LOCUS       HUMKIP2                 3158 bp    DNA     linear   HUM 09-FEB-2005
DEFINITION  Homo sapiens KIP2 gene for Cdk-inhibitor p57KIP2, complete cds
            (exon1-4).
ACCESSION   D64137
VERSION     D64137.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3158)
  AUTHORS   Nakamura,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-SEP-1995) to the DDBJ/EMBL/GenBank databases.
            Contact:Yusuke Nakamura
            Institute of Medical Science, The University of Tokyo, Laboratory
            of Molecular Medicine, Human Genome Center; 4-6-1 Shirokanedai,
            Minato-ku, Tokyo 108-8639, Japan
REFERENCE   2
  AUTHORS   Tokino,T., Urano,T., Furuhata,T., Matsushima,M., Miyatsu,T.,
            Sasaki,S. and Nakamura,Y.
  TITLE     Characterization of the human p57KIP2 gene: alternative splicing,
            Insertion/deletion polymorphisms in VNTR sequences in the coding
            region, and mutational analysis
  JOURNAL   Hum. Genet. 97, 625-631 (1996)
REFERENCE   3
  AUTHORS   Furuhata,T., Tokino,T., Urano,T. and Nakamura,Y.
  TITLE     Isolation of a novel GPI-anchored gene specifically regulated by
            p53; correlation between its expression and anti-cancer drug
            sensitivity
  JOURNAL   Oncogene 13, 1965-1970 (1996)
COMMENT     
FEATURES             Location/Qualifiers
     source          1..3158
                     /chromosome="11"
                     /db_xref="taxon:9606"
                     /map="11p15.5"
                     /mol_type="genomic DNA"
                     /organism="Homo sapiens"
     CAAT_signal     826..832
     TATA_signal     913..918
     mRNA            join(984..1084,1219..2047,2614..2749,2833..3114)
                     /note="alternative splicing type A2"
     mRNA            join(984..1084,1251..2047,2614..2749,2833..3114)
     mRNA            join(984..2047,2614..2749,2833..3114)
                     /note="alternative splicing type A1"
     exon            984..2047
                     /note="alternative splicing type A1 exon1"
                     /number=1
     exon            984..1084
                     /number=1
     exon            1219..2047
                     /note="alternative splicing type A2 exon2"
                     /number=2
     CDS             join(1228..2047,2614..2744)
                     /codon_start=1
                     /gene="KIP2"
                     /note="alternative splicing product"
                     /product="p57KIP2"
                     /protein_id="BAA11014.1"
                     /translation="MSDASLRSTSTMERLVARGTFPVLVRTSACRSLFGPVDHEELSR
                     ELQARLAELNAEDQNRWDYDFQQDMPLRGPGRLQWTEVDSDSVPAFYRETVQVGRCRL
                     LLAPRPVAVAVAVSPPLEPAAESLDGLEEAPEQLPSVPVPAPASTPPPVPVLAPAPAP
                     APAPVAAPVAAPVAVAVLAPAPAPAPAPAPAPAPVAAPAPAPAPAPAPAPAPAPAPDA
                     APQESAEQGANQGQRGQEPLADQLHSGISGRPAAGTAAASANGAAIKKLSGPLISDFF
                     AKRKRSAPEKSSGDVPAPCPSPSAAPGVGSVEQTPRKRLR"
     exon            1251..2047
                     /number=2
     CDS             join(1261..2047,2614..2744)
                     /codon_start=1
                     /function="Cdk-inhibitor"
                     /gene="KIP2"
                     /product="p57KIP2"
                     /protein_id="BAA11015.1"
                     /translation="MERLVARGTFPVLVRTSACRSLFGPVDHEELSRELQARLAELNA
                     EDQNRWDYDFQQDMPLRGPGRLQWTEVDSDSVPAFYRETVQVGRCRLLLAPRPVAVAV
                     AVSPPLEPAAESLDGLEEAPEQLPSVPVPAPASTPPPVPVLAPAPAPAPAPVAAPVAA
                     PVAVAVLAPAPAPAPAPAPAPAPVAAPAPAPAPAPAPAPAPAPAPDAAPQESAEQGAN
                     QGQRGQEPLADQLHSGISGRPAAGTAAASANGAAIKKLSGPLISDFFAKRKRSAPEKS
                     SGDVPAPCPSPSAAPGVGSVEQTPRKRLR"
     exon            2614..2749
                     /number=3
     exon            2833..3114
                     /number=4
BASE COUNT          442 a         1172 c         1113 g          431 t
ORIGIN      
