LOCUS       D50017                 17087 bp    DNA     linear   HUM 30-OCT-2007
DEFINITION  Homo sapiens PDGFRA gene for alpha-platelet-derived growth factor
            receptor, complete cds.
ACCESSION   D50017 D50001-D50016
VERSION     D50017.2
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 17087)
  AUTHORS   Kawagishi,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-APR-1995) to the DDBJ/EMBL/GenBank databases.
            Contact:Jun Kawagishi
            Tohoku University, Gene Research Center; 1-1
            Tsutsumidouri-Amamiyamachi, Aobaku, Sendai, Miyagi 981, Japan
REFERENCE   2
  AUTHORS   Kawagishi,J.
  TITLE     Homo sapiens DNA for alpha-platelet-derived growth factor receptor
  JOURNAL   Unpublished (1996)
REFERENCE   3
  AUTHORS   Kawagishi,J. and Ku,T.
  TITLE     Structure, organization, and transcription units of the human
            alpha-platelet-derived growth factor receptor gene, PDGFRA
  JOURNAL   Genomics 30, 224-232 (1995)
REFERENCE   4
  AUTHORS   Kumabe,T., Sohma,Y., Kayama,T., Yoshimoto,T. and Yamamoto,T.
  TITLE     Amplification of alpha-platelet-derived growth factor receptor
            gene lacking an exon coding for a portion of the extracellular
            region in a primary brain tumor of glial origin
  JOURNAL   Oncogene 7, 627-633 (1992)
COMMENT     
FEATURES             Location/Qualifiers
     source          1..17087
                     /chromosome="4"
                     /db_xref="taxon:9606"
                     /map="4q11-q13"
                     /mol_type="genomic DNA"
                     /organism="Homo sapiens"
                     /tissue_type="blood"
     misc_signal     99..105
                     /note="GCF (GC factor) binding site"
     misc_signal     319..324
                     /note="GATA motif"
     misc_signal     345..350
                     /note="GATA motif"
     misc_signal     373..378
                     /note="GATA motif"
     CAAT_signal     539..543
     misc_signal     708..715
                     /note="Oct-1 and Oct-2 like motif"
     exon            900..1280
                     /gene="PDGFRA"
                     /number=1
                     /product="alpha-platelet-derived growth factor receptor"
     intron          1281..>1768
                     /number=1
     gap             1769..1868
                     /estimated_length=unknown
     intron          <1869..2136
                     /number=1
     exon            2137..2197
                     /gene="PDGFRA"
                     /number=2
                     /product="alpha-platelet-derived growth factor receptor"
     CDS             join(2149..2197,3209..3526,3894..4154,4459..4589,
                     5271..5442,5534..5723,8602..8717,10362..10488,
                     11505..11698,11879..11973,12189..12321,12607..12711,
                     13040..13150,13606..13759,14038..14204,14468..14583,
                     14865..14987,15543..15654,15877..15976,16087..16192,
                     16409..16650,16886..17033)
                     /codon_start=1
                     /gene="PDGFRA"
                     /product="alpha-platelet-derived growth factor receptor"
                     /protein_id="BAA08742.1"
                     /translation="MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSS
                     FSLRCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYY
                     NHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVT
                     LHNSEGVVPASYDSRQGFNGTFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEM
                     EALKTVYKSGETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLT
                     VPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKH
                     FVVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHY
                     TIVAQNEDAVKSYTFELLTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMIC
                     KDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLG
                     AENRELKLVAPTLRSELTVAAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESIS
                     PDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKV
                     AVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDL
