LOCUS HM366442 5694 bp DNA linear PLN 26-JUN-2012 DEFINITION Candida glabrata strain ATCC 90030 beta-1,3-glucan synthase catalytic subunit (FKS2) gene, complete cds. ACCESSION HM366442 VERSION HM366442.1 KEYWORDS . SOURCE Nakaseomyces glabratus (Candida glabrata) ORGANISM Nakaseomyces glabratus Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Nakaseomyces. REFERENCE 1 (bases 1 to 5694) AUTHORS Niimi,K., Woods,M.A., Maki,K., Nakayama,H., Hatakenaka,K., Chibana,H., Ikeda,F., Ueno,K., Niimi,M., Cannon,R.D. and Monk,B.C. TITLE Reconstitution of high-level micafungin resistance detected in a clinical isolate of Candida glabrata identifies functional homozygosity in glucan synthase gene expression JOURNAL J. Antimicrob. Chemother. 67 (7), 1666-1676 (2012) PUBMED 22514266 REFERENCE 2 (bases 1 to 5694) AUTHORS Niimi,K. and Woods,M. TITLE Direct Submission JOURNAL Submitted (11-MAY-2010) Oral Sciences, School of Dentistry, University of Otago, 310 Great King Street, Dunedin, Otago 9054, New Zealand FEATURES Location/Qualifiers source 1..5694 /organism="Nakaseomyces glabratus" /mol_type="genomic DNA" /strain="ATCC 90030" /isolation_source="blood" /host="Homo sapiens" /culture_collection="ATCC:90030" /db_xref="taxon:5478" /country="USA" /identified_by="M. Pfaller" gene <1..>5694 /gene="FKS2" mRNA <1..>5694 /gene="FKS2" /product="beta-1,3-glucan synthase catalytic subunit" CDS 1..5694 /gene="FKS2" /codon_start=1 /product="beta-1,3-glucan synthase catalytic subunit" /protein_id="ADO14236.1" /translation="MSYDQGGNGNWQNTDPNGNYYYNGAENNEFYDQDYASQQPEQQQ GGEGYYDEYGQPNYNYMNDPQQGQMPQQQPGGYENDGYYDSYYNNQMNAGVGNGLGPD QTNFSDFSSYGPPPFQNNQANYTPSQLSYSNNGMGSNGMNMSGSSTPVYGNYDPNAIA MTLPNDPYPAWTADPQSPVSIEQIEDVFIDLTNKFGFQRDSMRNIFDLFMTLLDSRTS RMSPDQALLSVHADYIGGDTANYKKWYFAAQLDMDDEVGFRNMNLGKLSRKARKAKKK NKKAMEEANPEDAAEVLNKIEGDNSLEASDFRWKTKMNMLTPIERVRQVALYMLIWGE ANQVRFTSECLCFIYKCASDYLESPLCQQRTEPIPEGDYLNRVITPIYQFIRNQVYEI VDGRYVKREKDHNKIIGYDDVNQLFWYPEGITKIVLEDGTKLTDIPSEERYLRLGEVA WNDVFFKTYKETRTWLHLVTNFNRIWIMHVSVYWMYVAYNSPTFYTHNYQQLVNNQPV PAYRWASAALAGTVASAIQLFATVCEWWFVPRKWAGAQHLSRRFWFLCGILGVNLGPL IFVFAYEKDTVQSKAGHAVAAVTFFIAVATVLFFSIMPLGGLFTSYMQKSSRRYVASQ TFTASFAPLQGLDRWLSYLVWVTVFAAKYSESYFFLILSLRDPIRILSTTTMRCTGEY WWGSKLCRHQSKIVLGFMIATDFILFFLDTYLWYIVVNTVFSVGKSFYLGISILTPWR NIFTRLPKRIYSKILATTDMEIKYKPKVLISQIWNAIIISMYREHLLAIDHVQKLLYH QVPSEIEGKRTLRAPTFFVSQDDNNFETEFFPRNSEAERRISFFAQSLATPMPEPLPV DNMPTFTVLTPHYSERILLSLREIIREDDQFSRVTLLEYLKQLHPVEWECFVKDTKIL AEETAAYENEETQDPEKSDALKTQIDDLPFYCIGFKSAAPEYTLRTRIWASLRSQTLY RTVSGFMNYARAIKLLYRVENPEIVQMFGGNAEGLERELEKMARRKFKFLVSMQRLAK