LOCUS HUMMDR1 4646 bp mRNA linear HUM 03-DEC-1999 DEFINITION Homo sapiens P-glycoprotein (PGY1) mRNA, complete cds. ACCESSION M14758 VERSION M14758.1 KEYWORDS P-glycoprotein; drug resistance protein; transport protein. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 4646) AUTHORS Chen,C.J., Chin,J.E., Ueda,K., Clark,D.P., Pastan,I., Gottesman,M.M. and Roninson,I.B. TITLE Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells JOURNAL Cell 47 (3), 381-389 (1986) PUBMED 2876781 REFERENCE 2 (sites) AUTHORS Ueda,K., Clark,D.P., Chen,C.J., Roninson,I.B., Gottesman,M.M. and Pastan,I. TITLE The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation JOURNAL J. Biol. Chem. 262 (2), 505-508 (1987) PUBMED 3027054 REFERENCE 3 (bases 971 to 985; 3095 to 3109) AUTHORS Kioka,N., Tsubota,J., Kakehi,Y., Komano,T., Gottesman,M.M., Pastan,I. and Ueda,K. TITLE P-glycoprotein gene (MDR1) cDNA from human adrenal: normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance JOURNAL Biochem. Biophys. Res. Commun. 162 (1), 224-231 (1989) PUBMED 2568832 COMMENT Original source text: Human drug-resistant cell line KB-C2.5 cDNA to mRNA, clones lambda-HDR[10, 5, 104]. [2] sites. Draft entry and computer-readable sequence [1] kindly submitted by I.B.Roninson, 13-AUG-1987. The sequence shown is of a cDNA clone initiating at a minor upstream transcription initiation site and containing the major site of transcription initiation. FEATURES Location/Qualifiers source 1..4646 /db_xref="H-InvDB:HIT000194362" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /map="7q21" gene 1..4646 /gene="PGY1" variation 382 /gene="PGY1" /note="g in [1]; a in [2]" CDS 425..4267 /gene="PGY1" /note="P-glycoprotein" /codon_start=1 /protein_id="AAA59575.1" /translation="MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSN WLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTG FFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEI GWFDVHDVGELNTRLTDDVSKINEVIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVI LAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELER YNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTV FFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNL EFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGM VSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEAN AYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESE AVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFK LVTMQTAGNEVELENAADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKL STKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFT RIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLR QDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQ LTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTQEQ KFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFE DVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNT LEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYD PLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIV RAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATS ALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLA QKGIYFSMVSVQAGTKRQ" variation 964 /gene="PGY1" /note="t in [1]; c in [2]" variation 978..979 /gene="PGY1" /note="tt in [1]; ga in [2] Val->Gly" variation 1660 /gene="PGY1" /note="c in [1]; t in [2]" variation 2065 /gene="PGY1" /note="c in [1]; t in [2]" variation 3101 /gene="PGY1" /note="g in [1]; t in [2] Ala-> Ser" variation 3859 /gene="PGY1" /note="c in [1]; t in [2]" variation 4460 /gene="PGY1" /note="a in [1]; g in [2]" BASE COUNT 1371 a 892 c 1129 g 1254 t ORIGIN 154 bp upstream of AvaI site; chromosome 7q21.1. 1 cctactctat tcagatattc tccagattcc taaagattag agatcatttc tcattctcct 61 aggagtactc acttcaggaa gcaaccagat aaaagagagg tgcaacggaa gccagaacat 121 tcctcctgga aattcaacct gtttcgcagt ttctcgagga atcagcattc agtcaatccg 181 ggccgggagc agtcatctgt ggtgaggctg attggctggg caggaacagc gccggggcgt 241 gggctgagca cagcgcttcg ctctctttgc cacaggaagc ctgagctcat tcgagtagcg 301 gctcttccaa gctcaaagaa gcagaggccg ctgttcgttt cctttaggtc tttccactaa 361 agtcggagta tcttcttcca agatttcacg tcttggtggc cgttccaagg agcgcgaggt 421 cgggatggat cttgaagggg accgcaatgg aggagcaaag aagaagaact tttttaaact 481 gaacaataaa agtgaaaaag ataagaagga aaagaaacca actgtcagtg tattttcaat 541 gtttcgctat tcaaattggc ttgacaagtt gtatatggtg gtgggaactt tggctgccat 601 catccatggg gctggacttc ctctcatgat gctggtgttt ggagaaatga cagatatctt 661 tgcaaatgca ggaaatttag aagatctgat gtcaaacatc actaatagaa gtgatatcaa 721 tgatacaggg ttcttcatga atctggagga agacatgacc aggtatgcct attattacag 781 tggaattggt gctggggtgc tggttgctgc ttacattcag gtttcatttt ggtgcctggc 841 agctggaaga caaatacaca aaattagaaa acagtttttt catgctataa tgcgacagga 901 gataggctgg tttgatgtgc acgatgttgg ggagcttaac acccgactta cagatgatgt 961 ctctaagatt aatgaagtta ttggtgacaa aattggaatg ttctttcagt caatggcaac 1021 atttttcact gggtttatag taggatttac acgtggttgg aagctaaccc ttgtgatttt 1081 ggccatcagt cctgttcttg gactgtcagc tgctgtctgg gcaaagatac tatcttcatt 1141 tactgataaa gaactcttag cgtatgcaaa agctggagca gtagctgaag aggtcttggc 1201 agcaattaga actgtgattg catttggagg acaaaagaaa gaacttgaaa ggtacaacaa 1261 aaatttagaa gaagctaaaa gaattgggat aaagaaagct attacagcca atatttctat 1321 aggtgctgct ttcctgctga tctatgcatc ttatgctctg gccttctggt atgggaccac 1381 cttggtcctc tcaggggaat attctattgg acaagtactc actgtattct tttctgtatt 1441 aattggggct tttagtgttg gacaggcatc tccaagcatt gaagcatttg caaatgcaag 1501 aggagcagct tatgaaatct tcaagataat tgataataag ccaagtattg acagctattc 1561 gaagagtggg cacaaaccag ataatattaa gggaaatttg gaattcagaa atgttcactt 1621 cagttaccca tctcgaaaag aagttaagat cttgaagggc ctgaacctga aggtgcagag 1681 tgggcagacg gtggccctgg ttggaaacag tggctgtggg aagagcacaa cagtccagct 1741 gatgcagagg ctctatgacc ccacagaggg gatggtcagt gttgatggac aggatattag 1801 gaccataaat gtaaggtttc tacgggaaat cattggtgtg gtgagtcagg aacctgtatt 1861 gtttgccacc acgatagctg aaaacattcg ctatggccgt gaaaatgtca ccatggatga 1921 gattgagaaa gctgtcaagg aagccaatgc ctatgacttt atcatgaaac tgcctcataa 1981 atttgacacc ctggttggag agagaggggc ccagttgagt ggtgggcaga agcagaggat 2041 cgccattgca cgtgccctgg ttcgcaaccc caagatcctc ctgctggatg