LOCUS BC028006 2580 bp mRNA linear HUM 06-OCT-2003
DEFINITION Homo sapiens inducible T-cell co-stimulator, mRNA (cDNA clone
MGC:39850 IMAGE:5212706), complete cds.
ACCESSION BC028006
VERSION BC028006.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2580)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2580)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (08-APR-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Life Technologies, Inc.
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 62 Row: g Column: 9
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 15029517.
FEATURES Location/Qualifiers
source 1..2580
/db_xref="H-InvDB:HIT000040401"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:39850 IMAGE:5212706"
/tissue_type="Blood, adult leukocytes"
/clone_lib="NIH_MGC_118"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..2580
/gene="ICOS"
/gene_synonym="AILIM"
/gene_synonym="MGC39850"
/db_xref="GeneID:29851"
/db_xref="MIM:604558"
CDS 36..542
/gene="ICOS"
/gene_synonym="AILIM"
/gene_synonym="MGC39850"
/codon_start=1
/product="ICOS protein"
/protein_id="AAH28006.1"
/db_xref="GeneID:29851"
/db_xref="MIM:604558"
/translation="MKSGLWYFFLFCLRIKVLTGEINGSANYEMFIFHNGGVQILCKY
PDIVQQFKMQLLKGGQILCDLTKTKGSGNTVSIKSLKFCHSQLSNNSVSFFLYNLDHS
HANYYFCNLSIFDPPPFKVTLTGGYLHIYESQLCCQLKFWLPIGCAAFVVVCILGCIL
ICWLTKKM"
BASE COUNT 759 a 528 c 492 g 801 t
ORIGIN
1 ctgaacgcga ggactgttaa ctgtttctgg caaacatgaa gtcaggcctc tggtatttct
61 ttctcttctg cttgcgcatt aaagttttaa caggagaaat caatggttct gccaattatg
121 agatgtttat atttcacaac ggaggtgtac aaattttatg caaatatcct gacattgtcc
181 agcaatttaa aatgcagttg ctgaaagggg ggcaaatact ctgcgatctc actaagacaa
241 aaggaagtgg aaacacagtg tccattaaga gtctgaaatt ctgccattct cagttatcca
301 acaacagtgt ctcttttttt ctatacaact tggaccattc tcatgccaac tattacttct
361 gcaacctatc aatttttgat cctcctcctt ttaaagtaac tcttacagga ggatatttgc
421 atatttatga atcacaactt tgttgccagc tgaagttctg gttacccata ggatgtgcag
481 cctttgttgt agtctgcatt ttgggatgca tacttatttg ttggcttaca aaaaagatgt
541 gaccctataa tatggaactc tggcacccag gcatgaagca cgttggccag ttttcctcaa
601 cttgaagtgc aagattctct tatttccggg accacggaga gtctgactta actacataca
661 tcttctgctg gtgttttgtt caatctggaa gaatgactgt atcagtcaat ggggatttta
721 acagactgcc ttggtactgc cgagtcctct caaaacaaac accctcttgc aaccagcttt
781 ggagaaagcc cagctcctgt gtgctcactg ggagtggaat ccctgtctcc acatctgctc
841 ctagcagtgc atcagccagt aaaacaaaca catttacaag aaaaatgttt taaagatgcc
901 aggggtactg aatctgcaaa gcaaatgagc agccaaggac cagcatctgt ccgcatttca
961 ctatcatact acctcttctt tctgtaggga tgagaattcc tcttttaatc agtcaaggga
1021 gatgcttcaa agctggagct attttatttc tgagatgttg atgtgaactg tacattagta
1081 catactcagt actctccttc aattgctgaa ccccagttga ccattttacc aagactttag
1141 atgctttctt gtgccctcaa ttttcttttt aaaaatactt ctacatgact gcttgacagc
1201 ccaacagcca ctctcaatag agagctatgt cttacattct ttcctctgct gctcaatagt
1261 tttatatatc tatgcataca tatatacaca catatgtata taaaattcat aatgaatata
1321 tttgcctata ttctccctac aagaatattt ttgctccaga aagacatgtt cttttctcaa
1381 attcagttaa aatggtttac tttgttcaag ttagtggtag gaaacattgc ccggaattga
1441 aagcaaattt attttattat cctattttct accattatct atgttttcat ggtgctatta
1501 attacaagtt tagttctttt tgtagatcat attaaaattg caaacaaaat catctttaat
1561 gggccagcat tctcatgggg tagagcagaa tattcattta gcctgaaagc tgcagttact
1621 ataggttgct gtcagactat acccatggtg cctctgggct tgacaggtca aaatggtccc
1681 catcagcctg gagcagccct ccagacctgg gtggaattcc agggttgaga gactcccctg
1741 agccagaggc cactaggtat tcttgctccc agaggctgaa gtcaccctgg gaatcacagt
1801 ggtctacctg cattcataat tccaggatct gtgaagagca catatgtgtc agggcacaat
1861 tccctctcat aaaaaccaca cagcctggaa attggccctg gcccttcaag atagccttct
1921 ttagaatatg atttggctag aaagattctt aaatatgtgg aatatgatta ttcttagctg
1981 gaatattttc tctacttcct gtctgcatgc ccaaggcttc tgaagcagcc aatgtcgatg
2041 caacaacatt tgtaacttta ggtaaactgg gattatgttg tagtttaaca ttttgtaact
2101 gtgtgcttat agtttacaag tgagacccga tatgtcatta tgcatactta tattatctta
2161 agcatgtgta atgctggatg tgtacagtac agtactgaac ttgtaatttg aatctagtat
2221 ggtgttctgt tttcagctga cttggacaac ctgactggct ttgcacaggt gttccctgag
2281 ttgtttgcag gtttctgtgt gtggggtggg gtatggggag gagaaccttc atggtggccc
2341 acctggcctg gttgtccaag ctgtgcctcg acacatcctc atccccagca tgggacacct
2401 caagatgaat aataattcac aaaatttctg tgaaatcaaa tccagtttta agaggagcca
2461 cttatcaaag agattttaac agtagtaaga aggcaaagaa taaacatttg atattcagca
2521 actgaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//