LOCUS BC014158 3076 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens SHC (Src homology 2 domain containing) transforming
protein 1, mRNA (cDNA clone MGC:20839 IMAGE:4541216), complete cds.
ACCESSION BC014158
VERSION BC014158.2
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3076)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3076)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (10-SEP-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Aug 20, 2003 this sequence version replaced BC014158.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 30 Row: e Column: 8
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 34147725.
FEATURES Location/Qualifiers
source 1..3076
/db_xref="H-InvDB:HIT000036552"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:20839 IMAGE:4541216"
/tissue_type="Placenta, choriocarcinoma"
/clone_lib="NIH_MGC_21"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..3076
/gene="SHC1"
/gene_synonym="p52SHC"
/gene_synonym="p66"
/gene_synonym="p66SHC"
/gene_synonym="SHCA"
/db_xref="GeneID:6464"
/db_xref="HGNC:HGNC:10840"
/db_xref="MIM:600560"
CDS 121..1545
/gene="SHC1"
/gene_synonym="p52SHC"
/gene_synonym="p66"
/gene_synonym="p66SHC"
/gene_synonym="SHCA"
/codon_start=1
/product="SHC (Src homology 2 domain containing)
transforming protein 1"
/protein_id="AAH14158.1"
/db_xref="GeneID:6464"
/db_xref="HGNC:HGNC:10840"
/db_xref="MIM:600560"
/translation="MNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDK
VMGPGVSYLVRYMGCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPC
SRPLSSILGRSNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDT
AEYVAYVAKDPVNQRACHILECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDR
MAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMRLREGAAPGAARPTAPNAQT
PSHLGATLPVGQPVGGDPEVRKQMPPPPPCPAGRELFDDPSYVNVQNLDKARQAVGGA
GPPNPAINGSAPRDLFDMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEAL
LQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHRFESVSHLISYH
MDNHLPIISAGSELCLQQPVERKL"
BASE COUNT 682 a 862 c 826 g 706 t
ORIGIN
1 gtttctccag ggaggcaggg cccggggaga aagttggagc ggtaacctaa gctggcagtg
61 gcgtgatccg gcaccaaatc ggcccgcggt gcggtgcgga gactccatga ggccctggac
121 atgaacaagc tgagtggagg cggcgggcgc aggactcggg tggaaggggg ccagcttggg
181 ggcgaggagt ggacccgcca cgggagcttt gtcaataagc ccacgcgggg ctggctgcat
241 cccaacgaca aagtcatggg acccggggtt tcctacttgg ttcggtacat gggttgtgtg
301 gaggtcctcc agtcaatgcg tgccctggac ttcaacaccc ggactcaggt caccagggag
361 gccatcagtc tggtgtgtga ggctgtgccg ggtgctaagg gggcgacaag gaggagaaag
421 ccctgtagcc gcccgctcag ctctatcctg gggaggagta acctgaaatt tgctggaatg
481 ccaatcactc tcaccgtctc caccagcagc ctcaacctca tggccgcaga ctgcaaacag
541 atcatcgcca accaccacat gcaatctatc tcatttgcat ccggcgggga tccggacaca
601 gccgagtatg tcgcctatgt tgccaaagac cctgtgaatc agagagcctg ccacattctg
