaatttaa agttttggtc ttgggggagg 5221 atggatggag gtgaaagtag gggggtattt tctaggaagt ttaagggtct cagctttttc 5281 ttttctctct cctcttcagg atcatcttct cgaaccccga gtgacaagcc tgtagcccat 5341 gttgtaggta agagctctga ggatgtgtct tggaacttgg agggctagga tttggggatt 5401 gaagcccggc tgatggtagg cagaacttgg agacaatgtg agaaggactc gctgagctca 5461 agggaagggt ggaggaacag cacaggcctt agtgggatac tcagaacgtc atggccaggt 5521 gggatgtggg atgacagaca gagaggacag gaaccggatg tggggtgggc agagctcgag 5581 ggccaggatg tggagagtga accgacatgg ccacactgac tctcctctcc ctctctccct 5641 ccctccagca aaccctcaag ctgaggggca gctccagtgg ctgaaccgcc gggccaatgc 5701 cctcctggcc aatggcgtgg agctgagaga taaccagctg gtggtgccat cagagggcct 5761 gtacctcatc tactcccagg tcctcttcaa gggccaaggc tgcccctcca cccatgtgct 5821 cctcacccac accatcagcc gcatcgccgt ctcctaccag accaaggtca acctcctctc 5881 tgccatcaag agcccctgcc agagggagac cccagagggg gctgaggcca agccctggta 5941 tgagcccatc tatctgggag gggtcttcca gctggagaag ggtgaccgac tcagcgctga 6001 gatcaatcgg cccgactatc tcgactttgc cgagtctggg caggtctact ttgggatcat 6061 tgccctgtga ggaggacgaa catccaacct tcccaaacgc ctcccctgcc ccaatccctt 6121 tattaccccc tccttcagac accctcaacc tcttctggct caaaaagaga attgggggct 6181 tagggtcgga acccaagctt agaactttaa gcaacaagac caccacttcg aaacctggga 6241 ttcaggaatg tgtggcctgc acagtgaagt gctggcaacc actaagaatt caaactgggg 6301 cctccagaac tcactggggc ctacagcttt gatccctgac atctggaatc tggagaccag 6361 ggagcctttg gttctggcca gaatgctgca ggacttgaga agacctcacc tagaaattga 6421 cacaagtgga ccttaggcct tcctctctcc agatgtttcc agacttcctt gagacacgga 6481 gcccagccct ccccatggag ccagctccct ctatttatgt ttgcacttgt gattatttat 6541 tatttattta ttatttattt atttacagat gaatgtattt atttgggaga ccggggtatc 6601 ctgggggacc caatgtagga gctgccttgg ctcagacatg ttttccgtga aaacggagct 6661 gaacaatagg ctgttcccat gtagccccct ggcctctgtg ccttcttttg attatgtttt 6721 ttaaaatatt tatctgatta agttgtctaa acaatgctga tttggtgacc aactgtcact 6781 cattgctgag cctctgctcc ccaggggagt tgtgtctgta atcgccctac tattcagtgg 6841 cgagaaataa agtttgctta gaaaagaaac atggtctcct tcttggaatt aattctgcat 6901 ctgcctcttc ttgtgggtgg gaagaagctc cctaagtcct ctctccacag gctttaagat 6961 ccctcggacc cagtcccatc cttagactcc tagggccctg gagaccctac ataaacaaag 7021 cccaacagaa tattccccat cccccaggaa acaagagcct gaacctaatt acctctccct 7081 cagggcatgg gaatttccaa ctctgggaat tc //