LOCUS       HUMCYPIIE              14776 bp    DNA     linear   HUM 02-NOV-1994
DEFINITION  Human cytochrome P450IIE1 (ethanol-inducible) gene, complete cds.
ACCESSION   J02843
VERSION     J02843.1
KEYWORDS    cytochrome P450.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 14776)
  AUTHORS   Umeno,M., McBride,O.W., Yang,C.S., Gelboin,H.V. and Gonzalez,F.J.
  TITLE     Human ethanol-inducible P450IIE1: complete gene sequence, promoter
            characterization, chromosome mapping, and cDNA-directed expression
  JOURNAL   Biochemistry 27 (25), 9006-9013 (1988)
   PUBMED   3233219
REFERENCE   2  (sites)
  AUTHORS   Uematsu,F., Kikuchi,H., Abe,T., Motomiya,M., Ohmachi,T., Sagami,I.
            and Watanabe,M.
  TITLE     MspI polymorphism of the human CYP2E gene
  JOURNAL   Nucleic Acids Res. 19 (20), 5797 (1991)
   PUBMED   1719479
COMMENT     Original source text: Human (adult) liver DNA.
            Draft entry and computer-readable sequence for [1] kindly provided
            by F.J.Gonzales, 18-AUG-1988.
FEATURES             Location/Qualifiers
     source          1..14776
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /map="10"
     prim_transcript 2789..14198
                     /note="CYP2E mRNA and introns"
     CDS             join(2825..3001,3907..4066,7006..7155,7545..7705,
                     8113..8289,9172..9313,12151..12338,12838..12979,
                     13864..14048)
                     /note="cytochrome P450IIE1"
                     /codon_start=1
                     /protein_id="AAA52155.1"
                     /translation="MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGN
                     LFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGD
                     LPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRK
                     TQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLY
                     NNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKE
                     KHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIG
                     PSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPT
                     LDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLL
                     LCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPRS"
     gene            2825..3001
                     /gene="CYP2E"
     exon            <2825..3001
                     /gene="CYP2E"
                     /note="cytochrome P450IIE1; G00-119-833"
                     /number=1
     intron          3002..3906
                     /note="CYP2E intron A"
     exon            3907..4066
                     /number=2
     intron          4067..7005
                     /note="CYP2E intron B"
     exon            7006..7155
                     /number=3
     intron          7156..7544
                     /note="CYP2E intron C"
     exon            7545..7705
                     /number=4
     intron          7706..8112
                     /note="CYP2E intron D"
     exon            8113..8289
                     /number=5
     intron          8290..9171
                     /note="CYP2E intron E"
     exon            9172..9313
                     /number=6
     intron          9314..12150
                     /note="CYP2E intron F"
     exon            12151..12338
                     /number=7
     intron          12339..12837
                     /note="CYP2E intron G"
     exon            12838..12979
                     /number=8
     intron          12980..13863
                     /note="CYP2E intron H"
     exon            13864..>14048
                     /note="cytochrome P450IIE1"
                     /number=9
BASE COUNT         3635 a         3645 c         3772 g         3724 t
ORIGIN      2246 bp upstream of EcoRI site; chromosome 10.
