LOCUS BC039894 3466 bp mRNA linear HUM 15-JUL-2006 DEFINITION Homo sapiens glutamate-cysteine ligase, catalytic subunit, mRNA (cDNA clone MGC:47730 IMAGE:6052162), complete cds. ACCESSION BC039894 VERSION BC039894.1 KEYWORDS MGC. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3466) AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A. CONSRTM Mammalian Gene Collection Program Team TITLE Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002) PUBMED 12477932 REFERENCE 2 (bases 1 to 3466) CONSRTM NIH MGC Project TITLE Direct Submission JOURNAL Submitted (15-NOV-2002) National Institutes of Health, Mammalian Gene Collection (MGC), Bethesda, MD 20892-2590, USA REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov COMMENT Contact: MGC help desk Email: cgapbs-r@mail.nih.gov Tissue Procurement: ATCC cDNA Library Preparation: Life Technologies, Inc. cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL) DNA Sequencing by: National Institutes of Health Intramural Sequencing Center (NISC), Gaithersburg, Maryland; Web site: http://www.nisc.nih.gov/ Contact: nisc_mgc@nhgri.nih.gov Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B., Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S., Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P., Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R., Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C., McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W., Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L., Young,A., Zhang,L.-H. and Green,E.D. Clone distribution: MGC clone distribution information can be found through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov Series: IRAK Plate: 82 Row: o Column: 9 This clone was selected for full length sequencing because it passed the following selection criteria: matched mRNA gi: 45359851. FEATURES Location/Qualifiers source 1..3466 /db_xref="H-InvDB:HIT000052285" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /clone="MGC:47730 IMAGE:6052162" /tissue_type="Testis, embryonal carcinoma" /clone_lib="NIH_MGC_92" /lab_host="DH10B" /note="Vector: pCMV-SPORT6" gene 1..3466 /gene="GCLC" /gene_synonym="GCS" /db_xref="GeneID:2729" /db_xref="HGNC:HGNC:4311" /db_xref="MIM:606857" CDS 83..1996 /gene="GCLC" /gene_synonym="GCS" /codon_start=1 /product="glutamate-cysteine ligase, catalytic subunit" /protein_id="AAH39894.1" /db_xref="GeneID:2729" /db_xref="HGNC:HGNC:4311" /db_xref="MIM:606857" /translation="MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDV LKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMI EGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEV KPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFI ETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIV MALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDS YLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDA NESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTR VILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNST ELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRA SGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFR KVKYSGSKTDSSN" BASE COUNT 1072 a 643 c 748 g 1003 t ORIGIN 1 ccacgcgtcc gccgtctcgc gcccggagcg ggcgaccgcc gtcagcccgg aggaggagga 61 ggaggaggag gagggggcgg ccatggggct gctgtcccag ggctcgccgc tgagctggga 121 ggaaaccaag cgccatgccg accacgtgcg gcggcacggg atcctccagt tcctgcacat 181 ctaccacgcc gtcaaggacc ggcacaagga cgttctcaag tggggcgatg aggtggaata 241 catgttggta tcttttgatc atgaaaataa aaaagtccgg ttggtcctgt ctggggagaa 301 agttcttgaa actctgcaag agaaggggga aaggacaaac ccaaaccatc ctaccctttg 361 gagaccagag tatgggagtt acatgattga agggacacca