LOCUS EU852583 3843 bp mRNA linear HUM 05-AUG-2008
DEFINITION Homo sapiens multidrug resistance protein 1 mRNA, complete cds,
alternatively spliced.
ACCESSION EU852583
VERSION EU852583.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3843)
AUTHORS Jiang,Y., Sun,Q., Xie,Z., Liu,F., Xu,W. and Wang,Y.
TITLE Cloning of P-glycoprotein cDNA sequence from breast cancer MCF7
cell line
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 3843)
AUTHORS Jiang,Y., Sun,Q., Xie,Z., Liu,F., Xu,W. and Wang,Y.
TITLE Direct Submission
JOURNAL Submitted (26-JUN-2008) The Key Laboratory of Chemical Biology,
Graduate School at Shenzhen, Tsinghua University, University Town,
Xili, Nanshan, Shenzhen, Guangdong 518055, China
FEATURES Location/Qualifiers
source 1..3843
/db_xref="H-InvDB:HIT000558224"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="MCF7/ADR"
/PCR_primers="fwd_seq: tcttcttccaagatttcacgtc, rev_seq:
cagagttcactggcgctttg"
CDS 1..3843
/note="MDR1; P-glycoprotein; alternatively spliced"
/codon_start=1
/product="multidrug resistance protein 1"
/protein_id="ACF94687.1"
/translation="MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSN
WLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTG
FFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEI
GWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVI
LAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELER
YNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTV
FFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNL
EFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGM
VSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEAN
AYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESE
AVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFK
LVTMQTAGNEVELENAADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKL
STKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFT
RIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLR
QDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQ
LTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQ
KFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFE
DVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNT
LEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYD
PLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIV
RAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATS
ALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLA
QKGIYFSMVSVQAGTKRQ"
BASE COUNT 1130 a 740 c 955 g 1018 t
ORIGIN
1 atggatcttg aaggggaccg caatggagga gcaaagaaga agaacttttt taaactgaac
61 aataaaagtg aaaaagataa gaaggaaaag aaaccaactg tcagtgtatt ttcaatgttt
121 cgctattcaa attggcttga caagttgtat atggtggtgg gaactttggc tgccatcatc
181 catggggctg gacttcctct catgatgctg gtgtttggag aaatgacaga tatctttgca
241 aatgcaggaa atttagaaga tctgatgtca aacatcacta atagaagtga tatcaatgat
301 acagggttct tcatgaatct ggaggaagac atgaccaggt atgcctatta ttacagtgga
361 attggtgctg gggtgctggt tgctgcttac attcaggttt cattttggtg cctggcagct
421 ggaagacaaa tacacaaaat tagaaaacag ttttttcatg ctataatgcg acaggagata
481 ggctggtttg atgtgcacga tgttggggag cttaacaccc gacttacaga tgatgtctcc
541 aagattaatg aaggaattgg tgacaaaatt ggaatgttct ttcagtcaat ggcaacattt
601 ttcactgggt ttatagtagg atttacacgt ggttggaagc taacccttgt gattttggcc
661 atcagtcctg ttcttggact gtcagctgct gtctgggcaa agatactatc ttcatttact
721 gataaagaac tcttagcgta tgcaaaagct ggagcagtag ctgaagaggt cttggcagca
781 attagaactg tgattgcatt tggaggacaa aagaaagaac ttgaaaggta caacaaaaat
841 ttagaagaag ctaaaagaat tgggataaag aaagctatta cagccaatat ttctataggt
