LOCUS HUMCYPIIE 14776 bp DNA linear HUM 02-NOV-1994 DEFINITION Human cytochrome P450IIE1 (ethanol-inducible) gene, complete cds. ACCESSION J02843 VERSION J02843.1 KEYWORDS cytochrome P450. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 14776) AUTHORS Umeno,M., McBride,O.W., Yang,C.S., Gelboin,H.V. and Gonzalez,F.J. TITLE Human ethanol-inducible P450IIE1: complete gene sequence, promoter characterization, chromosome mapping, and cDNA-directed expression JOURNAL Biochemistry 27 (25), 9006-9013 (1988) PUBMED 3233219 REFERENCE 2 (sites) AUTHORS Uematsu,F., Kikuchi,H., Abe,T., Motomiya,M., Ohmachi,T., Sagami,I. and Watanabe,M. TITLE MspI polymorphism of the human CYP2E gene JOURNAL Nucleic Acids Res. 19 (20), 5797 (1991) PUBMED 1719479 COMMENT Original source text: Human (adult) liver DNA. Draft entry and computer-readable sequence for [1] kindly provided by F.J.Gonzales, 18-AUG-1988. FEATURES Location/Qualifiers source 1..14776 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /map="10" prim_transcript 2789..14198 /note="CYP2E mRNA and introns" CDS join(2825..3001,3907..4066,7006..7155,7545..7705, 8113..8289,9172..9313,12151..12338,12838..12979, 13864..14048) /note="cytochrome P450IIE1" /codon_start=1 /protein_id="AAA52155.1" /translation="MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGN LFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGD LPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRK TQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLY NNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKE KHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIG PSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPT LDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLL LCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPRS" gene 2825..3001 /gene="CYP2E" exon <2825..3001 /gene="CYP2E" /note="cytochrome P450IIE1; G00-119-833" /number=1 intron 3002..3906 /note="CYP2E intron A" exon 3907..4066 /number=2 intron 4067..7005 /note="CYP2E intron B" exon 7006..7155 /number=3 intron 7156..7544 /note="CYP2E intron C" exon 7545..7705 /number=4 intron 7706..8112 /note="CYP2E intron D" exon 8113..8289 /number=5 intron 8290..9171 /note="CYP2E intron E" exon 9172..9313 /number=6 intron 9314..12150 /note="CYP2E intron F" exon 12151..12338 /number=7 intron 12339..12837 /note="CYP2E intron G" exon 12838..12979 /number=8 intron 12980..13863 /note="CYP2E intron H" exon 13864..>14048 /note="cytochrome P450IIE1" /number=9 BASE COUNT 3635 a 3645 c 3772 g 3724 t ORIGIN 2246 bp upstream of EcoRI site; chromosome 10. 