LOCUS BC071576 4887 bp mRNA linear HUM 28-JUL-2005
DEFINITION Homo sapiens amyotrophic lateral sclerosis 2 (juvenile), mRNA (cDNA
clone MGC:87187 IMAGE:30347073), complete cds.
ACCESSION BC071576
VERSION BC071576.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4887)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 4887)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (01-JUN-2004) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Dr. Stefan Hansson
cDNA Library Preparation: Michael Brownstein / Ted Usdin
Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Sequencing Group at the Stanford Human Genome
Center, Stanford University School of Medicine, Stanford, CA 94305
Web site: http://www-shgc.stanford.edu
Contact: (Dickson, Mark) mcd@paxil.stanford.edu
Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
R. M.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 168 Row: o Column: 17
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 40316934.
FEATURES Location/Qualifiers
source 1..4887
/db_xref="H-InvDB:HIT000264405"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:87187 IMAGE:30347073"
/tissue_type="Placenta, normal"
/clone_lib="NIH_MGC_147"
/lab_host="DH10B"
/note="Vector: pBluescriptR"
gene 1..4887
/gene="ALS2"
/gene_synonym="ALS2CR6"
/gene_synonym="ALSJ"
/gene_synonym="IAHSP"
/gene_synonym="KIAA1563"
/gene_synonym="PLSJ"
/db_xref="GeneID:57679"
/db_xref="MIM:606352"
CDS 119..3832
/gene="ALS2"
/gene_synonym="ALS2CR6"
/gene_synonym="ALSJ"
/gene_synonym="IAHSP"
/gene_synonym="KIAA1563"
/gene_synonym="PLSJ"
/codon_start=1
/product="ALS2 protein"
/protein_id="AAH71576.1"
/db_xref="GeneID:57679"
/db_xref="MIM:606352"
/translation="MDSKKRSSTEAEGSKERGLVHIWQAGSFPITPERLPGWGGKTVL
QAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFH
SGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEE
HTLALSISREIWAWGTGCQLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQ
CLPSQDLKPVPERCNQCSQLLITMTDKEDHVIISDSHCCPLGVTLTESQAENHASTAL
SPSTETLDRQEEVFENTLVANDQSVATELNAVSAQITSSDAMSSQQNVMGTTEISSAR
NIPSYPDTQAVNEYLRKLSDHSVREDSEHGEKPVPSQPLLEEAIPNLHSPPTTSTSAL
NSLVVSCASAVGVRVAATYEAGALSLKKVMNFYSTTPCETGAQAGSSAIGPEGLKDSR
EEQVKQESMQGKKSSSLVDIREEETEGGSRRLSLPGLLSQVSPRLLRKAARVKTRTVV
LTPTYSGEADALLPSLRIEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEA
GGYHSLALTAKSQVYSWGSNTFGQLGHSDFPTTVPRLAKISSENGVWSIAAGRDYSLF
LVDTEDFQPGLYYSGRQDPTEGDNLPENHSGSKTPVLLSCSKLGYISRVTAGKDSYLA
LVDKNIMGYIASLHELATTERRFYSKLSDIKSQILRPLLSLENLGTTTTVQLLQEVAS
RFSKLCYLIGQHGASLSSFLHGVKEARSLVILKHSSLFLDSYTEYCTSITNFLVMGGF
QLLAKPAIDFLNKNQELLQDLSEVNDENTQLMEILNTLFFLPIRRLHNYAKVLLKLAT
CFEVASPEYQKLQDSSSCYECLALHLGRKRKEAEYTLGFWKTFPGKMTDSLRKPERRL
LCESSNRALSLQHAGRFSVNWFILFNDALVHAQFSTHHVFPLATLWAEPLSEEAGGVN
GLKITTPEEQFTLISSTPQEKTKWLRAISQAVDQALRGMSDLPPYGSGSSVQRQEPPI
SRSAKYTFYKDPRLKDATYDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGLEDGYGEYR
IPNKAMNKEDHYVGHWKEGKMCGQGVYSYASGEVFEGCFQDNMRHGHGLLRSGKLTSS
SPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNGVVVTQFGLYYEGNFHL
NKMMGNGVLLSEDDTIYEGEFSDDWTLSGKVGN"
BASE COUNT 1345 a 1001 c 1140 g 1401 t
ORIGIN
1 cactgggttg ccaagctcgc gccggatgcg gagcgcggtg ctgccggtgg agcttcaggt
61 cttgatagac tttctgtaaa gaaggaatga tttggtgatg gagtgttccc actgaccgat
121 ggactcaaag aagagaagct caacagaggc agaaggatcc aaggaaagag gcctggtcca
181 tatctggcag gcaggatcct ttcccataac accagagaga ttgccaggct ggggaggaaa
241 gactgttttg caggcagccc tcggagtgaa acatggagtt cttctgactg aagatggtga
301 ggtctacagc tttgggactc ttccctggag aagtggacca gtggagattt gtccaagtag
361 ccccattcta gaaaatgccc tggttgggca atatgttatt actgtggcaa caggaagctt
421 ccatagtgga gcagtgacag acaatggtgt cgcgtacatg tggggagaga attctgctgg
481 ccagtgtgca gtagccaacc agcagtatgt gccggaacca aatcctgtca gcattgctga
541 ttctgaggcc agccctttgt tagcagtcag gattttacag ttggcgtgtg gcgaggagca
601 cactctggca ttgtcaataa gcagagagat ttgggcatgg ggtaccggtt gtcagttggg
661 tctcattacc actgccttcc cagtgacaaa gccgcaaaag gtagaacatc ttgctgggcg
721 agtggtgctt caagttgcct gtggtgcttt ccacagctta gcccttgtac aatgcctccc
781 ttcccaggat ctgaagccag tcccagaacg atgcaaccag tgcagccagc tcttgattac
841 tatgactgac aaagaagacc atgtgattat atcagacagt cattgttgcc cattaggtgt
901 gacactgaca gaatctcagg cagaaaacca tgccagcact gctctcagcc cctccactga
961 aacccttgac aggcaggaag aagtatttga gaacactctt gtagcaaatg atcagtctgt
1021 tgctactgaa ctgaatgcag taagtgctca gatcacaagc agcgatgcca tgtcctctca
1081 acaaaatgtc atgggaacaa ctgaaatttc ctctgccaga aacataccat cataccctga
1141 cacccaagca gtcaatgaat acctacggaa actgtcagat cattcagtaa gagaggactc
1201 agagcatggt gaaaagccag tgccatctca gcctctttta gaagaagcaa ttcctaatct
1261 ccacagcccg cctaccacaa gcacctcagc cctaaacagc ctggtggtct cttgtgcatc
1321 tgctgttggt gtgagagtgg ctgctactta tgaagctggt gccttgtcac tgaagaaagt
1381 tatgaacttt tatagtacaa ccccttgtga aactggagct caggcaggca gtagtgccat
1441 tggccccgaa ggtttgaaag atagcaggga agaacaggtt aaacaggaat caatgcaagg
1501 aaagaaaagt tcaagtcttg tggatatcag agaagaagaa acagagggag gcagtcgaag
1561 actctccctc cctggattgt tgtcacaagt ttcccccagg ctcttaagaa aggctgcacg
1621 ggtgaaaacg aggacagtgg ttctgacccc cacatacagt ggagaagcag atgcgctcct
1681 gccttctctg agaatagaag tgtggacctg ggggaaaggg aaggaagggc agctggggca
1741 cggcgatgtt ctgcctaggc ttcaaccgtt gtgtgtaaaa tgtctggatg gcaaagaagt
1801 aatccatctg gaggcaggtg gttaccattc tcttgcactt actgcgaaat cccaggttta
1861 ctcatggggt agcaatacct ttggtcaact tgggcattcc gattttccaa caacagttcc
1921 tcgtcttgca aagataagca gtgaaaatgg agtctggagc atagctgcag gcagggatta
1981 ttccctgttt ttagtggata cagaagactt ccagcctggg ttatattaca gtggccgaca
2041 ggaccctaca gaaggtgaca accttccaga gaatcacagt ggttctaaga ctccagtact
2101 tctctcctgt agtaagcttg gatatataag cagagtgaca gcaggaaaag atagctattt
2161 agccttggtg gataaaaaca ttatggggta tattgccagt ctccacgagt tagctactac
2221 agaaagacga ttctattcaa aactaagtga tatcaaatct cagattctca ggcctcttct
2281 cagtttagaa aatttgggca ctacaactac agtccagctg ttgcaggagg tggctagccg
2341 attcagcaag ctgtgttacc tcattggtca gcatggagcc tcattgagca gcttccttca
