LOCUS       HUMFISP                 1963 bp    mRNA    linear   HUM 08-NOV-1994
DEFINITION  Human factor I (C3b/C4b inactivator) mRNA, complete cds.
ACCESSION   J02770
VERSION     J02770.1
KEYWORDS    C3b/C34 inactivator; complement cascade; factor I; serine protease.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1963)
  AUTHORS   Goldberger,G., Bruns,G.A., Rits,M., Edge,M.D. and Kwiatkowski,D.J.
  TITLE     Human complement factor I: analysis of cDNA-derived primary
            structure and assignment of its gene to chromosome 4
  JOURNAL   J. Biol. Chem. 262 (21), 10065-10071 (1987)
   PUBMED   2956252
COMMENT     Original source text: Human hepatoma cell line HepG2 and normal
            liver, cDNA to mRNA, clones lambda-G2-HI1971 and lambda-gt10.
            Draft entry and printed copy of sequence [1] kindly provided by
            G.Goldberger, 11-MAY-1987.
            There were no sequence differences between the sequences from the
            hepatoma cell line and the normal liver.
FEATURES             Location/Qualifiers
     source          1..1963
                     /db_xref="H-InvDB:HIT000191087"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /map="4q24-q25"
     gene            1..1963
                     /gene="IF"
     mRNA            <1..1963
                     /gene="IF"
                     /product="SPRC mRNA"
     CDS             15..1766
                     /gene="IF"
                     /note="prepro-C3b/C4B inactivator"
                     /codon_start=1
                     /protein_id="AAA52455.1"
                     /db_xref="GDB:G00-120-077"
                     /translation="MKLLHVFLLFLCFHLRFCKVTYTSQEDLVEKKCLAKKYTHLSCD
                     KVFCQPWQRCIEGTCVCKLPYQCPKNGTAVCATNRRSFPTYCQQKSLECLHPGTKFLN
                     NGTCTAEGKFSVSLKHGNTDSEGIVEVKLVDQDKTMFICKSSWSMREANVACLDLGFQ
                     QGADTQRRFKLSDLSINSTECLHVHCRGLETSLAECTFTKRRTMGYQDFADVVCYTQK
                     ADSPMDDFFQCVNGKYISQMKACDGINDCGDQSDELCCKACQGKGFHCKSGVCIPSQY
                     QCNGEVDCITGEDEVGCAGFASVAQEETEILTADMDAERRRIKSLLPKLSCGVKNRMH
                     IRRKRIVGGKRAQLGDLPWQVAIKDASGITCGGIYIGGCWILTAAHCLRASKTHRYQI
                     WTTVVDWIHPDLKRIVIEYVDRIIFHENYNAGTYQNDIALIEMKKDGNKKDCELPRSI
                     PACVPWSPYLFQPNDTCIVSGWGREKDNERVFSLQWGEVKLISNCSKFYGNRFYEKEM
                     ECAGTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENCGKPEFPGFYTKVANYF
                     DWISYHVGRPFISQYNV"
     sig_peptide     15..68
                     /gene="IF"
                     /note="C3b/C4b inactivator signal peptide"
     mat_peptide     69..1019
                     /gene="IF"
                     /product="C3b/C4b inactivator heavy chain"
     mat_peptide     1032..1763
                     /gene="IF"
                     /product="C3b/C4b inactivator light chain"
BASE COUNT          605 a          353 c          454 g          551 t
ORIGIN      Chromosome 4.
        1 cgaacacctc caacatgaag cttcttcatg ttttcctgtt atttctgtgc ttccacttaa
       61 ggttttgcaa ggtcacttat acatctcaag aggatctggt ggagaaaaag tgcttagcaa
      121 aaaaatatac tcacctctcc tgcgataaag tcttctgcca gccatggcag agatgcattg
      181 agggcacctg tgtttgtaaa ctaccgtatc agtgcccaaa gaatggcact gcagtgtgtg
      241 caactaacag gagaagcttc ccaacatact gtcaacaaaa gagtttggaa tgtcttcatc
      301 cagggacaaa gtttttaaat aacggaacat gcacagccga aggaaagttt agtgtttcct
      361 tgaagcatgg aaatacagat tcagagggaa tagttgaagt aaaacttgtg gaccaagata
      421 agacaatgtt catatgcaaa agcagctgga gcatgaggga agccaacgtg gcctgccttg
      481 accttgggtt tcaacaaggt gctgatactc aaagaaggtt taagttgtct gatctctcta
      541 taaattccac tgaatgtcta catgtgcatt gccgaggatt agagaccagt ttggctgaat
      601 gtacttttac taagagaaga actatgggtt accaggattt cgctgatgtg gtttgttata
      661 cacagaaagc agattctcca atggatgact tctttcagtg tgtgaatggg aaatacattt
      721 ctcagatgaa agcctgtgat ggtatcaatg attgtggaga ccaaagtgat gaactgtgtt
      781 gtaaagcatg ccaaggcaaa ggcttccatt gcaaatcggg tgtttgcatt ccaagccagt
      841 atcaatgcaa tggtgaggtg gactgcatta caggggaaga tgaagttggc tgtgcaggct
      901 ttgcatctgt ggctcaagaa gaaacagaaa ttttgactgc tgacatggat gcagaaagaa
      961 gacggataaa atcattatta cctaaactat cttgtggagt taaaaacaga atgcacattc
     1021 gaaggaaacg aattgtggga ggaaagcgag cacaactggg agacctccca tggcaggtgg
     1081 caattaagga tgccagtgga atcacctgtg ggggaattta tattggtggc tgttggattc
     1141 tgactgctgc acattgtctc agagccagta aaactcatcg ttaccaaata tggacaacag
     1201 tagtagactg gatacacccc gaccttaaac gtatagtaat tgaatacgtg gatagaatta
     1261 ttttccatga aaactacaat gcaggcactt accaaaatga catcgctttg attgaaatga
     1321 aaaaagacgg aaacaaaaaa gattgtgagc tgcctcgttc catccctgcc tgtgtcccct
     1381 ggtctcctta cctattccaa cctaatgata catgcatcgt ttctggctgg ggacgagaaa
     1441 aagataacga aagagtcttt tcacttcagt ggggtgaagt taaactaata agcaactgct
     1501 ctaagtttta cggaaatcgt ttctatgaaa aagaaatgga atgtgcaggt acatatgatg
     1561 gttccatcga tgcctgtaaa ggggactctg gaggcccctt agtctgtatg gatgccaaca
     1621 atgtgactta tgtctggggt gttgtgagtt ggggggaaaa ctgtggaaaa ccagagttcc
     1681 caggttttta caccaaagtg gccaattatt ttgactggat tagctaccat gtaggaaggc
     1741 cttttatttc tcagtacaat gtataaaatt gtgatctctc tcttcattct attctttttc
     1801 tctcaagagt tccatttaat ggaaataaaa cggtataatt aataattctc taggggggaa
     1861 aaatgaagca aatctcattg gatattttta aaggtctcca cagagtttat gccatattgg
     1921 aattttgttg tataattctc aaataaatat tttggtgaag cat
//