                     VNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTT
                     QYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSF
                     TYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTF
                     LPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYR
                     MAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKS
                     DHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPE
                     EEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDSSDLVEDSF
                     L"
     intron          2198..>2904
                     /number=2
     gap             2905..3004
                     /estimated_length=unknown
     intron          <3005..3208
                     /number=2
     exon            3209..3526
                     /gene="PDGFRA"
                     /number=3
                     /product="alpha-platelet-derived growth factor receptor"
     intron          3527..>3644
                     /number=3
     gap             3645..3744
                     /estimated_length=unknown
     intron          <3745..3893
                     /number=3
     exon            3894..4154
                     /gene="PDGFRA"
                     /number=4
                     /product="alpha-platelet-derived growth factor receptor"
     intron          4155..>4295
                     /number=4
     gap             4296..4395
                     /estimated_length=unknown
     intron          <4396..4458
                     /number=4
     exon            4459..4589
                     /gene="PDGFRA"
                     /number=5
                     /product="alpha-platelet-derived growth factor receptor"
     intron          4590..>4889
                     /number=5
     gap             4890..4989
                     /estimated_length=unknown
     intron          <4990..5270
                     /number=5
     exon            5271..5442
                     /gene="PDGFRA"
                     /number=6
                     /product="alpha-platelet-derived growth factor receptor"
     intron          5443..5533
                     /number=6
     exon            5534..5723
                     /gene="PDGFRA"
                     /number=7
                     /product="alpha-platelet-derived growth factor receptor"
     intron          5724..8601
                     /number=7
     repeat_region   7478..7505
                     /note="(ac)14"
                     /rpt_type=direct
     repeat_region   7632..7921
                     /rpt_family="Alu"
                     /rpt_type=inverted
     exon            8602..8717
                     /gene="PDGFRA"
                     /number=8
                     /product="alpha-platelet-derived growth factor receptor"
     intron          8718..10361
                     /number=8
     exon            10362..10488
                     /gene="PDGFRA"
                     /number=9
                     /product="alpha-platelet-derived growth factor receptor"
     intron          10489..11504
                     /number=9
     exon            11505..11698
                     /gene="PDGFRA"
                     /number=10
                     /product="alpha-platelet-derived growth factor receptor"
     intron          11699..>11749
                     /number=10
     gap             11750..11849
                     /estimated_length=unknown
     intron          <11850..11878
                     /number=10
     exon            11879..11973
                     /gene="PDGFRA"
                     /number=11
                     /product="alpha-platelet-derived growth factor receptor"
     intron          11974..12188
                     /number=11
     exon            12189..12321
                     /gene="PDGFRA"
                     /number=12
                     /product="alpha-platelet-derived growth factor receptor"
     intron          12322..>12468
                     /number=12
     gap             12469..12568
                     /estimated_length=unknown
     intron          <12569..12606
                     /number=12
     exon            12607..12711
                     /gene="PDGFRA"
                     /number=13
