LOCUS BC011399 2557 bp mRNA linear HUM 03-OCT-2003 DEFINITION Homo sapiens spleen tyrosine kinase, mRNA (cDNA clone MGC:9504 IMAGE:3870426), complete cds. ACCESSION BC011399 VERSION BC011399.1 KEYWORDS MGC. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2557) AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A. TITLE Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002) PUBMED 12477932 REFERENCE 2 (bases 1 to 2557) AUTHORS Strausberg,R. TITLE Direct Submission JOURNAL Submitted (25-JUL-2001) National Institutes of Health, Mammalian Gene Collection (MGC), Cancer Genomics Office, National Cancer Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590, USA REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov COMMENT Contact: MGC help desk Email: cgapbs-r@mail.nih.gov Tissue Procurement: ATCC cDNA Library Preparation: Life Technologies, Inc. cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL) DNA Sequencing by: Baylor College of Medicine Human Genome Sequencing Center Center code: BCM-HGSC Web site: http://www.hgsc.bcm.tmc.edu/cdna/ Contact: amg@bcm.tmc.edu Gunaratne, P.H., Garcia, A.M., Lu, X., Hulyk, S.W., Loulseged, H., Kowis, C.R., Sneed, A.J., Martin, R.G., Muzny, D.M., Nanavati, A.N., Gibbs, R.A. Clone distribution: MGC clone distribution information can be found through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov Series: IRAK Plate: 13 Row: j Column: 7 This clone was selected for full length sequencing because it passed the following selection criteria: matched mRNA gi: 21361552. FEATURES Location/Qualifiers source 1..2557 /db_xref="H-InvDB:HIT000035240" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /clone="MGC:9504 IMAGE:3870426" /tissue_type="Eye, retinoblastoma" /clone_lib="NIH_MGC_67" /lab_host="DH10B" /note="Vector: pCMV-SPORT6" gene 1..2557 /gene="SYK" /db_xref="GeneID:6850" /db_xref="MIM:600085" CDS 105..1943 /gene="SYK" /codon_start=1 /product="SYK protein" /protein_id="AAH11399.1" /db_xref="GeneID:6850" /db_xref="MIM:600085" /translation="MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQS RNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCL LKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIAT TAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRI DKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQL PGSHPASSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEE IRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKD ELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIE LVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTH GKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE RMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN" misc_feature 147..380 /gene="SYK" /note="SH2; Region: SH2 domain" /db_xref="CDD:pfam00017" misc_feature 606..836 /gene="SYK" /note="SH2; Region: SH2 domain" /db_xref="CDD:pfam00017" misc_feature 1155..1913 /gene="SYK" /note="TyrKc; Region: Tyrosine kinase, catalytic domain" /db_xref="CDD:smart00219" BASE COUNT 690 a 644 c 684 g 539 t ORIGIN 1 ggaggttacg gggaacgacg cgctgctttc atgccctttc ttgttctacc ttcatcggcc 61 gaggtggaca cctgcgcagg tgtgtgccct ccggcccctg aagcatggcc agcagcggca 121 tggctgacag cgccaaccac ctgcccttct ttttcggcaa catcacccgg gaggaggcag 181 aagattacct ggtccagggg ggcatgagtg atgggcttta tttgctgcgc cagagccgca 241 actacctggg tggcttcgcc ctgtccgtgg cccacgggag gaaggcacac cactacacca 301 tcgagcggga gctgaatggc acctacgcca tcgccggtgg caggacccat gccagccccg 361 ccgacctctg ccactaccac tcccaggagt ctgatggcct ggtctgcctc ctcaagaagc 421 ccttcaaccg gccccaaggg gtgcagccca agactgggcc ctttgaggat ttgaaggaaa 481 acctcatcag ggaatatgtg aagcagacat ggaacctgca gggtcaggct ctggagcagg 541 ccatcatcag tcagaagcct cagctggaga agctgatcgc taccacagcc catgaaaaaa 601 tgccttggtt ccatggaaaa atctctcggg aagaatctga gcaaattgtc ctgataggat 661 caaagacaaa tggaaagttc ctgatccgag ccagagacaa caacggctcc tacgccctgt 721 gcctgctgca cgaagggaag gtgctgcact atcgcatcga caaagacaag acagggaagc 781 tctccatccc cgagggaaag aagttcgaca cgctctggca gctagtcgag cattattctt 841 ataaagcaga tggtttgtta agagttctta ctgtcccatg tcaaaaaatc ggcacacagg 901 gaaatgttaa ttttggaggc cgtccacaac ttccaggttc ccatcctgcg tcctcccctg 961 cccaagggaa ccggcaagag agtactgtgt cattcaatcc gtatgagcca gaacttgcac 1021 cctgggctgc agacaaaggc ccccagagag aagccctacc catggacaca gaggtgtacg 1081 agagccccta cgcggacccc gaggagatca ggcccaagga ggtttacctg gaccgaaagc 1141 tgctgacgct ggaagacaaa gaactgggct ctggtaattt tggaactgtg aaaaagggct 1201 actaccaaat gaaaaaagtt gtgaaaaccg tggctgtgaa aatactgaaa aacgaggcca 1261 atgaccccgc tcttaaagat gagttattag cagaagcaaa tgtcatgcag cagctggaca 1321 acccgtacat cgtgcggatg atcgggatat gcgaggccga gtcctggatg ctggttatgg 1381 agatggcaga acttggtccc ctcaataagt atttgcagca gaacagacat gtcaaggata 1441 agaacatcat agaactggtt catcaggttt ccatgggcat gaagtacttg gaggagagca 1501 attttgtgca cagagatctg gctgcaagaa atgtgttgct agttacccaa cattacgcca 1561 agatcagtga tttcggactt tccaaagcac tgcgtgctga tgaaaactac tacaaggccc 1621 agacccatgg aaagtggcct gtcaagtggt acgctccgga atgcatcaac tactacaagt 1681 tctccagcaa aagcgatgtc tggagctttg gagtgttgat gtgggaagca ttctcctatg 1741 ggcagaagcc atatcgaggg atgaaaggaa gtgaagtcac cgctatgtta gagaaaggag 1801 agcggatggg gtgccctgca gggtgtccaa gagagatgta cgatctcatg aatctgtgct 1861 ggacatacga tgtggaaaac aggcccggat tcgcagcagt ggaactgcgg ctgcgcaatt 1921 actactatga cgtggtgaac taaccgctcc cgcacctgtc ggtggctgcc tttgatcaca 1981 ggagcaatca caggaaaatg tatccagagg aattgattgt cagccacctc cctctgccag 2041 tcgggagagc caggcttgga tggaacatgc ccacaacttg tcacccaaag cctgtcccag 2101 gactcaccct ccacaaagca aaggcagtcc cgggagaaaa gacggatggc aggatccaag 2161 gggctagctg gatttgtttg ttttcttgtc tgtgtgattt tcatacaggt tatttttacg 2221 atctgtttcc aaatcccttt catgtctttc cacttctctg ggtcccaggg tgcatttgtt 2281 actcatcggg cccagggaca ttgcagagtg gcctagagca ctctcacccc aagcggcctt 2341 ttccaaatgc ccaaggatgc cttagcatgt gactcctgaa gggaaggcaa aggcagagga 2401 atttggctgc ttctacggcc atgagactga tccctggcca ctgaaaagct ttcctgacaa 2461 taaaaatgtt ttgaggcttt aaaaagaaaa tcaagtttga ccagtgcagt ttctaagcat 2521 gtagccagtt aaggaaagaa agaaaaaaaa aaaaaaa //