1 cccccattga aaaattgtct ttctgatctt tataaacaat tatttaatat ccagtaaaat 61 cttctctata ttgctttact agtgagttct attaaaattt tgaagcacag aaaattcccc 121 tacagtataa agtatcccca gtcacagaga agacaggggt tttgcaatga tttctagaat 181 agtgcaattt ttatgcaaga acctaatata acacaaaaat tatagcccga ttttatttgt 241 gggtatagat gcaaaattac taaaaatact attaacaagt tgaatcctta gggtgttaaa 301 agagtatcac tccatgaacg agttggttgt gatgtggaac tatgaggtac ttttatgata 361 caatataaaa atttatggta attttatggt acattgtgag acagtgtttt cttctagcat 421 catactagca ggtctatgga gaaaaatcac aggattgtct caatcaaaaa aagatttcat 481 taacccaact ctcatccctg ataaacactg ttagttatct agagaaagaa gaaaattgtc 541 ccaatacagt cacctctttg ccacacccag ccaacagcag acgtgatgga agcctgaaga 601 acaccctgcc acgggcacag gcagaggcac aggcaccctg tcgtcctgat tatttcacct 661 tgtcacgggc agaggcacag gcaccctgtc gtcctgatta tttcaccttg tcacaggcac 721 aggcaccctg tcgtcctgat tatttcacct tgtcacaggc acaggcactc tgtcgtcctg 781 attatttcac cttgtcacgg gcagaggcac aggcactctg tcatcctgat tatttcacct 841 tgtcctagag tgtcctgcca atgggacaga tgcaaaacaa ataaaagccc cggcttctga 901 aaagaagcac acagaaatgt cattattttc aaacgaggtg ttcccgtata taaaatttga 961 tgttggttgg gcatctaaca gtattatggc cagaggactc agaccacagc tgcatccctg 1021 tgaggcacag actctccagg gcacgcgggt cccgctggga tgtgcacact caggtgagct 1081 gcacagacaa ggtgtcctca gcccagggga gccagaggcc tgctctgcct ctccaccctg 1141 atgcttcctg ttctcacccc accaaagcca aggcttcaat ttcagtctgt ggggagctga 1201 ctctgctgct ctcaagcact agaagaagga accagtaatc gaggaaactt gtggacccca 1261 atggtgtctg tcccggccag gcctggctgg gcccacacag gacaacaggg ttcaggggtc 1321 tggacagctg tttctgccca gggaattgtc cctgccacct cacactggcc actggaaagg 1381 aaagagagga ggaggcggca ggctaaccca cccgtgagcc agtcgagtct acattgtcag 1441 ttctcacctc gaggggtgcc aaaaaccaga gggaagcaaa ggcccctgaa gcctctgcca 1501 gaggccaacg ccccttcttg gttcaggaga ggtgcagtgt taggtgcagc acaaccaatg 1561 acttgcttat gtggctaata aattgtcaag agaaaaactg ggttagaatg caatatatag 1621 tatgtagtct catttttgta taaatacaag tatagaatgg cataactcaa aatccacaag 1681 tgatttggct ggattgtaaa tgacttttat tttcttcatt tctcatcata ttttctatta 1741 tacataaaga ttcattgtta atataaaagt acaaaattgc aacctatgaa ttaagaactt 1801 ctatatattg ccagttagaa gacagaatga aaaacattct cttcattcta accacacaca 1861 caaaaaactc cacaaaatac ctatggacta ccttcataga aggtggaaga gggtctgtat 1921 gaagaaaatg cttaatacat gaaagaagaa gctagtcaat gtggaggtct attgtgcgcc 1981 gggatcaaca aagacaagat atgtttaaaa tggtgttcta aatttaccct aatgtaaaac 2041 aaatccaata aaactctaat gtgatttttt aagaatttaa atttggaata attccaaaga 2101 acaatttttc ttaatttcta cagccagaat atataccttt aaaaaaaatg aaaacagaga 2161 ttaactttct cagaattggt tgactcactc tttcctttta tttttcttcc atggaatttt 2221 ccagttaact tgagaaagtg gaatcgaatt ccgatgttga attttccttc tggccccatt 2281 catgtggcag gtggtgattc aggtactact gggggctgct cagacaaacc tcctcatcag 2341 acatcaagag gctgttgcac caggagggcc ggtaccgtgt ctagaggtgg tcggcatggg 2401 gttggagttg tattacataa accctactcc aaacaaatgc atggggatgt ggctggagtt 2461 ccccgttgtc taaccagtgc caaagggcag gtcggtacct caccccacgt tcttaactat 2521 gggttggcaa catgttcctg gatgtgtttg ctggcacagt gacaggtgct agcaaccagg 2581 gtgttgacac agtccaactc catcctcacc aggtcactgg ctggaacccc tgggggccac 2641 cattgcggga atcagccttt gaaacgatgg ccaacagcag ctaataataa accagtaatt 2701 