                     /product="alpha-platelet-derived growth factor receptor"
     intron          12712..>12738
                     /number=13
     gap             12739..12838
                     /estimated_length=unknown
     intron          <12839..13039
                     /number=13
     exon            13040..13150
                     /gene="PDGFRA"
                     /number=14
                     /product="alpha-platelet-derived growth factor receptor"
     intron          13151..>13218
                     /number=14
     gap             13220..13319
                     /estimated_length=unknown
     intron          <13320..13605
                     /number=14
     exon            13606..13759
                     /gene="PDGFRA"
                     /number=15
                     /product="alpha-platelet-derived growth factor receptor"
     intron          13760..>13878
                     /number=15
     gap             13879..13978
                     /estimated_length=unknown
     intron          <13979..14037
                     /number=15
     exon            14038..14204
                     /gene="PDGFRA"
                     /number=16
                     /product="alpha-platelet-derived growth factor receptor"
     intron          14205..>14311
                     /number=16
     gap             14312..14411
                     /estimated_length=unknown
     intron          <14412..14467
                     /number=16
     exon            14468..14583
                     /gene="PDGFRA"
                     /number=17
                     /product="alpha-platelet-derived growth factor receptor"
     intron          14584..>14672
                     /number=17
     gap             14673..14772
                     /estimated_length=unknown
     intron          <14773..14864
                     /number=17
     exon            14865..14987
                     /gene="PDGFRA"
                     /number=18
                     /product="alpha-platelet-derived growth factor receptor"
     intron          14988..>15044
                     /number=18
     gap             15045..15144
                     /estimated_length=unknown
     intron          <15145..15542
                     /number=18
     exon            15543..15654
                     /gene="PDGFRA"
                     /number=19
                     /product="alpha-platelet-derived growth factor receptor"
     intron          15655..>15669
                     /number=19
     gap             15670..15769
                     /estimated_length=unknown
     intron          <15770..15876
                     /number=19
     exon            15877..15976
                     /gene="PDGFRA"
                     /number=20
                     /product="alpha-platelet-derived growth factor receptor"
     intron          15977..16086
                     /number=20
     exon            16087..16192
                     /gene="PDGFRA"
                     /number=21
                     /product="alpha-platelet-derived growth factor receptor"
     intron          16193..>16254
                     /number=21
     gap             16255..16354
                     /estimated_length=unknown
     intron          <16355..16408
                     /number=21
     exon            16409..16650
                     /gene="PDGFRA"
                     /number=22
                     /product="alpha-platelet-derived growth factor receptor"
     intron          16651..>16705
                     /number=22
     gap             16706..16805
                     /estimated_length=unknown
     intron          <16806..16885
                     /number=22
     exon            16886..>17087
                     /gene="PDGFRA"
                     /number=23
                     /product="alpha-platelet-derived growth factor receptor"
BASE COUNT         4025 a         3479 c         3421 g         4562 t
ORIGIN      
        1 gaattcaaaa atcagagagc gatgaaggtg aacgcgctcc cctcccccgc tgtcgctggg
       61 aagccccact ctgcccaggt ctggttcctg gagcatcagc gccccctttc cctcgccggc
      121 aggatcgttt cctcccgaca ctggcctctc gccttgggcg cagggtttgg ggctcagctg
      181 tcaattccaa ggaattcgta gggttcgacc cacgcggcgg gagggaacgg agggagaatc
