LOCUS HM366440 5592 bp DNA linear PLN 26-JUN-2012 DEFINITION Candida glabrata strain ATCC 90030 beta-1,3-glucan synthase catalytic subunit (FKS1) gene, complete cds. ACCESSION HM366440 VERSION HM366440.1 KEYWORDS . SOURCE Nakaseomyces glabratus (Candida glabrata) ORGANISM Nakaseomyces glabratus Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Nakaseomyces. REFERENCE 1 (bases 1 to 5592) AUTHORS Niimi,K., Woods,M.A., Maki,K., Nakayama,H., Hatakenaka,K., Chibana,H., Ikeda,F., Ueno,K., Niimi,M., Cannon,R.D. and Monk,B.C. TITLE Reconstitution of high-level micafungin resistance detected in a clinical isolate of Candida glabrata identifies functional homozygosity in glucan synthase gene expression JOURNAL J. Antimicrob. Chemother. 67 (7), 1666-1676 (2012) PUBMED 22514266 REFERENCE 2 (bases 1 to 5592) AUTHORS Niimi,K., Woods,M.A., Nakayama,H. and Chibana,H. TITLE Direct Submission JOURNAL Submitted (11-MAY-2010) Oral Sciences, School of Dentistry, University of Otago, 310 Great King Street, Dunedin, Otago 9054, New Zealand FEATURES Location/Qualifiers source 1..5592 /organism="Nakaseomyces glabratus" /mol_type="genomic DNA" /strain="ATCC 90030" /isolation_source="blood" /host="Homo sapiens" /culture_collection="ATCC:90030" /db_xref="taxon:5478" /country="USA" /identified_by="M. Pfaller" gene <1..>5592 /gene="FKS1" mRNA <1..>5592 /gene="FKS1" /product="beta-1,3-glucan synthase catalytic subunit" CDS 1..5592 /gene="FKS1" /codon_start=1 /product="beta-1,3-glucan synthase catalytic subunit" /protein_id="ADO14232.1" /translation="MSYNNNGQQMSDQGYYDNNQGYYQPEDQQNGQAMYGDEGYYDPN ISGGDYYNQPPPPPNMMGQDMENFSDFSSYGPPGVQGYDYQNMNQSGQYTPSQMSYNG DPNSGSSTPIYGNGMSAYDPNAIAMALPNDPYPAWTADSQSPVPIEQIEDVFIDLTNK FGFQRDSMRNMFDHFMTLLDSRTSRMAPDQALLSLHADYIGGDTANYKKWYFAAQLDM DDEVGFRNMSLGKLSRKARKAKKKNKKAMEEANPEDAEDILNKLEGDNSLEAADFRWK TKMNALTPIERVRQIALYLLIWGEANQVRFTSECLCFIYKCATDYLNSPLCQQRTEPM PEGDYLNRVITPLYRFIRNQVYEIVDGRYVKREKDHHKVIGYDDVNQLFWYPEGIAKI VFEDSTKLIEIPAEERYLRLGEVSWDDVFFKTYKETRSWFHMITNFNRIWIMHVTIFW MYVAYNSPTFYTHNYQQLVNNQPPAAYKWASAALGGTVASFIQLLATICEWSFVPRKW AGAQHLSRRFWFLCLIFAVNLGPIIFVFAYEKDTVQSKAGHAVAAVMFFVAVATLLFF SVMPLGGLFTSYMQKSTRRYVASQTFTASFAPLHGLDRWLSYLVWVTVFAAKYAESYY FLILSLRDPIRILSTTTMRCTGEYWWGSKLCRHQSKIVLGLMIATDFILFFLDTYLWY IVVNTVFSVGKSFYLGISILTPWRNIFTRLPKRIYSKILATTDMEIKYKPKVLISQVW NAIIISMYREHLLAIDHVQKLLYHQVPSEIEGKRTLRAPTFFVSQDDNNFETEFFPRN SEAERRISFFAQSLATPMPEPLPVDNMPTFTVLTPHYAERILLSLREIIREDDQFSRV TLLEYLKQLHPVEWECFVKDTKILAEETAAYEGMDDQDPEKEDALKNQIDDLPFYCIG FKSAAPEYTLRTRIWASLRSQTLYRTVSGFMNYARAIKLLYRVENPEIVQMFGGNAEG