        1 cccccattga aaaattgtct ttctgatctt tataaacaat tatttaatat ccagtaaaat
       61 cttctctata ttgctttact agtgagttct attaaaattt tgaagcacag aaaattcccc
      121 tacagtataa agtatcccca gtcacagaga agacaggggt tttgcaatga tttctagaat
      181 agtgcaattt ttatgcaaga acctaatata acacaaaaat tatagcccga ttttatttgt
      241 gggtatagat gcaaaattac taaaaatact attaacaagt tgaatcctta gggtgttaaa
      301 agagtatcac tccatgaacg agttggttgt gatgtggaac tatgaggtac ttttatgata
      361 caatataaaa atttatggta attttatggt acattgtgag acagtgtttt cttctagcat
      421 catactagca ggtctatgga gaaaaatcac aggattgtct caatcaaaaa aagatttcat
      481 taacccaact ctcatccctg ataaacactg ttagttatct agagaaagaa gaaaattgtc
      541 ccaatacagt cacctctttg ccacacccag ccaacagcag acgtgatgga agcctgaaga
      601 acaccctgcc acgggcacag gcagaggcac aggcaccctg tcgtcctgat tatttcacct
      661 tgtcacgggc agaggcacag gcaccctgtc gtcctgatta tttcaccttg tcacaggcac
      721 aggcaccctg tcgtcctgat tatttcacct tgtcacaggc acaggcactc tgtcgtcctg
      781 attatttcac cttgtcacgg gcagaggcac aggcactctg tcatcctgat tatttcacct
      841 tgtcctagag tgtcctgcca atgggacaga tgcaaaacaa ataaaagccc cggcttctga
      901 aaagaagcac acagaaatgt cattattttc aaacgaggtg ttcccgtata taaaatttga
      961 tgttggttgg gcatctaaca gtattatggc cagaggactc agaccacagc tgcatccctg
     1021 tgaggcacag actctccagg gcacgcgggt cccgctggga tgtgcacact caggtgagct
     1081 gcacagacaa ggtgtcctca gcccagggga gccagaggcc tgctctgcct ctccaccctg
     1141 atgcttcctg ttctcacccc accaaagcca aggcttcaat ttcagtctgt ggggagctga
     1201 ctctgctgct ctcaagcact agaagaagga accagtaatc gaggaaactt gtggacccca
     1261 atggtgtctg tcccggccag gcctggctgg gcccacacag gacaacaggg ttcaggggtc
     1321 tggacagctg tttctgccca gggaattgtc cctgccacct cacactggcc actggaaagg
     1381 aaagagagga ggaggcggca ggctaaccca cccgtgagcc agtcgagtct acattgtcag
     1441 ttctcacctc gaggggtgcc aaaaaccaga gggaagcaaa ggcccctgaa gcctctgcca
     1501 gaggccaacg ccccttcttg gttcaggaga ggtgcagtgt taggtgcagc acaaccaatg
     1561 acttgcttat gtggctaata aattgtcaag agaaaaactg ggttagaatg caatatatag
     1621 tatgtagtct catttttgta taaatacaag tatagaatgg cataactcaa aatccacaag
     1681 tgatttggct ggattgtaaa tgacttttat tttcttcatt tctcatcata ttttctatta
     1741 tacataaaga ttcattgtta atataaaagt acaaaattgc aacctatgaa ttaagaactt
     1801 ctatatattg ccagttagaa gacagaatga aaaacattct cttcattcta accacacaca
     1861 caaaaaactc cacaaaatac ctatggacta ccttcataga aggtggaaga gggtctgtat
     1921 gaagaaaatg cttaatacat gaaagaagaa gctagtcaat gtggaggtct attgtgcgcc
     1981 gggatcaaca aagacaagat atgtttaaaa tggtgttcta aatttaccct aatgtaaaac
     2041 aaatccaata aaactctaat gtgatttttt aagaatttaa atttggaata attccaaaga
