LOCUS       BC039894                3466 bp    mRNA    linear   HUM 15-JUL-2006
DEFINITION  Homo sapiens glutamate-cysteine ligase, catalytic subunit, mRNA
            (cDNA clone MGC:47730 IMAGE:6052162), complete cds.
ACCESSION   BC039894
VERSION     BC039894.1
KEYWORDS    MGC.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3466)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
REFERENCE   2  (bases 1 to 3466)
  CONSRTM   NIH MGC Project
  TITLE     Direct Submission
  JOURNAL   Submitted (15-NOV-2002) National Institutes of Health, Mammalian
            Gene Collection (MGC), Bethesda, MD 20892-2590, USA
  REMARK    NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT     Contact: MGC help desk
            Email: cgapbs-r@mail.nih.gov
            Tissue Procurement: ATCC
            cDNA Library Preparation: Life Technologies, Inc.
            cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
            DNA Sequencing by: National Institutes of Health Intramural
            Sequencing Center (NISC),
            Gaithersburg, Maryland;
            Web site: http://www.nisc.nih.gov/
            Contact: nisc_mgc@nhgri.nih.gov
            Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
            Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
            Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
            Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
            Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
            McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
            Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
            Young,A., Zhang,L.-H. and Green,E.D.
            
            Clone distribution: MGC clone distribution information can be found
            through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
            Series: IRAK Plate: 82 Row: o Column: 9
            This clone was selected for full length sequencing because it
            passed the following selection criteria: matched mRNA gi: 45359851.
FEATURES             Location/Qualifiers
     source          1..3466
                     /db_xref="H-InvDB:HIT000052285"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="MGC:47730 IMAGE:6052162"
                     /tissue_type="Testis, embryonal carcinoma"
                     /clone_lib="NIH_MGC_92"
                     /lab_host="DH10B"
                     /note="Vector: pCMV-SPORT6"
     gene            1..3466
                     /gene="GCLC"
                     /gene_synonym="GCS"
                     /db_xref="GeneID:2729"
                     /db_xref="HGNC:HGNC:4311"
                     /db_xref="MIM:606857"
     CDS             83..1996
                     /gene="GCLC"
                     /gene_synonym="GCS"
                     /codon_start=1
                     /product="glutamate-cysteine ligase, catalytic subunit"
                     /protein_id="AAH39894.1"
                     /db_xref="GeneID:2729"
                     /db_xref="HGNC:HGNC:4311"
                     /db_xref="MIM:606857"
                     /translation="MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDV
                     LKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMI
                     EGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEV
                     KPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFI
                     ETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIV
                     MALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDS
                     YLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDA
                     NESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTR
                     VILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNST
                     ELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRA
                     SGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFR
                     KVKYSGSKTDSSN"
BASE COUNT         1072 a          643 c          748 g         1003 t
ORIGIN      
        1 ccacgcgtcc gccgtctcgc gcccggagcg ggcgaccgcc gtcagcccgg aggaggagga
       61 ggaggaggag gagggggcgg ccatggggct gctgtcccag ggctcgccgc tgagctggga
