LOCUS HUMPKLR 2431 bp mRNA linear HUM 07-JAN-1995 DEFINITION Human pyruvate kinase type L mRNA, complete cds. ACCESSION M15465 J03640 VERSION M15465.1 KEYWORDS pyruvate kinase. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1383 to 2431) AUTHORS Tani,K., Fujii,H., Tsutsumi,H., Sukegawa,J., Toyoshima,K., Yoshida,M.C., Noguchi,T., Tanaka,T. and Miwa,S. TITLE Human liver type pyruvate kinase: cDNA cloning and chromosomal assignment JOURNAL Biochem. Biophys. Res. Commun. 143 (2), 431-438 (1987) PUBMED 3566732 REFERENCE 2 (bases 1 to 2431) AUTHORS Tani,K., Fujii,H., Nagata,S. and Miwa,S. TITLE Human liver type pyruvate kinase: complete amino acid sequence and the expression in mammalian cells JOURNAL Proc. Natl. Acad. Sci. U.S.A. 85 (6), 1792-1795 (1988) PUBMED 3126495 COMMENT Original source text: Homo sapiens (strain Japanese) adult liver cDNA to mRNA. Draft entry and clean copy of sequence in [1] were kindly provided by K.Tani,01-MAY-1987. Draft entry and computer readable copy of sequence [2] kindly provided by Tani,K. 20-MAY-1988. FEATURES Location/Qualifiers source 1..2431 /db_xref="H-InvDB:HIT000194396" /organism="Homo sapiens" /mol_type="mRNA" /strain="Japanese" /db_xref="taxon:9606" /map="1q21" /tissue_type="liver" /dev_stage="adult" gene 1..2431 /gene="PKLR" CDS 69..1700 /gene="PKLR" /EC_number="2.7.1.40" /codon_start=1 /product="pyruvate kinase" /protein_id="AAA60104.1" /db_xref="GDB:G00-120-294" /translation="MEGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCL LDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAETIAN VREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAF RTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKISPEGLVTQVENGGVLGSR KGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHG IKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGK PVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHR IAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSA QLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIES GKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS" BASE COUNT 491 a 727 c 708 g 505 t ORIGIN 77 bp upstream of HaeIII site; chromosome 1q21. 1 tgcctctgac aacccaacag tgtggagcag acccacagag agggagaccc agagaggtgt 61 gcagtggcat ggaagggcca gcggggtatc tgcggcgggc cagtgtggcc caactgaccc 121 aggagctggg cactgccttc ttccagcagc agcagctgcc agctgctatg gcagacacct 181 tcctggaaca cctctgccta ctggacattg actccgagcc cgtggctgct cgcagtacca 241 gcatcattgc caccatcggg ccagcatctc gctccgtgga gcgcctcaag gagatgatca 301 aggccgggat gaacattgcg cgactcaact tctcccacgg ctcccacgag taccatgctg 361 agaccatagc caacgtccgg gaggcggtgg agagctttgc aggttcccca ctcagctacc 421 ggcccgtggc catcgccctg gacaccaagg gaccggagat ccgcactggg atcctgcagg 481 ggggtccaga gtcggaagtg gagctggtga agggctccca ggtgctggtg actgtggacc 541 ccgcgttccg gacgcggggg aacgcgaaca ccgtgtgggt ggactacccc aatattgtcc 601 gggtcgtgcc ggtggggggc cgcatctaca ttgacgacgg gctcatctcc ctagtggtcc 661 agaaaatcag cccagaggga ctggtgaccc aagtggagaa cggcggcgtc ctgggcagcc 721 ggaagggcgt gaacttgcca ggggcccagg tggacttgcc cgggctgtcc gagcaggacg 781 tccgagacct gcgcttcggg gtggagcatg gggtggacat cgtctttgcc tcctttgtgc 841 ggaaagccag cgacgtggct gccgtcaggg ctgctctggg tccggaagga cacggcatca 901 agatcatcag caaaattgag aaccacgaag gcgtgaagag gtttgatgaa atcctggagg 961 tgagcgacgg catcatggtg gcacgggggg acctaggcat cgagatccca gcagagaagg 1021 ttttcctggc tcagaagatg atgattgggc gctgcaactt ggcgggcaag cctgttgtct 1081 gtgccacaca gatgctggag agcatgatta ccaagccccg gccaacgagg gcagagacaa 1141 gcgatgtcgc caatgctgtg ctggatgggg ctgactgcat catgctgtca ggggagactg 1201 ccaagggcaa cttccctgtg gaagcggtga agatgcagca tcggattgcc cgggaggcag 1261 aggccgcagt gtaccaccgg cagctgtttg aggagctacg tcgggcagcg ccactaagcc 1321 gtgatcccac tgaggtcacc gccattggtg ctgtggaggc tgccttcaag tgctgtgctg 1381 ctgccatcat tgtgctgacc acaactggcc gctcagccca gcttctgtct cggtaccgac 1441 ctcgggcagc agtcattgct gtcacccgct ctgcccaggc tgcccgccag gtccacttat 1501 gccgaggagt cttccccttg ctttaccgtg aacctccaga agccatctgg gcagatgatg 1561 tagatcgccg ggtgcaattt ggcattgaaa gtggaaagct ccgtggcttc ctccgtgttg 1621 gagacctggt gattgtggtg acaggctggc gacctggctc cggctacacc aacatcatga 1681 gggtgctaag catatcctga gacgcccctc ccccctctgg cccagcctac ccttgtaccc 1741 catcccttcc tccccagtct acgttctcca gcccacaccc ctccaaagcc ccacctttaa 1801 gtcctctctt ctctattcct gaccctccct acctgaggcc tatctgagac tataactgtc 1861 atctagcccc ttcgaggttg ccccttcccc atctccattt cacacaggtc ctgaaagtct 1921 gtgtccaatt atgcactggc cacccaacag caccaattgt acattctctg catccaatct 1981 gctcagcagg ccctaagatg ccttgagtct ttaatcccag gtttggctgg ttaattccat 2041 aaccccaggc atcccatccc ttggggtggg ggagagggga gacagggcaa tcttgtccac 2101 agtctcccat tctcatatgt agccctcatg ataatctggg catctcgtgc cagggcaggc 2161 taccccttca tggtgactaa cagttacatg aaagtccacg cttttgggaa aactgggtgg 2221 gatggatgct ggggagaagt gagggctggg cagctgattt tgtcactgtc ttcacaactc 2281 gtgctgggct tgtagaccac tgtcctggct gctctcatgc ctgcctgata ccctgcttgg 2341 tcaaatcccg gctgcttcct tctgcaccca gaaattcctt cccactcatg ttgttcccac 2401 acacaaacca agagccaaaa atgagtgtgt c //