LOCUS LC406757 6000 bp DNA linear PLN 08-MAY-2019 DEFINITION Acremonium egyptiacum F-1392 DNA, ascofuranone biosynthesis gene cluster, complete sequence. ACCESSION LC406757 VERSION LC406757.1 KEYWORDS . SOURCE Acremonium egyptiacum ORGANISM Acremonium egyptiacum Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes; Hypocreomycetidae; Hypocreales; Hypocreales incertae sedis; Acremonium. REFERENCE 1 (bases 1 to 6000) AUTHORS Matsuzaki,M. and Kita,K. TITLE Direct Submission JOURNAL Submitted (04-JUL-2018) to the DDBJ/EMBL/GenBank databases. Contact:Motomichi Matsuzaki RIKEN Center for Advanced Intelligence Project; 1-4-1 Nihonbashi, Chuo-ku, Tokyo 103-0027, Japan REFERENCE 2 AUTHORS Araki,Y., Awakawa,T., Matsuzaki,M., Cho,R., Matsuda,Y., Hoshino,S., Shinohara,Y., Yamamoto,M., Kido,Y., Inaoka,D.K., Nagamune,K., Ito,K., Abe,I. and Kita,K. TITLE Complete biosynthetic pathways of ascofuranone and ascochlorin in Acremonium egyptiacum JOURNAL Proc. Natl. Acad. Sci. U.S.A. 116, 8269-8274 (2019) REMARK DOI:10.1073/pnas.1819254116 COMMENT ##Assembly-Data-START## Assembly Method :: Mira v. 3.9.17 Sequencing Technology :: Ion PGM ##Assembly-Data-END## FEATURES Location/Qualifiers source 1..6000 /db_xref="taxon:749675" /mol_type="genomic DNA" /organism="Acremonium egyptiacum" /strain="F-1392" misc_feature 1..6000 /note="ascofuranone biosynthesis gene cluster" CDS complement(join(619..1004,1054..1491,1539..1605)) /codon_start=1 /gene="ascJ" /product="dehydrogenase" /protein_id="BBF25320.1" /transl_table=1 /translation="MTDIHIQDGDLSSLKDKVVVITGGSSGIGLATTNLLLDLGAKVV IGDLQPPTTRVDSERCSFHKVDVTVWSDQLTLFKEARELHGRIDHVFANAGVGPKADY LSTALDQNGDLVEPTFLTLDVNLKAVIYTATIACYYMREEQQSPAGGSIVIVSSVAGV SRFRAVDYATAKHGNLGFARGLHQRLTAENSPTRVNLIAPSWTNTGFMPPQIMAAVGV EPQEPASVGRAAAYLMADDSRKGQMIHIAKGRYREVEESIMLPAAEKVVDVENGGVME DDTLAKIIETMGIFKAKATQ" CDS join(2085..2431,2476..3283) /codon_start=1 /gene="ascI" /product="terpene cyclase" /protein_id="BBF25321.1" /transl_table=1 /translation="MPQLAGKLILAGLIPLGAWVLHGFASCNGLIQMFEDFGKQTVLS DGVTDYTGAFTGLEGLDRLLRTLLNFFWPVANGHDWALSLHAFMFAGQGVPLLVLNML EGARPGNKSLVVSYVTVFGILYMVVGLAIMAPLYLFLHLLTSRTATAPSKAKVAVDPN TAKAVGFGVFVGYVLPTIFMSLPHPSLLSTDTKVLSVVFWQAVPLWASVCAYFASTAL GQSATSRSSSNLPSALGAVYAASLIIATATHVATFAISANLSDTWSGIFTFLIPPNPF NTDMRISSFLEGATWFLQWDYTMMSLAYMVWAIGIRHGVEVPRSSHHFETLGKIALRS MAKLLVMGPIGAALSLVWERDQLLWQLDSESGEKGEKNRSRRMSRKWMFS" CDS join(3612..4725,4784..5003,5106..5310) /codon_start=1 /gene="ascH" /product="cytochrome P450 monooxygenase" /protein_id="BBF25322.1" /transl_table=1 /translation="MGLSLGYSPDRGSIGSWICAAPLILALFVISYRLFQSVIDYRLS HRNGCKPPPTYPHKDWYLGLHHVFGLLKAKKENRLPTAFSELFDASGPDVHTLGHYVL GKKSYWTRDPENIKAVLSSKFNDWGLPSARKATFRTCLGGGIFGVDGKEWEHSRAMLK PSFTRTQIGDTATLSKHADNLIARIPEGETVDLAELFPLLTMDVGTEMLFGESVGSLD PAEIKQATRFTTSFDYIVQTMSKHMALPILTKLRDKTLQGCVEFVDDFAADVVNRTIA NESKTEKPSSLGKYIFPTELAKMGLPEKQIRIEVINIMVAGRDTTAALLSLIWWYLAK RPDAVMKLHQELEPLGGRPPTGEEVKKMKYLRNFVNEILRLHPINPLNSRTAAKDTTL PRGGGPDGKSPVFIRKGTQLMFSSAALQRRKDLYGEDALDLRPERWERIRPSAFEYIP FGGGPRICPGQQLALTEASYFTARLLQEFQGVTSESSGPFQEAFAILVTSGDGVKVKF HKKH" BASE COUNT 1442 a 1598 c 1462 g 1498 t ORIGIN 1 tgccttcagg accaactgag aaattaaact ttcaaggcca ggcatagtgt catttgattg 61 caaacctggt gatgttcgat gttcacgacg ggtacgttcc tgaagatctt tggtaagacg 121 gacgattgtg tggccgtgca cctgccacaa agggaatatt gaagattgtt cagaaccaag 181 agatccaaag gtagcgcaaa agtctgagag gcccaacatg tgcaactcac taaacagtca 241 ggcaatgctt gcggtccaca aacaagggaa catccagact tgaaactgag ttgacgaggc 301 caccacttac ataggggtgt ggggccgtgt ccgatcacct gtgtaagtca gtccattgcc 361 tgttccagca ctgcctatac agcaagccgt ggacatttca cgaagtgttc attcaatcta 421 gtgtgatagg agatatttag ccatatggta gtatctagcc taacagcgag gtttgcatgt 481 agttgtggag ctaccaaact tcagttagct ctaacgtctc aggccagcag ctcatctact 541 agatgacact gttgagatgg gcgatacaga tctcgacgcc ctcaagcctc aaattaggtc 601 tcttccacac tccacagttc attgtgttgc cttcgctttg aatatgccca tggtctcaat 661 aatcttagcc agggtgtcgt cttccatcac acccccgttc tccacgtcaa caactttctc 721 agcagcgggc agcataatgc tctcttcaac ctcgcgatat cgccccttcg caatgtgaat 781 catctgtcct tttctcgagt catcagccat cagataagcc gcagctcgac ccaccgaggc 841 aggctcttga ggctcgacgc caacggccgc cataatctgg ggtggcatga agcccgtgtt 901 ggtccacgac ggagcgatga ggttgacgcg agttggcgag ttctcagccg tcaaccgctg 961 atgcagaccg cgggcgaaac caagatttcc gtgcttggca gtggctgatt atgtcagttt 1021 catcggagct aaccatctac tccttgatct taccatagtc gaccgccctg aagcgcgaca 1081 caccagcaac agacgagaca atgacgatgc ttcctccagc agggctttgc tgctcttccc 1141 gcatgtagta gcaagcaatg gtcgcggtgt agatgactgc cttcaagttg acatcgagcg 1201 tcaagaacgt tggctctacc aaatcgccat tctggtcaag tgccgttgat aggtagtcgg 1261 ctttaggccc aacgcctgcg ttggcaaaaa cgtggtcaat tcttccatgg agctctcgag 1321 cttccttgaa aagggtcagt tggtcagacc acacggtcac atctactttg tgaaagctgc 1381 atcgctcgct gtccacacgg gtcgtgggcg gttggagatc gccaatgacc acctttgcac 1441 cgaggtcgag cagaaggttc gtagtagcaa gaccgatacc tgaggagcca cctgattcaa 1501 attagattca tgctggcccg tgaaaatttc tcacttgcct gtgatcacca ccaccttgtc 1561 cttgagactc gagagatctc cgtcctgaat atgaatgtct gtcatggttt tagctaggat 1621 attaaatgtg atacgaatag cggtcttcaa tataaaaatg ttttatgcaa taactaatct 1681 atcctatacc