LOCUS HUMGLBA 2767 bp mRNA linear HUM 08-NOV-1994
DEFINITION Human co-beta glucosidase (proactivator) mRNA, complete cds.
ACCESSION J03077
VERSION J03077.1
KEYWORDS beta glucosidase; glucosidase activator; proactivator.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2767)
AUTHORS Rorman,E.G. and Grabowski,G.A.
TITLE Molecular cloning of a human co-beta-glucosidase cDNA: evidence
that four sphingolipid hydrolase activator proteins are encoded by
single genes in humans and rats
JOURNAL Genomics 5 (3), 486-492 (1989)
PUBMED 2515150
COMMENT Original source text: Human placenta, cDNA to mRNA, clone EGTISI.
Draft entry and computer-readable sequence for [1] kindly submitted
by G.A.Grabowski, 08-JUN-1989.
FEATURES Location/Qualifiers
source 1..2767
/db_xref="H-InvDB:HIT000191128"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="Unassigned"
gene 1..2767
/gene="GLBA"
CDS 39..1613
/gene="GLBA"
/note="co-beta glucosidase precursor"
/codon_start=1
/protein_id="AAA52560.1"
/db_xref="GDB:92"
/translation="MYALFLLASLLGAALAGPVLGLKECTRGSAVWCQNVKTASDCGA
VKHCLQTVWNKPTVKSLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNM
SASCKEIVDSYLPVILDIIKGEMSRPGEVCSALNLCESLQKHLAELNHQKQLESNKIP
ELDMTEVVAPFMANIPLLLYPQDGPRSKPQPKDNGDVCQDCIQMVTDIQTAVRTNSTF
VQALVEHVKEECDRLGPGMADICKNYISQYSEIAIQMMMHMQPKEICALVGFCDEVKE
MPMQTLVPAKVASKNVIPALELVEPIKKHEVPAKSDVYCEVCEFLVKEVTKLIDNNKT
EKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSILSILLEEVSPELVCSMLHLCSGTR
LPALTVHVTQPKDGGFCEVCKKLVGYLDRNLEKNSTKQEILAALEKGCSFLPDPYQKQ
CDQFVAEYEPVLIEILVEVMDPSFVCLKIGACPSAHKPLLGTEKCIWGPSYWCQNTET
AAQCNAVEHCKRHVWN"
sig_peptide 39..86
/gene="GLBA"
/note="co-beta glucosidase signal peptide (pot.);
putative"
mat_peptide 87..1610
/gene="GLBA"
/product="co-beta glucosidase (pot.); putative"
BASE COUNT 590 a 709 c 796 g 672 t
ORIGIN Chromosome 10q21.
1 gggcgggcgc attgcagact gcggagtcag acggtgctat gtacgccctc ttcctcctgg
61 ccagcctcct gggcgcggct ctagccggcc cggtccttgg actgaaagaa tgcaccaggg
121 gctcggcagt gtggtgccag aatgtgaaga cggcgtccga ctgcggggca gtgaagcact
181 gcctgcagac cgtttggaac aagccaacag tgaaatccct tccctgcgac atatgcaaag
241 acgttgtcac cgcagctggt gatatgctga aggacaatgc cactgaggag gagatccttg
301 tttacttgga gaagacctgt gactggcttc cgaaaccgaa catgtctgct tcatgcaagg
361 agatagtgga ctcctacctc cctgtcatcc tggacatcat taaaggagaa atgagccgtc
421 ctggggaggt gtgctctgct ctcaacctct gcgagtctct ccagaagcac ctagcagagc
481 tgaatcacca gaagcagctg gagtccaata agatcccaga gctggacatg actgaggtgg
541 tggccccctt catggccaac atccctctcc tcctctaccc tcaggacggc ccccgcagca