      241 aaaaggcatc ctcccccacg acgcggaggc ggtggtacga ttcctcaaac gcccaagctt
      301 gagctttttt tgtatgcgag atagaagcca gggcaacctc gcccagataa ccccgaaaac
      361 aaaggcacga ccagataagt gacttcaagg gagtaaaggt cgttctatcg gagaacgttc
      421 caaacctaca cagaccctct tttctttgta ccgtatttca gaccacccag tcttgtacac
      481 acacacacac cacacaaaac aaaaacccat cattgtcata ttggactcaa cagtttgccc
      541 aatcctatta aataactagc aactatatag cccttcccct aaaagacccc tagttcaaaa
      601 cggcgcaacc gcttggagat ttctcccgag ggccctattt ctcgttgggc cgagtttgta
      661 gaagggacat ttcttgattc tagatttata ttctctctgg gtattaaatg caattttgta
      721 tgttcctttt cttcttttca aagagaatac aaaactatag cagtctaaga aaataacccc
      781 aaaatgggga ggcaaactca ttctggaaat gatgggctgt ttgtagtttc acaaaacctc
      841 tttcccggca gagcaccaac acctccccct tccaccaccc cccatcccat ctggtctgct
      901 tctccccgcc ccccagttgt tgtcgaagtc tgggggttgg gactggaccc cctgattgcg
      961 taagagcaaa aagcgaaggc gcaatctgga cactgggaga ttcggagcgc agggagtttg
     1021 agagaaactt ttattttgaa gagaccaagg ttgagggggg gcttatttcc tgacagctat
     1081 ttacttagag caaatgatta gttttagaag gatggactat aacattgaat caattacaaa
     1141 acgcggtttt tgagcccatt actgttggag ctacagggag agaaacagag gaggagactg
     1201 caagagatca ttggaggccg tgggcacgct ctttactcca tgtgtgggac attcattgcg
     1261 gaataacatc ggaggagaag gtaagggaaa agaaaaaatg attttttgtt tataagggaa
     1321 gtccctgatc agactctggg actggagaaa gcgaagtaac ttcaaacttt gggcgacaag
     1381 aaaaaaaaaa aggagctgga ttccagttgt gtgtccagag agtaattttt ttttttcgga
     1441 ataaacttca cttggggacg ggtgggagat aaccatagag ttagaaagtc taggtatttt
     1501 ttttcaaaca cacattttcc agacctattt ttaaaaacaa tgtttttcta acaaccctat
     1561 ggcctcccaa agaaattgtt taggcttaca tttttgaggt ttcttttggg agtgggggtg
     1621 gtgttcgtga atactgggcc gaacaccaag gaactggggg tggaggcaga ggtgtttgcc
     1681 ctcttcttgg cagtgggtcc tggaaggcga caggttttaa atgagtgttt tcattcctcg
     1741 cctgcggttt ggcgggacag cgctgcagnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1801 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1861 nnnnnnnntt aatataaatg gtttaaagga ccattgaaaa ctgcatgcaa tcacagaagg
     1921 ttttggcttc aggcagctcc cgccatgatc ttggggcccc attgattctt tcatctttca
     1981 ggcgtcttac tgtttgaacc ttgaatttta acctgggaca tgtttgacta aaatgatgct
     2041 gttaatattt tctgttgtgc aaaacacaaa gagaactagg ctccagggtt gtttctattt
     2101 gctaatgctg tttctgttga cttttgactt ttctagtttc ccagagctat ggggacttcc
     2161 catccggcgt tcctggtctt aggctgtctt ctcacaggta cggagcccag tcctctctga
     2221 gttccttgtt tgggtgtctt gtttttttaa gctttgtgct gcatgggttt tttaccagta
     2281 ctctgcatac acagtccaaa agagtgaaaa gaaatagaaa actataggac gttatccaga
     2341 atgaccacaa accttcagtt ccctttgctg tattgcactt actccatttc aaaaggaatg
     2401 ctctccagtg gcagttttag tacatatata atgttggcat tgaaatgttg ttagtaataa
     2461 tgtctaaatt tacttactac tctcttcctt ttcctaggac aaggcttcta ttagagctgg
     2521 attagataaa ttcaggaatg gtcagctgtg ggaggtggca catctgttgt cccagcccct
     2581 tgagcagctg aggtgggatg atcccttaag gccaggagtt caaggttgca gtgcactgtg
     2641 ttatgcctgt gactagccac cacactccag caacatagca agacctcatt taaaaaaaat
     2701 gttcaaagga aataaataat agaaaattct tgcccaagaa atcatacttg tcttaaatca
     2761 taactctctt gaggaaagat gcttacattg cttctaaatc tcagagtcac ctttatcttc
     2821 tctaggaatc aaattgatag atgaatgttt ggctcttgga aaatcttaaa aactttccca
     2881 ccaaaaggat ccgttgacct gcagnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2941 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3001 nnnnggtgga gctatttgga acatttgctg ctctcagcag atgcagtggc tgttataatg
     3061 ggggagcttt catgggcatc caggctaacg gatttttgtg tagaaatggt cattgttcat
     3121 ctaagctgct actgttgctt ctctcagttg tcgggatgag actgtccttt ctgactgcat
     3181 cctattcaga gcgtgcttcc ttttgcaggg ctgagcctaa tcctctgcca gctttcatta
     3241 ccctctatcc ttccaaatga aaatgaaaag gttgtgcagc tgaattcatc cttttctctg
     3301 agatgctttg gggagagtga agtgagctgg cagtacccca tgtctgaaga agagagctcc
     3361 gatgtggaaa tcagaaatga agaaaacaac agcggccttt ttgtgacggt cttggaagtg
     3421 agcagtgcct cggcggccca cacagggttg tacacttgct attacaacca cactcagaca
     3481 gaagagaatg agcttgaagg caggcacatt tacatctatg tgccaggtga gttggctggg
     3541 tctccaggac caagcttctt ctcttcctgt ctctcctgtt aaatgtacta aggttttaaa