2401 tggggtaaag gaagccagga gtttggtcat cctgaagcat tcaagtctct tcttggatag
2461 ttatacagag tattgcacat ctattacaaa tttcctggtt atgggaggat tccagcttct
2521 tgctaagcct gccattgatt tcctaaataa aaaccaagag ctgttgcaag atttgtcaga
2581 agtgaatgac gaaaacactc agttgatgga aatactgaat actttgtttt tcttgccaat
2641 cagacgactt cataattacg caaaagtttt gctaaagctt gctacttgtt ttgaagtggc
2701 atctccagaa tatcagaaac tgcaggattc cagttcttgt tatgagtgtc ttgctctcca
2761 tctcggcagg aaaaggaagg aagcagaata cacactgggc ttctggaaga ccttccccgg
2821 aaaaatgacg gattccttga ggaagccaga gcgtcgactg ctgtgtgaga gtagtaaccg
2881 agccctgtct ctgcagcatg ctgggaggtt ttccgtgaat tggttcattc tctttaatga
2941 tgccctggtc catgcccagt tctccacgca ccatgttttc cctctggcca cgctgtgggc
3001 agagccactg tctgaagaag ctggtggtgt gaatggctta aagataacta cacctgagga
3061 gcagttcact ctcatttcat ctacacccca ggaaaagaca aagtggctac gagctataag
3121 ccaagccgta gatcaggctt tgagagggat gtctgatctc cccccttatg gaagtggtag
3181 cagtgttcag agacaggagc cacccatttc acgcagtgcc aaatatactt tctacaagga
3241 tcctcgccta aaggatgcca cctatgatgg acgctggctt tcagggaagc ctcatggcag
3301 aggggttttg aagtggcctg atggaaagat gtattctggc atgttcagga atggcttgga
3361 agatgggtat ggagaataca gaatcccaaa caaggcaatg aacaaagaag accattatgt
3421 gggccattgg aaagaaggaa aaatgtgcgg tcaaggagtc tacagctatg cttctggtga
3481 agtatttgag ggctgttttc aagataatat gcgtcatggt catggtcttc tacgaagtgg
3541 gaaattgacg tcctcttctc ctagtatgtt cattggccag tgggtaatgg ataagaaagc
3601 aggatatggt gtctttgatg atatcactag gggggaaaag tatatgggaa tgtggcaaga
3661 tgatgtgtgt caagggaatg gtgtggtggt tacccagttt ggattatact acgagggcaa
3721 ctttcacctt aataaaatga tgggaaatgg ggttttgctt tccgaagatg atactatcta
3781 tgaaggagaa ttttcagatg actggactct tagtggaaag gttggaaact agctttcttt
3841 ttttttctcc ctaataaatt cttttactaa ttttttttta ctttaaaaat agctgattta
3901 catgccataa aattcacccc tttcaagtgc acatttcagt gatttttggt caacatggct
3961 gtacaaacca ccaccacaat ccagtttcag aacatttccg tctcccaaga aaatcccttc
4021 tgctcattca gtgacttcca tttccaccta aagtcccagc caaccactaa tcacccttaa
4081 tcactctata gatttgcctt ttttgggcct tttgtataaa tggaatcata catgcaatct
4141 cctctatgtg gcttcttaca cttagtataa tgtttttgtt ttttccatat tgtggcatgt
4201 atagtatttg ttccttttta tggctgaata gtattccaaa actacatttt gtttatcctt
4261 ttaccagttg atggacattg ggttatttcc aactttagac tattgtaaat aatgctgcta
4321 taaacttttg aatgcagttt cttgtgtaga catatgtttt cattttcatt tctcaagtag
4381 atgcctggag tgtaattgct aagttgtatg gtaaattgat gtttaacata ttaagaaact
4441 gtcgaacttt tttccaaagt gtctgtacca ttttacattc ccatcagcaa tgtctgagga
4501 tactaatttc tccatatcaa aaaatatttc ttattttctg tcttttttct tatagccatt
4561 ccaatgggta tgaagtggta tctcctggtt ttaatttgca ttccatagtg actaatgatg
4621 tagaacatgc ttattagtga ttcatatatc ttctttgatg aaatgtctat tcagatcttg
4681 gcctatttct aaaattttgt ttgtactctt gttgaattgt atgggttctt tctgtattct
4741 ggatacatgt cctttatcag atatgatttg taaatatttt cttgcagtct gacttgtctt
4801 ttattttctt aatagtgtct tttgaaatag aaaagttttt cattttaata aactctataa
4861 aaaattttat gaaaaaaaaa aaaaaaa
//