LOCUS       HUMSAP                  2724 bp    mRNA    linear   HUM 31-JUL-1995
DEFINITION  Homo sapiens sphingolipid activator protein 1 mRNA, 3' end.
ACCESSION   J03015 J03086
VERSION     J03015.1
KEYWORDS    PSAP gene; glucosidase; saposin; sphingolipid activator protein;
            sulfatide activator.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 45 to 1618)
  AUTHORS   Dewji,N.N., Wenger,D.A. and O'Brien,J.S.
  TITLE     Nucleotide sequence of cloned cDNA for human sphingolipid activator
            protein 1 precursor
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 84 (23), 8652-8656 (1987)
   PUBMED   2825202
REFERENCE   2  (bases 45 to 1618)
  AUTHORS   O'Brien,J.S., Kretz,K.A., Dewji,N., Wenger,D.A., Esch,F. and
            Fluharty,A.L.
  JOURNAL   Unpublished
REFERENCE   3  (sites)
  AUTHORS   O'Brien,J.S., Kretz,K.A., Dewji,N., Wenger,D.A., Esch,F. and
            Fluharty,A.L.
  TITLE     Coding of two sphingolipid activator proteins (SAP-1 and SAP-2) by
            same genetic locus
  JOURNAL   Science 241 (4869), 1098-1101 (1988)
   PUBMED   2842863
REFERENCE   4  (bases 1 to 2724)
  AUTHORS   Nakano,T., Sandhoff,K., Stumper,J., Christomanou,H. and Suzuki,K.
  TITLE     Structure of full-length cDNA coding for sulfatide activator, a
            Co-beta-glucosidase and two other homologous proteins: two
            alternate forms of the sulfatide activator
  JOURNAL   J. Biochem. 105 (2), 152-154 (1989)
   PUBMED   2498298
COMMENT     Original source text: Homo sapiens (clone: lambda-S-[1.2,1.3])
            (clone library: Clontech) lung and skin cDNA to mRNA.
            [3]  sites; description of features.
            [2]  revises [1].
            Draft entry and computer-readable sequence for [2],[4] kindly
            provided by K.A.Kretz, 09-AUG-1988.
            Complete source information:
            Human hepatoma, cDNA to mRNA, clones lambda-S-[1.2,1.3]
            [1],[3],[2]; lungfibroblast cell line HL1011B (library of Clontech,
            and skin fibroblast (from Sandhoff disease patient), cDNA to mRNA
            [4].
FEATURES             Location/Qualifiers
     source          1..2724
                     /db_xref="H-InvDB:HIT000191119"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /map="10q21-q22"
                     /clone="lambda-S-[1.2,1.3]"
                     /cell_line="HL1011B"
                     /cell_type="fibroblast"
                     /tissue_type="lung and skin"
                     /clone_lib="Clontech"
     gene            1..2724
                     /gene="PSAP"
     mRNA            <1..2724
                     /gene="PSAP"
                     /note="G00-120-366"
     CDS             7..1581
                     /gene="PSAP"
                     /codon_start=1
                     /product="sphingolipid activator precursor"
                     /protein_id="AAB59494.1"
                     /db_xref="GDB:G00-120-366"
                     /translation="MYALFLLASLLGAALAGPVLGLKECTRGSAVWCQNVKTASDCGA
                     VKHCLQTVWNKPTVKSLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNM
                     SASCKEIVDSYLPVILDIIKGEMSRPGEVCSALNLCESLQKHLAELNHQKQLESNKIP
                     ELDMTEVVAPFMANIPLLLYPQDGPRSKPQPKDNGDVCQDCIQMVTDIQTAVRTNSTF
                     VQALVEHVKEECDRLGPGMADICKNYISQYSEIAIQMMMHMQPKEICALVGFCDEVKE
                     MPMQTLVPAKVASKNVIPALELVEPIKKHEVPAKSDVYCEVCEFLVKEVTKLIDNNKT
                     EKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSILSILLEEVSPELVCSMLHLCSGTR
                     LPALTVHVTQPKDGGFCEVCKKLVGYLDRNLEKNSTKQEILAALEKGCSFLPDPYQKQ
                     CDQFVAEYEPVLIEILVEVMDPSFVCLKIGACPSAHKPLLGTEKCIWGPSYWCQNTET
                     AAQCNAVEHCKRHVWN"
     sig_peptide     7..75
                     /gene="PSAP"
                     /note="G00-120-366"
                     /citation=[2]
     mat_peptide     184..435
                     /gene="PSAP"
                     /product="sphingolipid activator-like protein A"
                     /note="G00-120-366"
     mat_peptide     589..831
                     /gene="PSAP"
                     /product="sphingolipid activator protein B"
     mat_peptide     937..1176
                     /gene="PSAP"
                     /product="sphingolipid activator protein C"
     mat_peptide     1219..1467
                     /gene="PSAP"
                     /product="sphingolipid activator-like protein D"
                     /citation=[2]
     variation       783..784
                     /gene="PSAP"
                     /citation=[4]
                     /replace="gcaggatcagc"
BASE COUNT          585 a          696 c          776 g          667 t
ORIGIN      80 bp upstream of AcyI site; chromosome 10q21-q22.
