LOCUS BC040441 4172 bp mRNA linear HUM 25-MAR-2004
DEFINITION Homo sapiens pleckstrin homology domain containing, family M (with
RUN domain) member 2, mRNA (cDNA clone IMAGE:5590182), partial cds.
ACCESSION BC040441
VERSION BC040441.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4172)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 4172)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (29-NOV-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Invitrogen
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Institute for Systems Biology
http://www.systemsbiology.org
contact: amadan@systemsbiology.org
Anup Madan, Jessica Fahey, Erin Helton, Mark Ketteman, Anuradha
Madan, Stephanie Rodrigues, Amy Sanchez and Michelle Whiting
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 84 Row: i Column: 8.
FEATURES Location/Qualifiers
source 1..4172
/db_xref="H-InvDB:HIT000096166"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:5590182"
/tissue_type="Ovary, pooled from 3 adults"
/clone_lib="NIH_MGC_125"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene <1..4172
/gene="PLEKHM2"
/gene_synonym="KIAA0842"
/db_xref="GeneID:23207"
CDS <1..3290
/gene="PLEKHM2"
/gene_synonym="KIAA0842"
/codon_start=3
/product="PLEKHM2 protein"
/protein_id="AAH40441.1"
/db_xref="GeneID:23207"
/translation="LLPRRPRSGASGPRWSEGPGEARAGRRAPGPAAGTTEPPYGRRQ
RLAAAPGPRRGKRRRGGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKLQSYFA
ACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDLSSGYWVLVVHFTRREAIKQIEVLQ
HVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTL
VSGLEFIRFELDLDAPYLDLAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSV
TSTNLEWDDSAIAPSSEDYDFGDVFPAVPSVPSTDWEDGDLTDTVSGPRSTASDLTSS
KASTRSPTQRQNPFNEEPAETVSSSDTTPVHTTSQEKEEAQALDPPDACTELEVIRVT
KKKKIGKKKKSRSDEEASPLHPACSQKKCAKQGDGDSRNGSPSLGRDSPDTMLASPQE
EGEGPSSTTESSERSEPGLLIPEMKDTSMERLGQPLSKVIDQLNGQLDPSTWCSRAEP
PDQSFRTGSPGDAPERPPLCDFSEGLSAPMDFYRFTVESPSTVTSGGGHHDPAGLGQP
LHVPSSPEAAGQEEEGGGGEGQTPRPLEDTTREAQELEAQLSLVREGPVSEPEPGTQE
VLCQLKRDQPSPCLSSAEDSGVDEGQGSPSEMVHSSEFRVDNNHLLLLMIHVFRENEE
QLFKMIRMSTGHMEGNLQLLYVLLTDCYVYLLRKGATEKPYLVEEAVSYNELDYVSVG
LDQQTVKLVCTNRRKQFLLDTADVALAEFFLASLKSAMIKGCREPPYPSILTDATMEK
LALAKFVAQESKCEASAVTVRFYGLVHWEDPTDESLGPTPCHCSPPEGTITKEGMLHY
KAGTSYLGKEHWKTCFVVLSNGILYQYPDRTDVIPLLSVNMGGEQCGGCRRANTTDRP
HAFQVILSDRPCLELSAESEAEMAEWMQHLCQAVSKGVIPQGVAPSPCIPCCLVLTDD
RLFTCHEDCQTSFFRSLGTAKLGDISAVSTEPGKEYCVLEFSQDSQQLLPPWVIYLSC
TSELDRLLSALNSGWKTIYQVDLPHTAIQEASNKKKFEDALSLIHSAWQRSDSLCRGR
ASRDPWC"
misc_feature 360..686
/gene="PLEKHM2"
/gene_synonym="KIAA0842"
/note="RUN; Region: RUN domain. This domain is present in
several proteins that are linked to the functions of
