LOCUS       BC049368                3754 bp    mRNA    linear   HUM 17-JUL-2006
DEFINITION  Homo sapiens TYRO3 protein tyrosine kinase, mRNA (cDNA clone
            MGC:57186 IMAGE:4821587), complete cds.
ACCESSION   BC049368
VERSION     BC049368.1
KEYWORDS    MGC.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3754)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
REFERENCE   2  (bases 1 to 3754)
  CONSRTM   NIH MGC Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-MAR-2003) National Institutes of Health, Mammalian
            Gene Collection (MGC), Bethesda, MD 20892-2590, USA
  REMARK    NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT     Contact: MGC help desk
            Email: cgapbs-r@mail.nih.gov
            Tissue Procurement: Miklos Palkovits, M.D., Ph.D.
            cDNA Library Preparation: Michael J. Brownstein (NHGRI) &  Shiraki
            Toshiyuki and Piero Carninci (RIKEN)
            cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
            DNA Sequencing by: Institute for Systems Biology
            http://www.systemsbiology.org
            contact: amadan@systemsbiology.org
            Anup Madan, Jessica Fahey, Erin Helton, Mark Ketteman, Anuradha
            Madan, Stephanie Rodrigues, Amy Sanchez and Michelle Whiting
            
            Clone distribution: MGC clone distribution information can be found
            through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
            Series: IRAK Plate: 106 Row: d Column: 19.
FEATURES             Location/Qualifiers
     source          1..3754
                     /db_xref="H-InvDB:HIT000053368"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="MGC:57186 IMAGE:4821587"
                     /tissue_type="Testis"
                     /clone_lib="NIH_MGC_97"
                     /lab_host="DH10B"
                     /note="Vector: pBluescriptR"
     gene            1..3754
                     /gene="TYRO3"
                     /gene_synonym="Brt"
                     /gene_synonym="BYK"
                     /gene_synonym="Dtk"
                     /gene_synonym="Sky"
                     /gene_synonym="Tif"
                     /db_xref="GeneID:7301"
                     /db_xref="HGNC:HGNC:12446"
                     /db_xref="MIM:600341"
     CDS             11..2683
                     /gene="TYRO3"
                     /gene_synonym="Brt"
                     /gene_synonym="BYK"
                     /gene_synonym="Dtk"
                     /gene_synonym="Sky"
                     /gene_synonym="Tif"
                     /codon_start=1
                     /product="TYRO3 protein tyrosine kinase"
                     /protein_id="AAH49368.1"
                     /db_xref="GeneID:7301"
                     /db_xref="HGNC:HGNC:12446"
                     /db_xref="MIM:600341"
                     /translation="MALRRSMGRPGLPPLPLPPPLRLGLLLAALASLLLPESAAAGLK
                     LMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFL
                     SLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSC
                     EAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTAT
                     VHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVV
                     PVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRT
                     DSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIV
                     RVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALIL
                     LRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKL
                     EDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDSSFVKVAVKMLKADIIASSDIEEFL
                     REAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENP
                     FNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYS
                     GDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAE
                     IYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSA
                     SQDPLYINIERAEEPTAGGSMELPGGDQPYSGAGDGSGMGAVGGTPSDCRYILTPGGL
                     AEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC"
BASE COUNT          786 a         1061 c         1125 g          782 t
ORIGIN      
        1 gtcgccgccg atggcgctga ggcggagcat ggggcggccg gggctcccgc cgctgccgct
       61 gccgccgcca ctgcggctcg ggctgctgct ggcggctctg gcttctctgc tgctcccgga
      121 gtccgccgcc gcaggtctga agctcatggg agccccggtg aagctgacag tgtctcaggg
      181 gcagccggtg aagctcaact gcagtgtgga ggggatggag gagcctgaca tccagtgggt