        1 cgcgctatgt acgccctctt cctcctggcc agcctcctgg gcgcggctct agccggcccg
       61 gtccttggac tgaaagaatg caccaggggc tcggcagtgt ggtgccagaa tgtgaagacg
      121 gcgtccgact gcggggcagt gaagcactgc ctgcagaccg tttggaacaa gccaacagtg
      181 aaatcccttc cctgcgacat atgcaaagac gttgtcaccg cagctggtga tatgctgaag
      241 gacaatgcca ctgaggagga gatccttgtt tacttggaga agacctgtga ctggcttccg
      301 aaaccgaaca tgtctgcttc atgcaaggag atagtggact cctacctccc tgtcatcctg
      361 gacatcatta aaggagaaat gagccgtcct ggggaggtgt gctctgctct caacctctgc
      421 gagtctctcc agaagcacct agcagagctg aatcaccaga agcagctgga gtccaataag
      481 atcccagagc tggacatgac tgaggtggtg gcccccttca tggccaacat ccctctcctc
      541 ctctaccctc aggacggccc ccgcagcaag ccccagccaa aggataatgg ggacgtttgc
      601 caggactgca ttcagatggt gactgacatc cagactgctg tacggaccaa ctccaccttt
      661 gtccaggcct tggtggaaca tgtcaaggag gagtgtgacc gcctgggccc tggcatggcc
      721 gacatatgca agaactatat cagccagtat tctgaaattg ctatccagat gatgatgcac
      781 atgcaaccca aggagatctg tgcgctggtt gggttctgtg atgaggtgaa agagatgccc
      841 atgcagactc tggtccccgc caaagtggcc tccaagaatg tcatccctgc cctggaactg
      901 gtggagccca ttaagaagca cgaggtccca gcaaagtctg atgtttactg tgaggtgtgt
      961 gaattcctgg tgaaggaggt gaccaagctg attgacaaca acaagactga gaaagaaata
     1021 ctcgacgctt ttgacaaaat gtgctcgaag ctgccgaagt ccctgtcgga agagtgccag
     1081 gaggtggtgg acacgtacgg cagctccatc ctgtccatcc tgctggagga ggtcagccct
     1141 gagctggtgt gcagcatgct gcacctctgc tctggcacgc ggctgcctgc actgaccgtt
     1201 cacgtgactc agccaaagga cggtggcttc tgcgaagtgt gcaagaagct ggtgggttat
     1261 ttggatcgca acctggagaa aaacagcacc aagcaggaga tcctggctgc tcttgagaaa
     1321 ggctgcagct tcctgccaga cccttaccag aagcagtgtg atcagtttgt ggcagagtac
     1381 gagcccgtgc tgatcgagat cctggtggag gtgatggatc cttccttcgt gtgcttgaaa
     1441 attggagcct gcccctcggc ccataagccc ttgttgggaa ctgagaagtg tatatggggc
     1501 ccaagctact ggtgccagaa cacagagaca gcagcccagt gcaatgctgt cgagcattgc
     1561 aaacgccatg tgtggaacta ggaggaggaa tattccatct tggcagaaac cacagcattg
     1621 gtttttttct acttgtgtgt ctgggggaat gaacgcacag atctgtttga ctttgttata
     1681 aaaatagggc tcccccacct cccccatttc tgtgtccttt attgtagcat tgctgtctgc
     1741 aagggagccc ctagcccctg gcagacatag ctgcttcagt gccccttttc tctctgctag
     1801 atggatgttg atgcactgga ggtcttttag cctgcccttg catggcgcct gctggaggag
     1861 gagagagctc tgctggcatg agccacagtt tcttgactgg aggccatcaa ccctcttggt
     1921 tgaggccttg ttctgagccc tgacatgtgc ttgggcactg gtgggcctgg gcttctgagg
     1981 tggcctcctg ccctgatcag ggaccctccc cgctttcctg ggcctctcag ttgaaccaaa
     2041 gcagcaaaac aaaggcagtt ttatatgaaa gattagaagc ctggaataat caggcttttt
     2101 aaatgatgta attcccactg taatagcata gggattttgg aagcagctgc tggtggcttg
     2161 ggacatcagt ggggccaagg gttctctgtc cctggttcaa ctgtgatttg gctttcccgt
     2221 gtctttcctg gtgatgcctt gtttggggtt ctgtgggttt gggtgggaag agggcccatc
     2281 tgcctgaatg taacctgcta gctctccgaa gccctgcggg cctggcttgt gtgagcgtgt
     2341 ggacagtggt ggccgcgctg tgcctgctcg tgttgcctac atgtccctgg ctgttgaggc
     2401 gctgcttcag cctgcacccc tccctttgtc tcatagatgc tccttttgac cttttcaaat
     2461 aaatatggat ggcaagctcc taggcctctg cttcctggta gagggcggca tgccgaaggg
     2521 tctgctgggt gtggattgga tgctggggtg tgggggttgg aagctgtctg tggcccactt
     2581 gggcacccac gcttctgtcc acttctggtt gccaggagac agcaagcaaa gccagcagga
     2641 catgaagttg ctattaaatt gacttcgtga tttttgtttt gcactaaagt ttctgtgatt
     2701 taacaataaa attctgttag ccag
//