     2101 acaatttttc ttaatttcta cagccagaat atataccttt aaaaaaaatg aaaacagaga
     2161 ttaactttct cagaattggt tgactcactc tttcctttta tttttcttcc atggaatttt
     2221 ccagttaact tgagaaagtg gaatcgaatt ccgatgttga attttccttc tggccccatt
     2281 catgtggcag gtggtgattc aggtactact gggggctgct cagacaaacc tcctcatcag
     2341 acatcaagag gctgttgcac caggagggcc ggtaccgtgt ctagaggtgg tcggcatggg
     2401 gttggagttg tattacataa accctactcc aaacaaatgc atggggatgt ggctggagtt
     2461 ccccgttgtc taaccagtgc caaagggcag gtcggtacct caccccacgt tcttaactat
     2521 gggttggcaa catgttcctg gatgtgtttg ctggcacagt gacaggtgct agcaaccagg
     2581 gtgttgacac agtccaactc catcctcacc aggtcactgg ctggaacccc tgggggccac
     2641 cattgcggga atcagccttt gaaacgatgg ccaacagcag ctaataataa accagtaatt
     2701 tgggatagac gagtagcaag agggcattgg ttggtgggtc accctccttc tcagaacaca
     2761 ttataaaaac cttcctttcc acaggattgt cctcccgggc tggcagcagg gccccagcgg
     2821 caccatgtct gccctcggag tcaccgtggc cctgctggtg tgggcggcct tcctcctgct
     2881 ggtgtccatg tggaggcagg tgcacagcag ctggaatctg cccccaggcc ctttcccgct
     2941 tcccatcatc gggaacctct tccagttgga attgaagaat attcccaagt ccttcacccg
     3001 ggtaagagaa atagtgttga ttttagggag aataactcag caattggatc tggtatgtgt
     3061 gtattcaact catttgcaga caaattgtgg ttgttcaata ccagcctgtt gtgaattacc
     3121 tgaattgata gcatcctgga gcgacactca aaatgtgtcg cctgtggtgc agctggagcc
     3181 cggagcctgc gtgccaggcc ccggaggccc ccgccgtgcc ttgtcctggg gctgatgatg
     3241 gggaggccgg cgaggccggg ctgctgcgac gccaggataa ccgggctggc ggccagatgc
     3301 gcactcgctg ggcgtccgcc tgtgtttgcc aaagcacgag ttgaaacgtg aagtgttggg
     3361 ccagcccgtg tggcaccaat acctgccgcc tacgactgtt gtgaacactg aatgggccaa
     3421 caaacctaaa cgttaaatga actgataacg ccgtcagcac ggagcaggcg ctgggtgttt
     3481 gcgctcttgc gcgtgcgctg ctgtggggcg caggctgacg gcgggcgggg gtcgcctgct
     3541 ccagctcggg ctcccgcgcc agaaccgggt ccagaacctt gattccggaa gcgggcaacg
     3601 gggtggttgg tgggcgcgcc tgagggaagg gacgtgagga gccggagtcc gcggagttgc
     3661 cgcggagttg tccgcggagt ccaggcgggt ggggagcaga gcagctggaa ccccccgagc
     3721 gccctgcaga cgcagcagcc tcttgagggg agggtctccc ccacctcggg ctggacaaag
     3781 acagcttttc cccacgtccc tctgggttct ctagagcaac agcaataccc gcccggcagg
     3841 tgtggcttag agccccgcac ctcctcgccg cgcgcgggcc tgacttctag ccacgggtct
     3901 ccgcagttgg cccagcgctt cgggccggtg ttcacgctgt acgtgggctc gcagcgcatg
     3961 gtggtgatgc acggctacaa ggcggtgaag gaagcgctgc tggactacaa ggacgagttc
     4021 tcgggcagag gcgacctccc cgcgttccat gcgcacaggg acaggggtga gtccgcgtcc
     4081 ctggcacgga gcggggggtg cataacacgc cccgggacag ttacgggcgc tagccacgtc
     4141 ggcgatggcc aaataataaa ctaacagtaa tattatagta atagcatccg aaggatgaga
