LOCUS       HUMMGPHB                3816 bp    mRNA    linear   HUM 07-JAN-1995
DEFINITION  Human brain glycogen phosphorylase mRNA, complete cds.
ACCESSION   J03544
VERSION     J03544.1
KEYWORDS    glycogen phosphorylase.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3816)
  AUTHORS   Newgard,C.B., Littman,D.R., van Genderen,C., Smith,M. and
            Fletterick,R.J.
  TITLE     Human brain glycogen phosphorylase. Cloning, sequence analysis,
            chromosomal mapping, tissue expression, and comparison with the
            human liver and muscle isozymes
  JOURNAL   J. Biol. Chem. 263 (8), 3850-3857 (1988)
   PUBMED   3346228
COMMENT     Original source text: Human astrocytoma cell line U251, cDNA to
            mRNA.
            Draft entry and printed copy of sequence for [1] kindly provided by
            C.B.Newgard, 04-DEC-1987.
FEATURES             Location/Qualifiers
     source          1..3816
                     /db_xref="H-InvDB:HIT000191169"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /map="20"
     gene            1..3816
                     /gene="PYGB"
     mRNA            <1..3816
                     /gene="PYGB"
                     /product="brain glycogen phosphorylase mRNA"
     CDS             80..2671
                     /gene="PYGB"
                     /note="brain glycogen phosphorylase"
                     /codon_start=1
                     /protein_id="AAA59597.1"
                     /db_xref="GDB:G00-120-326"
                     /translation="MGEPLTDSEKRKQISVRGLAGLGDVAEVRKSFNRHLHFTLVKDR
                     NVATPRDYFFALAHTVRDHLVGRWIRTQQHYYERDPKRIYYLSLEFYMGRTLQNTMVN
                     LGLQNACDEAIYQLGLDLEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGI
                     RYEFGIFNQKIVNGWQVEEADDWLRYGNPWEKARPEYMLPVHFYGRVEHTPDGVKWLD
                     TQVVLAMPYDTPVPGYKNNTVNTMRLWSARAPNDFKLQDFNVGDYIEAVLDRNLAENI
                     SRVLYPNDNFFEGKELRLKQEYFVVGATLQDIIRRFKSSKFGCRDPVRTCFETFPDKV
                     AIQLNDTHPALSIPELMRILVDVEKVDWDKAWEITKKTCAYTNHTVLPEALERWPVSM
                     FEKLLPRHLEIIYAINQRHLDHVAALFPGDVDRLRRMSVIEEGDCKRINMAHLCVIGS
                     HAVNGVARIHSEIVKQSVFKDFYELEPEKFQNKTNGITPRRWLLLCNPGLADTIVEKI
                     GEEFLTDLSQLKKLLPLVSDEVFIRDVAKVKQENKLKFSAFLEKEYKVKINPSSMFDV
                     HVKRIHEYKRQLLNCLHVVTLYNRIKRDPAKAFVPRTVMIGGKAAPGYHMAKLIIKLV
                     TSIGDVVNHDPVVGDRLKVIFLENYRVSLAEKVIPAADLSQQISTAGTEASGTGNMKF
                     MLNGALTIGTMDGANVEMAEEAGAENLFIFGLRVEDVEALDRKGYNAREYYDHLPELK
                     QAVDQISSGFFSPKEPDCFKDIVNMLMHHDRFKVFADYEAYMQCQAQVDQLYRNPKEW
                     TKKVIRNIACSGKFSSDRTITEYAREIWGVEPSDLQLQHLPHPEWESGGATCWAPPEL
                     CTHLAMY"
BASE COUNT          795 a         1085 c         1141 g          795 t
ORIGIN      282 bp upstream of BamHI site; chromosome 20.
        1 gagcagctgc accatcccgg cgttcgcgtg tgccgccgct ttcctcctcc atctcttttc
       61 ctccgcctcc gccggcgcga tgggcgaacc gctgacggac agcgagaagc ggaagcagat
      121 cagcgtgcgc ggcctggcgg ggctaggcga cgtggccgag gtgcggaaga gcttcaaccg
      181 gcacttgcac ttcacgctgg tcaaggaccg caatgtggcc acgccccgcg actacttctt
      241 cgcgctggcg cacacggtgc gcgaccacct cgtgggccgc tggatccgca cgcagcagca
      301 ctactacgag cgcgacccca agcgaattta ttatctttcc ctggaattct acatgggtcg
      361 cacgctgcag aacacgatgg tgaacctggg ccttcagaat gcctgcgatg aagccatcta
      421 tcagttgggg ttagacttgg aggaactcga ggagatagaa gaagatgctg gccttgggaa
      481 tggaggcctg gggaggctgg cagcgtgttt ccttgactca atggctacct tgggcctggc
      541 agcatacggc tatggaatcc gctatgaatt tgggattttt aaccagaaga ttgtcaatgg
      601 ctggcaggta gaggaggccg atgactggct gcgctacggc aacccctggg agaaagcgcg
      661 gcctgagtat atgcttcccg tgcacttcta cggacgcgtg gagcacaccc ccgacggcgt
      721 gaagtggctg gacacacagg tggtgctggc catgccctac gacaccccag tgcccggcta