FKPHELENTEFLLRAYPDLQIAYLDEEPPLNEGEEPRIYSALIDGHCEMLENGRRRPK FRVQLSGNPILGDGKSDNQNHALIFYRGEYIQLIDANQDNYLEECLKIRSVLAEFEEL NAEPVYPYTPGVKYEDQKTNHPVAIVGAREYIFSENSGVLGDVAAGKEQTFGTLFART LAQIGGKLHYGHPDFINATFMTTRSGLSKAQKGLHLNEDIYAGMNALLRGGRIKHCEY YQCGKGRDLGFGTILNFTTKIGAGMGEQMLSREYYYLGTQLPVDRFLTFYYAHPGFHL NNLFIQLSLQMFMLTLVNLHALAHESILCIYDRNKPKTDVLYPIGCYNFSPAIDWIRR YTLSIFIVFWIAFVPIVVQELIERGLWKATQRFFRHILSLSPMFEVFAGQIYSAALLS DMTVGGARYISTGRGFATSRIPFSILYSRFASSAIYMGARSMLMLLFGTVAHWQAPLL WFWASLSALLFSPFIFNPHQFSWEDFFLDYRDYIRWLSRGNNKYHKNSWIGYVRMARS RITGFKRKLIGDDSEKAAGDANRAHRTNLILAELIPTAINAGSCFIGFTFINAQTGVK ATDDDRVNSVLRVVLCTLGPIAVDVGVLFFCLGMSCCSGPLFGMCCKKTGAVMAAVAH GVSVVIHIGFFIVMWVLEGFNFTRMLVGVATVIQCQRFIFQLMTILLLTREFKNDHAN TAFWTGKWYGSGFGYMAWTQPMRELTAKVIEMSEFAADFVLGHVILFAQFPVLCIPAI DKFHSIMLFWLKPSRHIRPPIYSLKQSRLRKRMVKRYLTLYIIIFLVFAGAIVGPAVA ASHVPQDIGHTLTGPFHNIVQPRNKSNNDTGLQISTYSNHYYTHTPSLKTWSTIK" BASE COUNT 1628 a 1097 c 1146 g 1823 t ORIGIN 1 atgtcttacg atcaaggtgg taatggcaat tggcagaaca ccgatcccaa tggtaactat 61 tactacaatg gggccgagaa caacgaattc tatgatcagg attatgcttc tcaacaacca 121 gaacaacaac aaggtggtga aggttactac gatgagtacg gacaacccaa ctataattac 181 atgaacgacc cacagcaagg tcaaatgcca caacaacaac ctggtggtta tgagaacgac 241 ggctactacg actcgtacta taacaaccag atgaacgctg gtgttggcaa tgggttggga 301 cctgaccaga ctaatttttc agattttagc agctacggac cacctccatt tcaaaataac 361 caagctaatt atacaccatc ccaactaagt tatagcaaca atgggatggg cagcaacggt 421 atgaatatgt ctggttcgtc aactccagta tacggtaact acgatccgaa cgctattgcg 481 atgacattac caaacgaccc atacccagct tggaccgctg atccacaaag tcccgtttcc 541 attgaacaaa tcgaagacgt cttcatcgat ctaaccaaca aatttggttt ccaaagagac 601 tctatgagaa acatcttcga cctgtttatg actttattgg actctagaac atccagaatg 661 tctccagacc aagcattgct atctgtccac gctgattata ttggtggtga cactgctaac 721 tacaagaaat ggtatttcgc agctcagctt gatatggatg atgaagttgg tttcagaaac 781 atgaatttgg gtaagttatc aagaaaagca aggaaagcta agaagaagaa caaaaaagca 841 atggaagagg ccaaccctga agacgctgct gaagtgctta ataaaatcga aggtgataac 901 tctcttgaag cttctgactt cagatggaag actaagatga acatgctaac tcctattgaa 961 agggttcgtc aagtggccct ttacatgtta atctggggtg aagctaacca agttagattc 1021 acttctgaat gtctatgttt catttacaaa tgtgcttctg actacctaga atcaccatta 1081 tgccaacaga gaacagagcc aatcccagaa ggtgattatc taaatagagt catcactcca 1141 atttatcaat ttatcagaaa ccaggtctat gaaattgtcg atggacgtta tgtcaaacgt 1201 gaaaaggacc ataacaagat tattggttat gatgatgtca atcaactgtt ttggtaccca 1261 gaaggtatca ctaagattgt attggaagat ggtactaaac taactgatat tccaagcgag 1321 gaacgttact taagacttgg ggaagtggct tggaacgatg tcttctttaa gacatacaag 