901 gctgctttcc tgctgatcta tgcatcttat gctctggcct tctggtatgg gaccaccttg
961 gtcctctcag gggaatattc tattggacaa gtactcactg tattcttttc tgtattaatt
1021 ggggctttta gtgttggaca ggcatctcca agcattgaag catttgcaaa tgcaagagga
1081 gcagcttatg aaatcttcaa gataattgat aataagccaa gtattgacag ctattcgaag
1141 agtgggcaca aaccagataa tattaaggga aatttggaat tcagaaatgt tcacttcagt
1201 tacccatctc gaaaagaagt taagatcttg aagggtctga acctgaaggt gcagagtggg
1261 cagacggtgg ccctggttgg aaacagtggc tgtgggaaga gcacaacagt ccagctgatg
1321 cagaggctct atgaccccac agaggggatg gtcagtgttg atggacagga tattaggacc
1381 ataaatgtaa ggtttctacg ggaaatcatt ggtgtggtga gtcaggaacc tgtattgttt
1441 gccaccacga tagctgaaaa cattcgctat ggccgtgaaa atgtcaccat ggatgagatt
1501 gagaaagctg tcaaggaagc caatgcctat gactttatca tgaaactgcc tcataaattt
1561 gacaccctgg ttggagagag aggggcccag ttgagtggtg ggcagaagca gaggatcgcc
1621 attgcacgtg ccctggttcg caaccccaag atcctcctgc tggatgaggc cacgtcagcc
1681 ttggacacag aaagcgaagc agtggttcag gtggctctgg ataaggccag aaaaggtcgg
1741 accaccattg tgatagctca tcgtttgtct acagttcgta atgctgacgt catcgctggt
1801 ttcgatgatg gagtcattgt ggagaaagga aatcatgatg aactcatgaa agagaaaggc
1861 atttacttca aacttgtcac aatgcagaca gcaggaaatg aagttgaatt agaaaatgca
1921 gctgatgaat ccaaaagtga aattgatgcc ttggaaatgt cttcaaatga ttcaagatcc
1981 agtctaataa gaaaaagatc aactcgtagg agtgtccgtg gatcacaagc ccaagacaga
2041 aagcttagta ccaaagaggc tctggatgaa agtatacctc cagtttcctt ttggaggatt
2101 atgaagctaa atttaactga atggccttat tttgttgttg gtgtattttg tgccattata
2161 aatggaggcc tgcaaccagc atttgcaata atattttcaa agattatagg cgtttttaca
2221 agaattgatg atcctgaaac aaaacgacag aatagtaact tgttttcact attgtttcta
2281 gcccttggaa ttatttcttt tattacattt ttccttcagg gtttcacatt tggcaaagct
2341 ggagagatcc tcaccaagcg gctccgatac atggttttcc gatccatgct cagacaggat
2401 gtgagttggt ttgatgaccc taaaaacacc actggagcat tgactaccag gctcgccaat
2461 gatgctgctc aagttaaagg ggctataggt tccaggcttg ctgtaattac ccagaatata
2521 gcaaatcttg ggacaggaat aattatatcc ttcatctatg gttggcaact aacactgtta
2581 ctcttagcaa ttgtacccat cattgcaata gcaggagttg ttgaaatgaa aatgttgtct
2641 ggacaagcac tgaaagataa gaaagaacta gaaggttctg ggaagatcgc tactgaagca
2701 atagaaaact tccgaaccgt tgtttctttg actcaggagc agaagtttga acatatgtat
2761 gctcagagtt tgcaggtacc atacagaaac tctttgagga aagcacacat ctttggaatt
2821 acattttcct tcacccaggc aatgatgtat ttttcctatg ctggatgttt ccggtttgga
2881 gcctacttgg tggcacataa actcatgagc tttgaggatg ttctgttagt attttcagct
2941 gttgtctttg gtgccatggc cgtggggcaa gtcagttcat ttgctcctga ctatgccaaa
3001 gccaaaatat cagcagccca catcatcatg atcattgaaa aaaccccttt gattgacagc
3061 tacagcacgg aaggcctaat gccgaacaca ttggaaggaa atgtcacatt tggtgaagtt
3121 gtattcaact atcccacccg accggacatc ccagtgcttc agggactgag cctggaggtg
3181 aagaagggcc agacgctggc tctggtgggc agcagtggct gtgggaagag cacagtggtc
3241 cagctcctgg agcggttcta cgaccccttg gcagggaaag tgctgcttga tggcaaagaa
3301 ataaagcgac tgaatgttca gtggctccga gcacacctgg gcatcgtgtc ccaggagccc
3361 atcctgtttg actgcagcat tgctgagaac attgcctatg gagacaacag ccgggtggtg
3421 tcacaggaag agattgtgag ggcagcaaag gaggccaaca tacatgcctt catcgagtca
3481 ctgcctaata aatatagcac taaagtagga gacaaaggaa ctcagctctc tggtggccag
3541 aaacaacgca ttgccatagc tcgtgccctt gttagacagc ctcatatttt gcttttggat
3601 gaagccacgt cagctctgga tacagaaagt gaaaaggttg tccaagaagc cctggacaaa
3661 gccagagaag gccgcacctg cattgtgatt gctcaccgcc tgtccaccat ccagaatgca
3721 gacttaatag tggtgtttca gaatggcaga gtcaaggagc atggcacgca tcagcagctg
3781 ctggcacaga aaggcatcta tttttcaatg gtcagtgtcc aggctggaac aaagcgccag
3841 tga
//