     4201 tcaggattag gcgatggccc ccgcgcgttg cctgccgagc gaggcgcact gagtcgccca
     4261 ggaatccggc ctctcggcga ctgtgcggga gagttttatg gggatgggcg gggctgcttc
     4321 tgagcaggag tcgccgcccc cacccccacc gttccgcctc tgggccgcag gctcctcccg
     4381 ggagcgcttt cccctcctgt tcaaccgccg gggtacaggt ggcttcgtcc accgaggtcc
     4441 cctcacccac gctgaggcgt cggaagctgc ggacactgct cgcttcaggg ctttgctcag
     4501 ctgcagctgg tgacctccag agagggagtc tctgatgtcc cgctggggtg gatgtcctga
     4561 gaccgggaag ggggaagaga cccactgaaa tcctatctcc cagcctcacc tctgctgtct
     4621 cctccacgct tcctgtctcc agagccccga gttcagcata agcagaaagc ggcctgttcc
     4681 ctctctaggg agaggagggt tgcggtctgg aggtctggct cgtctttatc tgcgcattct
     4741 cccagcctcc tggcttcaga cctcagcgag gcggcggctg cggccggctc tcctcttcct
     4801 gcctgcagac ctggcctgct gcttctttct ccttcctccc tccctgcctg ccctgcggtt
     4861 tcaaagtaga ttagaaataa cagtgtccca catggaagcc tctacttctt cctgggtcaa
     4921 ctttgatgac gaggctccag aaaacctttg caatgctgtg tggaattttt aaatcggtga
     4981 gctcgtgctc ttgccctatt tatttgtcca gcgtacattt ctgaacattg tgaacgtcga
     5041 atgggccaac aaatctaaaa attaaatgag ctgataaaga acgccgtcag cacagagcag
     5101 acgctgggtg ttcgcgctct tgagcgtgcg ctctgcgggg cgcgggctgg tggcgggcgg
     5161 gggtcgccgg ctccagctca ggttcccgcg ccaggaccgc gtccagaacc ttgtctccgg
     5221 aagcgggcaa cggggtggtt gtatcacaat tagtggcatt tggttttcct tcttctgcat
     5281 tgtgggtttt acttctctgg ggttgccaaa aacaaaatta accatctcag tccttgtcgt
     5341 taacgcagga gaagcattac tggaggaggc tctggggttc tgtggttgag gagctcagtt
     5401 ctggttccgg ggagccctta tctgccaccc acgggtccaa ggcacagtcg gaggcagcag
     5461 ggaggggagc ggaattcaca tcaacacaga tggggctcaa ggggactttg ctgcctctgc
     5521 ctggagggtc taaagtttca ttttcatatg acccgcaggg cgcagactgg cggaaaatta
     5581 gcagagccct gggcatgggc tgcacctggc cttaagggac aatgatggaa atattcctta
     5641 ttagcacaat actgagcaca ggctgtgtga taatgtgtca agggaactgc agacatcctt
     5701 tcagaaaaag ttcataaaac ggagaaagtt tggttcccaa cctagatttt taacctgttg
     5761 aactctgtct aaatgggtca tctcgggatg tcctccactc aacatgacca cagtctgccc
     5821 ctctgtccca cctgtctcct cagtccttcc tccccacctt tcaggatgaa atgaaaccct
     5881 cagtccagct gcacccctgc cccacccacc tcatctcatg tgccctcccg cccctctcag
     5941 gccggacagc cttgcttctg gaacacacga gcacagcttc accaggcact ttctgagcac
     6001 cctgcaggcg cctcccagga gtggtcagtg gtcaatcagc taatgaagct gcataggaca
     6061 tgacccttgt ttaccgcaga atgcccagag ctggcaggat gtcttatatg caggaagtac
     6121 ccaaaatgta tttattgagg aagtgatgat ggataagagg aagacggaga gcgagggaga
     6181 gaggggctag gggccctgcg gtgtaaaggg ggtgtggctg ggagtgtgca ggggaacagg
     6241 gatcatttca aggttcctat ctgggagaaa ataaaaaggt ttacagttag ttgagataag
     6301 cgtgggaata tgcgaacatt tttaaagaat aaaaagttta gctttaaatt tgttgattcc