1381 gaaacacgta cttggttaca tcttgtgacc aatttcaatc gtatttggat tatgcacgtt 1441 tccgtctact ggatgtatgt tgcttataac tctcctactt tctacactca caactatcaa 1501 caactggtaa acaatcaacc tgtccctgct tatagatggg caagtgccgc cttggctggt 1561 acagtggcta gtgcaatcca gttgtttgca actgtttgtg aatggtggtt cgttccaagg 1621 aaatgggctg gtgctcaaca tttatctcgt aggttttggt ttttatgtgg tatcctaggt 1681 gttaatcttg gtcctttaat ttttgtcttt gcttatgaaa aggacactgt tcaatcgaag 1741 gctggtcatg ctgtagcagc tgtgacattt ttcattgctg tggccactgt tttattcttc 1801 tcgattatgc cattaggtgg tcttttcacc tcatatatgc aaaaatcaag tagaagatat 1861 gttgcttctc agactttcac cgcatctttt gccccattac aaggtttgga tagatggtta 1921 tcttatttag tttgggttac agtttttgct gccaaatact ctgaatcgta cttcttcttg 1981 attttgtctc taagagaccc tatcagaatt ttatcaacta ctaccatgag atgtactggt 2041 gagtattggt ggggttcaaa gttatgtaga catcaatcga agattgtttt aggtttcatg 2101 attgctacag atttcatttt gttcttcctt gatacttatt tgtggtacat tgttgtcaac 2161 actgtcttct ctgttggtaa atccttctat ctaggtattt ccatcttaac tccttggaga 2221 aatatcttta caagattacc aaagagaatt tactcaaaga ttttggccac aactgatatg 2281 gagattaaat ataaaccaaa ggttctaatc tctcaaattt ggaatgcaat tattatttcc 2341 atgtacagag aacatttact tgctatcgac catgttcaga aactgttata ccatcaagtt 2401 ccatctgaaa ttgaaggtaa aagaactcta agagctccaa cgttctttgt atctcaggat 2461 gataacaatt ttgaaactga gtttttccca agaaactctg aagctgaacg tcgtatctca 2521 ttctttgccc aatcattggc taccccaatg ccagaaccat taccagttga caacatgcca 2581 acttttaccg tcttgactcc acactattct gaaagaatat tgctttctct aagagaaatc 2641 atcagagaag atgatcaatt ttcaagagtc actctattag aatatttgaa acaattgcat 2701 cctgttgaat gggaatgttt tgttaaggat accaagattc tggcagaaga aacagccgct 2761 tatgaaaatg aggagactca ggatccagag aaatctgacg ctttgaaaac tcaaattgat 2821 gatcttcctt tctactgtat tggtttcaag tctgctgctc cagaatacac tttacgtaca 2881 cgtatttggg catcgttgag atcccaaacc ttgtaccgta ctgtttctgg ttttatgaac 2941 tacgctagag cgattaaatt gctataccgt gtcgaaaacc cagagattgt tcaaatgttt 3001 ggtggcaatg ctgaaggtct tgagagagaa ttggagaaaa tggctagaag aaagtttaag 3061 tttttggttt caatgcaaag attggctaag tttaagccac atgaattaga aaatactgaa 3121 ttcttgttaa gagcttaccc tgatttacaa attgcttact tggatgaaga acctcctttg 3181 aacgagggag aagaaccaag aatttattct gccttgattg acggtcactg tgaaatgttg 3241 gaaaacggtc ggagacgtcc aaaattcaga gttcaattat ctggtaaccc tattcttggt 3301 gatggtaaat ctgataatca aaaccatgct ttgattttct acagaggtga atacattcaa 3361 ttaattgatg ctaaccaaga caactatttg gaagaatgtt tgaagattag atccgtttta 3421 gccgaatttg aggaattaaa tgccgaaccc gtctacccat acactcctgg tgttaaatat 3481 gaagaccaga agactaatca tccagtcgca attgttggtg ctagagaata tattttctcc 