     3601 catatatata aataattaat atttattgcg ggaaggtttg aaaannnnnn nnnnnnnnnn
     3661 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3721 nnnnnnnnnn nnnnnnnnnn nnnntacaat gccagtgggc aattcttctg atatatgtgt
     3781 aaaggtgaac ttcataccta atatcaataa tgccagtggg atagtttttc tggatttatg
     3841 tgtaaaggtg aaattaatgt ctaatagagt cttcattctt ttttaaacca cagacccaga
     3901 tgtagccttt gtacctctag gaatgacgga ttatttagtc atcgtggagg atgatgattc
     3961 tgccattata ccttgtcgca caactgatcc cgagactcct gtaaccttac acaacagtga
     4021 gggggtggta cctgcctcct acgacagcag acagggcttt aatgggacct tcactgtagg
     4081 gccctatatc tgtgaggcca ccgtcaaagg aaagaagttc cagaccatcc catttaatgt
     4141 ttatgcttta aaaggtactt gtatcatctc cttcttcttt aaataagagt aacaggcaaa
     4201 atcataaggt gcgtgtagga tttttttttt tttttaaatc accatcactg gtgatcctaa
     4261 attctgattt ggggatttag gaccccagct aatacnnnnn nnnnnnnnnn nnnnnnnnnn
     4321 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4381 nnnnnnnnnn nnnnnacctt tataagatcc tggctatcct gtggattttt aggcccttgt
     4441 atttgttctt ttttatagca acatcagagc tggatctaga aatggaagct cttaaaaccg
     4501 tgtataagtc aggggaaacg attgtggtca cctgtgctgt ttttaacaat gaggtggttg
     4561 accttcaatg gacttaccct ggagaagtgg taggtaccct caaaacgtgc aatggcttgg
     4621 agcagagcaa cagggctcag aagacctgca tttgagctcg gtctgtcact gatgggcaca
     4681 tcactgagtt tctctagacc ttagcttccc acctctggga tgaacacatt tgattaaatg
     4741 gcctttagga ctccttgatc aatgggagag tttgaaatga tagttcctgg accaggccct
     4801 tcagaataca taaagagtgt gccgtaagcc ttctttttca gaagtcagac agaaatagga
     4861 aggttctctg gctacaagat atcaaccaan nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4921 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4981 nnnnnnnnna tctcatgatt ttctaagcag ctagctttta ttctttaggt tttatctttt
     5041 agagcagttt taggtttaca ccaaaattga gaggtacaga gatttcccat gtgttcccta
     5101 cacccacaca tgtgtagcct cccaccttgt caacatccct accatccatt tgttataact
     5161 gctgaacctc cattgacaca tccatatcat ccagagtcca tagtttatct tagagttcac
     5221 tcctaggagc gagcttttta aaagtcggtt ttcttcccct tttgctgtag aaaggcaaag
     5281 gcatcacaat gctggaagaa atcaaagtcc catccatcaa attggtgtac actttgacgg
     5341 tccccgaggc cacggtgaaa gacagtggag attacgaatg tgctgcccgc caggctacca
     5401 gggaggtcaa agaaatgaag aaagtcacta tttctgtcca tggtacattc cgctttctaa
     5461 aatgtcagtt gtccatgctg ctcgggatcc atatgtggta atcattattt aatggaaact
     5521 cttccctgta cagagaaagg tttcattgaa atcaaaccca ccttcagcca gttggaagct
     5581 gtcaacctgc atgaagtcaa acattttgtt gtagaggtgc gggcctaccc acctcccagg
     5641 atatcctggc tgaaaaacaa tctgactctg attgaaaatc tcactgagat caccactgat
     5701 gtggaaaaga ttcaggaaat aaggtaaaga aactctctgc ccaagtatgc ctttttttag
     5761 tgtgcatcag aggcggactg aggtttgtgt gtgtcttaca acccagaccc aaagtcagtc
     5821 tagaaaatgt aacaatctga gttaagagat gcttgaaatc acatcccttt aatgataaca
     5881 ttgcaaagtg gtattagtat gctggtaagt atttaatgag aagatgagaa gaaagaacta
     5941 aaagctctgg cccctgggga aagacaggtc actggattca gctagggtgg aagaaaggaa
     6001 gtaaaattgg actcaccagg attgaataga ttgaatatat tccctgatgt tcatcatcca
     6061 tatcgcaagt agacagatta tggtgattac acccatgagg cagttatcac atcaccttac
     6121 gtgaaagtta acgtcatagg cttaatctgg aacccatttg ccctaattga ggactccaca
     6181 ggaaagaaga gtagagcctg gctaatcagg agagagatgt gcagtgagtt gcttggatcc
     6241 ctacctttta atcagaatgg tagattgctc tcatctctta attggtggtg gagttttgaa
     6301 tgagtcaccc ctcagccaca gtttcctcat ctacaatgta ggataaacaa taccttatgt
     6361 ccttcaaggc aaggaattgg atcagatgat atcatgaggc ctcttaaggt tttaagctgt
     6421 gattagaacc caagagtcag aagatacatc tcacagcacc cagctaacag ccctatactt
     6481 tgtcagaaat catctcagaa agacaaagtc agtcctgtat ttcaagcctt caggaggaag
     6541 aacagagcct ttctcatcag tccattcacc tcaggatttg cttcttcttt gtgaactaaa
     6601 tccacgtgta attgagaagc aatgtctgag aaaatggaat tttacagcct ctatagaata
     6661 gtaaaggaaa aatgaagtgg gatacgaatc tggaaggctt ctgttgacac aaaatgaagg
     6721 tgtacaacaa ggagggcagc tttccacgag gaacttccat gaggctgtgc agccagagag
     6781 gaatagggta acaaccctgg tacagctaac acctccaaca cgtgtgtgag cactgtctgc
     6841 aagccataac catagcagtg gcaggacagg ctcgccaact gagtggttct ggaaagctgc
     6901 cttttccttt tagtgattca aggatgcttc aacgtggatt ttttagttcc tgttatgagc
     6961 cagtgaatac aaagatgaac atggtagatg ggggatctgg cttctggagc ttaaaactcc