     6361 aaatgtgttc atactctcgg gaggatccat caagcaactc ttgggaggag agacagggca
     6421 gggcaggcct tgacagctca gaagggcgca gtagggacag ttcttggttt tcccagctct
     6481 gatgctttgc acagtcgctt gtgtgacctg caagatttta gtgaagaaac ttgctgtgga
     6541 gtcggaaagc tgcaagttga ggtgtgtgtg gtgtgagggt taaaaatctg tgagaacaga
     6601 atgaatggct tttcaagaat gttgtcgata gataggaaag aggtgggagg tgttcttgga
     6661 gtggccatat gtggttttat gtagcatggg gaagactcag cagaaaggaa aaagaaagaa
     6721 ggtaaattga cagcatgaag tagagcaccc aggagaggct acatgtgatg aagaaaccac
     6781 agtgcagact gtgaggaccc cagaaaggct cctccccaaa acctgaccag tggccggtgc
     6841 tggcagctcc caggctggga caccctctgt ctctctgtcc ctctgccccc tctgtcactt
     6901 ctttatacac ctgtaaatcc tgccctgctc tccaaggccc tctgtagccc atttctcccc
     6961 aaaatgggta tttagaataa ccttctgctg gcccctctgc cttaggaatc atttttaata
     7021 atggacctac ctggaaggac atccggcggt tttccctgac caccctccgg aactatggga
     7081 tggggaaaca gggcaatgag agccggatcc agagggaggc ccacttcctg ctggaagcac
     7141 tcaggaagac ccaaggtgcg tatctgctgc ctagcagggc ccagtcctct tgcagaccag
     7201 cggtgtgggg agccctggct gggactccta gactgcatct gaaccacagg gacctacgga
     7261 caaggagagg gtctcgtgag tccccagata ctgcatttta caactctagg ttccagctac
     7321 acagttcagg gagcaagggt ggccattaaa cacgtgactt gtatcctaaa tactgttgaa
     7381 aagcaaagga aactcaaaca ggttcagaca ttcactatct ttcgtaaact ggcagttttc
     7441 agggcacctt ctcacaggcc ttggtgaacc tcagtgggtg actgagcagg tggaggagtc
     7501 tcctcacccc catcttctgg ttgccctgac tgcctgtttt gtaggccagc ctttcgaccc
     7561 caccttcctc atcggctgcg cgccctgcaa cgtcatagcc gacatcctct tccgcaagca
     7621 ttttgactac aatgatgaga agtttctaag gctgatgtat ttgtttaatg agaacttcca
     7681 cctactcagc actccctggc tccaggtgaa gccactttcc tctttcatca gtcatcaact
     7741 gtagagttta cgttagaaaa agaaggaaaa tttgggttat atgtgataga caggactgca
     7801 aaagccaaac aacatagctt cgaggggtgt ttgattagac agcccaaata ttcctcccag
     7861 agacatctct ggggccccac gcaccccctt tcctaacgtc aggatgtgta tcgacctgtg
     7921 tgtgcacatt tgccatgcag agtttgcact gctgaggaga atggtgccca agaaggacac
     7981 tgttgaccca aaatattcca aataaacaat gattacagcc acaaattcag gtttggagaa
     8041 agttgttggt ccaacacaca caattatgtt gcatccagaa aaaagtagta aaatattttt
     8101 ttccctctct agctttacaa taattttccc agctttctac actacttgcc tggaagccac
     8161 agaaaagtca taaaaaatgt ggctgaagta aaagagtatg tgtctgaaag ggtgaaggag
     8221 caccatcaat ctctggaccc caactgtccc cgggacctca ccgactgcct gctcgtggaa
     8281 atggagaagg taggctcggc ctcccatgat gtgggctctc cggggtgggc agagaatgca
     8341 caatttcaga tttacagagt gagctgcact tgctggtgtc cagacctccc accgcagcat
     8401 gctctgagtt tcatacacac actcttggct tcagcatgac cactggacgc aagtcagcct