3541 gaaaactctg gtgtgcttgg tgatgtcgcc gctggtaagg aacagacttt tggtacattg 3601 tttgctcgta cattggctca aattggtggt aaactgcatt atggtcaccc ggatttcatc 3661 aatgctacgt ttatgacaac aagaagtggt ctatccaagg ctcaaaaggg tttacatttg 3721 aacgaagata tttacgccgg tatgaatgcc ctattacgtg gtggtcgtat taagcactgt 3781 gaatattatc aatgtggtaa aggtagagat ttaggttttg gtacaatttt gaatttcaca 3841 actaagattg gtgcaggtat gggtgaacaa atgttgtccc gtgagtacta ctatttaggt 3901 acacaattgc ccgtagaccg tttcttgact ttctactatg cgcatcctgg tttccatttg 3961 aataacttgt tcattcaatt gtctttgcaa atgtttatgc taactttggt caatttgcat 4021 gcgcttgccc acgaatccat tctttgtatt tacgatagaa ataagcctaa gactgatgtc 4081 ttgtatccta tcggttgtta caatttctca ccagccattg attggatcag acgttataca 4141 ttgtccattt tcattgtttt ctggattgcc tttgttccta ttgttgttca agagttgatt 4201 gaacgtggtc tatggaaggc tactcaaaga tttttccgtc acattctatc tctatcccca 4261 atgtttgaag tttttgctgg tcaaatttat tctgctgctc tattgagtga catgactgtg 4321 ggtggtgctc gttatatatc caccggtcgt ggttttgcaa catcccgtat tccattctca 4381 attttatact ccagatttgc cagctctgcc atttatatgg gggccagatc tatgctgatg 4441 ttattattcg gtacagtggc acattggcaa gctccattac tatggttctg ggcatctcta 4501 tctgctttac tgttctctcc attcatattt aatccacatc aattttcctg ggaagatttc 4561 ttcttggact acagagacta tattagatgg ttatcaagag gtaacaataa gtaccacaaa 4621 aattcttgga ttggctacgt aagaatggca agatcacgta ttacaggttt caaacgtaag 4681 ttgattggtg atgattctga aaaggctgca ggtgatgcta acagagctca tagaacaaac 4741 ttaatactag ctgaattgat tccaactgca attaatgcag gtagttgttt cattggtttt 4801 accttcatta acgctcaaac cggtgttaag gccaccgatg atgacagagt caactctgtt 4861 ctaagagttg tcttgtgtac acttggtcca atcgctgttg atgttggtgt attatttttc 4921 tgtttgggta tgtcctgttg ttctggtcca ttgtttggta tgtgctgtaa gaagacaggt 4981 gctgttatgg cggcggttgc acacggtgtc tcagttgtga ttcatattgg tttcttcatt 5041 gtaatgtggg ttctagaagg ttttaacttc actagaatgc tggttggtgt tgccacagtt 5101 atccaatgtc aaagatttat tttccaatta atgacaattt tactattgac cagagaattc 5161 aagaatgacc atgctaacac ggctttctgg acaggtaagt ggtatggttc tggctttggt 5221 tacatggctt ggactcaacc aatgagagaa ttgactgcaa aggttataga gatgtctgaa 5281 tttgcagctg attttgttct tggtcatgtc atcttatttg cccaattccc tgtgctttgt 5341 attcctgcca ttgataaatt ccactcaatc atgctgttct ggttgaaacc atctcgtcat 5401 attcgcccac caatttattc attaaagcaa tcccgtttaa gaaagagaat ggtgaagaga 5461 tacttgactc tttacatcat tattttcttg gtgtttgcag gcgccattgt tggcccagct 5521 gtcgccgcta gccatgtgcc acaggatatt ggccatacat tgactggccc attccataac 5581 attgttcaac ctagaaacaa gagtaacaat gatactggtt tgcaaatttc gacatatagt 5641 aatcattact acacacatac gccatctcta aagacctggt ccactataaa ataa //