LOCUS       HUMTGFAM                 867 bp    mRNA    linear   HUM 14-JAN-1995
DEFINITION  Human (cell line 1027 F57) transforming growth factor-alpha mRNA,
            complete cds.
ACCESSION   K03222
VERSION     K03222.1
KEYWORDS    growth factor; transforming gene; transforming growth factor alpha.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 867)
  AUTHORS   Derynck,R., Roberts,A.B., Winkler,M.E., Chen,E.Y. and Goeddel,D.V.
  TITLE     Human transforming growth factor-alpha: precursor structure and
            expression in E. coli
  JOURNAL   Cell 38 (1), 287-297 (1984)
   PUBMED   6088071
COMMENT     Original source text: Human renal carcinoma cell line 1027 F57,
            cDNA to mRNA, clone pTGF-Cl.
            [1] also sequenced exons 1 and 2 of this gene from the genomic DNA
            library of Lawn et al. (see separate entries).
FEATURES             Location/Qualifiers
     source          1..867
                     /db_xref="H-InvDB:HIT000191425"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /map="2p13"
                     /cell_line="1027 F57"
                     /tissue_type="renal carcinoma"
     gene            1..867
                     /gene="TGFA"
     CDS             35..517
                     /gene="TGFA"
                     /note="precursor"
                     /codon_start=1
                     /product="transforming growth factor alpha"
                     /protein_id="AAA61159.1"
                     /db_xref="GDB:G00-120-435"
                     /translation="MVPSAGQLALFALGIVLAACQALENSTSPLSADPPVAAAVVSHF
                     NDCPDSHTQFCFHGTCRFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAITA
                     LVVVSIVALAVLIITCVLIHCCQVRKHCEWCRALICRHEKPSALLKGRTACCHSETVV
                     "
     sig_peptide     35..151
                     /gene="TGFA"
                     /note="G00-120-435"
     mat_peptide     152..301
                     /gene="TGFA"
                     /product="transforming growth factor alpha"
                     /note="G00-120-435"
BASE COUNT          175 a          240 c          254 g          198 t
ORIGIN      Chromosome 2p13.
        1 aggctggaga gcctgctgcc cgcccgcccg taaaatggtc ccctcggctg gacagctcgc
       61 cctgttcgct ctgggtattg tgttggctgc gtgccaggcc ttggagaaca gcacgtcccc
      121 gctgagtgca gacccgcccg tggctgcagc agtggtgtcc cattttaatg actgcccaga
      181 ttcccacact cagttctgct tccatggaac ctgcaggttt ttggtgcagg aggacaagcc
      241 agcatgtgtc tgccattctg ggtacgttgg tgcacgctgt gagcatgcgg acctcctggc
      301 cgtggtggct gccagccaga agaagcaggc catcaccgcc ttggtggtgg tctccatcgt
      361 ggccctggct gtccttatca tcacatgtgt gctgatacac tgctgccagg tccgaaaaca
      421 ctgtgagtgg tgccgggccc tcatctgccg gcacgagaag cccagcgccc tcctgaaggg
      481 aagaaccgct tgctgccact cagaaacagt ggtctgaaga gcccagagga ggagtttggc
      541 caggtggact gtggcagatc aataaagaaa ggcttcttca ggacagcact gccagagatg
      601 cctgggtgtg ccacagacct tcctacttgg cctgtaatca cctgtgcagc cttttgtggg
      661 ccttcaaaac tctgtcaaga actccgtcgg cttggggtta ttcagtgtga cctagagaag
      721 aaatcagcgg accacgattt caagacttgt taaaaaagaa ctgcaaagag acggactcct
      781 gttcacctag gtgaggtgtg tgcagcagtt ggtgtctgag tccacatgtg tgcagttgtc
      841 ttctgccagc catggattcc aggccgt
//