LOCUS       HUMFXM                  1443 bp    mRNA    linear   HUM 08-NOV-1994
DEFINITION  Human factor X mRNA, partial signal pept and complete mature pept
            cds.
ACCESSION   K03194
VERSION     K03194.1
KEYWORDS    blood coagulation factor; factor X.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2)
  AUTHORS   MacGillivray,R.T.A.
  JOURNAL   Unpublished
REFERENCE   2  (bases 3 to 1443)
  AUTHORS   Fung,M.R., Hay,C.W. and MacGillivray,R.T.
  TITLE     Characterization of an almost full-length cDNA coding for human
            blood coagulation factor X
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 82 (11), 3591-3595 (1985)
   PUBMED   2582420
COMMENT     Original source text: Human adult liver, cDNA to mRNA, clones
            pcHX[5,8,14].
            During conversion of factor X to factor X-a, a glycopeptide of 52
            amino acids (encoded by positions 513-668 in this sequence) is
            released.
            A polyadenylation signal is located at position 1424-1429. This
            sequence was kindly submitted over electronic mail by
            R.T.A.MacGillivray (23-SEP-1985).
FEATURES             Location/Qualifiers
     source          1..1443
                     /db_xref="H-InvDB:HIT000191414"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /map="13q34"
     gene            1..1443
                     /gene="F10"
     mRNA            <1..1443
                     /gene="F10"
                     /product="X mRNA"
     CDS             1..1433
                     /gene="F10"
                     /note="factor X prepeptide"
                     /codon_start=3
                     /protein_id="AAA52490.1"
                     /db_xref="GDB:G00-119-890"
                     /translation="SLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERE
                     CMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLE
                     GFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPC
                     GKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDN
                     NLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRV
                     GDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPER
                     DWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFC
                     AGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGESCARKGKYGIYTKVTAFLKWI
                     DRSMKTRGLPKAKSHAPEVITSSPLK"
     sig_peptide     <1..86
                     /gene="F10"
                     /note="factor X signal peptide"
     mat_peptide     87..503
                     /gene="F10"
                     /product="factor X light chain"
     mat_peptide     513..1430
                     /gene="F10"
                     /product="factor X heavy chain"
     variation       1117
                     /gene="F10"
                     /note="a in pcHX8; t in pcHX5"
BASE COUNT          361 a          416 c          435 g          231 t
ORIGIN      24 bp upstream of AvaI site.
        1 cctccctggc tggcctcctg ctgctcgggg aaagtctgtt catccgcagg gagcaggcca
       61 acaacatcct ggcgagggtc acgagggcca attcctttct tgaagagatg aagaaaggac
      121 acctcgaaag agagtgcatg gaagagacct gctcatacga agaggcccgc gaggtctttg
      181 aggacagcga caagacgaat gaattctgga ataaatacaa agatggcgac cagtgtgaga
      241 ccagtccttg ccagaaccag ggcaaatgta aagacggcct cggggaatac acctgcacct
      301 gtttagaagg attcgaaggc aaaaactgtg aattattcac acggaagctc tgcagcctgg
      361 acaacgggga ctgtgaccag ttctgccacg aggaacagaa ctctgtggtg tgctcctgcg
      421 cccgcgggta caccctggct gacaacggca aggcctgcat tcccacaggg ccctacccct
      481 gtgggaaaca gaccctggaa cgcaggaaga ggtcagtggc ccaggccacc agcagcagcg
      541 gggaggcccc tgacagcatc acatggaagc catatgatgc agccgacctg gaccccaccg
      601 agaacccctt cgacctgctt gacttcaacc agacgcagcc tgagaggggc gacaacaacc
      661 tcaccaggat cgtgggaggc caggaatgca aggacgggga gtgtccctgg caggccctgc
      721 tcatcaatga ggaaaacgag ggtttctgtg gtggaactat tctgagcgag ttctacatcc
      781 taacggcagc ccactgtctc taccaagcca agagattcaa ggtgagggta ggggaccgga
      841 acacggagca ggaggagggc ggtgaggcgg tgcacgaggt ggaggtggtc atcaagcaca
      901 accggttcac aaaggagacc tatgacttcg acatcgccgt gctccggctc aagaccccca
      961 tcaccttccg catgaacgtg gcgcctgcct gcctccccga gcgtgactgg gccgagtcca
     1021 cgctgatgac gcagaagacg gggattgtga gcggcttcgg gcgcacccac gagaagggcc
     1081 ggcagtccac caggctcaag atgctggagg tgccctacgt ggaccgcaac agctgcaagc
     1141 tgtccagcag cttcatcatc acccagaaca tgttctgtgc cggctacgac accaagcagg
     1201 aggatgcctg ccagggggac agcgggggcc cgcacgtcac ccgcttcaag gacacctact
     1261 tcgtgacagg catcgtcagc tggggagaga gctgtgcccg taaggggaag tacgggatct
     1321 acaccaaggt caccgccttc ctcaagtgga tcgacaggtc catgaaaacc aggggcttgc
     1381 ccaaggccaa gagccatgcc ccggaggtca taacgtcctc tccattaaag tgagatccca
     1441 ctc
//