      241 gaaggatggg gctgtggtcc agaacttgga ccagttgtac atcccagtca gcgagcagca
      301 ctggatcggc ttcctcagcc tgaagtcagt ggagcgctct gacgccggcc ggtactggtg
      361 ccaggtggag gatgggggtg aaaccgagat ctcccagcca gtgtggctca cggtagaagg
      421 tgtgccattt ttcacagtgg agccaaaaga tctggcagtg ccacccaatg cccctttcca
      481 actgtcttgt gaggctgtgg gtccccctga acctgttacc attgtctggt ggagaggaac
      541 tacgaagatc gggggacccg ctccctctcc atctgtttta aatgtaacag gggtgaccca
      601 gagcaccatg ttttcctgtg aagctcacaa cctaaaaggc ctggcctctt ctcgcacagc
      661 cactgttcac cttcaagcac tgcctgcagc ccccttcaac atcaccgtga caaagctttc
      721 cagcagcaac gctagtgtgg cctggatgcc aggtgccgat ggccgagctc tgctacagtc
      781 ctgtacagtt caggtgacac aggccccagg aggctgggaa gtcctggctg ttgtggtccc
      841 tgtgcccccc tttacctgcc tgctccggga cctggtgcct gccaccaact acagcctcag
      901 ggtgcgctgt gccaatgcct tggggccctc tccctatgct gactgggtgc cctttcagac
      961 caagggtcta gccccagcca gcgctcccca aaacctccat gccatccgca cagattcagg
     1021 cctcatcttg gagtgggaag aagtgatccc cgaggcccct ttggaaggcc ccctgggacc
     1081 ctacaaactg tcctgggttc aagacaatgg aacccaggat gagctgacag tggaggggac
     1141 cagggccaat ttgacaggct gggatcccca aaaggacctg atcgtacgtg tgtgcgtctc
     1201 caatgcagtt ggctgtggac cctggagtca gccactggtg gtctcttctc atgaccgtgc
     1261 aggccagcag ggccctcctc acagccgcac atcctgggta cctgtggtcc ttggtgtgct
     1321 aacggccctg gtgacggctg ctgccctggc cctcatcctg cttcgaaaga gacggaaaga
     1381 gacgcggttt gggcaagcct ttgacagtgt catggcccgg ggagagccag ccgttcactt
     1441 ccgggcagcc cggtccttca atcgagaaag gcccgagcgc atcgaggcca cattggacag
     1501 cttgggcatc agcgatgaac taaaggaaaa actggaggat gtgctcatcc cagagcagca
     1561 gttcaccctg ggccggatgt tgggcaaagg agagtttggt tcagtgcggg aggcccagct
     1621 gaagcaagag gatagctcct ttgtgaaagt ggctgtgaag atgctgaaag ctgacatcat
     1681 tgcctcaagc gacattgaag agttcctcag ggaagcagct tgcatgaagg agtttgacca
     1741 tccacacgtg gccaaacttg ttggggtaag cctccggagc agggctaaag gccgtctccc
     1801 catccccatg gtcatcttgc ccttcatgaa gcatggggac ctgcatgcct tcctgctcgc
     1861 ctcccggatt ggggagaacc cctttaacct acccctccag accctgatcc ggttcatggt
     1921 ggacattgcc tgcggcatgg agtacctgag ctctcggaac ttcatccacc gagacctggc
     1981 tgctcggaat tgcatgctgg cagaggacat gacagtgtgt gtggctgact tcggactctc
     2041 ccggaagatc tacagtgggg actactatcg tcaaggctgt gcctccaaac tgcctgtcaa
     2101 gtggctggcc ctggagagcc tggccgacaa cctgtatact gtgcagagtg acgtgtgggc
     2161 gttcggggtg accatgtggg agatcatgac acgtgggcag acgccatatg ctggcatcga
     2221 aaacgctgag atttacaact acctcattgg cgggaaccgc ctgaaacagc ctccggagtg
     2281 tatggaggac gtgtatgatc tcatgtacca gtgctggagt gctgacccca agcagcgccc
     2341 gagctttact tgtctgcgaa tggaactgga gaacatcttg ggccagctgt ctgtgctatc
     2401 tgccagccag gaccccttat acatcaacat cgagagagct gaggagccca ctgcgggagg
     2461 cagcatggag ctacctggcg gggatcagcc ctacagtggg gctggggatg gcagtggcat
     2521 gggggcagtg ggtggcactc ccagtgactg tcggtacata ctcacccccg gagggctggc
     2581 tgagcagcca gggcaggcag agcaccagcc agagagtccc ctcaatgaga cacagaggct
     2641 tttgctgctg cagcaagggc tactgccaca cagtagctgt tagcccacag gcagagggca
     2701 tcggggccat ttggccggct ctggtggcca ctgagctggc tgactaagcc ccgtctgacc
     2761 ccagcccaga cagcaaggtg tggaggctcc tgtggtagtc ctcccaagct gtgctgggaa
     2821 gcccggactg accaaatcac ccaatcccag ttcttcctgc aaccactctg tggccagcct
     2881 ggcatcagtt taggccttgg cttgatggaa gtgggccagt cctggttgtc tgaacccagg
     2941 cagctggcag gagtggggtg gttatgtttc catggttacc atgggtgtgg atggcagtgt
     3001 ggggagggca ggtccagctc tgtgggccct accctcctgc tgagctgccc ctgctgctta
     3061 agtgcatgca ttgagctgcc tccagcctgg tggcccagct attaccacac ttggggttta
     3121 aatatccagg tgtgcccctc caagtcacaa agagatgtcc ttgtaatatt cccttttagg
     3181 tgagggttgg taaggggttg gtatctcagg tctgaatctt caccatcttt ctgattccgc
     3241 accctgccta cgccaggaga agttgagggg agcatgcttc cctgcagctg accgggtcac
     3301 acaaaggcat gctggagtac ccagcctatc aggtgcccct cttccaaagg cagcgtgccg
     3361 agccagcaag aggaaggggt gctgtgaggc ttgcccagga gcaagtgagg ccggagagga
     3421 gttcaggaac ccttctccat acccacaatc tgagcacgct accaaatctc aaaatatcct
     3481 aagactaaca aaggcagctg tgtctgagcc caacccttct aaacggtgac ctttagtgcc
     3541 aacttcccct ctaactggac agcctcttct gtcccaagtc tccagagaga aatcaggcct
     3601 gatgaggggg aattcctgga acctggaccc cagccttggt gggggagcct ctggaatgca
     3661 tggggcgggt cctagctgtt agggacattt ccaagctgtt agttgctgtt taaaatagaa
     3721 ataaaattga agactaaaga aaaaaaaaaa aaaa
//