ggacagccct acggaggaac 421 aatgtccgag ttcaatacag ttgaggccaa catgcgaaaa cgccggaagg aggctacttc 481 tatattagaa gaaaatcagg ctctttgcac aataacttca tttcccagat taggctgtcc 541 tgggttcaca ctgcccgagg tcaaacccaa cccagtggaa ggaggagctt ccaagtccct 601 cttctttcca gatgaagcaa taaacaagca ccctcgcttc agtaccttaa caagaaatat 661 ccgacatagg agaggagaaa aggttgtcat caatgtacca atatttaagg acaagaatac 721 accatctcca tttatagaaa catttactga ggatgatgaa gcttcaaggg cttctaagcc 781 ggatcatatt tacatggatg ccatgggatt tggaatgggc aattgctgtc tccaggtgac 841 attccaagcc tgcagtatat ctgaggccag atacctttat gatcagttgg ctactatctg 901 tccaattgtt atggctttga gtgctgcatc tcccttttac cgaggctatg tgtcagacat 961 tgattgtcgc tggggagtga tttctgcatc tgtagatgat agaactcggg aggagcgagg 1021 actggagcca ttgaagaaca ataactatag gatcagtaaa tcccgatatg actcaataga 1081 cagctattta tctaagtgtg gtgagaaata taatgacatc gacttgacga tagataaaga 1141 gatctacgaa cagctgttgc aggaaggcat tgatcatctc ctggcccagc atgttgctca 1201 tctctttatt agagacccac tgacactgtt tgaagagaaa atacacctgg atgatgctaa 1261 tgagtctgac cattttgaga atattcagtc cacaaattgg cagacaatga gatttaagcc 1321 ccctcctcca aactcagaca ttggatggag agtagaattt cgacccatgg aggtgcaatt 1381 aacagacttt gagaactctg cctatgtggt gtttgtggta ctgctcacca gagtgatcct 1441 ttcctacaaa ttggattttc tcattccact gtcaaaggtt gatgagaaca tgaaggtagc 1501 acagaaaaga gatgctgtct tgcagggaat gttttatttc aggaaagata tttgcaaagg 1561 tggcaatgca gtggtggatg gttgtggcaa ggcccagaac agcacggagc tcgctgcaga 1621 ggagtacacc ctcatgagca tagacaccat catcaatggg aaggaaggtg tgtttcctgg 1681 actgatccca attctgaact cttaccttga aaacatggaa gtggatgtgg acaccagatg 1741 tagtattctg aactacctaa agctaattaa gaagagagca tctggagaac taatgacagt 1801 tgccagatgg atgagggagt ttatcgcaaa ccatcctgac tacaagcaag acagtgtcat 1861 aactgatgaa atgaattata gccttatttt gaagtgtaac caaattgcaa atgaattatg 1921 tgaatgccca gagttacttg gatcagcatt taggaaagta aaatatagtg gaagtaaaac 1981 tgactcatcc aactagacat tctacagaaa gaaaaatgca ttattgacga actggctaca 2041 gtaccatgcc tctcagccag cccgtgtgta taatatgaag accaaatgat agaactgtac 2101 tgttttctgg gccagtgagc cagaaattga ttaaggcttt ctttggtagg taaatctaga 2161 gtttatacag tgtacatgta catagtaaag tatttttgat taacaatgta ttttaataac 2221 atatctaaag tcatcatgaa ctggcttgta catttttaaa ttcttactct ggagcaacct 2281 actgtctaag cagttttgta aatgtactgg taattgtaca atacttgcat tccagagtta 2341 aaatgtttac tgtaaatttt tgttctttta aagactacct gggacctgat ttattgaaat 2401 ttttctcttt aaaaacattt tctctcgtta attttccttt gtcatttcct ttgttgtcta 2461 cattaaatca cttgaatcca ttgaaagtgc ttcaagggta atcttgggtt tctagcacct 2521 tatctatgat gtttcttttg caattggaat aatcacttgg tcaccttgcc ccaagctttc 2581 ccctctgaat aaatacccat tgaactctga tggctgttat caaaggaact tttctttgtt 2641 taaatttgct gatgcaggaa ttaagtttaa acacaactct atagaaagaa aggagattat 2701 tacccagaat tcacatgtag tgattattaa ggacaatttt tttttttaac taaaaaagtt 2761 ggtggcaggg gtggggggtg gcaatcattt ttcttcctat acatacaaag gatattgtca 2821 aaatggcgtt cttctcttgt ggcctgttat tctgattgct gctgtataca gttttgtcac 2881 tctttagttt ttagttaagc atactgatag actttcctct aaaagccatt cactccagat 2941 tttacctggg gaatattcta catactgctt actttctcta taaaactcat caataaatca 3001 tgaaaggcac tgagttttgt aaatcaggac cctaaatgtt taattgtaaa taagtttcag 3061 ataattatta tagctttgcg ttgaagtttg ttgttttttt tctcaactag ttaagtcaac 3121 tgcttctgaa ataactctgt attgtagatt atgcagatct ttacaggcat aaatatttaa 3181 actgtaatat gctaacttga agagattgca ataaagctgc ttcagctaac cctgtttatg 3241 tttaaatact agggtttgtt ctatatttta tacatgcatt ttggatgatt aaagaatgcc 3301 tggttttcgt ttgcaatttg cttgtgtaaa tcaggttgta aaaaggcaga taaattgaaa 3361 tgtttgtggt atgaggaaat aaaagaatgg aattagcttt cattcagaaa aaaaaaaaaa 3421 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa //