LOCUS       BC050743                2485 bp    mRNA    linear   HUM 17-NOV-2006
DEFINITION  Homo sapiens SMAD family member 3, mRNA (cDNA clone MGC:60396
            IMAGE:6094328), complete cds.
ACCESSION   BC050743
VERSION     BC050743.1
KEYWORDS    MGC.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2485)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
REFERENCE   2  (bases 1 to 2485)
  CONSRTM   NIH MGC Project
  TITLE     Direct Submission
  JOURNAL   Submitted (08-APR-2003) National Institutes of Health, Mammalian
            Gene Collection (MGC), Bethesda, MD 20892-2590, USA
  REMARK    NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT     Contact: MGC help desk
            Email: cgapbs-r@mail.nih.gov
            Tissue Procurement: ATCC
            cDNA Library Preparation: Life Technologies, Inc.
            cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
            DNA Sequencing by: Sequencing Group at the Stanford Human Genome
            Center, Stanford University School of Medicine, Stanford, CA  94305
            Web site:       http://www-shgc.stanford.edu
            Contact:  (Dickson, Mark) mcd@paxil.stanford.edu
            Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
            R. M.
            
            Clone distribution: MGC clone distribution information can be found
            through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
            Series: IRAK Plate: 110 Row: i Column: 23
            This clone was selected for full length sequencing because it
            passed the following selection criteria: matched mRNA gi: 52352808.
FEATURES             Location/Qualifiers
     source          1..2485
                     /db_xref="H-InvDB:HIT000053585"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="MGC:60396 IMAGE:6094328"
                     /tissue_type="Pancreas, epithelioid carcinoma"
                     /clone_lib="NIH_MGC_70"
                     /lab_host="DH10B"
                     /note="Vector: pCMV-SPORT6"
     gene            1..2485
                     /gene="SMAD3"
                     /gene_synonym="DKFZP586N0721"
                     /gene_synonym="HSPC193"
                     /gene_synonym="HsT17436"
                     /gene_synonym="JV15-2"
                     /gene_synonym="MGC60396"
                     /gene_synonym="Smad 3"
                     /db_xref="GeneID:4088"
                     /db_xref="HGNC:6769"
                     /db_xref="MIM:603109"
     CDS             217..1494
                     /gene="SMAD3"
                     /gene_synonym="DKFZP586N0721"
                     /gene_synonym="HSPC193"
                     /gene_synonym="HsT17436"
                     /gene_synonym="JV15-2"
                     /gene_synonym="MGC60396"
                     /gene_synonym="Smad 3"
                     /codon_start=1
                     /product="SMAD family member 3"
                     /protein_id="AAH50743.1"
                     /db_xref="GI:29792115"
                     /db_xref="GeneID:4088"
                     /db_xref="HGNC:6769"
                     /db_xref="MIM:603109"
                     /translation="MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKK
                     TGQLDELEKAITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHE
                     LRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSI
                     PENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNN
                     LDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSN
                     VNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKI
                     PPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTST
                     PCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS"
BASE COUNT          568 a          752 c          669 g          496 t
ORIGIN      
        1 gccgtgggag ccgctccggg cgcagggccg cgcgccgagc cccgcaggct gcagcgccgc
       61 ggcccggccc ggcgccccgg caacttcgcc gagagttgag gcgaagtttg ggcgaccgcg
      121 gcaggccccg gccgagctcc cctctgcgcc cccggcgtcc cgtcgagccc agccccgccg
      181 ggggcgctcc tcgccgcccg cgcgccctcc ccagccatgt cgtccatcct gcctttcact
      241 cccccgatcg tgaagcgcct gctgggctgg aagaagggcg agcagaacgg gcaggaggag
      301 aaatggtgcg agaaggcggt caagagcctg gtcaagaaac tcaagaagac ggggcagctg
      361 gacgagctgg agaaggccat caccacgcag aacgtcaaca ccaagtgcat caccatcccc
      421 aggtccctgg atggccggtt gcaggtgtcc catcggaagg ggctccctca tgtcatctac
      481 tgccgcctgt ggcgatggcc agacctgcac agccaccacg agctgcgggc catggagctg
      541 tgtgagttcg ccttcaatat gaagaaggac gaggtctgcg tgaatcccta ccactaccag
      601 agagtagaga caccagttct acctcctgtg ttggtgccac gccacacaga gatcccggcc
      661 gagttccccc cactggacga ctacagccat tccatccccg aaaacactaa cttccccgca
      721 ggcatcgagc cccagagcaa tattccagag accccacccc ctggctacct gagtgaagat
      781 ggagaaacca gtgaccacca gatgaaccac agcatggacg caggttctcc aaacctatcc
      841 ccgaatccga tgtccccagc acataataac ttggacctgc agccagttac ctactgcgag
      901 ccggccttct ggtgctccat ctcctactac gagctgaacc agcgcgtcgg ggagacattc
      961 cacgcctcgc agccatccat gactgtggat ggcttcaccg acccctccaa ttcggagcgc
     1021 ttctgcctag ggctgctctc caatgtcaac aggaatgcag cagtggagct gacacggaga
     1081 cacatcggaa gaggcgtgcg gctctactac atcggagggg aggtcttcgc agagtgcctc
     1141 agtgacagcg ctatttttgt ccagtctccc aactgtaacc agcgctatgg ctggcacccg
     1201 gccaccgtct gcaagatccc accaggatgc aacctgaaga tcttcaacaa ccaggagttc
     1261 gctgccctcc tggcccagtc ggtcaaccag ggctttgagg ctgtctacca gttgacccga
     1321 atgtgcacca tccgcatgag cttcgtcaaa ggctggggag cggagtacag gagacagact
     1381 gtgaccagta ccccctgctg gattgagctg cacctgaatg ggcctttgca gtggcttgac
     1441 aaggtcctca cccagatggg ctccccaagc atccgctgtt ccagtgtgtc ttagagacat
     1501 caagtatggt aggggagggc aggcttgggg aaaatggcca tgcaggaggt ggagaaaatt
     1561 ggaactctac tcaacccatt gttgtcaagg aagaagaaat ctttctccct caactgaagg
     1621 ggtgcaccca cctgttttct gaaacacacg agcaaaccca gaggtggatg ttatgaacag
     1681 ctgtgtctgc caaacacatt taccctttgg ccccactttg aagggcaaga aatggcgtct
     1741 gctctggtgg cttaagtgag cagaacaggt agtattacac caccggcccc ctccccccag
     1801 actctttttt tgagtgacag ctttctggga tgtcacagtc caaccagaaa cacccctctg
     1861 tctaggactg cagtgtggag ttcaccttgg aagggcgttc taggtaggaa gagcccgcag
     1921 ggccatgcag acctcatgcc cagctctctg acgcttgtga cagtgcctct tccagtgaac
     1981 attcccagcc cagccccgcc ccgccccgcc ccaccactcc agcagacctt gccccttgtg
     2041 agctggatag acttgggatg gggagggagg gagttttgtc tgtctccctc ccctctcaga
     2101 acatactgat tgggaggtgc gtgttcagca gaacctgcac acaggacagc gggaaaaatc
     2161 gatgagcgcc acctctttaa aaactcactt acgtttgtcc tttttcactt tgaaaagttg
     2221 gaaggatctg ctgaggccca gtgcatatgc aatgtatagt gtctattatc acattaatct
     2281 caaagagatt cgaatgacgg taagtgttct catgaagcag gaggcccttg tcgtgggatg
     2341 gcatttggtc tcaggcagca ccacactggg tgcgtctcca gtcatctgta agagcttgct
     2401 ccagattctg atgcatacgg ctatattggt ttatgtagtc agttgcattc attaaatcaa
     2461 ctttatcata aaaaaaaaaa aaaaa
//