661 gagtgtcccg aagggcttgc ccaggatgtc atcagcacca ttggccaggc cttcgagttg
721 cgcttcaaac aatacctcag gaacccaccc aaactggtca cccctcatga caggatggct
781 ggctttgatg gctcagcatg ggatgaggag gaggaagagc cacctgacca tcagtactat
841 aatgacttcc cggggaagga accccccttg gggggggtgg tagacatgag gcttcgggaa
901 ggagccgctc caggggctgc tcgacccact gcacccaatg cccagacccc cagccacttg
961 ggagctacat tgcctgtagg acagcctgtt gggggagatc cagaagtccg caaacagatg
1021 ccacctccac caccctgtcc agcaggcaga gagctttttg atgatccctc ctatgtcaac
1081 gtccagaacc tagacaaggc ccggcaagca gtgggtggtg ctgggccccc caatcctgct
1141 atcaatggca gtgcaccccg ggacctgttt gacatgaagc ccttcgaaga tgctcttcgc
1201 gtgcctccac ctccccagtc ggtgtccatg gctgagcagc tccgagggga gccctggttc
1261 catgggaagc tgagccggcg ggaggctgag gcactgctgc agctcaatgg ggacttcctg
1321 gtacgggaga gcacgaccac acctggccag tatgtgctca ctggcttgca gagtgggcag
1381 cctaagcatt tgctactggt ggaccctgag ggtgtggttc ggactaagga tcaccgcttt
1441 gaaagtgtca gtcaccttat cagctaccac atggacaatc acttgcccat catctctgcg
1501 ggcagcgaac tgtgtctaca gcaacctgtg gagcggaaac tgtgatctgc cctagcgctc
1561 tcttccagaa gatgccctcc aatcctttcc accctattcc ctaactctcg ggacctcgtt
1621 tgggagtgtt ctgtgggctt ggccttgtgt cagagctggg agtagcatgg actctgggtt
1681 tcatatccag ctgagtgaga gggtttgagt caaaagcctg ggtgagaatc ctgcctctcc
1741 ccaaacatta atcaccaaag tattaatgta cagagtggcc cctcacctgg gcctttcctg
1801 tgccaacctg atgccccttc cccaagaagg tgagtgcttg tcatggaaaa tgtcctgtgg
1861 tgacaggccc agtggaacag tcacccttct gggcaagggg gaacaaatca cacctctggg
1921 cttcagggta tcccagaccc ctctcaacac ccgccccccc catgtttaaa ctttgtgcct
1981 ttgaccatct cttaggtcta atgatatttt atgcaaacag ttcttggacc cctgaattca
2041 atgacaggga tgccaacacc ttcttggctt ctgggacctg tgttcttgct gagcaccctc
2101 tccggtttgg gttgggataa cagaggcagg agtggcagct gtcccctctc cctggggata
2161 tgcaaccctt agagattgcc ccagagcccc actcccggcc aggcgggaga tggacccctc
2221 ccttgctcag tgcctcctgg ccggggcccc tcaccccaag gggtctgtat atacatttca
2281 taaggcctgc cctcccatgt tgcatgccta tgtactctac gccaaagtgc agcccttcct
2341 cctgaagcct ctgccctgcc tccctttctg ggagggcggg gtgggggtga ctgaatttgg
2401 gcctcttgta cagttaactc tcccaggtgg attttgtgga ggtgagaaaa ggggcattga
2461 gactataaag cagtagacaa tccccacata ccatctgtag agttggaact gcattctttt
2521 aaagttttat atgcatatat tttagggctg tagacttact ttcctatttt cttttccatt
2581 gcttattctt gagcacaaaa tgataatcaa ttattacatt tatacatcac ctttttgact
2641 tttccaagcc cttttacagc tcttggcatt ttcctcgcct aggcctgtga ggtaactggg
2701 atcgcacctt ttataccaga gacctgaggc agatgaaatt tatttccatc taggactaga
2761 aaaacttggg tctcttaccg cgagactgag aggcagaagt cagcccgaat gcctgtcagt
2821 ttcatggagg ggaaacgcaa aacctgcagt tcctgagtac cttctacagg cccggcccag
2881 cctaggcccg gggtggccac accacagcaa gccggccccc cctcttttgg ccttgtggat
2941 aagggagagt tgaccgtttt catcctggcc tccttttgct gtttggatgt ttccacgggt
3001 ctcacttata ccaaagggaa aactcttcat taaagtccgt atttcttcta aaaaaaaaaa
3061 aaaaaaaaaa aaaaaa
//