LOCUS       BC032657                4071 bp    mRNA    linear   HUM 17-JUL-2006
DEFINITION  Homo sapiens tousled-like kinase 1, mRNA (cDNA clone MGC:45427
            IMAGE:5532877), complete cds.
ACCESSION   BC032657
VERSION     BC032657.1
KEYWORDS    MGC.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4071)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
REFERENCE   2  (bases 1 to 4071)
  CONSRTM   NIH MGC Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-JUN-2002) National Institutes of Health, Mammalian
            Gene Collection (MGC), Bethesda, MD 20892-2590, USA
  REMARK    NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT     Contact: MGC help desk
            Email: cgapbs-r@mail.nih.gov
            Tissue Procurement: ATCC
            cDNA Library Preparation: Life Technologies, Inc.
            cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
            DNA Sequencing by: National Institutes of Health Intramural
            Sequencing Center (NISC),
            Gaithersburg, Maryland;
            Web site: http://www.nisc.nih.gov/
            Contact: nisc_mgc@nhgri.nih.gov
            Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
            Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
            Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
            Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
            Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
            McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
            Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
            Young,A., Zhang,L.-H. and Green,E.D.
            
            Clone distribution: MGC clone distribution information can be found
            through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
            Series: IRAK Plate: 69 Row: j Column: 11.
FEATURES             Location/Qualifiers
     source          1..4071
                     /db_xref="H-InvDB:HIT000041656"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="MGC:45427 IMAGE:5532877"
                     /tissue_type="Uterus, leiomyosarcoma"
                     /clone_lib="NIH_MGC_71"
                     /lab_host="DH10B"
                     /note="Vector: pCMV-SPORT6"
     gene            1..4071
                     /gene="TLK1"
                     /gene_synonym="KIAA0137"
                     /gene_synonym="PKU-BETA"
                     /db_xref="GeneID:9874"
                     /db_xref="HGNC:HGNC:11841"
                     /db_xref="MIM:608438"
     CDS             34..2334
                     /gene="TLK1"
                     /gene_synonym="KIAA0137"
                     /gene_synonym="PKU-BETA"
                     /codon_start=1
                     /product="tousled-like kinase 1"
                     /protein_id="AAH32657.1"
                     /db_xref="GeneID:9874"
                     /db_xref="HGNC:HGNC:11841"
                     /db_xref="MIM:608438"
                     /translation="MSVQSSSGSLEGPPSWSQLSTSPTPGSAAAARSLLNHTPPSGRP
                     REGAMDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLG
                     SLSDKESETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSP
                     VRGIPPAIRSPQNSHSHSTPSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTM
                     LKLAALESNKIQDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKK
                     LLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQ
                     QREDIERQRKLLAKRKPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLT
                     LAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHP
                     TLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACRE
                     YRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVM
                     QIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGM
                     DLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQD
                     ILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHMRR
                     SNSSGNLHMAGLTASPTPPSSSIITY"
BASE COUNT         1355 a          716 c          820 g         1180 t
ORIGIN      
        1 ccacgcgtcc gcgggttccc agaaagtagc ttgatgagtg tccaaagtag cagtggaagt
       61 ttggaggggc cgccatcttg gtcccagctc tccacgtctc caaccccggg ctcggcggcg
      121 gcggccaggt ccctgctgaa tcacacgccg ccatccggga ggcccaggga aggtgcaatg
      181 gatgagcttc atagtctgga tccaagaagg caagagttat tggaagctag atttactgga
      241 gttgcaagtg ggagcactgg aagtacgggc agttgcagtg ttggagctaa agcctcaaca
      301 aataacgaaa gctctaatca cagttttgga agcttgggat ctttaagtga caaagaatca