aggccacgtc 2101 agccttggac acagaaagcg aagcagtggt tcaggtggct ctggataagg ccagaaaagg 2161 tcggaccacc attgtgatag ctcatcgttt gtctacagtt cgtaatgctg acgtcatcgc 2221 tggtttcgat gatggagtca ttgtggagaa aggaaatcat gatgaactca tgaaagagaa 2281 aggcatttac ttcaaacttg tcacaatgca gacagcagga aatgaagttg aattagaaaa 2341 tgcagctgat gaatccaaaa gtgaaattga tgccttggaa atgtcttcaa atgattcaag 2401 atccagtcta ataagaaaaa gatcaactcg taggagtgtc cgtggatcac aagcccaaga 2461 cagaaagctt agtaccaaag aggctctgga tgaaagtata cctccagttt ccttttggag 2521 gattatgaag ctaaatttaa ctgaatggcc ttattttgtt gttggtgtat tttgtgccat 2581 tataaatgga ggcctgcaac cagcatttgc aataatattt tcaaagatta taggggtttt 2641 tacaagaatt gatgatcctg aaacaaaacg acagaatagt aacttgtttt cactattgtt 2701 tctagccctt ggaattattt cttttattac atttttcctt cagggtttca catttggcaa 2761 agctggagag atcctcacca agcggctccg atacatggtt ttccgatcca tgctcagaca 2821 ggatgtgagt tggtttgatg accctaaaaa caccactgga gcattgacta ccaggctcgc 2881 caatgatgct gctcaagtta aaggggctat aggttccagg cttgctgtaa ttacccagaa 2941 tatagcaaat cttgggacag gaataattat atccttcatc tatggttggc aactaacact 3001 gttactctta gcaattgtac ccatcattgc aatagcagga gttgttgaaa tgaaaatgtt 3061 gtctggacaa gcactgaaag ataagaaaga actagaaggt gctgggaaga tcgctactga 3121 agcaatagaa aacttccgaa ccgttgtttc tttgactcag gagcagaagt ttgaacatat 3181 gtatgctcag agtttgcagg taccatacag aaactctttg aggaaagcac acatctttgg 3241 aattacattt tccttcaccc aggcaatgat gtatttttcc tatgctggat gtttccggtt 3301 tggagcctac ttggtggcac ataaactcat gagctttgag gatgttctgt tagtattttc 3361 agctgttgtc tttggtgcca tggccgtggg gcaagtcagt tcatttgctc ctgactatgc 3421 caaagccaaa atatcagcag cccacatcat catgatcatt gaaaaaaccc ctttgattga 3481 cagctacagc acggaaggcc taatgccgaa cacattggaa ggaaatgtca catttggtga 3541 agttgtattc aactatccca cccgaccgga catcccagtg cttcagggac tgagcctgga 3601 ggtgaagaag ggccagacgc tggctctggt gggcagcagt ggctgtggga agagcacagt 3661 ggtccagctc ctggagcggt tctacgaccc cttggcaggg aaagtgctgc ttgatggcaa 3721 agaaataaag cgactgaatg ttcagtggct ccgagcacac ctgggcatcg tgtcccagga 3781 gcccatcctg tttgactgca gcattgctga gaacattgcc tatggagaca acagccgggt 3841 ggtgtcacag gaagagatcg tgagggcagc aaaggaggcc aacatacatg ccttcatcga 3901 gtcactgcct aataaatata gcactaaagt aggagacaaa ggaactcagc tctctggtgg 3961 ccagaaacaa cgcattgcca tagctcgtgc ccttgttaga cagcctcata ttttgctttt 4021 ggatgaagcc acgtcagctc tggatacaga aagtgaaaag gttgtccaag aagccctgga 4081 caaagccaga gaaggccgca cctgcattgt gattgctcac cgcctgtcca ccatccagaa 4141 tgcagactta atagtggtgt ttcagaatgg cagagtcaag gagcatggca cgcatcagca 4201 gctgctggca cagaaaggca tctatttttc aatggtcagt gtccaggctg gaacaaagcg 4261 ccagtgaact ctgactgtat gagatgttaa atacttttta atatttgttt agatatgaca 4321 tttattcaaa gttaaaagca aacacttaca gaattatgaa gaggtatctg tttaacattt 4381 cctcagtcaa gttcagagtc ttcagagact tcgtaattaa aggaacagag tgagagacat 4441 catcaagtgg agagaaatca tagtttaaac tgcattataa attttataac agaattaaag 4501 tagattttaa aagataaaat gtgtaatttt gtttatattt tcccatttgg actgtaactg 4561 actgccttgc taaaagatta tagaagtagc aaaaagtatt gaaatgtttg cataaagtgt 4621 ctataataaa actaaacttt catgtg //