      781 caagaacaac accgtcaaca ccatgcggct gtggtccgca agggctccca acgacttcaa
      841 gctgcaggac ttcaacgtgg gagactacat cgaggcggtc ctggaccgga acttggctga
      901 gaacatctcc agggtcctgt atccaaatga taacttcttt gaggggaagg agctgcggct
      961 gaagcaggag tacttcgtgg tgggcgccac gctccaggac atcatccgcc gcttcaagtc
     1021 gtccaagttc ggctgccggg accctgtgag aacctgtttc gagacgttcc cagacaaggt
     1081 ggccatccag ctgaacgaca cccaccccgc cctctccatc cctgagctca tgcggatcct
     1141 ggtggacgtg gagaaggtgg actgggacaa ggcctgggaa atcacgaaga agacctgtgc
     1201 atacaccaac cacactgtgc tgcctgaggc cttggagcgc tggcccgtgt ccatgtttga
     1261 gaagctgctg ccgcggcacc tggagataat ctatgccatc aaccagcggc acctggacca
     1321 cgtggccgcg ctgtttcccg gcgatgtgga ccgcctgcgc aggatgtctg tgatcgagga
     1381 gggggactgc aagcggatca acatggccca cctgtgtgtg attgggtccc atgctgtcaa
     1441 tggtgtggcg aggatccact cggagatcgt gaaacagtcg gtctttaagg atttttatga
     1501 actggagcca gagaagttcc agaataagac caatggcatc accccccgcc ggtggctgct
     1561 gctgtgcaac ccggggctgg ccgataccat cgtggagaaa attggggagg agttcctgac
     1621 tgacctgagc cagctgaaga agctgctgcc gctggtcagt gacgaggtgt tcatcaggga
     1681 cgtggccaag gtcaaacagg agaacaagct caagttctcg gccttcctgg agaaggagta
     1741 caaggtgaag atcaacccct cctccatgtt cgatgtgcat gtgaagagga tccacgagta
     1801 caagcggcag ctgctcaact gcctgcacgt cgtcaccctg tacaatcgaa tcaagagaga
     1861 cccggccaag gcttttgtgc ccaggactgt tatgattggg ggcaaggcag cgcccggtta
     1921 ccacatggcc aagctgatca tcaagttggt cacctccatc ggcgacgtcg tcaatcatga
     1981 cccagttgtg ggtgacaggt tgaaagtgat cttcctggag aactaccgtg tgtccttggc
     2041 tgagaaagtg atcccggccg ctgatctgtc gcagcagatc tccactgcag gcaccgaggc
     2101 ctcaggcaca ggcaacatga agttcatgct caacggggcc ctcaccatcg gcaccatgga
     2161 cggcgccaac gtggagatgg ccgaggaggc cggggccgag aacctcttca tcttcggcct
     2221 gcgggtggag gatgtcgagg ccttggaccg gaaagggtac aatgccaggg agtactacga
     2281 ccacctgccc gagctgaagc aggccgtgga ccagatcagc agtggctttt tttctcccaa
     2341 ggagccagac tgcttcaagg acatcgtgaa catgctgatg caccatgaca ggttcaaggt
     2401 gtttgcagac tatgaagcct acatgcagtg ccaggcacag gtggaccagc tgtaccggaa
     2461 ccccaaggag tggaccaaga aggtcatcag gaacatcgcc tgctcgggca agttctccag
     2521 tgaccggacc atcacggagt atgcacggga gatctggggt gtggagccct ccgacctgca
     2581 gcttcagcac ctgccccacc cagagtggga gtcaggtgga gccacctgct gggctccccc
     2641 agaactttgc acacatcttg ctatgtatta gccgatggct ttagtgttga gcctctggat
     2701 tctggggtct gcggcagtgg ccatagtgaa gcctgggaat gagtgttact gcagcatctg
     2761 gctgccagcc acagggaagg gccaagcccc atgtagcccc agtcatcctg cccagccctg
     2821 cctcctggcc atgccgggag gggtcggatc ctctaggcat cgcttcacag ccccctgccc
     2881 cctgccctct gtcctggctc tgcacctggt atatgggtca tggaccagat ggggctttcc
     2941 ctttgtagcc atccaatggg cattgtgtgg gtgcttggaa cccgggatga ctgaggggga
     3001 cactggagtg ggtgcttgtg tctgctgtct cagaggcctt ggtcaggatg aagttggctg
     3061 acacagctta gcttggtttt gcttattcaa aagagaaaat aactacacat ggaaatgaaa
     3121 ctagtgaagc cttttcttgt tttagaatga aaattgtact tggtcacttt tgtgcttgag
     3181 gaggcccatt ttctagcctg gcaggggcag gtcctgtgcc ctcccgcttg actcctgctg
     3241 tgtcctgagg tgcatttcct gtttgttaca cacaagggcc aggctccatt ctccctccct
     3301 ttccaccagt gccacagcct cgtctggaaa aaggaccagg ggtcccggag gaacccattt
     3361 gtgctctgct tggacagcag gcctggcact gggaggtggg gtgagcccct cacagccttg
     3421 cccctcccca aggctcgaac ctgcctccca ttgcccaaga gagaggggca gggaacaggc
     3481 tactgtcctt ccctgtggaa ttgccgagaa atctagcacc ttgcatgctg gatctgggct
     3541 gcggggaggc tctttttctc cctggcctcc agtgcccacc aggaggatct gcgcacggtg
     3601 cacagcccac cagagcacta cagcctttta ttgagtgggg caagtgctgg gctgtggtcg
     3661 tgccctgaca gcatcttccc caggcagcgg ctctgtggag gaggccatac tcccctagtt
     3721 ggccactggg gccaccaccc tgaccaccac tgtgcccctc attgttactg ccttgtgaga
     3781 taaaaactga ttaaaccttt gtggctttgg ttggtt
//