LOCUS BC082992 4922 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens v-erb-b2 erythroblastic leukemia viral oncogene
homolog 3 (avian), mRNA (cDNA clone MGC:88033 IMAGE:6147464),
complete cds.
ACCESSION BC082992
VERSION BC082992.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4922)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 4922)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (24-SEP-2004) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC/DCTD/DTP
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 174 Row: j Column: 18
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 54792099.
FEATURES Location/Qualifiers
source 1..4922
/db_xref="H-InvDB:HIT000266029"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:88033 IMAGE:6147464"
/tissue_type="Skin, melanotic melanoma."
/clone_lib="NIH_MGC_72"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..4922
/gene="ERBB3"
/gene_synonym="c-erbB-3"
/gene_synonym="c-erbB3"
/gene_synonym="ErbB-3"
/gene_synonym="erbB3-S"
/gene_synonym="HER3"
/gene_synonym="MDA-BF-1"
/gene_synonym="p180-ErbB3"
/gene_synonym="p45-sErbB3"
/gene_synonym="p85-sErbB3"
/db_xref="GeneID:2065"
/db_xref="HGNC:HGNC:3431"
/db_xref="MIM:190151"
CDS 116..4144
/gene="ERBB3"
/gene_synonym="c-erbB-3"
/gene_synonym="c-erbB3"
/gene_synonym="ErbB-3"
/gene_synonym="erbB3-S"
/gene_synonym="HER3"
/gene_synonym="MDA-BF-1"
/gene_synonym="p180-ErbB3"
/gene_synonym="p45-sErbB3"
/gene_synonym="p85-sErbB3"
/codon_start=1
/product="v-erb-b2 erythroblastic leukemia viral oncogene
homolog 3 (avian)"
/protein_id="AAH82992.1"
/db_xref="GeneID:2065"
/db_xref="HGNC:HGNC:3431"
/db_xref="MIM:190151"
/translation="MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAEN
QYQTLYKLYERCEVVMGNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNL
RVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHMDT
IDWRDIVRDRDAEIVVKDNGRSCPPCHEVCKGRCWGPGSEDCQTLTKTICAPQCNGHC
FGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNP
HTKYQYGGVCVASCPHNFVVDQTSCVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGT
GSGSRFQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTVRE
ITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEIS
AGRIYISANRQLCYHHSLNWTKVLRGPTEERLDIKHNRPRRDCVAEGKVCDPLCSSGG
CWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFAHEAECFSCHPECQPMEGTATCN
GSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGPIYKYPDVQNECRPCHENCTQGCKGP
ELQDCLGQTLVLIGKTHLTMALTVIAGLVVIFMMLGGTFLYWRGRRIQNKRAMRRYLE
RGESIEPLDPSEKANKVLARIFKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVC
IKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDH
VRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVA
DLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAG
LRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDP
PRYLVIKRESGPGIAPGPEPHGLTNKKLEEVELEPELDLDLDLEAEEDNLATTTLGSA
LSLPVGTLNRPRGSQSLLSPSSGYMPMNQGNLGESCQESAVSGSSERCPRPVSLHPMP
RGCLASESSEGHVTGSEAELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPL
SPPGLEEEDVNGYVMPDTHLKGTPSSREGTLSSVGLSSVLGTEEEDEDEEYEYMNRRR
RHSPPHPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPTAGTTPDEDYEY
MNRQRDGGGPGGDYAAMGACPASEQGYEEMRAFQGPGHQAPHVHYARLKTLRSLEATD
SAFDNPDYWHSRLFPKANAQRT"
BASE COUNT 1210 a 1267 c 1314 g 1131 t
ORIGIN
1 cgtcgccgca gcagccacca attcgccagc ggttcaggtg gctcttgcct cgatgtccta
61 gcctaggggc ccccgggccg gacttggctg ggctcccttc accctctgcg gagtcatgag
121 ggcgaacgac gctctgcagg tgctgggctt gcttttcagc ctggcccggg gctccgaggt
181 gggcaactct caggcagtgt gtcctgggac tctgaatggc ctgagtgtga ccggcgatgc
241 tgagaaccaa taccagacac tgtacaagct ctacgagagg tgtgaggtgg tgatggggaa
301 ccttgagatt gtgctcacgg gacacaatgc cgacctctcc ttcctgcagt ggattcgaga
361 agtgacaggc tatgtcctcg tggccatgaa tgaattctct actctaccat tgcccaacct
421 ccgcgtggtg cgagggaccc aggtctacga tgggaagttt gccatcttcg tcatgttgaa
481 ctataacacc aactccagcc acgctctgcg ccagctccgc ttgactcagc tcaccgagat
541 tctgtcaggg ggtgtttata ttgagaagaa cgataagctt tgtcacatgg acacaattga
601 ctggagggac atcgtgaggg accgagatgc tgagatagtg gtgaaggaca atggcagaag
661 ctgtcccccc tgtcatgagg tttgcaaggg gcgatgctgg ggtcctggat cagaagactg
721 ccagacattg accaagacca tctgtgctcc tcagtgtaat ggtcactgct ttgggcccaa
781 ccccaaccag tgctgccatg atgagtgtgc cgggggctgc tcaggccctc aggacacaga
841 ctgctttgcc tgccggcact tcaatgacag tggagcctgt gtacctcgct gtccacagcc
901 tcttgtctac aacaagctaa ctttccagct ggaacccaat ccccacacca agtatcagta
961 tggaggagtt tgtgtagcca gctgtcccca taactttgtg gtggatcaaa catcctgtgt
1021 cagggcctgt cctcctgaca agatggaagt agataaaaat gggctcaaga tgtgtgagcc
1081 ttgtggggga ctatgtccca aagcctgtga gggaacaggc tctgggagcc gcttccagac
1141 tgtggactcg agcaacattg atggatttgt gaactgcacc aagatcctgg gcaacctgga
1201 ctttctgatc accggcctca atggagaccc ctggcacaag atccctgccc tggacccaga
1261 gaagctcaat gtcttccgga cagtacggga gatcacaggt tacctgaaca tccagtcctg
1321 gccgccccac atgcacaact tcagtgtttt ttccaatttg acaaccattg gaggcagaag
1381 cctctacaac cggggcttct cattgttgat catgaagaac ttgaatgtca catctctggg
1441 cttccgatcc ctgaaggaaa ttagtgctgg gcgtatctat ataagtgcca ataggcagct
1501 ctgctaccac cactctttga actggaccaa ggtgcttcgg gggcctacgg aagagcgact
1561 agacatcaag cataatcggc cgcgcagaga ctgcgtggca gagggcaaag tgtgtgaccc
1621 actgtgctcc tctgggggat gctggggccc aggccctggt cagtgcttgt cctgtcgaaa
1681 ttatagccga ggaggtgtct gtgtgaccca ctgcaacttt ctgaatgggg agcctcgaga
1741 atttgcccat gaggccgaat gcttctcctg ccacccggaa tgccaaccca tggagggcac
1801 tgccacatgc aatggctcgg gctctgatac ttgtgctcaa tgtgcccatt ttcgagatgg
1861 gccccactgt gtgagcagct gcccccatgg agtcctaggt gccaagggcc caatctacaa
1921 gtacccagat gttcagaatg aatgtcggcc ctgccatgag aactgcaccc aggggtgtaa
1981 aggaccagag cttcaagact gtttaggaca aacactggtg ctgatcggca aaacccatct
2041 gacaatggct ttgacagtga tagcaggatt ggtagtgatt ttcatgatgc tgggcggcac
2101 ttttctctac tggcgtgggc gccggattca gaataaaagg gctatgaggc gatacttgga
2161 acggggtgag agcatagagc ctctggaccc cagtgagaag gctaacaaag tcttggccag
2221 aatcttcaaa gagacagagc taaggaagct taaagtgctt ggctcgggtg tctttggaac
2281 tgtgcacaaa ggagtgtgga tccctgaggg tgaatcaatc aagattccag tctgcattaa
2341 agtcattgag gacaagagtg gacggcagag ttttcaagct gtgacagatc atatgctggc
