LOCUS       HUMSUR1RNA              4892 bp    mRNA    linear   HUM 11-JUN-1996
DEFINITION  Homo sapiens sulfonylurea receptor (SUR1) mRNA, complete cds.
ACCESSION   L78207
VERSION     L78207.1
KEYWORDS    membrane protein; potassium ion channel; sulfonylurea receptor.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4892)
  AUTHORS   Gonzalez,G., Aguilar-Bryan,L. and Bryan,J.
  TITLE     Human beta cell sulfonylurea receptor, SUR1, expression
  JOURNAL   Unpublished
COMMENT     On Jun 12, 1996 this sequence version replaced gi:1369843.
            Original source text: Homo sapiens cDNA to mRNA.
FEATURES             Location/Qualifiers
     source          1..4892
                     /db_xref="H-InvDB:HIT000194053"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /cell_type="beta cell"
     gene            1..4892
                     /gene="SUR1"
     5'UTR           <1..38
                     /gene="SUR1"
     CDS             39..4784
                     /gene="SUR1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="homologous to ciusur and ratsur"
                     /codon_start=1
                     /product="sulfonylurea receptor"
                     /protein_id="AAB02278.1"
                     /db_xref="GI:1369844"
                     /translation="MPLAFCGSENHSAAYRVDQGVLNNGCFVDVLNVVPHVFLLFITF
                     PILFIGWGSQSSKVHIHHSTWLHFPGHNLRWILTFMLLFVLVCEIAEGILSDGVTESH
                     HLHLYMPAGMAFMAAVTSVVYYHNIETSNFPKLLIALLVYWTLAFITKTIKFVKFLDH
                     AIAFSQVRFCLTGLLVILYGMLLLVEVNVIRVRRYIFFKTPREVKPPEDLQDLGVRFL
                     QPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALTNYQRLCEAFDAQVRK
                     DIQGTQGARAIWQALSHAFGRRLVLSSTFRILADLLGFAGPLCIFGIVDHLGKENDVF
                     QPKTQFLGVYFVSSQEFLANAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQ
                     TKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVI
                     LLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRTTLEYSNERLKQTNEMLRGIKL
                     LKLYAWENIFRTRVETTRRKEMTSLRAFAIYTSISIFMNTAIPIAAVLITFVGHVSFF
                     KEADFSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIREEQC
                     APHEPTPQGPASKYQAVPLRVVNRKRPAREDCRGLTGPLQSLVPSADGDADNCCVQIM
                     GGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWS
                     SLPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNKQRY
                     KMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPF
                     SALDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLK
                     DFQRSECQLFEHWKTLMNRQDQELEKETVTERKATEPPQGLSRAMSSRDGLLQDEEEE
                     EEEAAESEEDDNLSSMLHQRAEIPWRACAKYLSSAGILLLSLLVFSQLLKHMVLVAID
                     YWLAKWTDSALTLTPAARNCSLSQECTLDQTVYAMVFTAVCSLGIVLCLVTSVTVEWT
                     GLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRST
                     LLCVSALAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFA
                     ETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIA
                     AVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKT
                     EAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALISPGQKIGICG
                     RTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIR
                     FNLDPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARA
                     FVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLK
                     RGAILEFDKPEKLLSRKDSVFASFVRADK"
     3'UTR           4785..>4892
                     /gene="SUR1"
     polyA_signal    4866..4871
                     /gene="SUR1"
BASE COUNT         1042 a         1525 c         1288 g         1037 t
ORIGIN      
        1 gccagctgag cccgagccca gaccgcgccc gcgccgccat gcccctggcc ttctgcggca
       61 gcgagaacca ctcggccgcc taccgggtgg accagggggt cctcaacaac ggctgctttg
      121 tggacgtcct caacgtggtg ccgcacgtct tcctactctt catcaccttc cccatcctct
      181 tcattggatg gggaagtcag agctccaagg tgcacatcca ccacagcaca tggcttcatt
      241 tccctgggca caacctgcgg tggatcctga ccttcatgct gctcttcgtc ctggtgtgtg
      301 agattgcaga gggcatcctg tctgatgggg tgaccgaatc ccaccatctg cacctgtaca
      361 tgccagccgg gatggcgttc atggctgctg tcacctccgt ggtctactat cacaacatcg
      421 agacttccaa cttccccaag ctgctaattg ccctgctggt gtattggacc ctggccttca
      481 tcaccaagac catcaagttt gtcaagttct tggaccacgc catcgcgttc tcgcaggtac
      541 gcttctgcct cacagggctg ctggtgatcc tctatgggat gctgctcctc gtggaggtca
      601 atgtcatcag ggtgaggaga tacatcttct tcaagacacc gagggaggtg aagcctcccg
      661 aggacctgca agacctgggg gtacgcttcc tgcagccctt cgtgaatctg ctgtccaaag
      721 gcacctactg gtggatgaac gccttcatca agactgccca caagaagccc atcgacttgc
      781 gagccatcgg gaagctgccc atcgccatga gggccctcac caactaccaa cggctctgcg
      841 aggcctttga cgcccaggtg cggaaggaca ttcagggcac tcaaggtgcc cgggccatct
      901 ggcaggcact cagccatgcc ttcgggaggc gcctggtcct cagcagcact ttccgcatct
      961 tggccgacct gctgggcttc gccgggccac tgtgcatctt tgggatcgtg gaccaccttg
     1021 ggaaggagaa cgacgtcttc cagcccaaga cacaatttct cggggtttac tttgtctcat
     1081 cccaagagtt ccttgccaat gcctacgtct tagctgtgct tctgttcctt gccctcctac
     1141 tgcaaaggac atttctgcaa gcatcctact atgtggccat tgaaactgga attaacttga
     1201 gaggagcaat acagaccaag atttacaata aaattatgca cctgtccacc tccaacctgt
     1261 ccatgggaga aatgactgct ggacagatct gtaatctggt tgccatcgac accaatcagc
     1321 tcatgtggtt tttcttcttg tgcccaaacc tctgggctat gccagtacag atcattgtgg
     1381 gtgtgattct cctctactac atactcggag tcagtgcctt aattggagca gctgtcatca
     1441 ttctactggc tcctgtccag tacttcgtgg ccaccaagct gtctcaggcc cagcggacga
     1501 cactggagta ttccaatgag cggctgaagc agaccaacga gatgctccgc ggcatcaagc
     1561 tgctgaagct gtacgcctgg gagaacatct tccgcacgcg ggtggagacg acccgcagga
     1621 aggagatgac cagcctcagg gcctttgcca tctatacctc catctccatt ttcatgaaca
     1681 cggccatccc cattgcagct gtcctcataa ctttcgtggg ccatgtcagc ttcttcaaag
     1741 aggccgactt ctcgccctcc gtggcctttg cctccctctc cctcttccat atcttggtca
     1801 caccgctgtt cctgctgtcc agtgtggtcc gatctaccgt caaagctcta gtgagcgtgc
     1861 aaaagctaag cgagttcctg tccagtgcag agatccgtga ggagcagtgt gccccccatg
     1921 agcccacacc tcagggccca gccagcaagt accaggcggt gcccctcagg gttgtgaacc
     1981 gcaagcgtcc agcccgggag gattgtcggg gcctcaccgg cccactgcag agcctggtcc
     2041 ccagtgcaga tggcgatgct gacaactgct gtgtccagat catgggaggc tacttcacgt
     2101 ggaccccaga tggaatcccc acactgtcca acatcaccat tcgtatcccc cgaggccagc
     2161 tgactatgat cgtggggcag gtgggctgcg gcaagtcctc gctccttcta gccgcactgg
     2221 gggagatgca gaaggtctca ggggctgtct tctggagcag ccttcctgac agcgagatag
     2281 gagaggaccc cagcccagag cgggagacag cgaccgactt ggatatcagg aagagaggcc
     2341 ccgtggccta tgcttcgcag aaaccatggc tgctaaatgc cactgtggag gagaacatca
     2401 tctttgagag tcccttcaac aaacaacggt acaagatggt cattgaagcc tgctctctgc
     2461 agccagacat cgacatcctg ccccatggag accagaccca gattggggaa cggggcatca
     2521 acctgtctgg tggtcaacgc cagcgaatca gtgtggcccg agccctctac cagcacgcca
     2581 acgttgtctt cttggatgac cccttctcag ctctggatat ccatctgagt gaccacttaa
     2641 tgcaggccgg catccttgag ctgctccggg acgacaagag gacagtggtc ttagtgaccc
     2701 acaagctaca gtacctgccc catgcagact ggatcattgc catgaaggat ggcaccatcc
     2761 agagggaggg taccctcaag gacttccaga ggtctgaatg ccagctcttt gagcactgga
     2821 agaccctcat gaaccgacag gaccaagagc tggagaagga gactgtcaca gagagaaaag
     2881 ccacagagcc accccagggc ctatctcgtg ccatgtcctc gagggatggc cttctgcagg
     2941 atgaggaaga ggaggaagag gaggcagctg agagcgagga ggatgacaac ctgtcgtcca
     3001 tgctgcacca gcgtgctgag atcccatggc gagcctgcgc caagtacctg tcctccgccg
     3061 gcatcctgct cctgtcgttg ctggtcttct cacagctgct caagcacatg gtcctggtgg
     3121 ccatcgacta ctggctggcc aagtggaccg acagcgccct gaccctgacc cctgcagcca
     3181 ggaactgctc cctcagccag gagtgcaccc tcgaccagac tgtctatgcc atggtgttca
     3241 cggctgtctg cagcctgggc attgtgctgt gcctcgtcac gtctgtcact gtggagtgga
     3301 cagggctgaa ggtggccaag agactgcacc gcagcctgct aaaccggatc atcctagccc
     3361 ccatgaggtt ttttgagacc acgccccttg ggagcatcct gaacagattt tcatctgact
     3421 gtaacaccat cgaccagcac atcccatcca cgctggagtg cctgagccgc tccaccctgc
     3481 tctgtgtctc agccctggcc gtcatctcct atgtcacacc tgtgttcctc gtggccctct
     3541 tgcccctggc catcgtgtgc tacttcatcc agaagtactt ccgggtggcg tccagggacc
     3601 tgcagcagct ggatgacacc acccagcttc cacttctctc acactttgcc gaaaccgtag
     3661 aaggactcac caccatccgg gccttcaggt atgaggcccg gttccagcag aagcttctcg
     3721 aatacacaga ctccaacaac attgcttccc tcttcctcac agctgccaac agatggctgg
     3781 aagtccgaat ggagtacatc ggtgcatgtg tggtgctcat cgcagcggtg acctccatct
     3841 ccaactccct gcacagggag ctctctgctg gcctggtggg cctgggcctt acctacgccc
     3901 taatggtctc caactacctc aactggatgg tgaggaacct ggcagacatg gagctccagc
     3961 tgggggctgt gaagcgcatc catgggctcc tgaaaaccga ggcagagagc tacgagggac
     4021 tcctggcacc atcgctgatc ccaaagaact ggccagacca agggaagatc cagatccaga
     4081 acctgagcgt gcgctacgac agctccctga agccggtgct gaagcacgtc aatgccctca
     4141 tctcccctgg acagaagatc gggatctgcg gccgcaccgg cagtgggaag tcctccttct
     4201 ctcttgcctt cttccgcatg gtggacacgt tcgaagggca catcatcatt gatggcattg
     4261 acatcgccaa actgccgctg cacaccctgc gctcacgcct ctccatcatc ctgcaggacc
     4321 ccgtcctctt cagcggcacc atccgattta acctggaccc tgagaggaag tgctcagata
     4381 gcacactgtg ggaggccctg gaaatcgccc agctgaagct ggtggtgaag gcactgccag
     4441 gaggcctcga tgccatcatc acagaaggcg gggagaattt cagccaggga cagaggcagc
     4501 tgttctgcct ggcccgggcc ttcgtgagga agaccagcat cttcatcatg gacgaggcca
     4561 cggcttccat tgacatggcc acggaaaaca tcctccaaaa ggtggtgatg acagccttcg
     4621 cagaccgcac tgtggtcacc atcgcgcatc gagtgcacac catcctgagt gcagacctgg
     4681 tgatcgtcct gaagcggggt gccatccttg agttcgataa gccagagaag ctgctcagcc
     4741 ggaaggacag cgtcttcgcc tccttcgtcc gtgcagacaa gtgacctgcc agagcccaag
     4801 tgccatccca cattcggacc ctgcccatac ccctgcctgg gttttctaac tgtaaatcac
     4861 ttgtaaataa atagatttga ttatttccta aa
//