LOCUS BC040630 1402 bp mRNA linear HUM 07-OCT-2003
DEFINITION Homo sapiens aquaporin 8, mRNA (cDNA clone MGC:50607
IMAGE:5759105), complete cds.
ACCESSION BC040630
VERSION BC040630.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1402)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1402)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (29-NOV-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Life Technologies, Inc.
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Sequencing Group at the Stanford Human Genome
Center, Stanford University School of Medicine, Stanford, CA 94305
Web site: http://www-shgc.stanford.edu
Contact: (Dickson, Mark) mcd@paxil.stanford.edu
Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
R. M.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 88 Row: o Column: 1.
FEATURES Location/Qualifiers
source 1..1402
/db_xref="H-InvDB:HIT000052436"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:50607 IMAGE:5759105"
/tissue_type="Colon, Kidney, Stomach, adult, whole pooled"
/clone_lib="NIH_MGC_116"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..1402
/gene="AQP8"
/db_xref="GeneID:343"
/db_xref="MIM:603750"
CDS 69..836
/gene="AQP8"
/codon_start=1
/product="AQP8 protein"
/protein_id="AAH40630.1"
/db_xref="GeneID:343"
/db_xref="MIM:603750"
/translation="MCEPEFGNDKAREPSVGGRWRVSWYERFVQPCLVELLGSALFIF
IGCLSVIENGTDTGLLQPALAHGLALGLVIATLGNISGGHFNPAVSLAAMLIGGLNLV
MLLPYWVSQLLGGMLGAALAKAVSPEERFWNASGAAFVTVQEQGQVAGALVAEIILTT
LLALAVCMGAINEKTKGPLAPFSIGFAVTVDILAGGPVSGGCMNPARAFGPAVVANHW
NFHWIYWLGPLLAGLLVGLLIRCFIGDGKTRLILKAR"
misc_feature 150..743
/gene="AQP8"
/note="MIP; Region: Major intrinsic protein. MIP (Major
Intrinsic Protein) family proteins exhibit essentially two
distinct types of channel properties: (1) specific water
transport by the aquaporins, and (2) small neutral solutes
transport, such as glycerol by the glycerol facilitators"
/db_xref="CDD:pfam00230"
BASE COUNT 343 a 355 c 397 g 307 t
ORIGIN
1 tgtctgtgaa ggatcgtcat ctatacactc agtcctggct caggctgtca cggtgactgc
61 agatagccat gtgtgagcct gaatttggca atgacaaggc cagggagccg agcgtgggtg
121 gcaggtggcg agtgtcctgg tacgaacggt ttgtgcagcc atgtctggtc gaactgctgg
181 gctctgctct cttcatcttc atcgggtgcc tgtcggtcat tgagaatggg acggacactg
241 ggctgctgca gccggccctg gcccacgggc tggctttggg gctcgtgatt gccacgctgg
301 ggaatatcag tggtggacac ttcaaccctg cggtgtccct ggcagccatg ctgatcggag
361 gcctcaacct ggtgatgctc ctcccgtact gggtctcaca gctgctcggg gggatgctcg
421 gggctgcctt ggccaaggcg gtgagtcctg aggagaggtt ctggaatgca tctggggcgg
481 cctttgtgac agtccaggag caggggcagg tggcaggggc gttggtggca gagatcatcc
541 tgacgacgct gctggccctg gctgtatgca tgggtgccat caatgagaag acaaagggcc
601 ctctggcccc gttctccatc ggctttgccg tcaccgtgga tatcctggct gggggccctg
661 tgtctggagg ctgcatgaat cccgcccgtg cttttggacc tgcggtggtg gccaaccact
721 ggaacttcca ctggatctac tggctgggcc cactcctggc tggcctgctt gttggactgc
781 tcattaggtg cttcattgga gatgggaaga cccgcctcat cctgaaggct cggtgaagca
841 gagctcgtgg gattcctgct gctccaggtg tcctcagctc acctgtccca gactgaggac
901 aggggagttc ctgcatttcc tgccagggca gaggcccaga ggagcgaccc cctgcttcca
961 ctgcttgggc ctgctttctc agatagactg actgctgagg aggctctagg ttcttggaat
1021 tcctttgtgc tcatcagaga ccccagcctg gggaacacgc tgcccgcact gcccagagag
1081 cagtgcaaac accacaacac gagcgtgttt cttgagagga atgtccccga gttggacaag
1141 gaggctgttt ctgcacatca gctcatttcc cgcaccccat ttcttgcttg attgctttgt
1201 tgggggcctg gccacttcct tgcttctcaa gctgacaatt ctcactttgc aataaatagt
1261 ccagtgtttc cttccaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
1321 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
1381 aaaaaaaaaa aaaaaaaaaa aa
//