GTPases in the Rap and Rab families. They could hence play
important roles in multiple Ras-like GTPase signaling
pathways"
/db_xref="CDD:pfam02759"
misc_feature 2544..2849
/gene="PLEKHM2"
/gene_synonym="KIAA0842"
/note="PH; Region: PH domain. PH stands for pleckstrin
homology"
/db_xref="CDD:pfam00169"
BASE COUNT 858 a 1304 c 1278 g 732 t
ORIGIN
1 gcctccttcc ccgccggccg cgctccggag cctccgggcc gcggtggagc gagggcccag
61 gcgaggcgag ggccgggcgg cgggcgccgg gccccgcggc cggcacgacg gagcccccgt
121 acggccggcg gcagcggttg gcggcggccc ccggcccccg gcgcgggaag cggcggcggg
181 gcggcggcgg cggcggtggc ggtggcggtg gcggcgacgg tggcagcgcc atggagccgg
241 gggaggtgaa ggaccggatc ctggagaaca tctcgctgtc ggtgaagaag ttgcagagct
301 attttgctgc atgtgaggat gagatccctg ccatccggaa ccatgacaag gtcctacagc
361 gtctgtgtga gcacctggac cacgccctgc tgtacggact gcaagacctc tcctctggct
421 actgggtgct cgtggtgcat tttactcgga gagaggccat caagcagatc gaggtgctgc
481 agcacgtggc caccaacctg gggcgcagcc gtgcctggct gtacctggcc ctcaacgaga
541 actccttgga gagctacctg cggttgttcc aggagaacct gggcctgctg cataagtact
601 acgtcaagaa tgccctggtc tgcagccacg atcacctgac gctcttcctg accttggtgt
661 ccgggctaga gttcattcgt ttcgagctgg atctggatgc cccttaccta gacctggccc
721 cctacatgcc cgactactac aaacctcagt acctgctgga ctttgaagac cgccttccca
781 gctcggtcca cggctcagac agtctgtccc tcaactcttt caactccgtc acctccacca
841 acctggagtg ggatgacagt gcgattgccc catctagtga ggattatgat tttggagatg
901 tgtttccagc agtgccgtct gtacccagca cagactggga agatggagac ctcacagaca
961 cggtcagtgg tccccgctcc acagcctccg acctgaccag cagcaaggcc tccaccagga
1021 gccccaccca gcgccagaac cccttcaacg aggagccggc agagactgtg tcctcctctg
1081 acaccacccc cgtgcacacc acctctcagg agaaggagga ggcccaggcc ctggacccgc
1141 cggatgcctg cacggagctc gaggtcatca gggtcaccaa gaagaagaaa attggcaaga
1201 agaaaaagag cagatcagat gaggaggcaa gtccactcca ccccgcctgc agccagaaga
1261 aatgtgccaa gcagggggac ggtgacagcc gcaacggcag cccaagcctt gggcgggact
1321 cgccagacac tatgcttgcc tccccccagg aggagggaga ggggccgagc agcaccacgg
1381 agagcagcga gcgctccgag ccgggcctgc tgatccctga gatgaaggac acctccatgg
1441 agcgcttggg gcagcccctg agcaaggtta tcgaccagct caacgggcag ctggacccca
1501 gcacctggtg ctcccgtgct gagcccccag accagtcctt tcggaccggc tctcccgggg
1561 atgccccgga gaggccgccg ctttgcgact ttagtgaggg gctttcagcc ccaatggact
1621 tctaccgctt taccgtcgag agtccaagca ctgttacatc aggtggcggc caccatgacc
1681 ctgcagggct tggccaaccg ctgcatgttc ctagtagccc tgaggctgct ggccaagaag
1741 aagagggagg aggaggagag ggacagacgc ctcggcccct agaggatacc acgagggagg
1801 ctcaggagct ggaggcccag ctgtccctgg tcagggaggg gcctgtgtct gagccagagc
1861 ctgggaccca ggaggttctc tgccagctca agcgagacca gcccagcccg tgtctgagta
1921 gcgctgagga ttctggggtg gatgagggac aggggagccc ttcggagatg gtccattcct