     7021 aggatgggga tctggcttcc tggagcaaga aaaccagtgg ttttcttggc cgaagaagtg
     7081 aagagaacaa acagcagagg ataatttggt aatcagcatc ctagtgtgcc ccagggtact
     7141 ctcttaagga aatccagtcc tggagcacac ccagtatggt ccagcctgct gtcttcgtag
     7201 gtctgagtgc cccagtattt gcaaagtgtt ttggagccta tgaaatgctt tcacacatac
     7261 aaatctcctt taattaactc tcacaatgac tctgtgccat gtgtacaatt atcacgtttt
     7321 acacacaagg aaactgaggc atggagcatt gtaataatac ccgagatctt ctcactccat
     7381 gaccaatgct tttcttctcc attccagttg ctttttcaac tgtgatgatt tataaggaca
     7441 atcaaatggg cacataccta tatttatgca catacataca cacacacaca cacacacaca
     7501 cacacaacca gatgtcattt ataatccatg taaaatattt ttggggaagt ttctctttaa
     7561 taaagtttga agagacatat attttttttt tttgaagagg catatttttt ctaacttttt
     7621 tttttttttt tgagatggag tcttgctctg tcacccaggc tggagtgcag ccggtacgat
     7681 cacggctcac tgcaacctcc gcctcctggg ttcaagcgat tcttcagctt cagcctcctg
     7741 agtagctggg attacagcat gtgccaccat gcctggctaa tttttttttt tttgtatttt
     7801 tagtagagat gggggtttca ccatgtttgt gaggctggtc tcgaactcct gacctcaagt
     7861 gattcaccta ccttggcctc ccaaagtgct gggattacag tgtgagtcat cacacccagc
     7921 ctataacttt tttttaatag gtgatagaat cccgtgcttg aaaaataatc aaacaaaaag
     7981 agaatgcatt gtaagaagcc tcactgtact cctgtcccca gctgcccagt tctcccctcc
     8041 tcccacaggg aaacatcttc attagtttca ttaggttctt atgaaacctt ccagagtttc
     8101 tttaagcaaa atacaagcaa gtaggactgt catatcctgc agaccgctac atacaaatac
     8161 atagaaagtg tcctcattct atcctccagt gatattccat tttttggctg aaccacctaa
     8221 atgatggata tttaggggaa gcaagtattt tttaaaaaag gtaaaaatca aaggttttta
     8281 ttttttattt ttttaaagaa aagttggtag gctgtgttta ttcattcaga agtcaggccg
     8341 tggctgaact gatagctctt ggagatggcc attgctcatc tctgaatgtc tggttttctc
     8401 ttgtaagaat tgtgtgtatg atccagacct tcagtgtgtg cactatatat tgagaattcc
     8461 agaagagatg atatggacaa gaaaaaaaga tgactttact ttttacagta aaaataaaac
     8521 ttaaattgaa gagtacaatt gtttaaacaa ttggaactta cttagctact gcttgttgaa
     8581 acaaaatcct ttttttaaaa ggtatcgaag caaattaaag ctgatccgtg ctaaggaaga
     8641 agacagtggc cattatacta ttgtagctca aaatgaagat gctgtgaaga gctatacttt
     8701 tgaactgtta actcaaggta tgtaaaggga gtataaagat aatgctagct ctgtagatga
     8761 gtgtcttcca aggaaagcct ggcacttttc tccccggtca tggaagaaaa gcagcactta
     8821 ggggagaagc agtgtctgca tatgtcacat atcgggaata cctctgctgg actcatgaat
     8881 tcaggtattt ctgggaggtt ctgggttact ctagagtagg cgaggaatcc ctaggctcca
     8941 ccagctagct ttatttttgt agagatggag tcttgccatg ttgctcaggc tggtctcctg
     9001 ggttcaagct atcttcccac cttggcctct caaagtactg ggattacagg tgtgagccac
     9061 tgcacctggc ctccaccagc ttacttagca cctgcttctc aatctgagaa gagagaagca
     9121 gatgacctta gattgttctg gagagttttg ctacaagttt tccttataga cattgtacag
     9181 tggtccttac cagaagggag tcccaagtct gtttacattc aggctcagca cctatccaga
     9241 gtcccagcca tgagccaggt gctgtctgag gtgcgctcat gtgatcctca cagtaaaacc
     9301 tgtgatacaa gcaacaccgt atatctaatt tatttgacca cagatttaga aaagaatctt
     9361 taaaacctaa taacatacca cagatgcatt ttggtaaatg ctgctttaga ttatacttta
     9421 gctgaatcca ttagttgaat cctaagctat aatataattt taagaacctc cttgcctttc
     9481 aagccaaata accaagggac tttctctcct ctttccctcc ctcccttcct tccttccttc
     9541 cttcttctct ccctcccttg ttatctcttt tccttccctt tctctccttc cttccctctt
     9601 ccctttttcc tttctctcct tccttccttc cttgcttcct tcttccctcc ctcctttgtt
     9661 ctctcttttc ctttcctttc tctttttctt tccttccttc cttcctcact cactcttttc
     9721 ttttcctttc tctccttcct tccttccttc ctccctccct cactctctct tttctttgcc
     9781 tttctctcct tccttccttc cttttcctcc ctccctccct cccttgttct cccttttcct
     9841 tccttccttc tttccttcct tccttccttc cctcttccct cactctctct tttcctttcc
     9901 tctcctttcc ttccttcctt cattctcccc tcccctcccc cctcccctcc ccccccccct
     9961 cccccctccc cccctcccct ccccttccct tcccttccca tttttcttct caccatgttg
    10021 cccaggcttg ctcaaactcc tgggctcaag tgtttctctt ccacctcagc ctcccaagta
    10081 gctggggcta catgtgtgag gcatcacaac catggacttt tcactttctt cactccaggt
    10141 taaaaacatc acagggataa atctcaaaac accaaaactg tgaaaatgct gctaaccatg
    10201 tgggtctgtc taaactggag tgttacttgt acaactggtt tcagccctcc ggagtgtttt
    10261 gaatgccatg tagatgagtt gtgaactcat attccacttt gtagtctcat atgttctggg
    10321 acacgagcta ttccattctg acttctttct gcctcttgca gttccttcat ccattctgga