ctgatatcaa gaagttccaa cgttgtgtct atctgcacgc tgtcggcgca 1741 tttaaagtgg ctagggtgcg ccacgaagtc tggagaggac tctcggtgca ttattccaca 1801 actatgtgag accccgcgtt ccatgtgtct cgcgggatcg tctctcatcc tacagactca 1861 tgcatggaac agttccaaga atgtggcatt tcgatcctca gtcacaggca aatccgccga 1921 atgatacttc ttccatcagg caacgaatcc ttcatcttta gagtacaaat tttggaactg 1981 ttgacatgga actgactgca ttctgatcat tcaaactcga agcacctcca gtatctgttt 2041 atcatttgtt gcaaatcgat cagtgtctgc ccgttgtatt caggatgccc cagctcgcag 2101 gtaagttaat actggcaggg ctcattcccc tgggtgcatg ggtcctccat ggtttcgcct 2161 cctgcaacgg actcatccag atgttcgaag acttcgggaa gcagacagtc ctgtcagacg 2221 gagtgaccga ttacactggg gctttcaccg gccttgaggg cctggatcgc ctcctcagga 2281 ctctgctcaa ttttttctgg ccagttgcca acggacatga ttgggcactg tcgctgcatg 2341 ctttcatgtt tgctggccaa ggagtcccgc tcctggtgct taacatgctg gaaggggctc 2401 gacctgggaa caagtctctg gtcgtcagct agtaagtgct tccgccttct ctgagctgct 2461 gagactgacc agcagcgtta ccgtcttcgg aattctgtac atggtggttg gattagccat 2521 catggccccc ttgtatctct tccttcacct cttgacatct cgaaccgcca ctgcaccgtc 2581 caaggctaaa gtggccgtgg accctaacac ggcaaaagcc gtcggcttcg gcgtgttcgt 2641 aggctacgta ctgcccacaa ttttcatgtc attgcctcat ccttcgcttc tgtccacgga 2701 cacaaaggtc ttgtcagttg tcttctggca agcagtgccg ctgtgggcct cagtgtgtgc 2761 atactttgca tctacagctc ttggccagtc ggcaacttca cggtcgtcca gcaacctgcc 2821 ttcggcattg ggagcggtat atgccgcctc tctcatcatc gcaactgcca ctcacgttgc 2881 cacattcgcc atatccgcaa atctatcgga tacctggagc ggcattttca cctttttgat 2941 tccaccgaat cccttcaaca cggatatgag gatctcatcc ttccttgagg gcgcaacttg 3001 gttcttgcag tgggactaca caatgatgtc cttggcatac atggtctggg ccatcggtat 3061 ccggcacggg gttgaagtac ctcggagctc gcaccacttc gagacactcg gaaagatcgc 3121 cctgcgctcg atggcgaagt tgttggtcat gggacccatt ggcgcagcgc tcagtcttgt 3181 atgggagaga gatcaactac tgtggcaact tgacagcgag agcggtgaga agggtgagaa 3241 aaataggtct aggaggatgt caaggaagtg gatgttctca tagaacgata cctagtcttt 3301 ggcagtcact aatgtaacct ccaatcaagg cgatatcgcc aaccgcggta cgaaatagtc 3361 tccttcttcc tttgataatg atcgcacatt gtatgaaagg atccttgttc ggtctattta 3421 cgatacccta ccctcaaatt cggggctttc ccacaaactg aacctgcaga gactgccgat 3481 tcacgccctt ttcacttctt ccactaatct cgcttgagtt ttgcttggac atttcacatc 3541 gctaagcgag gttcaactta ccgggtttgc ggagacacta atcgactttt caatcgattg 3601 gttctatcaa tatggggcta tcactcggtt acagccccga tcgaggcagc attgggtctt 3661 ggatctgtgc tgcgccgcta attctggctc ttttcgtcat ctcgtaccgt ctttttcaat 3721 ctgtgatcga ctatcgactg tcgcaccgca acggctgcaa accaccccct acgtaccctc 3781 acaaggattg gtatcttggc ctccaccacg ttttcggcct cctgaaagcg aagaaagaaa 3841 accgtctgcc