      361 gagacaccgg agaagaaaca atcggaatca tccaggggaa gaaagagaaa agcagaaaac
      421 cagaatgaaa gtagtcaggg aaaaagtatt gggggacgtg gccacaaaat tagcgactat
      481 tttgaatacc agggtggaaa tggctcaagt ccagtaagag gcatacctcc tgcaatccgt
      541 tctcctcaaa attcacattc acattccact ccttcctcat ctgttcgacc gaatagccct
      601 tctcctactg cattagcatt tggggaccac cctattgtac aaccaaagca attatccttt
      661 aaaattattc agactgatct cacaatgctg aaattagcag cattagaaag taataaaatc
      721 caggacctgg aaaagaagga gggacgtata gatgatttgc tcagggctaa ctgtgatctc
      781 agacggcaaa tagatgaaca acaaaaatta cttgaaaaat acaaagaacg attaaataag
      841 tgcatatcaa tgagcaagaa acttcttatt gaaaagagta cacaagaaaa gctgtcaagc
      901 agagagaaga gtatgcaaga tcgattacgc cttgggcact ttacaacagt tagacatggc
      961 gcttcattta ctgaacaatg gacagatggt tttgcatttc agaatcttgt gaagcaacaa
     1021 gaatgggtga atcagcaaag ggaagatatt gaaaggcaaa ggaaacttct agccaaacgc
     1081 aaacctccca cagctaataa ttctcaggca ccctctacca attctgaacc aaaacaaagg
     1141 aaaaacaaag cagtcaatgg agcagagaat gatccctttg ttagaccaaa tttaccacaa
     1201 ctgttgactt tggcagaata tcatgaacag gaagaaattt tcaaacttag actaggacat
     1261 ctcaaaaagg aagaggcaga aatccaggca gaacttgaac gtttggaaag agtcagaaat
     1321 cttcacatac gtgagctgaa aagaataaac aatgaagata attcacagtt caaagatcac
     1381 ccaacattaa atgaaagata tttattactt catctgcttg gtagaggtgg ctttagtgaa
     1441 gtgtataagg cttttgacct ttatgaacaa agatatgctg ctgtgaagat acatcagctt
     1501 aataaaagct ggagagatga gaagaaagaa aactaccaca aacatgcctg cagagagtat
     1561 agaatacaca aagaactgga tcaccccaga atagttaaac tctatgatta tttctccttg
     1621 gatacagata cgttttgtac agtgttagaa tactgtgaag gcaatgactt ggatttctat
     1681 ctgaagcaac acaagttaat gtcagagaaa gaagctcggt ctattgtaat gcagattgta
     1741 aatgcactaa gatatctcaa tgagatcaaa ccccctatta tacattatga tcttaagcca
     1801 ggaaacatcc tactggtaga tggaacagca tgtggtgaaa tcaaaatcac tgattttggt
     1861 ctgtccaaga ttatggatga tgatagctat ggtgtagatg gaatggatct aacttcccag
     1921 ggggcaggca cttactggta tttacctcct gagtgttttg tagttggaaa agagccacca
     1981 aagatttcca acaaggttga tgtatggtcg gttggagtca tcttctttca gtgtctttat
     2041 ggtagaaagc catttggtca caatcaatct caacaagaca ttcttcaaga aaatacaata
     2101 ttaaaagcca cagaagtcca gttccctgta aaaccggttg taagcagtga agccaaggca
     2161 tttataagac gctgtttggc atatcgaaaa gaagatcgat ttgatgtgca ccagctggca
     2221 aatgacccat accttctccc acacatgaga agatcaaatt cttcaggaaa cctacacatg
     2281 gctgggctga cagcatcccc tacaccccct tcttcaagca taattactta ctgactttcc
     2341 tccaagattg gcatgatatc tttgaatttg cttccagatg cacacttaag tttgagagca
     2401 tttgagtgtt tgttttcttt ttcttttttt tttttttttt ttttacacaa gacgtggtta
     2461 agaactgttt gtgaactgaa gttcctcata gtgtcatttg tatgagagag gatcatggac
     2521 aatgaataaa tgcacacttc tgactataat tttgagcagt gaaggaagga tgactgcctg
     2581 ttacacagaa acaggaatac catgttaaga tagaggaaaa aaattttgtt tatttggggg
     2641 aacactgtaa ataacgttta taatacttaa atacatttgg ttgttactag agagttctaa
     2701 tatgaagggt agtttttcat tatttaaaaa cacatggaaa aatatgagac atatttctaa
     2761 catacgaact atagtgcctg gatacattct tcagcatttg gcagttaatc tgctgaaacc
     2821 aaagtaagaa ctgaatgaca gtgacagttg tgttttatag taatagaatg tgagagttag
     2881 aatctttgga caaagttagg ctttgtcatt tgcctattca gacttttacc aagttgtacc
     2941 tcgagatcac atgtccgttt tctttcactg gttatattaa agggagagct attatttcta
     3001 aatactttac acctttgaca aaatgagctg cttgtgttga aatcagttga attcactaaa
     3061 ttataatatt gccagtgttt tcaacacgtt agaattgata acaggtattt ttcttttgtt
     3121 accaggcctt gttcatcaaa acaggtgaca gtgagtaacc aaatgcagac cagttctatg
     3181 caggataatg ataaattccc ttctagctct attgtaaatt gttgtacaga tgtcatattt
     3241 caattactaa gtttcagcag cttattcttg tacaaatgtt taaaatatgg cttttctaat
     3301 tggatattgt atttttttta agtcttcttg aaggcactct aattgctgct aaatgatgtt
     3361 gcttctttgc taaaaaatta aatgacctag aaggtgcaag ttgactgtac atcatagata
     3421 ttaaaaagca gacagtcatt aacaatcaag atgtaaaagt gatccatgtt ggacataatt
     3481 gagtttttaa atcagtttat tgggttctag ggctgtagaa cacatagata ctagattttt
     3541 aatttgttca tggttattct acatttctag aaagttctta tcagcaagat ggtcccataa
     3601 gcaaatttct tgtggtttgt acagatttgt taaaatgtga acgttttcta actgcctcgt
     3661 agggtagaaa ccaatatttt tcaggatgct gtatttcact cctgtaagga ctttttcttt
     3721 attgtcacat tcataatgct gatacttaca tgtaagttgt tcatgttgca gaaaaaggtt
     3781 atacgtacca cggattctct ttaatattgt acagttaaac tgtatttctg atgttgcaag
     3841 ccattttgtt ttttcattgt acatagacac attgtctctt taaaatgctg ctgaaattgt
     3901 agagagtata gccaaaacag taataaacaa tgacagttaa aatgtaaaga ctatgaaaat
     3961 tacattggaa gggagctttc aagatggtag gatattgact aactgagctc cttcacttaa
     4021 aaatcagctg aataaattcc ttaagtatac ttcaaaaaaa aaaaaaaaaa a
//