LOCUS HUMFX 1126 bp mRNA linear HUM 08-NOV-1994 DEFINITION Human factor X mRNA. ACCESSION K01886 VERSION K01886.1 KEYWORDS Stuart factor; factor X; serine protease. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1126) AUTHORS Leytus,S.P., Chung,D.W., Kisiel,W., Kurachi,K. and Davie,E.W. TITLE Characterization of a cDNA coding for human factor X JOURNAL Proc. Natl. Acad. Sci. U.S.A. 81 (12), 3699-3702 (1984) PUBMED 6587384 COMMENT Original source text: Human liver, cDNA to mRNA, clone lambda-X-1137. In processing, factor X (Stuart factor) is converted to Xa by cleavage of a glycopeptide from the amino-terminal end of the heavy chain. It then acts as a serine protease in converting prothrombin to thrombin. FEATURES Location/Qualifiers source 1..1126 /db_xref="H-InvDB:HIT000191371" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /map="13q34" gene 1..1126 /gene="F10" mRNA <1..1126 /gene="F10" /product="factor X mRNA" CDS <1..1116 /gene="F10" /note="factor X precursor peptide" /codon_start=1 /protein_id="AAA52486.1" /db_xref="GDB:G00-119-890" /translation="GFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLA DNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFD LLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTA AHCLYQAKRFEGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFR MNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLS SSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGI YTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK" mat_peptide <1..195 /gene="F10" /product="factor X light chain" mat_peptide 205..1113 /gene="F10" /product="factor X heavy chain" mat_peptide 361..1113 /gene="F10" /product="factor Xa heavy chain" BASE COUNT 269 a 341 c 342 g 174 t ORIGIN 5 bp upstream of TaqI site. 1 ggattcgaag gcaaaaactg tgaattattc acacggaagc tctgcagcct ggacaacggg 61 gactgtgacc agttctgcca cgaggaacag aactctgtgg tgtgctcctg cgcccgcggg 121 tacaccctgg ctgacaacgg caaggcctgc attcccacag ggccctaccc ctgtgggaaa 181 cagaccctgg aacgcaggaa gaggtcagtg gcccaggcca ccagcagcag cggggaggcc 241 cctgacagca tcacatggaa gccatatgat gcagccgacc tggaccccac cgagaacccc 301 ttcgacctgc ttgacttcaa ccagacgcag cctgagaggg gcgacaacaa cctcaccagg 361 atcgtgggag gccaggaatg caaggacggg gagtgtccct ggcaggccct gctcatcaat 421 gaggaaaacg agggtttctg tggtggaacc attctgagcg agttctacat cctaacggca 481 gcccactgtc tctaccaagc caagagattc gaaggggacc ggaacacgga gcaggaggag 541 ggcggtgagg cggtgcacga ggtggaggtg gtcatcaagc acaaccggtt cacaaaggag 601 acctatgact tcgacatcgc cgtgctccgg ctcaagaccc ccatcacctt ccgcatgaac 661 gtggcgcctg cctgcctccc cgagcgtgac tgggccgagt ccacgctgat gacgcagaag 721 acggggattg tgagcggctt cgggcgcacc cacgagaagg gccggcagtc caccaggctc 781 aagatgctgg aggtgcccta cgtggaccgc aacagctgca agctgtccag cagcttcatc 841 atcacccaga acatgttctg tgccggctac gacaccaagc aggaggatgc ctgccagggg 901 gacagcgggg gcccgcacgt cacccgcttc aaggacacct acttcgtgac aggcatcgtc 961 agctggggag agggctgtgc ccgtaagggg aagtacggga tctacaccaa ggtcaccgcc 1021 ttcctcaagt ggatcgacag gtccatgaaa accaggggct tgcccaaggc caagagccat 1081 gccccggagg tcataacgtc ctctccatta aagtgagatc ccactc //