      121 ggaaaccaag cgccatgccg accacgtgcg gcggcacggg atcctccagt tcctgcacat
      181 ctaccacgcc gtcaaggacc ggcacaagga cgttctcaag tggggcgatg aggtggaata
      241 catgttggta tcttttgatc atgaaaataa aaaagtccgg ttggtcctgt ctggggagaa
      301 agttcttgaa actctgcaag agaaggggga aaggacaaac ccaaaccatc ctaccctttg
      361 gagaccagag tatgggagtt acatgattga agggacacca ggacagccct acggaggaac
      421 aatgtccgag ttcaatacag ttgaggccaa catgcgaaaa cgccggaagg aggctacttc
      481 tatattagaa gaaaatcagg ctctttgcac aataacttca tttcccagat taggctgtcc
      541 tgggttcaca ctgcccgagg tcaaacccaa cccagtggaa ggaggagctt ccaagtccct
      601 cttctttcca gatgaagcaa taaacaagca ccctcgcttc agtaccttaa caagaaatat
      661 ccgacatagg agaggagaaa aggttgtcat caatgtacca atatttaagg acaagaatac
      721 accatctcca tttatagaaa catttactga ggatgatgaa gcttcaaggg cttctaagcc
      781 ggatcatatt tacatggatg ccatgggatt tggaatgggc aattgctgtc tccaggtgac
      841 attccaagcc tgcagtatat ctgaggccag atacctttat gatcagttgg ctactatctg
      901 tccaattgtt atggctttga gtgctgcatc tcccttttac cgaggctatg tgtcagacat
      961 tgattgtcgc tggggagtga tttctgcatc tgtagatgat agaactcggg aggagcgagg
     1021 actggagcca ttgaagaaca ataactatag gatcagtaaa tcccgatatg actcaataga
     1081 cagctattta tctaagtgtg gtgagaaata taatgacatc gacttgacga tagataaaga
     1141 gatctacgaa cagctgttgc aggaaggcat tgatcatctc ctggcccagc atgttgctca
     1201 tctctttatt agagacccac tgacactgtt tgaagagaaa atacacctgg atgatgctaa
     1261 tgagtctgac cattttgaga atattcagtc cacaaattgg cagacaatga gatttaagcc
     1321 ccctcctcca aactcagaca ttggatggag agtagaattt cgacccatgg aggtgcaatt
     1381 aacagacttt gagaactctg cctatgtggt gtttgtggta ctgctcacca gagtgatcct
     1441 ttcctacaaa ttggattttc tcattccact gtcaaaggtt gatgagaaca tgaaggtagc
     1501 acagaaaaga gatgctgtct tgcagggaat gttttatttc aggaaagata tttgcaaagg
     1561 tggcaatgca gtggtggatg gttgtggcaa ggcccagaac agcacggagc tcgctgcaga
     1621 ggagtacacc ctcatgagca tagacaccat catcaatggg aaggaaggtg tgtttcctgg
     1681 actgatccca attctgaact cttaccttga aaacatggaa gtggatgtgg acaccagatg
     1741 tagtattctg aactacctaa agctaattaa gaagagagca tctggagaac taatgacagt
     1801 tgccagatgg atgagggagt ttatcgcaaa ccatcctgac tacaagcaag acagtgtcat
     1861 aactgatgaa atgaattata gccttatttt gaagtgtaac caaattgcaa atgaattatg
     1921 tgaatgccca gagttacttg gatcagcatt taggaaagta aaatatagtg gaagtaaaac
     1981 tgactcatcc aactagacat tctacagaaa gaaaaatgca ttattgacga actggctaca
     2041 gtaccatgcc tctcagccag cccgtgtgta taatatgaag accaaatgat agaactgtac
     2101 tgttttctgg gccagtgagc cagaaattga ttaaggcttt ctttggtagg taaatctaga
     2161 gtttatacag tgtacatgta catagtaaag tatttttgat taacaatgta ttttaataac
     2221 atatctaaag tcatcatgaa ctggcttgta catttttaaa ttcttactct ggagcaacct
     2281 actgtctaag cagttttgta aatgtactgg taattgtaca atacttgcat tccagagtta
     2341 aaatgtttac tgtaaatttt tgttctttta aagactacct gggacctgat ttattgaaat
     2401 ttttctcttt aaaaacattt tctctcgtta attttccttt gtcatttcct ttgttgtcta
     2461 cattaaatca cttgaatcca ttgaaagtgc ttcaagggta atcttgggtt tctagcacct
     2521 tatctatgat gtttcttttg caattggaat aatcacttgg tcaccttgcc ccaagctttc
     2581 ccctctgaat aaatacccat tgaactctga tggctgttat caaaggaact tttctttgtt
     2641 taaatttgct gatgcaggaa ttaagtttaa acacaactct atagaaagaa aggagattat
     2701 tacccagaat tcacatgtag tgattattaa ggacaatttt tttttttaac taaaaaagtt
     2761 ggtggcaggg gtggggggtg gcaatcattt ttcttcctat acatacaaag gatattgtca
     2821 aaatggcgtt cttctcttgt ggcctgttat tctgattgct gctgtataca gttttgtcac
     2881 tctttagttt ttagttaagc atactgatag actttcctct aaaagccatt cactccagat
     2941 tttacctggg gaatattcta catactgctt actttctcta taaaactcat caataaatca
     3001 tgaaaggcac tgagttttgt aaatcaggac cctaaatgtt taattgtaaa taagtttcag
     3061 ataattatta tagctttgcg ttgaagtttg ttgttttttt tctcaactag ttaagtcaac
     3121 tgcttctgaa ataactctgt attgtagatt atgcagatct ttacaggcat aaatatttaa
     3181 actgtaatat gctaacttga agagattgca ataaagctgc ttcagctaac cctgtttatg
     3241 tttaaatact agggtttgtt ctatatttta tacatgcatt ttggatgatt aaagaatgcc
     3301 tggttttcgt ttgcaatttg cttgtgtaaa tcaggttgta aaaaggcaga taaattgaaa
     3361 tgtttgtggt atgaggaaat aaaagaatgg aattagcttt cattcagaaa aaaaaaaaaa
     3421 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//