1981 cggagttcag agtagacaac aatcacctgc tcctgctcat gatccacgtg ttccgagaaa
2041 acgaagagca gctgttcaaa atgatccgga tgagcaccgg gcacatggag ggcaacctgc
2101 agctgctgta cgtgctgctc acagactgct atgtctacct gctccggaaa ggggccacag
2161 agaagccata cctggtggaa gaggccgttt cttacaatga acttgactat gtgtcggttg
2221 gccttgacca gcagacggtg aagctggtgt gcaccaaccg caggaagcag tttctgctgg
2281 acacggctga tgtggcgctg gctgagttct ttttggcttc tttgaagtca gccatgatca
2341 aaggctgtcg agaacctccc taccccagca tcctgacgga tgccaccatg gagaagctgg
2401 cactggccaa atttgtggcc caagaatcga agtgtgaggc atctgctgtc accgtgcgct
2461 tctacggcct tgtgcactgg gaggacccca cagacgagtc cctgggcccc acgccctgcc
2521 actgctcacc ccccgagggc accatcacca aagaaggcat gctgcactac aaggcgggca
2581 cctcctacct gggcaaggaa cactggaaga cgtgcttcgt ggtgctcagc aacgggatcc
2641 tctaccagta cccggaccgc accgacgtca tccctctgct ctcggtgaac atgggggggg
2701 agcagtgcgg tggctgccgg agagccaaca ccacggatcg gccccacgcc ttccaggtca
2761 ttctctccga ccggccctgc ctggagctaa gtgccgagag cgaggccgag atggccgagt
2821 ggatgcagca tctctgccag gctgtgtcca aaggggtcat cccccagggc gtagctccca
2881 gcccctgcat accctgctgc ctggtcctca cggatgaccg cctctttacg tgccatgagg
2941 attgccagac cagcttcttc cgctctttgg gcacagccaa gctgggcgac atcagcgccg
3001 tctccaccga gccgggcaag gagtactgcg tcttggagtt ctcccaggac agccagcagc
3061 tcctcccgcc ctgggtcatc tacctgagct gcacttctga actggaccga ttgctgtctg
3121 cactgaactc tgggtggaaa accatctatc aggtggacct cccccacacg gcgatccagg
3181 aagcctccaa caagaagaaa ttcgaggatg ccttgagcct catccacagc gcctggcagc
3241 ggagcgacag tctctgccgc ggccgagcct cccgagaccc ctggtgctga ggcagagctg
3301 gttggcgtcc ctggtgggca ggaaaggaag gcacgccagc cggcaggcac actgtcacgg
3361 ctgttgtcat gctgtcggga gcctacagtc cacccctgcc ctgggcggca gaaccaccga
3421 gtgtggctta agacagggtc cctccactcc agggatccag atcaggtgcc cggcacccct
3481 gggcatcctg cccgacaggt agcgaatgga ggtcgctggg ggcagagggt ccgagccctg
3541 tgggctctgc ggatgcacgc cctcctcccg ggcctccgcc tcagtctgca gaatttctgc
3601 cgagtggcac cgagaacacc atccatctaa ggacgaacaa aagaaccagg agggcgggac
3661 ccccctcttc ctctcctggg ttgggggctg gggccctgag tgcccagcca tccttgttcg
3721 tgtttgaaca ctctcctggc cacgtgggga agcgggaaca cggggtgtct gcgcatgttt
3781 cctcctccta gctccatcac tgcgcacaca gctgcctgcc tcgccagatg caggggggcg
3841 ggcagccctc cctggctgcc aggaggctct gcatgcccac agtcctgccc tgcctgtccc
3901 ctcaacccgg cagtgcctgt agcaccgagg agcaaagggg gtggatgggg ggcttggaga
3961 agggcggagc ccaccagcct ggcatccatg ttgacatctt ctgactgtcc cctgcttggc
4021 tggagccagg cccttcccta gagtttcgtc aagagcctcc tggggaaggg gtcaggtggt
4081 ttgggttttg ttttttaaaa taaaatagac atgttatatt gccaaaaaaa aaaaaaaaaa
4141 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//