gactgcattt agcgagcttt tcgacgccag tggccctgat gttcacactc 3901 tgggccacta tgtccttggc aaaaagtctt actggacaag agaccccgag aacatcaaag 3961 ctgtcctgtc gtccaagttc aacgactggg gtcttccgtc tgcgaggaag gcaactttca 4021 ggacatgtct tgggggcggc atctttggtg tcgatggcaa agagtgggag cactcaagag 4081 caatgctcaa gccttcattc acccggactc agattgggga cactgcgact ctgtccaagc 4141 acgccgacaa cctcatcgca aggattccag agggggagac ggtggaccta gctgagctat 4201 ttcccctcct taccatggat gttggaacgg aaatgctctt cggcgaaagc gtcgggagcc 4261 tggatccagc ggagatcaag caggccacta ggttcactac atcatttgac tacattgttc 4321 agacaatgtc caagcacatg gccttgccta tccttacaaa gcttcgcgat aagacactac 4381 aaggatgcgt tgaatttgtc gacgacttcg cagctgatgt ggtaaatcgg accatcgcca 4441 atgaaagcaa aacggagaag ccgagctccc ttgggaagta catctttcct actgagctgg 4501 ccaagatggg cttgccggag aaacaaatca ggatcgaggt tatcaacatc atggttgctg 4561 gaagagatac gactgctgca ctcctgagtc tcatctggtg gtacttagcg aaacgacctg 4621 atgccgtcat gaagcttcat caggagcttg agccgctcgg aggacggccg ccaacaggtg 4681 aagaggtcaa gaagatgaag tacctcagaa acttcgtcaa tgaaagtgag ccatgcccag 4741 ttcgctttac ctatcattaa gaactcaggc taatcagaga cagtcctgag gctccaccca 4801 atcaacccct tgaactcccg taccgccgcc aaagacacta ccctgccacg cggtggggga 4861 ccggacggga agtcccctgt attcatacga aagggaacac agctcatgtt ctcttctgct 4921 gccctgcaac gtagaaagga tctgtacgga gaagatgctt tggatctgag gcccgagaga 4981 tgggagcgca tccgaccatc cgcgtaagtc catacagtta aacagtcgcc tcgccttttg 5041 aatgattgga ttatcataca tactctacca caaatgataa ccgattgctg acccaagcgt 5101 cccaggtttg aatacattcc cttcggtggc ggtccaagga tttgtccagg tcaacagctt 5161 gccttgacag aagcatcata cttcactgca agactcttgc aagagtttca gggagtgact 5221 tccgagtcga gcggaccgtt ccaggaagca ttcgctattc tcgtgaccag cggagacggg 5281 gtcaaggtta agttccacaa gaagcactga gattgagaag acggccttgc ggtagccttg 5341 ccgatttggt ggacaaagat cgtcgggttc tgcgaaagtc acgtcgggga attatggatt 5401 ggaataagag gaatacacgc cggaagaacg gatagaagtc taaccgaaaa gaaattgctg 5461 ttgcgaatgt ccaccgtacg ctatgctatg ctatgcagac cgaaagctcc atcccatcct 5521 ttgattaatc tgtgggatgc agatcgcttg tactgaatgt ttccccgatg aacgccatgc 5581 caaactcctc taactataaa ttgataaccg tgagcaccga gcctctatca tgcaatttcc 5641 attcccaatc ccaaaatcaa tcccgtaaac aatacacgta cccaatatca tccgtccata 5701 cactgcttgt cacacactga gacaggtctg cggctacttc ctgctcgttt ttgagtagtc 5761 cgagggaggg gtttgtctgc tttctgcttt atccatcaac aacaaagaaa agagcccaaa 5821 acaacagtca tttcatggcc caaagtaccg catagattcc cgctcctcgg gtatcgctgt 5881 caaggtagtt gcgacctgtc tttgatctag tttgacagat gcaagacggt gaggcggcac 5941 cggagtgacc aggtcgtcct ccgtcgctcc cctgttccaa ggccctggtg tttctgggct //