LERELEKMARRKFKFLVSMQRLAKFKPHELENAEFLLRAYPDLQIAYLDEEPPLNEGE EPRIYSALIDGHCEILENGRRRPKFRVQLSGNPILGDGKSDNQNHALIFYRGEYIQLI DANQDNYLEECLKIRSVLAEFEELNAEQVYPYSPGVKYEDQNTNHPVAIVGAREYIFS ENSGVLGDVAAGKEQTFGTLFARTLAQIGGKLHYGHPDFINATFMTTRGGISKAQKGL HLNEDIYAGMNALLRGGRIKHCEYYQCGKGRDLGFGTILNFTTKIGAGMGEQMLSREY YYLGTQLPIDRFLTFYYAHPGFHLNNLFIQLSLQMFMLTLVNLHALAHESIICIYDKN KPKTDVLYPIGCYNFSPAIDWVRRYTLSIFIVFWIAFVPIVVQELIERGLWKATQRFF RHILSLSPMFEVFAGQIYSSALLSDLTVGGARYISTGRGFATSRIPFSILYSRFAGSA IYMGARSMLMLLFGTVAHWQAPLLWFWASLSALLFSPFIFNPHQFSWEDFFLDYRDYI RWLSRGNSKYHRNSWIGYVRMARSRITGFKRKLVGDESEKAAGDASRAHRTNLILAEI IPNAIYAAGCFVGFTFINAQTGVKTTDDDRVNSVLRIIICTLAPIVIDIGVLFFVLGM SCCSGPLFGMCCKRTGSVMAGFAHGIAVIVHIGFFIVMWVLEGFNFTRMLLGVVTMIQ CQRLIFQCMTVLMLTREFKNDHANTAFWTGKWYGSGFGYMAWTQPTRELTAKVIELSE FAADFVLGHVILFAQFPVLCIPAIDKFHSIMLFWLKPSRQIRPPIYSLKQSRLRKRMV KRYLTLYIIVFLVFAGCIVGPAVASSHVAKDLGHQLTGTFHNLVQPRNVSNNDTGFGI STYSNHYYTHTPSLKTWSTIK" BASE COUNT 1523 a 1179 c 1129 g 1761 t ORIGIN 1 atgtcttaca ataataacgg acaacaaatg tccgatcagg gctactatga taataaccaa 61 ggttattacc aaccggaaga ccaacagaat ggtcaagcca tgtacggtga cgaaggttac 121 tacgacccaa acatcagcgg tggtgactac tacaaccaac caccaccacc tccaaacatg 181 atgggccaag acatggagaa cttctctgat ttcagcagtt acggccctcc tggtgtgcaa 241 ggttacgact atcagaacat gaaccaatct ggtcaataca cgccatctca aatgagttac 301 aacggcgatc caaactctgg atcctcaact cctatatacg gtaatggcat gtctgcttac 361 gatcctaatg ccatcgctat ggcgttgcct aacgatccat acccagcatg gaccgcagac 421 agccaatcac cagtgccaat cgaacagatc gaggatgtct tcattgacct aacgaacaaa 481 ttcggtttcc aaagagactc catgagaaac atgttcgacc acttcatgac tcttctagat 541 tctagaactt ctagaatggc tccagaccaa gctttgctgt ctttgcacgc cgattatatc 601 ggtggtgata cagccaacta caagaaatgg tacttcgccg cccaactaga tatggatgat 661 gaagtcggtt tcagaaacat gagcttgggt aaactatcca gaaaggccag aaaggccaag 721 aagaagaata agaaggccat ggaggaggcc aatccagagg atgctgaaga cattctaaat 781 aaactggaag gtgacaactc tttagaagcc gctgatttca gatggaagac taagatgaat 841 gccttaactc caatcgaaag agttcgtcaa atcgctctat accttttgat ctggggtgaa 901 gctaaccaag tcagattcac ctcggagtgt ctgtgtttca tttacaagtg cgccactgac 961 tacttgaact ctcctctatg ccaacagaga accgagccaa tgccagaagg tgactacttg 1021 aacagagtta tcactccact ttaccgtttc atcagaaacc aagtctacga aattgtcgac 1081 ggtcgttacg ttaagcgtga aaaggaccac cacaaggtca ttggttatga tgatgttaac 1141 cagctattct ggtatccaga aggtatcgct aagattgtct tcgaagacag cactaagttg 1201 atcgagattc cagctgaaga acgttacttg agattaggtg aggttagctg ggatgacgtt 1261 ttcttcaaga cttacaaaga aacccgttct tggttccaca tgatcacaaa ctttaaccgt 1321 atttggatca