    10381 cttggtcgat gatcaccatg gctcaactgg gggacagacg gtgaggtgca cagctgaagg
    10441 cacgccgctt cctgatattg agtggatgat atgcaaagat attaagaagt atggaaaaca
    10501 gatgtgtctt cttctttcgt ggtcagaata tttctccctt gacacaaatg atgtcaaata
    10561 cattttactt attgactata agatagggtt ttgggtgtga tagcttcagg gtgtgtatct
    10621 tttgtcatga atagctgtga gaagaaggtc cagggctctc attagacctt caaaatgtct
    10681 ccaatctaaa aacaagagtg aattttaaga accactgttc taagaagatt tttactaccc
    10741 tggctcacat atcttatttg gtgaactttg tttggtagtc ggactgcatg taaacataaa
    10801 tgtgactgct tagtccctta tctgcccacc tgctgtttgg tgggttaatt cgccattccc
    10861 tcctccctcc cccgagtcct cagccttctt aaatgggcac atgagcaatg tgtttacact
    10921 tcatccatgg taactggttg tgttcagaag cctcagttgt ttcttcctct agacagagac
    10981 tcctcatctt aacttctagg gctaagaaca gacttggatg ttgactgggg tttctagtag
    11041 attccagtgt ggagcaggat tctaggtctt ataactcaat ctgaggatca tcgcaaccct
    11101 agtgacaccc taggggctct tcccagtgtg agtgttgaga agggagggct ccaggccttt
    11161 ttgaaggggt gggagattga gatcattaaa tatggttgaa gttgaactgt tcagtttgct
    11221 cataggttca agattgggga atggtagtca tattttatta aacttgatta tctctgcctg
    11281 ctatgtaaac acttagcttt cagttgttca tgtgtgagtt attccctctt cagcacatgc
    11341 agacaagttt taatgttcat ctgcatgtaa aataaatcag tgtgtattgc cccgaaatgc
    11401 agacaaggtc ccaactcctt gccatcttag agtgttcccg tggctccact cattgccatg
    11461 actctcagga attggcccta tacttaggcc ctttttctct ctagatgtaa taatgaaact
    11521 tcctggacta ttttggccaa caatgtctca aacatcatca cggagatcca ctcccgagac
    11581 aggagtaccg tggagggccg tgtgactttc gccaaagtgg aggagaccat cgccgtgcga
    11641 tgcctggcta agaatctcct tggagctgag aaccgagagc tgaagctggt ggctcccagt
    11701 gagttcctca acagtcagga caactcatca gctgagccgc atctgccccn nnnnnnnnnn
    11761 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    11821 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnt cattgtgcct ctctctcttg tcacgtagcc
    11881 ctgcgttctg aactcacggt ggctgctgca gtcctggtgc tgttggtgat tgtgatcatc
    11941 tcacttattg tcctggttgt catttggaaa caggtagata ttttctcata aaactaaaga
    12001 tctttgaagc caatgagaac aagcatagca acctagttca gtgcttggca cagagaagga
    12061 gctcagcaat tacatgtgga gtgaacgttg ttggactcta ctgtgtccag tcactgtgct
    12121 gcttcagtga agctctggtg cactgggact ttggtaattc accagttacc tgtcctggtc
    12181 atttatagaa accgaggtat gaaattcgct ggagggtcat tgaatcaatc agcccggatg
    12241 gacatgaata tatttatgtg gacccgatgc agctgcctta tgactcaaga tgggagtttc
    12301 caagagatgg actagtgctt ggtaagttcc atggggtaac ctcccaagac tcccttttcc
    12361 cttgcacaca actttacaat ttataggcct tggcagaata gagatctgag cttgtgctta
    12421 gtaagaacta ggcaatggaa atttgctttc agaaatacat ttctgtctnn nnnnnnnnnn
    12481 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    12541 nnnnnnnnnn nnnnnnnnnn nnnnnnnnga gtttttgggg tgttaatgat tcttgcctgc
    12601 ccacaggtcg ggtcttgggg tctggagcgt ttgggaaggt ggttgaagga acagcctatg
    12661 gattaagccg gtcccaacct gtcatgaaag ttgcagtgaa gatgctaaaa cgtaagtgct
    12721 ccttcctggg gattttttnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    12781 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnntg
    12841 ttatttccag tgacgtcttt ttactagaaa gaccaggaag tagttattag cactgaggcc
    12901 aagtagctat ctgcttcttt tagacttctg gtaaatagaa tgatatccaa tcacaggatt
    12961 agtcatattc ttggtttttt tctgagaaca ggaagatggt agctcagctg gactgatatg
    13021 tgatttattc tttcaacagc cacggccaga tccagtgaaa aacaagctct catgtctgaa
    13081 ctgaagataa tgactcacct ggggccacat ttgaacattg taaacttgct gggagcctgc
    13141 accaagtcag gtgggctcac tgacctggag tgaggatttt cactggacac atgtggttgt
    13201 gaaaactgtt caatcaggcn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    13261 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnng
    13321 ttggggaagg gccgatcggt gcgggcctcc ttcgctatta cgccagctgg cgaaaggggg
    13381 atgtgctgca aggcgattaa gttgggtaac gccagggttt tcccagtcac gacgttgtaa
    13441 aacgacggcc agtgaattgt aatacgactc actatagggc gaattggagc tccaccgcgg
    13501 tggcggccgc tctagaacta gtggatcccc cgggctgcag gacaattcat ggcttttctg
    13561 ttcttcattt tcatacccat ctcctaacgg cttttgtccc cataggcccc atttacatca
    13621 tcacagagta ttgcttctat ggagatttgg tcaactattt gcataagaat agggatagct
    13681 tcctgagcca ccacccagag aagccaaaga aagagctgga tatctttgga ttgaaccctg
