LOCUS       BC015620                2586 bp    mRNA    linear   HUM 16-SEP-2003
DEFINITION  Homo sapiens actinin, alpha 4, mRNA (cDNA clone IMAGE:4843317),
            partial cds.
ACCESSION   BC015620
VERSION     BC015620.2
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2586)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
REFERENCE   2  (bases 1 to 2586)
  AUTHORS   Strausberg,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-OCT-2001) National Institutes of Health, Mammalian
            Gene Collection (MGC), Cancer Genomics Office, National Cancer
            Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
            USA
  REMARK    NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT     On Aug 19, 2003 this sequence version replaced BC015620.1.
            Contact: MGC help desk
            Email: cgapbs-r@mail.nih.gov
            Tissue Procurement: ATCC
            cDNA Library Preparation: Rubin Laboratory
            cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
            DNA Sequencing by: National Institutes of Health Intramural
            Sequencing Center (NISC),
            Gaithersburg, Maryland;
            Web site: http://www.nisc.nih.gov/
            Contact: nisc_mgc@nhgri.nih.gov
            Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
            Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
            Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
            Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
            Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
            McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
            Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
            Young,A., Zhang,L.-H. and Green,E.D.
            
            Clone distribution: MGC clone distribution information can be found
            through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
            Series: IRAL Plate: 33 Row: o Column: 3.
FEATURES             Location/Qualifiers
     source          1..2586
                     /db_xref="H-InvDB:HIT000088751"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="IMAGE:4843317"
                     /tissue_type="Eye, normal, pigmented retinal epithelium"
                     /clone_lib="NIH_MGC_43"
                     /lab_host="DH10B-R"
                     /note="Vector: pOTB7"
     gene            <1..2586
                     /gene="ACTN4"
                     /gene_synonym="FSGS"
                     /gene_synonym="FSGS1"
                     /db_xref="GeneID:81"
                     /db_xref="MIM:604638"
     CDS             <1..1906
                     /gene="ACTN4"
                     /gene_synonym="FSGS"
                     /gene_synonym="FSGS1"
                     /codon_start=2
                     /product="ACTN4 protein"
                     /protein_id="AAH15620.2"
                     /db_xref="GeneID:81"
                     /db_xref="MIM:604638"
                     /translation="ANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVP
                     QKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKM
                     VSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLK
                     HRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRC
                     QKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQD
                     MFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPY
                     TTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKM
                     EEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNY
                     TMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDKDHGGAL
                     GPEEFKACLISLGYDVENDRQGEAEFNRIMSLVDPNHSGLVTFQAFIDFMSRETTDTD
                     TADQVIASFKVLAGDKNFITAEELRRELPPDQAEYCIARMAPYQGPDAVPGALDYKSF
                     STALYGESDL"
     misc_feature    47..379
                     /gene="ACTN4"
                     /gene_synonym="FSGS"
                     /gene_synonym="FSGS1"
                     /note="spectrin; Region: Spectrin repeat. Spectrin repeats
                     are found in several proteins involved in cytoskeletal
                     structure. These include spectrin, alpha-actinin and
                     dystrophin. The sequence repeat used in this family is
                     taken from the structural repeat in reference. The
                     spectrin repeat forms a three helix bundle. The second
                     helix is interrupted by proline in some sequences. The
                     repeats are defined by a characteristic tryptophan (W)
                     residue at position 17 in helix A and a leucine (L) at 2
                     residues from the carboxyl end of helix C"