        1 gatccctcga tcccggggct ggagtggtct ggcccaaggc tgagaagggc tgggaccccc
       61 gacagtgaca tgatgggctc agcccctgtt ccatctactg ggcagggtgg gcctccgcag
      121 atagcggctt cagactccag ctccaggggg ctggcgggag tctctcaagg tgtcccacac
      181 atggtccctc ggggaaagag tggagctgac ccctgtcccc cctcccgact cgagggcctt
      241 agggccagca ggtgtgtgag ggctccaggc gcgcggagcc ctcgaaggga caccagccca
      301 gcagcagcag gccgcggccc gggggcagcc gaagacccca tccggcgcag gccaggcccg
      361 agctggcagc ggcgggtcca agcctcgtca gctggcgcag gaggcccacg ggcgagcgcg
      421 ggacggagct gggcgccggg gtccggaccg ggccggggtc gagttgggcc tggccggaca
      481 ccggacccgc caggagccgg cccctgccgc gctgggctga ggcccccgcc tgcagacaaa
      541 ggagccggcg gggggcggga gccggggggg tggggagtgt tgcagggggg atggggcgag
      601 ggggcggggc gtcgcggtgt cacgttaccg cccgcagcgc cctttaactc ccgcccccgc
      661 cccgctcacc gcccccttcc cctgctacag cgcgctcgcc ccgcggccgc caatcagccg
      721 cgcgcgccgg ccgcgcgccc cgccccgccc ccggtgggtg tgcgcgcggc caatgggcgg
      781 tgcgcggggg ccgggccgcg gcggggcggg gcagcggggc ggccgccaat cgccgtggtg
      841 ttgttgaaac tgaaaatact acattatgct aatcgcggcc gggcccgcgc gcacgggggt
      901 ggggcccgcg cgtataaagg gggcgcaggc gggctgggcg ttccacaggc caagtgcgct
      961 gtgctcgagg ggtgccggcc aggcctgagc gagcgagcta gccagcaggc atcgaggggg
     1021 cgcggctgcc gtccggacga gacaggcgaa cccgacgcag aagagtccac caccggacag
     1081 ccaggtagcc gccgcgtccc tcgcacacgc agagtcgggc ggcgcggggt ctcccttgcg
     1141 cccggcctcc gccctctcct cctctccttt ccccttcttc tcgctgtcct ctcctctctc
     1201 gtgcccgcgt ttgcgcagcc ccgggccatg tccgacgcgt ccctccgcag cacatccacg
     1261 atggagcgtc ttgtcgcccg tgggaccttc ccagtactag tgcgcaccag cgcctgccgc
     1321 agcctcttcg ggccggtgga ccacgaggag ctgagccgcg agctgcaggc ccgcctggcc
     1381 gagctgaacg ccgaggacca gaaccgctgg gattacgact tccagcagga catgccgctg
     1441 cggggccctg gacgcctgca gtggaccgaa gtggacagcg actcggtgcc cgcgttctac
     1501 cgcgagacgg tgcaggtggg gcgctgccgc ctgctgctgg cgccgcggcc cgtcgcggtc
     1561 gcggtggctg tcagcccgcc cctcgagccg gccgctgagt ccctcgacgg cctcgaggag
     1621 gcgccggagc agctgcctag tgtcccggtc ccggccccgg cgtccacccc gcccccagtc
     1681 ccggtcctgg ctccagcccc ggccccggct ccggctccgg tcgcggctcc ggtcgcggct
     1741 ccggtcgcgg tcgcggtcct ggccccggcc ccggccccgg ctccggctcc ggctccggcc
     1801 ccggctccag tcgcggcccc ggccccagcc ccggccccgg ccccggcccc ggcccccgcc
     1861 ccggccccgg ccccggacgc ggcgcctcaa gagagcgccg agcagggcgc gaaccagggg
     1921 cagcgcggcc aggagcctct cgctgaccag ctgcactcgg ggatttcggg acgtcccgcg
     1981 gccggcaccg cggccgccag cgccaacggc gcggcgatca agaagctgtc cgggcctctg
     2041 atctccggtg agccccgcac ggccccgccc cggcccgggc cggccccgct ttgtccggcc
     2101 ggccggtccc cccagccctc gggggcctcg ctgggttccc gcctcctccc gtggcattaa
     2161 agggcccgca gcgctcaggg cgcggctgcg cttacccccc tccccgcccc gttgttgtgc
     2221 cctccagcgg cttcgcggcc ccgttcttct cgggtggagc ggcttcgcgc gggccggggt
     2281 gggaggctga atcccggccg cgaccccccg ggagcgcagt tttcgccccc ggccgcggga
     2341 gcccctcccc gggcgcgccc gcgccccgtg agcacggcgt ggagggggtt aagcgcggcg
     2401 gcggccccgg ggggcttggc cgcgggacaa ggggaaatgc ttacacagca cattgcgcgg
     2461 cgacgtaaac aaagctgacc cgccgcggac ctcggcgcgg gcggggacgg cgcccccacc
     2521 ccggccggcc cgcgccccgc gccctctccc ggccccctct cgggtctccg ggccggcccc
     2581 cgccctgacc ggccgcgcgc ctgtcgcccg cagatttctt cgccaagcgc aagagatcag
     2641 cgcctgagaa gtcgtcgggc gatgtccccg cgccgtgtcc ctctccaagc gccgcccctg
     2701 gcgtgggctc ggtggagcag accccgcgca agaggctgcg gtgagccaag tgagtacagc
     2761 gcacctgggg gggcgcggag ggccgacccg ccgggtcccc gccggctttg ctgaccgccc
     2821 ctctcctcgc agtttagagc ccaaagagcc ccgagggaac ctgccggggc agcggacgtt
     2881 ggaagggcgc tgggcctcgg ctgggaccgt tcatgtagca gcaaccggcg gcggctgccg
     2941 cagagcagcg ttcggttttg tttttaaatt ttgaaaactg tgcaatgtat taataacgtc
     3001 tttttatatc taaatgtatt ctgcacgaga aggtacactg gtcccaaggt gtaaagcttt
     3061 aagagtcatt tatataaaat gtttaatctc tgctgaaact cagtgcaaaa aaaagaaaaa
     3121 gaaaaaaaaa aggaaaaaat aaaaaaacca tgtacaaa
//