    13741 ctgatgaaag cacacggagg tgggtgcaaa gagagatgtt gctgtctatc attatcttac
    13801 aggcatcaca aatggaaaga cccatgtcct gatagatatc atgtctgcag gaattcgata
    13861 tcaagcttat cgataccgnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    13921 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnag
    13981 tggaatgacc acttcagaag ggcaccctgg gtaagatttc tctttctgtt tttacagcta
    14041 tgttatttta tcttttgaaa acaatggtga ctacatggac atgaagcagg ctgatactac
    14101 acagtatgtc cccatgctag aaaggaaaga ggtttctaaa tattccgaca tccagagatc
    14161 actctatgat cgtccagcct catataagaa gaaatctatg ttaggtaaaa gtgtctatac
    14221 tcactctggg tgttgggact ttccagtggt ttaatatgat acttaaagta tttagaggga
    14281 agtgtatagg gatggtaagt gaacctggca gnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    14341 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    14401 nnnnnnnnnn nacctgatga tttcctgctg cctgccagca ccaatacatt taatttcttt
    14461 tctgcagact cagaagtcaa aaacctcctt tcagatgata actcagaagg ccttacttta
    14521 ttggatttgt tgagcttcac ctatcaagtt gcccgaggaa tggagttttt ggcttcaaaa
    14581 aatgtaagtt caaggcaaca cagacctttt tagacccaga tttcagtgag tggagtgtgg
    14641 aaggagatgc taggagatag atgttggaaa ggnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    14701 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    14761 nnnnnnnnnn nnagtgccac catggatcag ccagtcttgc aggggtgatg ctatatcagc
    14821 tacagatggc ttgatcctga gtcatttctt ccttttccat gcagtgtgtc caccgtgatc
    14881 tggctgctcg caacgtcctc ctggcacaag gaaaaattgt gaagatctgt gactttggcc
    14941 tggccagaga catcatgcat gattcgaact atgtgtcgaa aggcagtgta cgtccacact
    15001 tcccacactg gacaggctca tcctcccaca ctttactctc taaannnnnn nnnnnnnnnn
    15061 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    15121 nnnnnnnnnn nnnnnnnnnn nnnntgaact catgtgcccg tgatacctgt aatcggctca
    15181 taagatcatt ggatctgttc ttagttttgt tcccaggaat atctaaaaat aggaaactgg
    15241 tccattcagg gcttacacct tttgggtgaa aattcaggat taatgttttt ggatattatt
    15301 cctttggagg acataaaagg caatattgac cattcatcat tcatctagta tttattgagc
    15361 acctactatg tgccagggac tgagagttca gtaatgaaca aaacacatgt aaaagacact
    15421 caaatgggac aagataatta gcacaagtta ttaagagccc aaggggaacc cttttctatt
    15481 tccactgctg tggatcatca gtgagtagac atgggtttaa ctgtctccct ccttccttgc
    15541 agacctttct gcccgtgaag tggatggctc ctgagagcat ctttgacaac ctctacacca
    15601 cactgagtga tgtctggtct tatggcattc tgctctggga gatcttttcc cttggtatgg
    15661 gcctgacatn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    15721 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnna ggctatagga
    15781 tctgtgaggg tttctaacag tgttctatca tgccaagtgt ttcaccgatg cactgagcgt
    15841 ttgttagtac ctggtgtttt attgtttggc ttttaggtgg caccccttac cccggcatga
    15901 tggtggattc tactttctac aataagatca agagtgggta ccggatggcc aagcctgacc
    15961 acgctaccag tgaagtgtga gctccttccc catcccgggg gcctgtgttc acagtctgtg
    16021 ggtctagggg gagggagggg ccctgagact tccccctgtg cccactcttg agttctgtcc
    16081 ccacagctac gagatcatgg tgaaatgctg gaacagtgag ccggagaaga gaccctcctt
    16141 ttaccacctg agtgagattg tggagaatct gctgcctgga caatataaaa aggtgtgttt
    16201 ggatctgtgg gtggaaaggt ctggataaag ctggaagtta taccagtgag ctgtnnnnnn
    16261 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    16321 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnttttga ggtttggttg ttaacacttg
    16381 attaaatatg ttcaatgaat gtttatagag ttatgaaaaa attcacctgg acttcctgaa
    16441 gagtgaccat cctgctgtgg cacgcatgcg tgtggactca gacaatgcat acattggtgt
    16501 cacctacaaa aacgaggaag acaagctgaa ggactgggag ggtggtctgg atgagcagag
    16561 actgagcgct gacagtggct acatcattcc tctgcctgac attgaccctg tccctgagga
    16621 ggaggacctg ggcaagagga acagacacag gtagctgtgg gggcagcctc ggtgtctcac
    16681 ctttcccctc ccctataggc cctgannnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    16741 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    16801 nnnnntcgtt tgtctctggg gggccacagt cctaggtcta gttctgtgta ggagttgtaa
    16861 tattgctctt ctctccctcc tccagctcgc agacctctga agagagtgcc attgagacgg
    16921 gttccagcag ttccaccttc atcaagagag aggacgagac cattgaagac atcgacatga
    16981 tggacgacat cggcatagac tcttcagacc tggtggaaga cagcttcctg taactggcgg
    17041 attcgagggg ttccttccac ttctggggcc acctctggat cccgttc
//