2401 cattggcagc ctggaccatg cccacattgt aaggctgctg ggactatgcc cagggtcatc
2461 tctgcagctt gtcactcaat atttgcctct gggttctctg ctggatcatg tgagacaaca
2521 ccggggggca ctggggccac agctgctgct caactgggga gtacaaattg ccaagggaat
2581 gtactacctt gaggaacatg gtatggtgca tagaaacctg gctgcccgaa acgtgctact
2641 caagtcaccc agtcaggttc aggtggcaga ttttggtgtg gctgacctgc tgcctcctga
2701 tgataagcag ctgctataca gtgaggccaa gactccaatt aagtggatgg cccttgagag
2761 tatccacttt gggaaataca cacaccagag tgatgtctgg agctatggtg tgacagtttg
2821 ggagttgatg accttcgggg cagagcccta tgcagggcta cgattggctg aagtaccaga
2881 cctgctagag aagggggagc ggttggcaca gccccagatc tgcacaattg atgtctacat
2941 ggtgatggtc aagtgttgga tgattgatga gaacattcgc ccaaccttta aagaactagc
3001 caatgagttc accaggatgg cccgagaccc accacggtat ctggtcataa agagagagag
3061 tgggcctgga atagcccctg ggccagagcc ccatggtctg acaaacaaga agctagagga
3121 agtagagctg gagccagaac tagacctaga cctagacttg gaagcagagg aggacaacct
3181 ggcaaccacc acactgggct ccgccctcag cctaccagtt ggaacactta atcggccacg
3241 tgggagccag agccttttaa gtccatcatc tggatacatg cccatgaacc agggtaatct
3301 tggggagtct tgccaggagt ctgcagtttc tgggagcagt gaacggtgcc cccgtccagt
3361 ctctctacac ccaatgccac ggggatgcct ggcatcagag tcatcagagg ggcatgtaac
3421 aggctctgag gctgagctcc aggagaaagt gtcaatgtgt aggagccgga gcaggagccg
3481 gagcccacgg ccacgcggag atagcgccta ccattcccag cgccacagtc tgctgactcc
3541 tgttacccca ctctccccac ccgggttaga ggaagaggat gtcaacggtt atgtcatgcc
3601 agatacacac ctcaaaggta ctccctcctc ccgggaaggc accctttctt cagtgggtct
3661 cagttctgtc ctgggtactg aagaagaaga tgaagatgag gagtatgaat acatgaaccg
3721 gaggagaagg cacagtccac ctcatccccc taggccaagt tcccttgagg agctgggtta
3781 tgagtacatg gatgtggggt cagacctcag tgcctctctg ggcagcacac agagttgccc
3841 actccaccct gtacccatca tgcccactgc aggcacaact ccagatgaag actatgaata
3901 tatgaatcgg caacgagatg gaggtggtcc tgggggtgat tatgcagcca tgggggcctg
3961 cccagcatct gagcaagggt atgaagagat gagagctttt caggggcctg gacatcaggc
4021 cccccatgtc cattatgccc gcctaaaaac tctacgtagc ttagaggcta cagactctgc
4081 ctttgataac cctgattact ggcatagcag gcttttcccc aaggctaatg cccagagaac
4141 gtaactcctg ctccctgtgg cactcaggga gcatttaatg gcagctagtg cctttagagg
4201 gtaccgtctt ctccctattc cctctctctc ccaggtccca gccccttttc cccagtccca
4261 gacaattcca ttcaatcttt ggaggctttt aaacattttg acacaaaatt cttatggtat
4321 gtagccagct gtgcactttc ttctctttcc caaccccagg aaaggttttc cttattttgt
4381 gtgctttccc agtcccattc ctcagcttct tcacaggcac tcctggagat atgaaggatt
4441 actctccata tcccttcctc tcaggctctt gactacttgg aactaggctc ttatgtgtgc
4501 ctttgtttcc catcagactg tcaagaagag gaaagggagg aaacctagca gaggaaagtg
4561 taattttggt ttatgactct taacccccta gaaagacaga agcttaaaat ctgtgaagaa
4621 agaggttagg agtagatatt gattactatc ataattcagc acttaactat gagccaggca
4681 tcatactaaa cttcacctac attatctcac ttagtccttt atcatcctta aaacaattct
4741 gtgacataca tattatctca ttttacacaa agggaagtcg ggcatggtgg ctcatgcctg
4801 taatctcagc actttgggag gctgaggcag aaggattacc tgaggcaagg agtttgagac
4861 cagcttagcc aacatagtaa gacccccatc tctttaaaaa aaaaaaaaaa aaaaaaaaaa
4921 aa
//