tgcacgttac cattttctgg atgtacgttg cctacaactc tccaactttc 1381 tacacacata actatcaaca attggtcaac aatcaaccac cagctgccta caaatgggct 1441 agtgctgctc ttggtggtac tgttgccagt ttcatccaac ttctagctac aatctgtgaa 1501 tggtcttttg ttccaagaaa atgggcaggt gctcaacatc tttcccgtag attttggttc 1561 ttatgtttga tttttgcagt taacttgggt ccaattattt ttgtcttcgc ttatgaaaag 1621 gacactgttc aatcaaaggc aggccacgcg gttgctgcgg tcatgttctt tgttgcagtc 1681 gctacattgc tatttttctc agtcatgcca ttgggtggtc tgttcacgtc ctacatgcaa 1741 aagtctacca gacgttacgt cgcttctcaa accttcactg cctcctttgc acctttgcat 1801 ggtcttgaca gatggttgtc ttacctggtt tgggttactg tttttgctgc taagtacgct 1861 gaatcatact acttcttgat tctatctcta agagatccaa tcagaatttt gtctaccact 1921 accatgagat gtactggtga atactggtgg ggttcaaagc tatgtagaca tcaatcaaag 1981 attgttttgg gtttgatgat tgctaccgat tttattctgt tcttcttgga tacctatctg 2041 tggtacattg ttgtcaacac tgtcttttcc gttggtaaat ctttctactt gggtatttct 2101 attttgactc catggagaaa cattttcact agattgccaa agagaattta ctccaagatt 2161 ttggctacta ctgatatgga aatcaaatac aagccaaagg ttttaatttc ccaagtctgg 2221 aacgctatca ttatctcaat gtacagagaa catttgcttg ccattgacca tgtccaaaag 2281 ttattatacc atcaagttcc atctgaaatt gaaggtaaga gaactttgag agccccaact 2341 ttctttgttt ctcaggatga taacaacttt gaaactgagt ttttcccaag aaactctgaa 2401 gctgaacgtc gtatttcttt ctttgcccaa tccttggcca ccccaatgcc agaaccattg 2461 ccagttgaca acatgccaac ttttaccgtt ttgactcctc actatgctga aagaattttg 2521 ttgtctttga gagaaattat cagagaggat gaccaattct ccagagttac tctattggaa 2581 tacttgaagc aattacaccc agttgaatgg gaatgttttg ttaaggacac caaaatcttg 2641 gccgaagaga ctgctgctta tgaaggtatg gatgatcaag atcctgagaa ggaagatgca 2701 ttgaagaacc aaattgatga tcttccattc tactgtattg gtttcaagtc tgctgctcct 2761 gaatatactc tacgtacacg tatttgggct tctttgagat ctcaaacttt gtaccgtact 2821 gtttctggtt ttatgaacta tgctagagct atcaaattgc tataccgtgt cgaaaaccct 2881 gaaattgttc aaatgtttgg tggtaatgcc gaaggtcttg aaagggaatt ggaaaaaatg 2941 gctagaagaa agtttaagtt cttggtttct atgcaaagat tggctaagtt taaaccacat 3001 gaactggaaa acgctgaatt cttgttgaga gcttaccctg atctacaaat tgcttacttg 3061 gatgaagaac ctccactaaa cgaaggtgaa gaaccaagaa tttactcagc cttgattgac 3121 ggtcactgtg aaatcttgga gaatggtcgt agacgtccta agttcagagt ccaactgtct 3181 ggtaacccta ttcttggtga tggtaaatct gataaccaga accatgcttt gattttctac 3241 agaggtgaat atatccaatt gatcgatgct aaccaagaca actatttgga agaatgtttg 3301 aagattagat ctgttcttgc tgaatttgaa gaattgaatg ctgaacaagt gtacccatac 3361 tctccaggtg taaaatacga agatcaaaac acaaatcacc cagttgctat tgttggtgcc 3421 agagaatata ttttctctga aaactctggt gttcttggtg