601 agccccagcc aaaggataat ggggacgttt gccaggactg cattcagatg gtgactgaca
661 tccagactgc tgtacggacc aactccacct ttgtccaggc cttggtggaa catgtcaagg
721 aggagtgtga ccgcctgggc cctggcatgg ccgacatatg caagaactat atcagccagt
781 attctgaaat tgctatccag atgatgatgc acatgcaacc caaggagatc tgtgcgctgg
841 ttgggttctg tgatgaggtg aaagagatgc ccatgcagac tctggtcccc gccaaagtgg
901 cctccaagaa tgtcatccct gccctggaac tggtggagcc cattaagaag cacgaggtcc
961 cagcaaagtc tgatgtttac tgtgaggtgt gtgaattcct ggtgaaggag gtgaccaagc
1021 tgattgacaa caacaagact gagaaagaaa tactcgacgc ttttgacaaa atgtgctcga
1081 agctgccgaa gtccctgtcg gaagagtgcc aggaggtggt ggacacgtac ggcagctcca
1141 tcctgtccat cctgctggag gaggtcagcc ctgagctggt gtgcagcatg ctgcacctct
1201 gctctggcac gcggctgcct gcactgaccg ttcacgtgac tcagccaaag gacggtggct
1261 tctgcgaagt gtgcaagaag ctggtgggtt atttggatcg caacctggag aaaaacagca
1321 ccaagcagga gatcctggct gctcttgaga aaggctgcag cttcctgcca gacccttacc
1381 agaagcagtg tgatcagttt gtggcagagt acgagcccgt gctgatcgag atcctggtgg
1441 aggtgatgga tccttccttc gtgtgcttga aaattggagc ctgcccctcg gcccataagc
1501 ccttgttggg aactgagaag tgtatatggg gcccaagcta ctggtgccag aacacagaga
1561 cagcagccca gtgcaatgct gtcgagcatt gcaaacgcca tgtgtggaac taggaggagg
1621 aatattccat cttggcagaa accacagcat tggttttttt ctacttgtgt gtctggggga
1681 atgaacgcac agatctgttt gactttgtta taaaaatagg gctcccccac ctcccccatt
1741 tctgtgtcct ttattgtagc attgctgtct gcaagggagc ccctagcccc tagcccctgg
1801 cagacatagc tgcttcagtg ccccttttct ctctgctaga tggatgttga tgcactggag
1861 gtcttttagc ctgcccttgc atggcgcctg ctggaggagg agagagctct gctggcatga
1921 gccacagttt cttgactgga ggccatcaac cctcttggtt gaggccttgt tctgagccct
1981 gacatgtgct tgggcactgg tgggcctggg cttctgaggt ggcctcctgc cctgatcagg
2041 gaccctcccc gctttcctgg gcctctcagt tgaacaaagc agcaaaacaa aggcagtttt
2101 atatgaaaga ttagaagcct ggaataatca ggctttttaa atgatgtaat tcccactgta
2161 atagcatagg gattttggaa gcagctgctg gtggcttggg acatcagtgg ggccaagggt
2221 tctctgtccc tggttcaact gtgatttggc tttcccgtgt ctttcctggt gatgccttgt
2281 ttggggttct gtgggtttgg gtgggaagag ggccatctgc ctgaatgtaa cctgctagct
2341 ctccgaagcc ctgcgggcct ggcttgtgtg agcgtgtgga cagtggtggc cgcgctgtgc
2401 ctgctcgtgt tgcctacatg tccctggctg ttgaggcgct gcttcagcct gcacccctcc
2461 cttgtctcat agatgctcct tttgaccttt tcaaataaat atggatggcg agctcctagg
2521 cctctggctt cctggtagag ggcggcatgc cgaagggtct gtctgggtgt ggattggatg
2581 ctgggggtgt gggggttgga agctgtctgt ggcccacttg ggcacccacg cttctgtcca
2641 cttctggttg ccaggagaca gcaagcaaag ccagcaggac atgaagttgc tattaaatgg
2701 acttcgtgat ttttgttttg cactaaagtt tctgtgattt aacaataaaa ttctgttagc
2761 ccccccg
//