LOCUS       HUMGLUC                 1062 bp    mRNA    linear   HUM 08-NOV-1994
DEFINITION  Human glucagon mRNA, complete cds.
ACCESSION   J04040
VERSION     J04040.1
KEYWORDS    glicentin; glucagon.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1062)
  AUTHORS   Drucker,D.J. and Asa,S.
  TITLE     Glucagon gene expression in vertebrate brain
  JOURNAL   J. Biol. Chem. 263 (27), 13475-13478 (1988)
   PUBMED   2901414
COMMENT     Original source text: Human (neonate) brainstem, cDNA to mRNA,
            clones BS[3,A,B].
FEATURES             Location/Qualifiers
     source          1..1062
                     /db_xref="H-InvDB:HIT000191226"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /map="2q36-q37"
     gene            1..1062
                     /gene="GCG"
     mRNA            <1..1062
                     /gene="GCG"
                     /product="GCG mRNA"
     CDS             38..580
                     /gene="GCG"
                     /note="preproglucagon"
                     /codon_start=1
                     /protein_id="AAA52567.1"
                     /db_xref="GDB:G00-119-265"
                     /translation="MKSIYFVAGLFVMLVQGSWQRSLQDTEEKSRSFSASQADPLSDP
                     DQMNEDKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNRNNIAKRHDEFERHAEGT
                     FTSDVSSYLEGQAAKEFIAWLVKGRGRRDFPEEVAIVEELGRRHADGSFSDEMNTILD
                     NLAARDFINWLIQTKITDRK"
     sig_peptide     38..97
                     /gene="GCG"
                     /note="glucagon signal peptide"
     mat_peptide     98..304
                     /gene="GCG"
                     /product="glicentin"
     mat_peptide     194..280
                     /gene="GCG"
                     /product="glucagon"
     mat_peptide     287..304
                     /gene="GCG"
                     /product="intervening peptide I"
     mat_peptide     311..421
                     /gene="GCG"
                     /product="glucagon-like peptide I"
     mat_peptide     428..466
                     /gene="GCG"
                     /product="intervening peptide II"
     mat_peptide     473..571
                     /gene="GCG"
                     /product="glucagon-like peptide II"
BASE COUNT          340 a          200 c          215 g          307 t
ORIGIN      81 bp upstream of RsaI site; chromosome 2q36-q37.
        1 gctctgttct acagcacact accagaagac agcagaaatg aaaagcattt actttgtggc
       61 tgggttattt gtaatgctgg tacaaggcag ctggcaacgt tcccttcaag acacagagga
      121 gaaatccaga tcattctcag cttcccaggc agacccactc agtgatcctg atcagatgaa
      181 cgaggacaag cgccattcac agggcacatt caccagtgac tacagcaagt atctggactc
      241 caggcgtgcc caagattttg tgcagtggtt gatgaatacc aagaggaaca ggaataacat
      301 tgccaaacgt cacgatgaat ttgagagaca tgctgaaggg acctttacca gtgatgtaag
      361 ttcttatttg gaaggccaag ctgccaagga attcattgct tggctggtga aaggccgagg
      421 aaggcgagat ttcccagaag aggtcgccat tgttgaagaa cttggccgca gacatgctga
      481 tggttctttc tctgatgaga tgaacaccat tcttgataat cttgccgcca gggactttat
      541 aaactggttg attcagacca aaatcactga caggaaataa ctatatcact attcaagatc
      601 atcttcacaa catcacctgc tagccacgtg ggatgtttga aatgttaagt cctgtaaatt
      661 taagaggtgt attctgaggc cacattgctt tgcatgccaa taaataaatt ttcttttagt
      721 gttgtgtagc caaaaattac aaatggaata aagttttatc aaaatattgc taaaatatca
      781 gctttaaaat atgaaagtgc tagattctgt tattttcttc ttattttgga tgaagtaccc
      841 caacctgttt acatttagcg ataaaattat ttttctatga tataatttgt aaatgtaaat
      901 tattccgatc tgacatatct gcattataat aataggagaa tagaagaact ggtagccaca
      961 gtggtgaaat tggaaagaga actttcttcc tgaaaccttt gtcttaaaaa tactcagctt
     1021 tcaatgtatc aaagatacaa ttaaataaaa ttttcaagct tc
//