LOCUS       BC018122                3574 bp    mRNA    linear   HUM 15-JUL-2006
DEFINITION  Homo sapiens thioredoxin reductase 1, mRNA (cDNA clone MGC:9145
            IMAGE:3883490), complete cds.
ACCESSION   BC018122
VERSION     BC018122.1
KEYWORDS    MGC.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3574)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
REFERENCE   2  (bases 1 to 3574)
  CONSRTM   NIH MGC Project
  TITLE     Direct Submission
  JOURNAL   Submitted (03-DEC-2001) National Institutes of Health, Mammalian
            Gene Collection (MGC), Bethesda, MD 20892-2590, USA
  REMARK    NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT     Contact: MGC help desk
            Email: cgapbs-r@mail.nih.gov
            Tissue Procurement: DCTD/DTP/Gazdar
            cDNA Library Preparation: Life Technologies, Inc.
            cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
            DNA Sequencing by: Sequencing Group at the Stanford Human Genome
            Center, Stanford University School of Medicine, Stanford, CA  94305
            Web site:       http://www-shgc.stanford.edu
            Contact:  (Dickson, Mark) mcd@paxil.stanford.edu
            Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
            R. M.
            
            Clone distribution: MGC clone distribution information can be found
            through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
            Series: IRAK Plate: 22 Row: a Column: 14
            This clone was selected for full length sequencing because it
            passed the following selection criteria: matched mRNA gi: 33519429.
FEATURES             Location/Qualifiers
     source          1..3574
                     /db_xref="H-InvDB:HIT000038280"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="MGC:9145 IMAGE:3883490"
                     /tissue_type="Lung, large cell carcinoma"
                     /clone_lib="NIH_MGC_68"
                     /lab_host="DH10B"
                     /note="Vector: pCMV-SPORT6"
     gene            1..3574
                     /gene="TXNRD1"
                     /gene_synonym="GRIM-12"
                     /gene_synonym="MGC9145"
                     /gene_synonym="TR"
                     /gene_synonym="TR1"
                     /gene_synonym="TRXR1"
                     /gene_synonym="TXNR"
                     /db_xref="GeneID:7296"
                     /db_xref="HGNC:HGNC:12437"
                     /db_xref="MIM:601112"
     CDS             188..1687
                     /gene="TXNRD1"
                     /gene_synonym="GRIM-12"
                     /gene_synonym="MGC9145"
                     /gene_synonym="TR"
                     /gene_synonym="TR1"
                     /gene_synonym="TRXR1"
                     /gene_synonym="TXNR"
                     /codon_start=1
                     /transl_except=(pos:1679..1681,aa:Sec)
                     /product="thioredoxin reductase 1"
                     /protein_id="AAH18122.2"
                     /db_xref="GeneID:7296"
                     /db_xref="HGNC:HGNC:12437"
                     /db_xref="MIM:601112"
                     /translation="MNGPEDLPKSYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFV
                     TPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQALQDSRNYGWKVEETVKHDWDRMI
                     EAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEKIYSAERFLIA
                     TGERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLAGIGLDVTV
                     MVRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVVAQSTNS
                     EEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYIYAIGD
                     ILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEEKAVE
                     KFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKIICNTKDNERVVGFHVLGPNAGEVTQ
                     GFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGCUG"
BASE COUNT         1008 a          675 c          843 g         1048 t
ORIGIN      
        1 cctgaaggag ggcctgatgt cttcatcatt ctcaaattct taggacggtc gggccctgga
       61 aggaacgctc tcggaattgg ccgcggaaac cgatctgccc gttgtgtttg tgaaacagag
      121 aaagataggc ggccatggtc caaccttgaa ggcttatcag gagggcagac ttcaaaagct
      181 actaaaaatg aacggccctg aagatcttcc caagtcctat gactatgacc ttatcatcat
      241 tggaggtggc tcaggaggtc tggcagctgc taaggaggca gcccaatatg gcaagaaggt
      301 gatggtcctg gactttgtca ctcccacccc tcttggaact agatggggtc ttggaggaac
      361 atgtgtgaat gtgggttgca tacctaaaaa actgatgcat caagcagctt tgttaggaca
      421 agccctgcaa gactctcgaa attatggatg gaaagtcgag gagacagtta agcatgattg
      481 ggacagaatg atagaagctg tacagaatca cattggctct ttgaattggg gctaccgagt
      541 agctctgcgg gagaaaaaag tcgtctatga gaatgcttat gggcaattta ttggtcctca
      601 caggattaag gcaacaaata ataaaggcaa agaaaaaatt tattcagcag agagatttct
      661 cattgccact ggtgaaagac cacgttactt gggcatccct ggtgacaaag aatactgcat
      721 cagcagtgat gatcttttct ccttgcctta ctgcccgggt aagaccctgg ttgttggagc
      781 atcctatgtc gctttggagt gcgctggatt tcttgctggt attggtttag acgtcactgt
      841 tatggttagg tccattcttc ttagaggatt tgaccaggac atggccaaca aaattggtga
      901 acacatggaa gaacatggca tcaagtttat aagacagttc gtaccaatta aagttgaaca
      961 aattgaagca gggacaccag gccgactcag agtagtagct cagtccacca atagtgagga
     1021 aatcattgaa ggagaatata atacggtgat gctggcaata ggaagagatg cttgcacaag
     1081 aaaaattggc ttagaaaccg taggggtgaa gataaatgaa aagactggaa aaatacctgt
     1141 cacagatgaa gaacagacca atgtgcctta catctatgcc attggcgata tattggagga
     1201 taaggtggag ctcaccccag ttgcaatcca ggcaggaaga ttgctggctc agaggctcta
     1261 tgcaggttcc actgtcaagt gtgactatga aaatgttcca accactgtat ttactccttt
     1321 ggaatatggt gcttgtggcc tttctgagga gaaagctgtg gagaagtttg gggaagaaaa
     1381 tattgaggtt taccatagtt acttttggcc attggaatgg acgattccgt caagagataa
     1441 caacaaatgt tatgcaaaaa taatctgtaa tactaaagac aatgaacgtg ttgtgggctt
     1501 tcacgtactg ggtccaaatg ctggagaagt tacacaaggc tttgcagctg cgctcaaatg
     1561 tggactgacc aaaaagcagc tggacagcac aattggaatc caccctgtct gtgcagaggt
     1621 attcacaaca ttgtctgtga ccaagcgctc tggggcaagc atcctccagg ctggctgctg
     1681 aggttaagcc ccagtgtgga tgctgttgcc aagactgcaa accactggct cgtttccgtg
     1741 cccaaatcca aggcgaagtt ttctagaggg ttcttgggct cttggcacct gcgtgtcttg
     1801 tgcttaccac cgcccaaggc ccccttggat ctcttggata ggagttggtg aatagaaggc
     1861 aggcagcatc acactggggt cactgacaga cttgaagctg acatttggca gggcatcgaa
     1921 gggatgcatc catgaagtca ccagtctcaa gcccatgtgg taggcggtga tggaacaact
     1981 gtcaaatcag ttttagcatg acctttcctt gtggattttc ttattctcgt tgtcaagttt
     2041 tctagggttg aatttttttc ttttttctcc atggtgttaa tgatattaga gatgaaaaac
     2101 gttagcagtt gatttttgtc caaaagcaag tcatggctag agtatccatg caaggtgtct
     2161 tgttgcatgg aagggatagt ttggctccct tggaggctat gtaggcttgt cccgggaaag
     2221 agaactgtcc tgcagctgaa atggactgtt ctttactgac ctgctcagca gtttcttctc
     2281 tcatatattc ccaaaacaag tacatctgcg atcaactcta gccaaatttg cccctgtgtg
     2341 ctacatgatg gatgattatt attttaaggt ctgtttagga agggaaatgg ctacttggcc
     2401 agccattgcc tggcatttgg tagtatagta tgattctcac cattatttgt catggaggca
     2461 gacatacacc agaaatgggg gagaaacagt acatatcttt ctgtctttag tttattgtgt
     2521 gctggtctaa gcaagctgag atcatttgca atggaaaaca cgtaacttgt ttaaaagttt
     2581 ttctggtagc tttagcttta tgctaaaaaa aataatgaca ttgggtatct atttctttct
     2641 aagactacat tagtaggaaa ataagtcttt tcatgcttat gatttagctg ttttgtggta
     2701 attgcttttt aaaggaagtt attaatatca taagttatta ttaatatttt gaacacaggt
     2761 ggatgtgaag gattttcatt taaaaaccaa gtggttttga ctttttctgt tgaatgaaca
     2821 actgtgcctt gtggaatttt tgcagaagtg tttatgcttt gttagcattt caacttgcat
     2881 tattataaag aggtattaat gcctcagtta tgtgtttgtc aatgtactgg ctgaggattc
     2941 tatctcagct gtcttttcta actgtgtagg ttgagttttg aacacgtgct tgtggacatc
     3001 aggcctcctg ccagcagttc ttgaagcttc tttttcattc ctgctactct acctgtattt
     3061 ctcagttgca gcactgagtg gtcaaaatac atttctgggc cacctcaggg aacccatgca
     3121 tctgcctggc atttaggcag cagagcccct gaccgtcccc cacagggctc tgcctcacgt
     3181 cctcatctca tttggctgtg taaagaaatg ggaaaaggga aaaggagaga gcaattgagg
     3241 cagttgacca tattcagttt tatttattta tttttaattt gtttttttct ccaagtccac
     3301 cagtctctga aattagaaca gtaggcggta tgagataatc aggcctaatc atgttgtgat
     3361 tctcttttct tagtggagtg gaatgttcta tccccacaag aaggattata tcttatagac
     3421 ttgtcttgtt cagattctgt atttacccat tttattgaaa catatactaa gttccatgta
     3481 tttttgttac aaatcttctg aaaaaaaaca aaacaatgtg aaacattaaa attaaaaggc
     3541 attaataata aaaaaaaaaa aaaaaaaaaa aaaa
//