tgggatagac gagtagcaag agggcattgg ttggtgggtc accctccttc tcagaacaca 2761 ttataaaaac cttcctttcc acaggattgt cctcccgggc tggcagcagg gccccagcgg 2821 caccatgtct gccctcggag tcaccgtggc cctgctggtg tgggcggcct tcctcctgct 2881 ggtgtccatg tggaggcagg tgcacagcag ctggaatctg cccccaggcc ctttcccgct 2941 tcccatcatc gggaacctct tccagttgga attgaagaat attcccaagt ccttcacccg 3001 ggtaagagaa atagtgttga ttttagggag aataactcag caattggatc tggtatgtgt 3061 gtattcaact catttgcaga caaattgtgg ttgttcaata ccagcctgtt gtgaattacc 3121 tgaattgata gcatcctgga gcgacactca aaatgtgtcg cctgtggtgc agctggagcc 3181 cggagcctgc gtgccaggcc ccggaggccc ccgccgtgcc ttgtcctggg gctgatgatg 3241 gggaggccgg cgaggccggg ctgctgcgac gccaggataa ccgggctggc ggccagatgc 3301 gcactcgctg ggcgtccgcc tgtgtttgcc aaagcacgag ttgaaacgtg aagtgttggg 3361 ccagcccgtg tggcaccaat acctgccgcc tacgactgtt gtgaacactg aatgggccaa 3421 caaacctaaa cgttaaatga actgataacg ccgtcagcac ggagcaggcg ctgggtgttt 3481 gcgctcttgc gcgtgcgctg ctgtggggcg caggctgacg gcgggcgggg gtcgcctgct 3541 ccagctcggg ctcccgcgcc agaaccgggt ccagaacctt gattccggaa gcgggcaacg 3601 gggtggttgg tgggcgcgcc tgagggaagg gacgtgagga gccggagtcc gcggagttgc 3661 cgcggagttg tccgcggagt ccaggcgggt ggggagcaga gcagctggaa ccccccgagc 3721 gccctgcaga cgcagcagcc tcttgagggg agggtctccc ccacctcggg ctggacaaag 3781 acagcttttc cccacgtccc tctgggttct ctagagcaac agcaataccc gcccggcagg 3841 tgtggcttag agccccgcac ctcctcgccg cgcgcgggcc tgacttctag ccacgggtct 3901 ccgcagttgg cccagcgctt cgggccggtg ttcacgctgt acgtgggctc gcagcgcatg 3961 gtggtgatgc acggctacaa ggcggtgaag gaagcgctgc tggactacaa ggacgagttc 4021 tcgggcagag gcgacctccc cgcgttccat gcgcacaggg acaggggtga gtccgcgtcc 4081 ctggcacgga gcggggggtg cataacacgc cccgggacag ttacgggcgc tagccacgtc 4141 ggcgatggcc aaataataaa ctaacagtaa tattatagta atagcatccg aaggatgaga 4201 tcaggattag gcgatggccc ccgcgcgttg cctgccgagc gaggcgcact gagtcgccca 4261 ggaatccggc ctctcggcga ctgtgcggga gagttttatg gggatgggcg gggctgcttc 4321 tgagcaggag tcgccgcccc cacccccacc gttccgcctc tgggccgcag gctcctcccg 4381 ggagcgcttt cccctcctgt tcaaccgccg gggtacaggt ggcttcgtcc accgaggtcc 4441 cctcacccac gctgaggcgt cggaagctgc ggacactgct cgcttcaggg ctttgctcag 4501 ctgcagctgg tgacctccag agagggagtc tctgatgtcc cgctggggtg gatgtcctga 4561 gaccgggaag ggggaagaga cccactgaaa tcctatctcc cagcctcacc tctgctgtct 4621 cctccacgct tcctgtctcc agagccccga gttcagcata agcagaaagc ggcctgttcc 4681 ctctctaggg agaggagggt tgcggtctgg aggtctggct cgtctttatc tgcgcattct 4741 cccagcctcc tggcttcaga cctcagcgag gcggcggctg cggccggctc tcctcttcct 4801 gcctgcagac ctggcctgct gcttctttct ccttcctccc tccctgcctg ccctgcggtt 4861 tcaaagtaga ttagaaataa cagtgtccca catggaagcc tctacttctt cctgggtcaa 4921 ctttgatgac gaggctccag aaaacctttg caatgctgtg tggaattttt aaatcggtga 4981 gctcgtgctc ttgccctatt tatttgtcca gcgtacattt ctgaacattg tgaacgtcga 5041 atgggccaac aaatctaaaa attaaatgag ctgataaaga acgccgtcag cacagagcag 5101 acgctgggtg ttcgcgctct tgagcgtgcg