LOCUS BC033756 2756 bp mRNA linear HUM 07-OCT-2003 DEFINITION Homo sapiens toll-like receptor 2, mRNA (cDNA clone MGC:45301 IMAGE:5213439), complete cds. ACCESSION BC033756 VERSION BC033756.1 KEYWORDS MGC. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2756) AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A. TITLE Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002) PUBMED 12477932 REFERENCE 2 (bases 1 to 2756) AUTHORS Strausberg,R. TITLE Direct Submission JOURNAL Submitted (02-JUL-2002) National Institutes of Health, Mammalian Gene Collection (MGC), Cancer Genomics Office, National Cancer Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590, USA REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov COMMENT Contact: MGC help desk Email: cgapbs-r@mail.nih.gov Tissue Procurement: Life Technologies, Inc. cDNA Library Preparation: Life Technologies, Inc. cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL) DNA Sequencing by: National Institutes of Health Intramural Sequencing Center (NISC), Gaithersburg, Maryland; Web site: http://www.nisc.nih.gov/ Contact: nisc_mgc@nhgri.nih.gov Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B., Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S., Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P., Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R., Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C., McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W., Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L., Young,A., Zhang,L.-H. and Green,E.D. Clone distribution: MGC clone distribution information can be found through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov Series: IRAK Plate: 68 Row: o Column: 16 This clone was selected for full length sequencing because it passed the following selection criteria: matched mRNA gi: 19718733. FEATURES Location/Qualifiers source 1..2756 /db_xref="H-InvDB:HIT000041939" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /clone="MGC:45301 IMAGE:5213439" /tissue_type="Blood, adult leukocytes" /clone_lib="NIH_MGC_118" /lab_host="DH10B" /note="Vector: pCMV-SPORT6" gene 1..2756 /gene="TLR2" /gene_synonym="TIL4" /db_xref="GeneID:7097" /db_xref="MIM:603028" CDS 151..2505 /gene="TLR2" /gene_synonym="TIL4" /codon_start=1 /product="TLR2 protein" /protein_id="AAH33756.1" /db_xref="GeneID:7097" /db_xref="MIM:603028" /translation="MPHTLWMVWVLGVIISLSKEESSNQASLSCDRNGICKGSSGSLN SIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSL EHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMD TFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFV DVTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQI SGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSL TERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTL ILRQNHLASLEKTGETLLTLKNLTNIDISKNSFHSMPETCQWPEKMKYLNLSSTRIHS VTGCIPKTLEILDVSNNNLNLFSLNLPQLKELYISRNKLMTLPDASLLPMLLVLKISR NAITTFSKEQLDSFHTLKTLEAGGNNFICSCEFLSFTQEQQALAKVLIDWPANYLCDS PSHVRGQQVQDVRLSVSECHRTALVSGMCCALFLLILLTGVLCHRFHGLWYMKMMWAW LQAKRKPRKAPSRNICYDAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDFIPG KWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPI EKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRAAIKS" misc_feature 1747..1908 /gene="TLR2" /gene_synonym="TIL4" /note="LRRCT; Region: Leucine rich repeat C-terminal domain" /db_xref="CDD:smart00082" misc_feature 2077..2502 /gene="TLR2" /gene_synonym="TIL4" /note="TIR; Region: TIR domain. The TIR domain