     8461 gcctggctgc caagctggcc tggggtttgg ggcacatggg cgggacgctt agctctctcc
     8521 aggccctgct gctcaaccct ttctagtctg cagactttga gaattgcatt ttgtctgagg
     8581 agaagccctc agccttcctt gtgggcatgc actccccaac tgtgcgcacg tgcaggactt
     8641 ccaggcctcc ccagcttcat ccacctgcag gtgctcagga tcctgatccc ctgccccctt
     8701 cccaccttgg tgaaacttct tgtatccttg tcttgtcctt tcctatggct tgtggctcaa
     8761 gaacaaatgt ggagcccaca ctgatttccc aggactgtct gagcatcttc tccaccagtt
     8821 tggcccctcg tggcagcaga cactagccct gtagcaggag gggttagcag gagccgttta
     8881 gctcctgcct gagctatgac caaggtcagg gggatctcac ctctcccagg atggccctca
     8941 tgctgtggag ggagacagag ccctggcctg ccctcagcag atttctggga gcctcagttt
     9001 ccctggctgt gagtggagat gactctgtct gtcacagctc caagtcacag ttccactggg
     9061 agagcctctt ggacactgtc tcctgtgtcc ctgtggagct gggaggtggc tggttctgtg
     9121 ctgaaaggag acaagcagcc ccttctctcc ggtctgtctc cggtatcaca ggaaaagcac
     9181 agtgcagagc gcttgtacac aatggacggt atcaccgtga ctgtggccga cctgttcttt
     9241 gcggggacag agaccaccag cacaactctg agatatgggc tcctgattct catgaaatac
     9301 cctgagatcg aaggtaggca agtgactgaa gggacaccgt gcgtgcggct gcatctccct
     9361 ggatggccag ccttgcacat tttaggctgc agctttctgt ctgaagctgc ttgttaaccc
     9421 tcatggtgat gtggtgagat ggctggatgc actgctgtga ggggaggtgt tatggtctgt
     9481 gctgaacact ggtactcttg cacactggtt ggtccatacc ccactaagac acccctggtt
     9541 gcagaaaaga acatcccaac accagagtgg agagaggtgg cagggtctgc attctgctcc
     9601 ataaataacc tctttatgac agagaagata atgtcccagt tccccccaag taagacctgg
     9661 tcttctaggc agagcaggtg gggaggttgg agctggaggg gagggtcctt gctggggcgt
     9721 cttcctcaaa tgcggacgtg aggagggaag tccaggaaga agcagctaca gctccccctg
     9781 gacccttgtc gttccttcca cagggctcct cccagcggca cctggggcag ctgggactct
     9841 gtgcctggag gaggtgtgaa aggtctgggt ctaggtgggc agagggtcat gccctgagaa
     9901 acacccatct gggccaagta gaggtgatgt gagggcaccg catgcaaaca ggccagtcag
     9961 ggttgggtcc aagtaaaggg gaggaaaggg agctgcagcc tggctggaga gtgccggggg
    10021 gcccagagcc cctgcctctc gctgggctgg aaacagggct gggcagcctc tgcccgaggc
    10081 agttcacagc ctgagtggtg tgtgccgccc tcctcctgaa gctgctgcta atggtcactt
    10141 gtggtcttaa ggctcgtcag ttcctgaaag caggtattat aggctatgaa gttatttccc
    10201 ccaagaaagt cgacatgtga tggatccagg gtcagaccct ggcttttctt gttctttcct
    10261 tcttcttctt ctttttattt atttattttt tttttgaggg gacagggtct cactctgttg
    10321 cccaggctgg agtgcggtga tgcaatcatg gctcattgta gcttctacct attgggctca
    10381 agcgatcctc ccacctcagc ctcccaagta actgggccac aggtgcacac caccacaccc
    10441 agctgattaa aaatttaaaa aaattatttt ggctgggcac agtggctcat acctgtaatc
    10501 ctggcacttt gggaggctga ggcaggcgat cacgaggtca ggagttcgag accttcctgg
