LOCUS HUMAMY 1549 bp mRNA linear HUM 26-JAN-1994
DEFINITION Human AD amyloid mRNA, complete cds.
ACCESSION L08850
VERSION L08850.1
KEYWORDS AD amyloid; Alzheimer's disease; NACP; amyloid.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1549)
AUTHORS Ueda,K., Fukushima,H., Masliah,E., Xia,Y., Iwai,A., Yoshimoto,M.,
Otero,D.A., Kondo,J., Ihara,Y. and Saitoh,T.
TITLE Molecular cloning of cDNA encoding an unrecognized component of
amyloid in Alzheimer disease
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 90 (23), 11282-11286 (1993)
PUBMED 8248242
COMMENT Original source text: Homo sapiens cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..1549
/db_xref="H-InvDB:HIT000191921"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_lib="ATCC 37432 of A. Lazzarini"
regulatory 35..473
/regulatory_class="terminator"
CDS 53..475
/standard_name="NACP"
/codon_start=1
/product="AD amyloid"
/protein_id="AAA16117.1"
/translation="MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKT
KEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGK
NEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA"
regulatory 1023..1028
/regulatory_class="polyA_signal_sequence"
polyA_site 1023
regulatory 1079..1084
/regulatory_class="polyA_signal_sequence"
regulatory 1529..1534
/regulatory_class="polyA_signal_sequence"
polyA_site 1549
BASE COUNT 471 a 248 c 342 g 488 t
ORIGIN
1 gctctcggag tggccattcg acgacagtgt ggtgtaaagg aattcattag ccatggatgt
61 attcatgaaa ggactttcaa aggccaagga gggagttgtg gctgctgctg agaaaaccaa
121 acagggtgtg gcagaagcag caggaaagac aaaagagggt gttctctatg taggctccaa
181 aaccaaggag ggagtggtgc atggtgtggc aacagtggct gagaagacca aagagcaagt
241 gacaaatgtt ggaggagcag tggtgacggg tgtgacagca gtagcccaga agacagtgga
301 gggagcaggg agcattgcag cagccactgg ctttgtcaaa aaggaccagt tgggcaagaa
361 tgaagaagga gccccacagg aaggaattct ggaagatatg cctgtggatc ctgacaatga
421 ggcttatgaa atgccttctg aggaagggta tcaagactac gaacctgaag cctaagaaat
481 atctttgctc ccagtttctt gagatctgct gacagatgtt ccatcctgta caagtgctca
541 gttccaatgt gcccagtcat gacatttctc aaagttttta cagtgtatct cgaagtcttc
601 catcagcagt gattgaagta tctgtacctg cccccactca gcatttcggt gcttcccttt
661 cactgaagtg aatacatggt agcagggtct ttgtgtgctg tggattttgt ggcttcaatc
721 tacgatgtta aaacaaatta aaaacaccta agtgactacc acttatttct aaatcctcac
781 tatttttttg ttgctgttgt tcagaagttg ttagtgattt gctatcatat attataagat
841 ttttaggtgt cttttaatga tactgtctaa gaataatgac gtattgtgaa atttgttaat
901 atatataata cttaaaaata tgtgagcatg aaactatgca cctataaata ctaaatatga
961 aattttacca ttttgcgatg tgttttattc acttgtgttt gtatataaat ggtgagaatt
1021 aaaataaaac gttatctcat tgcaaaaata ttttattttt atcccatctc actttaataa
1081 taaaaatcat gcttataagc aacatgaatt aagaactgac acaaaggaca aaaatataaa
1141 gttattaata gccatttgaa gaaggaggaa ttttagaaga ggtagagaaa atggaacatt
1201 aaccctacac tcggaattcc ctgaagcaac actgccagaa gtgtgttttg gtatgcactg
1261 gttccttaag tggctgtgat taattattga aagtggggtg ttgaagaccc caactactat
1321 tgtagagtgg tctatttctc ccttcaatcc tgtcaatgtt tgctttatgt attttgggga
1381 actgttgttt gatgtgtatg tgtttataat tgttatacat ttttaattga gccttttatt
1441 aacatatatt gttatttttg tctcgaaata attttttagt taaaatctat tttgtctgat
1501 attggtgtga atgctgtacc tttctgacaa taaataatat tcgaccatg
//