                     /db_xref="CDD:pfam00435"
     misc_feature    407..721
                     /gene="ACTN4"
                     /gene_synonym="FSGS"
                     /gene_synonym="FSGS1"
                     /note="spectrin; Region: Spectrin repeat. Spectrin repeats
                     are found in several proteins involved in cytoskeletal
                     structure. These include spectrin, alpha-actinin and
                     dystrophin. The sequence repeat used in this family is
                     taken from the structural repeat in reference. The
                     spectrin repeat forms a three helix bundle. The second
                     helix is interrupted by proline in some sequences. The
                     repeats are defined by a characteristic tryptophan (W)
                     residue at position 17 in helix A and a leucine (L) at 2
                     residues from the carboxyl end of helix C"
                     /db_xref="CDD:pfam00435"
     misc_feature    1454..1783
                     /gene="ACTN4"
                     /gene_synonym="FSGS"
                     /gene_synonym="FSGS1"
                     /note="FRQ1; Region: COG5126, FRQ1, Ca2+-binding protein
                     (EF-Hand superfamily) [Signal transduction mechanisms /
                     Cytoskeleton / Cell division and chromosome partitioning /
                     General function prediction only]"
                     /db_xref="CDD:COG5126"
BASE COUNT          597 a          840 c          741 g          408 t
ORIGIN      
        1 cgccaaccgg atctgtaagg tgctggctgt caaccaagag aacgagcacc tgatggagga
       61 ctacgagaag ctggccagcg acctcctgga gtggatccgg cgcaccatcc cctggctgga
      121 ggaccgtgtg ccccaaaaga ctatccagga gatgcagcag aagctggagg acttccgcga
      181 ctaccggcgt gtgcacaagc cgcccaaggt gcaggagaag tgccagctgg agatcaactt
      241 caacacgctg cagaccaagc tgcgcctcag caaccggccc gccttcatgc cctccgaggg
      301 caagatggtc tcggacatca acaatggctg gcagcacttg gagcaggctg agaagggcta
      361 cgaggagtgg ctgctgaatg agatccgcag gctggagcgg ctcgaccacc tggcagagaa
      421 gttccggcag aaggcctcca tccacgaggc ctggactgac gggaaggaag ccatgctgaa
      481 gcaccgggac tacgagacgg ccacactatc ggacatcaaa gccctcattc gcaagcacga
      541 ggccttcgag agcgacctgg ctgcgcacca ggaccgcgtg gagcagatcg ccgccattgc
      601 ccaggagctc aacgagctgg attactacga ctcccacaat gtcaacaccc ggtgccagaa
      661 gatctgtgac cagtgggacg ccctcggctc tctgacacat agtcgcaggg aagccctgga
      721 gaaaacagag aagcagctgg aggccatcga ccagctgcac ctggaatacg ccaagcgcgc
      781 ggcccccttc aacaactgga tggagagcgc catggaggac ctccaggaca tgttcatcgt
      841 ccataccatc gaggagattg agggcctgat ctcagcccat gaccagttca agtccaccct
      901 gccggacgcc gatagggagc gcgaggccat cctggccatc cacaaggagg cccagaggat
      961 cgctgagagc aaccacatca agctgtcggg cagcaacccc tacaccaccg tcaccccgca
     1021 aatcatcaac tccaagtggg agaaggtgca gcagctggtg ccaaaacggg accatgccct
     1081 cctggaggag cagagcaagc agcagtccaa cgagcacctg cgccgccagt tcgccagcca
     1141 ggccaatgtt gtggggccct ggatccagac caagatggag gagatcgggc gcatctccat
     1201 tgagatgaac gggaccctgg aggaccagct gagccacctg aagcagtatg aacgcagcat
     1261 cgtggactac aagcccaacc tggacctgct ggagcagcag caccagctca tccaggaggc
     1321 cctcatcttc gacaacaagc acaccaacta taccatggag cacatccgcg tgggctggga
     1381 gcagctgctc accaccattg cccgcaccat caacgaggtg gagaaccaga tcctcacccg
     1441 cgacgccaag ggcatcagcc aggagcagat gcaggagttc cgggcgtcct tcaaccactt
     1501 cgacaaggat catggcgggg cgctggggcc cgaggagttc aaggcctgcc tcatcagcct
     1561 gggctacgac gtggagaacg accggcaggg tgaggccgag ttcaaccgca tcatgagcct
     1621 ggtcgacccc aaccatagcg gccttgtgac cttccaagcc ttcatcgact tcatgtcgcg
     1681 ggagaccacc gacacggaca cggctgacca ggtcatcgct tccttcaagg tcctagcagg
     1741 ggacaagaac ttcatcacag ctgaggagct gcggagagag ctgccccccg accaggccga
     1801 gtactgcatc gcccgcatgg cgccatacca gggccctgac gccgtgcccg gtgccctcga
     1861 ctacaagtcc ttctccacgg ccttgtatgg cgagagcgac ctgtgaggcc ccagagacct
     1921 gacccaacac ccccgacggc ctccaggagg ggcctgggca gccccacagt cccattcctc
     1981 cactctgtat ctatgcaaag cactctctgc agtcctccgg ggtgggtggg tgggcaggga
     2041 ggggctgggg caggctctct cctctctctc tttgtgggtt ggccaggagg ttcccccgac
     2101 caggttgggg agacttgggg ccagcgcttc tggtctggta aatatgtatg atgtgttgtg
     2161 cttttttaac caaggagggg ccagtggatt cccacagcac aaccggtccc ttccatgccc
     2221 tgggatgcct caccacaccc aggtctcttc ctttgctctg aggtcccttc aaggcctccc
     2281 caatccaggc caaagcccca tgtgccttgt ccaggaactg cctgggccat gcgaggggcc
     2341 agcagagggc gccaccacca cctgacggct ggggacccac ccagcccctc tcccctctct
     2401 gctccagact cacttgccat tgccaggaga tggccccaac aagcaccccg cttttgcagc
     2461 agaggagctg agttggcaga ccgggccccc ctgaaccgca ccccatccca ccagccccgg
     2521 ccttgctttg tctggcctca cgtgtctcag attttctaag aaccaaaaaa aaaaaaaaaa
     2581 aaaaaa
//