    10561 ccaacatgat gaaaccctgt ctctcctaaa atacaaaaaa gtagccgggt gtggtggcac
    10621 gcgcctatag tcacagctac tcaggaggct gaggcaggag aatcgcttca acctcagagg
    10681 cacagggtgc agtgatccga gattgcaccc cactgcactc tagcctgaca acagagcaag
    10741 aatcagtcta aaaaaaaaat tgtagagaca agttgttact atgttttgta ggctggtctt
    10801 gaactcctgg gctcaagtca tcctcctgcc ttggcctccc aaagtgctgg ggttacaggt
    10861 gtggccaccg tgccccatcc ctggcctttg ctttttcaat cacatggaaa tgtgaagggt
    10921 gaaggagcca aaagtttagg gaaggaatca ttgtatggat ctgcagtgat tataagagaa
    10981 ctttcgacta ctctgcacta ggggaaccat ggaatcaaaa aatgttttaa attattattt
    11041 atgaggaggt tccaatatag acaaaaggaa aataaatatg attgacatgt atatatccat
    11101 tgccaaattg aacgtttatt aacattttgc gatacttcca tcagagctct taaaaagaaa
    11161 atgtgttaca gagccagcca aagtctacct cctcacatct ccccacctct ctcaccagaa
    11221 atggcttcag aattgctgtg tggctttgca cttttaacag ttgttaatta tcagcacagt
    11281 attcatatta ttgctgtatg tgtttaatat tttacctggg tactgtacat aacattttgc
    11341 agcttggttt tttcactcaa catatgatga tgttccatgg gaactccaaa cacggggagg
    11401 ctaggcgact tgctcaaggc agctgttacc tctgtcagaa agacagaggc tttcagattc
    11461 aagaagtaga ccctgcatgt ctgattctgt tctgtaaacc cccttcatac tcagaagcat
    11521 gcaataaaca agcctggggt aattatcaat gcaaaggtta ccctcccaga agaaatttcc
    11581 aaaacacttt cattattctc tgctcttgac atgaagagaa ctgaataagc catcatcaac
    11641 tgagataatg gatgccaaaa catccagtaa ataacctcat agagcttagc tctcactaag
    11701 tttttggagc attttccagt aattcaaagg acctggggaa ccttaagcac tgcttaggat
    11761 gctccataaa catcttctgc gtgggtaggg gagtggatgg atggctggat gggtgggtgg
    11821 atggacggac ggatggatgg atggatggat ggatggatgg ttggatggat gggtgggtgg
    11881 atggatggat gggtcaatgg atgtgtggat ggatggaagg gtgggtggat gggtggatgg
    11941 ctggctggtt gggtgggtgg gtggatggat gcatgggtgg atggatggag gatggatgga
    12001 tggatggagg ggtgtataga tggaggggtg gatggatgtg taggtgggca gatggataaa
    12061 agcgtgattg aatagatggg tggatgatgg gtggatgccc aactggccag gaaccaatcc
    12121 ctgaaatttg tcccattcat atcttggcag agaagctcca tgaagaaatt gacagggtga
    12181 ttgggccaag ccgaatccct gccatcaagg ataggcaaga gatgccctac atggatgctg
    12241 tggtgcatga gattcagcgg ttcatcaccc tcgtgccctc caacctgccc catgaagcaa
    12301 cccgagacac cattttcaga ggatacctca tccccaaggt taagcaatga gcctgcagca
    12361 cacagcatga acaccatcct atcactaatc gccttcctgc cagggagcag gatgggggcc
    12421 ccaagaccct tccctttggc aggggtcact gaggggaagg gctggcccca ctcccaccct
    12481 gtgggatact gcatctccag gagtgctcac attggcctgg tgaccagaga ggtggaggaa
    12541 atctggaaaa gagcctcagc agatagtgcc tgggactgta gtgaattcta atgccaggaa
    12601 caaactatca caaccagccc tggggttaat cctgtgagaa gattagggct ttcatcttca