is an intracellular signaling domain found in MyD88, interleukin 1 receptor and the Toll receptor. Called TIR (by SMART?) for Toll - Interleukin - Resistance" /db_xref="CDD:pfam01582" BASE COUNT 833 a 558 c 567 g 798 t ORIGIN 1 gagaaagcgc agccaggcgg ctgctcggcg ttctctcagg tgactgctcg gagttctccc 61 agtgtttggt gttgcaagca ggatccaaag gagacctata gtgactccca ggagctctta 121 gtgaccaagt gaaggttgaa gcactggaca atgccacata ctttgtggat ggtgtgggtc 181 ttgggggtca tcatcagcct ctccaaggaa gaatcctcca atcaggcttc tctgtcttgt 241 gaccgcaatg gtatctgcaa gggcagctca ggatctttaa actccattcc ctcagggctc 301 acagaagctg taaaaagcct tgacctgtcc aacaacagga tcacctacat tagcaacagt 361 gacctacaga ggtgtgtgaa cctccaggct ctggtgctga catccaatgg aattaacaca 421 atagaggaag attctttttc ttccctgggc agtcttgaac atttagactt atcctataat 481 tacttatcta atttatcgtc ttcctggttc aagccccttt cttctttaac attcttaaac 541 ttactgggaa atccttacaa aaccctaggg gaaacatctc ttttttctca tctcacaaaa 601 ttgcaaatcc tgagagtggg aaatatggac accttcacta agattcaaag aaaagatttt 661 gctggactta ccttccttga ggaacttgag attgatgctt cagatctaca gagctatgag 721 ccaaaaagtt tgaagtcaat tcagaacgta agtcatctga tccttcatat gaagcagcat 781 attttactgc tggagatttt tgtagatgtt acaagttccg tggaatgttt ggaactgcga 841 gatactgatt tggacacttt ccatttttca gaactatcca ctggtgaaac aaattcattg 901 attaaaaagt ttacatttag aaatgtgaaa atcaccgatg aaagtttgtt tcaggttatg 961 aaacttttga atcagatttc tggattgtta gaattagagt ttgatgactg tacccttaat 1021 ggagttggta attttagagc atctgataat gacagagtta tagatccagg taaagtggaa 1081 acgttaacaa tccggaggct gcatattcca aggttttact tattttatga tctgagcact 1141 ttatattcac ttacagaaag agttaaaaga atcacagtag aaaacagtaa agtttttctg 1201 gttccttgtt tactttcaca acatttaaaa tcattagaat acttggatct cagtgaaaat 1261 ttgatggttg aagaatactt gaaaaattca gcctgtgagg atgcctggcc ctctctacaa 1321 actttaattt taaggcaaaa tcatttggca tcattggaaa aaaccggaga gactttgctc 1381 actctgaaaa acttgactaa cattgatatc agtaagaata gttttcattc tatgcctgaa 1441 acttgtcagt ggccagaaaa gatgaaatat ttgaacttat ccagcacacg aatacacagt 1501 gtaacaggct gcattcccaa gacactggaa attttagatg ttagcaacaa caatctcaat 1561 ttattttctt tgaatttgcc gcaactcaaa gaactttata tttccagaaa taagttgatg 1621 actctaccag atgcctccct cttacccatg ttactagtat tgaaaatcag taggaatgca 1681 ataactacgt tttctaagga gcaacttgac tcatttcaca cactgaagac tttggaagct 1741 ggtggcaata acttcatttg ctcctgtgaa ttcctctcct tcactcagga gcagcaagca 1801 ctggccaaag tcttgattga ttggccagca aattacctgt gtgactctcc atcccatgtg 1861 cgtggccagc aggttcagga tgtccgcctc tcggtgtcgg aatgtcacag gacagcactg 1921 gtgtctggca tgtgctgtgc tctgttcctg ctgatcctgc tcacgggggt cctgtgccac 1981 cgtttccatg gcctgtggta tatgaaaatg atgtgggcct ggctccaggc caaaaggaag 2041 cccaggaaag ctcccagcag gaacatctgc tatgatgcat ttgtttctta cagtgagcgg 2101 gatgcctact gggtggagaa ccttatggtc caggagctgg agaacttcaa tccccccttc 2161 aagttgtgtc ttcataagcg ggacttcatt cctggcaagt ggatcattga caatatcatt 2221 gactccattg aaaagagcca caaaactgtc tttgtgcttt ctgaaaactt tgtgaagagt 2281 gagtggtgca agtatgaact ggacttctcc catttccgtc tttttgatga gaacaatgat 2341 gctgccattc tcattcttct ggagcccatt gagaaaaaag ccattcccca gcgcttctgc 2401 aagctgcgga agataatgaa caccaagacc tacctggagt ggcccatgga cgaggctcag 2461 cgggaaggat tttgggtaaa tctgagagct gcgataaagt cctaggttcc catatttaag 2521 accagtcttt gtctagttgg gatctttatg tcactagtta tagttaagtt cattcagaca 2581 taattatata aaaactacgt ggatgtaccg tcatttgagg acttgcttac taaaactaca 2641 aaacttcaaa ttttgtctgg ggtgctgttt tataaacata tgccagattt aaaaaaaaaa 2701 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa //