LOCUS HUMD4C 1504 bp mRNA linear HUM 27-FEB-2002 DEFINITION Homo sapiens dopamine receptor D4 (DRD4) mRNA, complete cds. ACCESSION L12398 X58497 VERSION L12398.1 KEYWORDS dopamine D4 receptor; dopamine receptor. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1504) AUTHORS Van Tol,H.H., Bunzow,J.R., Guan,H.C., Sunahara,R.K., Seeman,P., Niznik,H.B. and Civelli,O. TITLE Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine JOURNAL Nature 350 (6319), 610-614 (1991) PUBMED 1840645 REFERENCE 2 (bases 1 to 1504) AUTHORS Van Tol,H.H., Wu,C.M., Guan,H.C., Ohara,K., Bunzow,J.R., Civelli,O., Kennedy,J., Seeman,P., Niznik,H.B. and Jovanovic,V. TITLE Multiple dopamine D4 receptor variants in the human population JOURNAL Nature 358 (6382), 149-152 (1992) PUBMED 1319557 COMMENT On Feb 26, 2002 this sequence version replaced gi:30414. FEATURES Location/Qualifiers source 1..1504 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="11" /map="11p15.5" gene 1..1504 /gene="DRD4" CDS 1..1404 /gene="DRD4" /codon_start=1 /product="dopamine receptor D4" /protein_id="AAB59386.1" /db_xref="GDB:G00-127-782" /translation="MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLL IGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWL LSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATW LLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRG LQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGP DCAPAAPGLPPDPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGLP QDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKA MRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTV FNAEFRNVFRKALRACC" repeat_region 744..1080 /gene="DRD4" /note="the 48bp direct repeat unit is polymorphic with respect to the number of repeated units (7 units for D4.7) (-8 &10 units; cit. #2; feature c) and seq. of the individual units (feature e, unpubl.); G00-127-782" /rpt_type=direct /rpt_unit_range=744..792 variation 791..1033 /gene="DRD4" /note="this sequence was deleted in the D4 variant with a 2-fold repeat (D4.2); this polymorphic variant was isolated as a partial cDNA from the neuroepithelioma SK-N-MC (see cit #3); G00-127-782" /phenotype="dopamine D4.2 receptor" /replace="cc" variation 839..985 /gene="DRD4" /note="this group of nucleotides is deleted in the polymorphic variant of the D4 receptor with a 4-fold repeat (D4.4); isolated as a partial cDNA from human pituitary and substantia nigra cDNA library; G00-127-782" /phenotype="dopamine D4.4 receptor" /replace="cc" variation 985 /gene="DRD4" /note="G00-127-782" /phenotype="dopamine D4.4 receptor" /replace="g" variation 994 /gene="DRD4" /note="G00-127-782" /phenotype="dopamine D4.4 receptor" /replace="a" polyA_site 1504 /gene="DRD4" /experiment="experimental evidence, no additional details recorded" /note="four independently isolated cDNA clones contain a poly A tail after this nucleotide; G00-127-782" BASE COUNT 153 a 633 c 487 g 231 t ORIGIN 1 atggggaacc gcagcaccgc ggacgcggac gggctgctgg ctgggcgcgg gccggccgcg 61 ggggcatctg cgggggcatc tgcggggctg gctgggcagg gcgcggcggc gctggtgggg 121 ggcgtgctgc tcatcggcgc ggtgctcgcg gggaactcgc tcgtgtgcgt gagcgtggcc 181 accgagcgcg ccctgcagac gcccaccaac tccttcatcg tgagcctggc ggccgccgac 241 ctcctcctcg ctctcctggt gctgccgctc ttcgtctact ccgaggtcca gggtggcgcg 301 tggctgctga gcccccgcct gtgcgacgcc ctcatggcca tggacgtcat gctgtgcacc 361 gcctccatct tcaacctgtg cgccatcagc gtggacaggt tcgtggccgt ggccgtgccg 421 ctgcgctaca accggcaggg tgggagccgc cggcagctgc tgctcatcgg cgccacgtgg 481 ctgctgtccg cggcggtggc ggcgcccgta ctgtgcggcc tcaacgacgt gcgcggccgc 541 gaccccgccg tgtgccgcct ggaggaccgc gactacgtgg tctactcgtc cgtgtgctcc 601 ttcttcctac cctgcccgct catgctgctg ctctactggg ccacgttccg cggcctgcag 661 cgctgggagg tggcacgtcg cgccaagctg cacggccgcg cgccccgccg acccagcggc 721 cctggcccgc cttcccccac gccacccgcg ccccgcctcc cccaggaccc ctgcggcccc 781 gactgtgcgc cccccgcgcc cggccttccc cggggtccct gcggccccga ctgtgcgccc 841 gccgcgcccg gcctcccccc ggacccctgc ggccccgact gtgcgccccc cgcgcccggc 901 ctcccccagg acccctgcgg ccccgactgt gcgccccccg cgcccggcct tccccggggt 961 ccctgcggcc ccgactgtgc gccccccgcg cccggcctcc cccaggaccc ctgcggcccc 1021 gactgtgcgc cccccgcgcc cggcctcccc ccggacccct gcggctccaa ctgtgctccc 1081 cccgacgccg tcagagccgc cgcgctccca ccccagactc caccgcagac ccgcaggagg 1141 cggcgtgcca agatcaccgg ccgggagcgc aaggccatga gggtcctgcc ggtggtggtc 1201 ggggccttcc tgctgtgctg gacgcccttc ttcgtggtgc acatcacgca ggcgctgtgt 1261 cctgcctgct ccgtgccccc gcggctggtc agcgccgtca cctggctggg ctacgtcaac 1321 agcgccctca accccgtcat ctacactgtc ttcaacgccg agttccgcaa cgtcttccgc 1381 aaggccctgc gtgcctgctg ctgagccggg cacccccgga cgccccccgg cctgatggcc 1441 aggcctcagg gaccaaggag atggggaggg cgcttttgta cgttaattaa acaaattcct 1501 tccc //