atgttgccgc tggtaaagaa 3481 caaacatttg gtactctttt tgctcgtaca ttggctcaaa ttggtggtaa actgcattat 3541 ggtcacccgg atttcatcaa cgctactttc atgactacca gaggtggtat ttcaaaggct 3601 caaaagggtt tgcatttgaa cgaagatatt tacgccggta tgaatgccct attacgtggt 3661 ggtcgtatta agcactgtga atactatcaa tgtggtaaag gtagagattt aggttttggt 3721 acaattttga atttcacaac taagattggt gctggtatgg gtgaacaaat gttgtcccgt 3781 gaatactact atctaggtac acaacttcca attgaccgtt tcttgacttt ctactatgcg 3841 caccctggtt tccatttgaa taacttgttc attcaattgt ctcttcaaat gtttatgttg 3901 actttggtta atttacacgc tcttgcacac gaatctatta tttgtattta cgataagaac 3961 aagccaaaga cagatgtatt gtatccaatt ggttgttaca acttctctcc agctattgac 4021 tgggtcagac gttacacatt atctattttc attgttttct ggattgcctt tgttcctatt 4081 gttgtgcaag aattgattga acgtggtctg tggaaggcta cccaaagatt cttccgtcac 4141 attctttccc tatccccaat gtttgaagtg tttgctggtc aaatctactc atctgctttg 4201 ttgagcgatt tgactgttgg tggtgctcgt tatatttcta ctggtagagg ttttgcaacc 4261 tcacgtatcc cattctccat tttgtactcc agatttgcag gctctgccat ttacatgggt 4321 gctagatcaa tgctaatgtt gcttttcggt accgttgccc actggcaagc tcctctccta 4381 tggttctggg cctcactgtc cgccctgctg ttctctccat ttattttcaa cccacatcaa 4441 ttctcctggg aagacttctt cttggattac agagactaca ttagatggtt atctagaggt 4501 aatagtaaat accacagaaa ctcctggatt ggttacgtta gaatggctag atctcgtatt 4561 accggtttca aacgtaagtt ggttggtgat gaatctgaaa aggctgcagg tgatgcaagc 4621 agagctcaca gaaccaactt gattctagcc gagattattc caaatgctat ttacgctgca 4681 ggttgttttg ttggtttcac tttcattaac gcccaaacag gtgttaagac tactgatgac 4741 gatagagtga actctgttct acgtattatc atctgtactt tggctccaat tgtcattgat 4801 attggtgttc tgttcttcgt tttgggtatg tcttgttgtt ctggtccatt gttcggtatg 4861 tgctgtaaga gaactggttc agttatggct ggttttgctc acggtattgc cgtcattgtt 4921 cacattggtt tcttcatcgt catgtgggtt cttgaaggtt tcaacttcac tagaatgttg 4981 cttggtgttg ttactatgat tcaatgtcaa agattgatct tccaatgtat gactgtcttg 5041 atgttgacta gagaattcaa gaatgaccat gcaaacactg ccttctggac aggtaaatgg 5101 tacggttccg gttttggtta catggcttgg actcaaccaa caagagaatt aactgctaag 5161 gtcatcgaac tttctgaatt tgctgctgat ttcgttctag gtcatgttat tctatttgcc 5221 caattcccag ttctatgtat tccagccatt gacaagttcc actccatcat gttattctgg 5281 ttaaagccat cgcgtcaaat ccgtccacca atttattctt tgaaacaatc tcgtctaaga 5341 aagagaatgg tcaagagata cctaaccctt tacattatcg ttttcctagt atttgctggt 5401 tgcatcgtag gcccagcagt tgcttcttcc catgttgcta aggacttggg tcaccaatta 5461 actggtactt tccacaattt ggtgcaacca agaaatgtaa gcaacaacga tactggtttt 5521 ggtatttcca catacagtaa ccattactac acgcatactc catctctaaa gacctggtct 5581 acaatcaaat aa //