ctctgcgggg cgcgggctgg tggcgggcgg 5161 gggtcgccgg ctccagctca ggttcccgcg ccaggaccgc gtccagaacc ttgtctccgg 5221 aagcgggcaa cggggtggtt gtatcacaat tagtggcatt tggttttcct tcttctgcat 5281 tgtgggtttt acttctctgg ggttgccaaa aacaaaatta accatctcag tccttgtcgt 5341 taacgcagga gaagcattac tggaggaggc tctggggttc tgtggttgag gagctcagtt 5401 ctggttccgg ggagccctta tctgccaccc acgggtccaa ggcacagtcg gaggcagcag 5461 ggaggggagc ggaattcaca tcaacacaga tggggctcaa ggggactttg ctgcctctgc 5521 ctggagggtc taaagtttca ttttcatatg acccgcaggg cgcagactgg cggaaaatta 5581 gcagagccct gggcatgggc tgcacctggc cttaagggac aatgatggaa atattcctta 5641 ttagcacaat actgagcaca ggctgtgtga taatgtgtca agggaactgc agacatcctt 5701 tcagaaaaag ttcataaaac ggagaaagtt tggttcccaa cctagatttt taacctgttg 5761 aactctgtct aaatgggtca tctcgggatg tcctccactc aacatgacca cagtctgccc 5821 ctctgtccca cctgtctcct cagtccttcc tccccacctt tcaggatgaa atgaaaccct 5881 cagtccagct gcacccctgc cccacccacc tcatctcatg tgccctcccg cccctctcag 5941 gccggacagc cttgcttctg gaacacacga gcacagcttc accaggcact ttctgagcac 6001 cctgcaggcg cctcccagga gtggtcagtg gtcaatcagc taatgaagct gcataggaca 6061 tgacccttgt ttaccgcaga atgcccagag ctggcaggat gtcttatatg caggaagtac 6121 ccaaaatgta tttattgagg aagtgatgat ggataagagg aagacggaga gcgagggaga 6181 gaggggctag gggccctgcg gtgtaaaggg ggtgtggctg ggagtgtgca ggggaacagg 6241 gatcatttca aggttcctat ctgggagaaa ataaaaaggt ttacagttag ttgagataag 6301 cgtgggaata tgcgaacatt tttaaagaat aaaaagttta gctttaaatt tgttgattcc 6361 aaatgtgttc atactctcgg gaggatccat caagcaactc ttgggaggag agacagggca 6421 gggcaggcct tgacagctca gaagggcgca gtagggacag ttcttggttt tcccagctct 6481 gatgctttgc acagtcgctt gtgtgacctg caagatttta gtgaagaaac ttgctgtgga 6541 gtcggaaagc tgcaagttga ggtgtgtgtg gtgtgagggt taaaaatctg tgagaacaga 6601 atgaatggct tttcaagaat gttgtcgata gataggaaag aggtgggagg tgttcttgga 6661 gtggccatat gtggttttat gtagcatggg gaagactcag cagaaaggaa aaagaaagaa 6721 ggtaaattga cagcatgaag tagagcaccc aggagaggct acatgtgatg aagaaaccac 6781 agtgcagact gtgaggaccc cagaaaggct cctccccaaa acctgaccag tggccggtgc 6841 tggcagctcc caggctggga caccctctgt ctctctgtcc ctctgccccc tctgtcactt 6901 ctttatacac ctgtaaatcc tgccctgctc tccaaggccc tctgtagccc atttctcccc 6961 aaaatgggta tttagaataa ccttctgctg gcccctctgc cttaggaatc atttttaata 7021 atggacctac ctggaaggac atccggcggt tttccctgac caccctccgg aactatggga 7081 tggggaaaca gggcaatgag agccggatcc agagggaggc ccacttcctg ctggaagcac 7141 tcaggaagac ccaaggtgcg tatctgctgc ctagcagggc ccagtcctct tgcagaccag 7201 cggtgtgggg agccctggct gggactccta gactgcatct gaaccacagg gacctacgga 7261 caaggagagg gtctcgtgag tccccagata ctgcatttta caactctagg ttccagctac 7321 acagttcagg gagcaagggt ggccattaaa cacgtgactt gtatcctaaa tactgttgaa 7381 aagcaaagga aactcaaaca ggttcagaca ttcactatct ttcgtaaact ggcagttttc 7441 agggcacctt ctcacaggcc ttggtgaacc tcagtgggtg actgagcagg tggaggagtc 7501 tcctcacccc catcttctgg ttgccctgac tgcctgtttt gtaggccagc ctttcgaccc 7561 caccttcctc atcggctgcg cgccctgcaa cgtcatagcc gacatcctct tccgcaagca 7621 ttttgactac aatgatgaga agtttctaag gctgatgtat ttgtttaatg agaacttcca 7681 cctactcagc actccctggc tccaggtgaa gccactttcc tctttcatca gtcatcaact 7741 gtagagttta cgttagaaaa agaaggaaaa tttgggttat atgtgataga caggactgca 7801 aaagccaaac aacatagctt cgaggggtgt ttgattagac agcccaaata ttcctcccag 7861 agacatctct ggggccccac gcaccccctt tcctaacgtc aggatgtgta tcgacctgtg 7921 tgtgcacatt tgccatgcag agtttgcact gctgaggaga atggtgccca agaaggacac 7981 tgttgaccca aaatattcca aataaacaat gattacagcc acaaattcag gtttggagaa 8041 agttgttggt ccaacacaca caattatgtt gcatccagaa aaaagtagta aaatattttt 8101 ttccctctct agctttacaa taattttccc agctttctac actacttgcc tggaagccac 8161 agaaaagtca taaaaaatgt ggctgaagta aaagagtatg tgtctgaaag ggtgaaggag 8221 caccatcaat ctctggaccc caactgtccc cgggacctca ccgactgcct gctcgtggaa 8281 atggagaagg taggctcggc ctcccatgat gtgggctctc cggggtgggc agagaatgca 8341 caatttcaga tttacagagt gagctgcact tgctggtgtc cagacctccc accgcagcat 8401 gctctgagtt tcatacacac actcttggct tcagcatgac cactggacgc aagtcagcct 8461 gcctggctgc caagctggcc tggggtttgg ggcacatggg cgggacgctt agctctctcc 8521 aggccctgct gctcaaccct ttctagtctg cagactttga gaattgcatt ttgtctgagg 8581 agaagccctc agccttcctt gtgggcatgc actccccaac tgtgcgcacg tgcaggactt 8641 ccaggcctcc ccagcttcat ccacctgcag gtgctcagga tcctgatccc ctgccccctt 8701 cccaccttgg tgaaacttct tgtatccttg tcttgtcctt tcctatggct tgtggctcaa 8761 gaacaaatgt ggagcccaca ctgatttccc aggactgtct gagcatcttc tccaccagtt 8821 tggcccctcg tggcagcaga cactagccct gtagcaggag gggttagcag gagccgttta 8881 gctcctgcct gagctatgac caaggtcagg gggatctcac ctctcccagg atggccctca 8941 tgctgtggag ggagacagag ccctggcctg ccctcagcag atttctggga gcctcagttt 9001 ccctggctgt gagtggagat gactctgtct gtcacagctc caagtcacag ttccactggg 9061 agagcctctt ggacactgtc tcctgtgtcc ctgtggagct gggaggtggc tggttctgtg 9121 ctgaaaggag acaagcagcc ccttctctcc ggtctgtctc cggtatcaca ggaaaagcac 9181 agtgcagagc gcttgtacac aatggacggt atcaccgtga ctgtggccga cctgttcttt 9241 gcggggacag agaccaccag cacaactctg agatatgggc tcctgattct catgaaatac 9301 cctgagatcg aaggtaggca agtgactgaa gggacaccgt gcgtgcggct gcatctccct 9361 ggatggccag ccttgcacat tttaggctgc agctttctgt ctgaagctgc ttgttaaccc 9421 tcatggtgat gtggtgagat ggctggatgc actgctgtga ggggaggtgt tatggtctgt 9481 gctgaacact ggtactcttg cacactggtt ggtccatacc ccactaagac acccctggtt 9541 gcagaaaaga acatcccaac accagagtgg agagaggtgg cagggtctgc attctgctcc 9601 ataaataacc tctttatgac agagaagata atgtcccagt tccccccaag taagacctgg 9661 tcttctaggc agagcaggtg gggaggttgg agctggaggg gagggtcctt gctggggcgt 9721 cttcctcaaa tgcggacgtg aggagggaag tccaggaaga agcagctaca gctccccctg 9781 gacccttgtc gttccttcca cagggctcct cccagcggca cctggggcag ctgggactct 9841 gtgcctggag gaggtgtgaa aggtctgggt ctaggtgggc agagggtcat gccctgagaa 9901 acacccatct gggccaagta gaggtgatgt gagggcaccg catgcaaaca ggccagtcag 9961 ggttgggtcc aagtaaaggg gaggaaaggg agctgcagcc tggctggaga gtgccggggg 10021 gcccagagcc cctgcctctc gctgggctgg aaacagggct gggcagcctc tgcccgaggc 10081 agttcacagc ctgagtggtg tgtgccgccc tcctcctgaa gctgctgcta atggtcactt 10141 gtggtcttaa ggctcgtcag ttcctgaaag caggtattat aggctatgaa gttatttccc 10201 ccaagaaagt cgacatgtga tggatccagg gtcagaccct ggcttttctt gttctttcct 10261 tcttcttctt ctttttattt atttattttt tttttgaggg gacagggtct cactctgttg 10321 cccaggctgg agtgcggtga tgcaatcatg gctcattgta gcttctacct attgggctca 10381 agcgatcctc ccacctcagc ctcccaagta actgggccac aggtgcacac caccacaccc 10441 agctgattaa aaatttaaaa aaattatttt ggctgggcac agtggctcat acctgtaatc 10501 ctggcacttt gggaggctga ggcaggcgat cacgaggtca ggagttcgag accttcctgg 10561 ccaacatgat gaaaccctgt ctctcctaaa atacaaaaaa gtagccgggt gtggtggcac 10621 gcgcctatag tcacagctac tcaggaggct gaggcaggag aatcgcttca acctcagagg 10681 cacagggtgc agtgatccga gattgcaccc cactgcactc tagcctgaca acagagcaag 10741 aatcagtcta aaaaaaaaat tgtagagaca agttgttact atgttttgta ggctggtctt 10801 gaactcctgg gctcaagtca tcctcctgcc ttggcctccc aaagtgctgg ggttacaggt 10861 gtggccaccg tgccccatcc ctggcctttg ctttttcaat cacatggaaa tgtgaagggt 10921 gaaggagcca aaagtttagg gaaggaatca ttgtatggat ctgcagtgat tataagagaa 10981 ctttcgacta ctctgcacta ggggaaccat ggaatcaaaa aatgttttaa attattattt 11041 atgaggaggt tccaatatag acaaaaggaa aataaatatg attgacatgt atatatccat 11101 tgccaaattg aacgtttatt aacattttgc gatacttcca tcagagctct taaaaagaaa 11161 atgtgttaca gagccagcca aagtctacct cctcacatct ccccacctct ctcaccagaa 11221 atggcttcag aattgctgtg tggctttgca cttttaacag ttgttaatta tcagcacagt 11281 attcatatta ttgctgtatg tgtttaatat tttacctggg tactgtacat aacattttgc 11341 agcttggttt tttcactcaa catatgatga tgttccatgg gaactccaaa cacggggagg 11401 ctaggcgact tgctcaaggc agctgttacc tctgtcagaa agacagaggc tttcagattc 11461 aagaagtaga ccctgcatgt ctgattctgt tctgtaaacc cccttcatac tcagaagcat 11521 gcaataaaca agcctggggt aattatcaat gcaaaggtta ccctcccaga agaaatttcc 11581 aaaacacttt cattattctc tgctcttgac atgaagagaa ctgaataagc catcatcaac 11641 tgagataatg gatgccaaaa catccagtaa ataacctcat agagcttagc tctcactaag 11701 tttttggagc attttccagt aattcaaagg acctggggaa ccttaagcac tgcttaggat 11761 gctccataaa catcttctgc gtgggtaggg gagtggatgg atggctggat gggtgggtgg 11821 atggacggac ggatggatgg atggatggat ggatggatgg ttggatggat gggtgggtgg 11881 atggatggat gggtcaatgg atgtgtggat ggatggaagg gtgggtggat gggtggatgg 11941 ctggctggtt gggtgggtgg gtggatggat gcatgggtgg atggatggag gatggatgga 12001 tggatggagg ggtgtataga tggaggggtg gatggatgtg taggtgggca gatggataaa 12061 agcgtgattg aatagatggg tggatgatgg gtggatgccc aactggccag gaaccaatcc 12121 ctgaaatttg tcccattcat atcttggcag agaagctcca tgaagaaatt gacagggtga 12181 ttgggccaag ccgaatccct gccatcaagg ataggcaaga gatgccctac atggatgctg 12241 tggtgcatga gattcagcgg ttcatcaccc tcgtgccctc caacctgccc catgaagcaa 12301 cccgagacac cattttcaga ggatacctca tccccaaggt taagcaatga gcctgcagca 12361 cacagcatga acaccatcct atcactaatc gccttcctgc cagggagcag gatgggggcc 12421 ccaagaccct tccctttggc aggggtcact gaggggaagg gctggcccca ctcccaccct 12481 gtgggatact gcatctccag gagtgctcac attggcctgg tgaccagaga ggtggaggaa 12541 atctggaaaa gagcctcagc agatagtgcc tgggactgta gtgaattcta atgccaggaa 12601 caaactatca caaccagccc tggggttaat cctgtgagaa gattagggct ttcatcttca 12661 tttagacctg acccctgact gctttctatc taatccttca ctaagcaact ccttcaactc 12721 gaaatatact atcctatata gcataatatt caaaacaaca ttcttcactg ggggtttcca 12781 gatgaaagcc cacattttgt taacatgact cactgagaca gtctttgttt ctcctagggc 12841 acagtcgtag tgccaactct ggactctgtt ttgtatgaca accaagaatt tcctgatcca 12901 gaaaagttta agccagaaca cttcctgaat gaaaatggaa agttcaagta cagtgactat 12961 ttcaagccat tttccacagg tgagaaagat cagaggcagt accttccctt gaggagcagc 13021 ccacactcct catctcccct ccacatgtgc tctgccctcg tcccaggcac ccactgacac 13081 cccaaacctc actgtgtgcc ctgtttctat tgacaacatg acccaaatgt gctcttccct 13141 gttcagagaa gttacataac atcttttagc agcaatcctg ggaatgaagt gttgtaggtg 13201 gatttttttt ttcccaaaga ctagacattt tacatcattc attgctaaat tttgtttcta 13261 ttttaacaag acttagtgaa aagctctcaa agccatatta cccaattctc cctaatttta 13321 aaccagagct actaaacaaa acctaacctt tggttaccta gaatcatcac aggaagcatc 13381 aaagccttcc tgggatgtga ctcagtgatt ttctttgagg cacttgtcct ccttcccagg 13441 gcctcatctt agggattgtt gtgggaagat catacaacca actccatact tttcacaccc 13501 agtgctggag ccccagcttc taacagggca ctatttccct cctgtaggca tcactgatga 13561 gcactggggg tgccttcttt actgggcaga catggtcttc ccaacttaac accggttttt 13621 gcagttgagc tctggataat tgagattgta tgaaggctgg tccccgaatt agtcagtgtc 13681 gctggtatcc ttccactcaa gtacattttg tgcttctttt aataggcaga gaggggtgag 13741 tcctgccctg tgatggccgt ttgcccacag cctcctcctc cccgcttccc ctagtctcac 13801 tgttaacagt gtcgtgtctc tgaaactccc tcagtgtctc atcaatacca ttgttacttc 13861 taggaaaacg agtgtgtgct ggagaaggcc tggctcgcat ggagttgttt cttttgttgt 13921 gtgccatttt gcagcatttt aatttgaagc ctctcgttga cccaaaggat atcgacctca 13981 gccctataca tattgggttt ggctgtatcc caccacgtta caaactctgt gtcattcccc 14041 gctcatgagt gtgtggagga caccctgaac cccccgcttt caaacaagat ttcgaattgt 14101 ttgaggtcag gatttctcaa actgattcct ttctttgcat atgagtattt gaaaataaat 14161 attttcccag aatataaata aatcatcaca tgattatttt aactatatgt taagtcatgg 14221 aatatcttaa ttgtttaagt gattctcaca gagaggtttt tttttttttt tttttttttt 14281 tgagagtttt gctcttgttg accaggatgg agtgcagtgg catgatcttg gctcactgca 14341 acctctgtgt cctgggttca agtgattctc ctccctcagc ctcccgaata gctgggatta 14401 caggcaccca ccaccatgcc agctaattct ttgtattttt agcagagaca gggtttcacc 14461 atgttggtca ggctggtctt gaacccctga cctcaggtga tccacctacc tcggcctccc 14521 aaagtgctgg gattacagca tgagccaccg cgcccagcca gagagaggtt ttaaatatat 14581 atgtttactt taatattaag ttataacata attttcatgt tattgaaaag ctcttccatc 14641 taggatcaca ccacttcagt gtcagaatca tattgaggtg gggaatttgt attagtcagg 14701 tttctctaaa gggacagaaa caataggata gatgtatata cgaaagggag tttattagga 14761 gaattgactc acatga //