    12661 tttagacctg acccctgact gctttctatc taatccttca ctaagcaact ccttcaactc
    12721 gaaatatact atcctatata gcataatatt caaaacaaca ttcttcactg ggggtttcca
    12781 gatgaaagcc cacattttgt taacatgact cactgagaca gtctttgttt ctcctagggc
    12841 acagtcgtag tgccaactct ggactctgtt ttgtatgaca accaagaatt tcctgatcca
    12901 gaaaagttta agccagaaca cttcctgaat gaaaatggaa agttcaagta cagtgactat
    12961 ttcaagccat tttccacagg tgagaaagat cagaggcagt accttccctt gaggagcagc
    13021 ccacactcct catctcccct ccacatgtgc tctgccctcg tcccaggcac ccactgacac
    13081 cccaaacctc actgtgtgcc ctgtttctat tgacaacatg acccaaatgt gctcttccct
    13141 gttcagagaa gttacataac atcttttagc agcaatcctg ggaatgaagt gttgtaggtg
    13201 gatttttttt ttcccaaaga ctagacattt tacatcattc attgctaaat tttgtttcta
    13261 ttttaacaag acttagtgaa aagctctcaa agccatatta cccaattctc cctaatttta
    13321 aaccagagct actaaacaaa acctaacctt tggttaccta gaatcatcac aggaagcatc
    13381 aaagccttcc tgggatgtga ctcagtgatt ttctttgagg cacttgtcct ccttcccagg
    13441 gcctcatctt agggattgtt gtgggaagat catacaacca actccatact tttcacaccc
    13501 agtgctggag ccccagcttc taacagggca ctatttccct cctgtaggca tcactgatga
    13561 gcactggggg tgccttcttt actgggcaga catggtcttc ccaacttaac accggttttt
    13621 gcagttgagc tctggataat tgagattgta tgaaggctgg tccccgaatt agtcagtgtc
    13681 gctggtatcc ttccactcaa gtacattttg tgcttctttt aataggcaga gaggggtgag
    13741 tcctgccctg tgatggccgt ttgcccacag cctcctcctc cccgcttccc ctagtctcac
    13801 tgttaacagt gtcgtgtctc tgaaactccc tcagtgtctc atcaatacca ttgttacttc
    13861 taggaaaacg agtgtgtgct ggagaaggcc tggctcgcat ggagttgttt cttttgttgt
    13921 gtgccatttt gcagcatttt aatttgaagc ctctcgttga cccaaaggat atcgacctca
    13981 gccctataca tattgggttt ggctgtatcc caccacgtta caaactctgt gtcattcccc
    14041 gctcatgagt gtgtggagga caccctgaac cccccgcttt caaacaagat ttcgaattgt
    14101 ttgaggtcag gatttctcaa actgattcct ttctttgcat atgagtattt gaaaataaat
    14161 attttcccag aatataaata aatcatcaca tgattatttt aactatatgt taagtcatgg
    14221 aatatcttaa ttgtttaagt gattctcaca gagaggtttt tttttttttt tttttttttt
    14281 tgagagtttt gctcttgttg accaggatgg agtgcagtgg catgatcttg gctcactgca
    14341 acctctgtgt cctgggttca agtgattctc ctccctcagc ctcccgaata gctgggatta
    14401 caggcaccca ccaccatgcc agctaattct ttgtattttt agcagagaca gggtttcacc
    14461 atgttggtca ggctggtctt gaacccctga cctcaggtga tccacctacc tcggcctccc
    14521 aaagtgctgg gattacagca tgagccaccg cgcccagcca gagagaggtt ttaaatatat
    14581 atgtttactt taatattaag ttataacata attttcatgt tattgaaaag ctcttccatc
    14641 taggatcaca ccacttcagt gtcagaatca tattgaggtg gggaatttgt attagtcagg
    14701 tttctctaaa gggacagaaa caataggata gatgtatata cgaaagggag tttattagga
    14761 gaattgactc acatga
//