LOCUS HUMAPX 1420 bp mRNA linear HUM 18-DEC-2002
DEFINITION Homo sapiens mRNA for apurinic/apyrimidinic endonuclease, complete
cds.
ACCESSION D90373
VERSION D90373.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1420)
AUTHORS Seki,S.
TITLE Direct Submission
JOURNAL Submitted (03-APR-1991) to the DDBJ/EMBL/GenBank databases.
Contact:Shuji Seki
Okayama University Medical School, Department of Biochemistry,
Cancer Institute; 2-5-1 Shikata-cho, Okayama, Okayama 700, Japan
REFERENCE 2
AUTHORS Seki,S., Hatsushika,M., Watanabe,S., Akiyama,K., Nagao,K. and
Tsutsui,K.
TITLE cDNA cloning, sequencing, expression and possible domain structure
of human APEX nuclease homologous to Escherichia coli exonuclease
III
JOURNAL Biochim. Biophys. Acta 1131, 287-299 (1992)
COMMENT
FEATURES Location/Qualifiers
source 1..1420
/clone="I1h"
/db_xref="H-InvDB:HIT000102086"
/db_xref="taxon:9606"
/dev_stage="adult"
/mol_type="mRNA"
/organism="Homo sapiens"
/sex="male"
/tissue_type="bone marrow"
CDS 206..1162
/codon_start=1
/note="APEX nuclease precursor, APX"
/product="apurinic/apyrimidinic endonuclease"
/protein_id="BAA14381.1"
/translation="MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPAL
YEDPPDHKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSEN
KLPAELQELPGLSHQYWSAPSDKEGYSGVGLLSRQCPLKVSYGIGDEEHDQEGRVIVA
EFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEI
DLRNPKGNKKNAGFTPQERQGFGELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSK
NVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL"
regulatory 212..226
/note="nuclear location signal"
/regulatory_class="other"
regulatory 275..286
/note="nuclear location signal"
/regulatory_class="other"
regulatory 1402..1407
/regulatory_class="polyA_signal_sequence"
BASE COUNT 379 a 343 c 366 g 332 t
ORIGIN
1 tgccatcggg ccggtgcaga tacggggttg ctcttttgct cataagaggg gcttcgctgg
61 cagtctgaac ggcaagcttg agtcaggacc cttaattaag atcctcaatt ggctggaggg
121 cagatctcgc gagtagggca acgcggtaaa aatattgctt cggtgggtga cgcggtacag
181 ctgcccaagg gcgttcgtaa cgggaatgcc gaagcgtggg aaaaagggag cggtggcgga
241 agacggggat gagctcagga cagagccaga ggccaagaag agtaagacgg ccgcaaagaa
301 aaatgacaaa gaggcagcag gagagggccc agccctgtat gaggaccccc cagatcacaa
361 aacctcaccc agtggcaaac ctgccacact caagatctgc tcttggaatg tggatgggct
421 tcgagcctgg attaagaaga aaggattaga ttgggtaaag gaagaagccc cagatatact
481 gtgccttcaa gagaccaaat gttcagagaa caaactacca gctgaacttc aggagctgcc
541 tggactctct catcaatact ggtcagctcc ttcggacaag gaagggtaca gtggcgtggg
601 cctgctttcc cgccagtgcc cactcaaagt ttcttacggc ataggcgatg aggagcatga
661 tcaggaaggc cgggtgattg tggctgaatt tgactcgttt gtgctggtaa cagcatatgt
721 acctaatgca ggccgaggtc tggtacgact ggagtaccgg cagcgctggg atgaagcctt
781 tcgcaagttc ctgaagggcc tggcttcccg aaagcccctt gtgctgtgtg gagacctcaa
841 tgtggcacat gaagaaattg accttcgcaa ccccaagggg aacaaaaaga atgctggctt
901 cacgccacaa gagcgccaag gcttcgggga attactgcag gctgtgccac tggctgacag
961 ctttaggcac ctctacccca acacacccta tgcctacacc ttttggactt atatgatgaa
1021 tgctcgatcc aagaatgttg gttggcgcct tgattacttt ttgttgtccc actctctgtt
1081 acctgcattg tgtgacagca agatccgttc caaggccctc ggcagtgatc actgtcctat
1141 caccctatac ctagcactgt gacaccaccc ctaaatcact ttgagcctgg gaaataagcc
1201 ccctcaacta ccattccttc tttaaacact cttcagagaa atctgcattc tatttctcat
1261 gtataaaact aggaatcctc caaccaggct cctgtgatag agttctttta agcccaagat
1321 tttttatttg agggtttttt gttttttaaa aaaaaattga acaaagacta ctaatgactt
1381 tgtttgaatt atccacatga aaataaagag ccatagtttc
//