LOCUS BC008837 1551 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens aldo-keto reductase family 1, member B10 (aldose
reductase), mRNA (cDNA clone MGC:14103 IMAGE:3639480), complete
cds.
ACCESSION BC008837
VERSION BC008837.2
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1551)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1551)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (25-MAY-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Aug 20, 2003 this sequence version replaced BC008837.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 20 Row: a Column: 23
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 24497578.
FEATURES Location/Qualifiers
source 1..1551
/db_xref="H-InvDB:HIT000034010"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:14103 IMAGE:3639480"
/tissue_type="Pancreas, adenocarcinoma"
/clone_lib="NIH_MGC_39"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..1551
/gene="AKR1B10"
/gene_synonym="AKR1B12"
/gene_synonym="ALDRLn"
/gene_synonym="ARL-1"
/gene_synonym="ARL1"
/gene_synonym="HIS"
/gene_synonym="HSI"
/gene_synonym="MGC14103"
/db_xref="GeneID:57016"
/db_xref="HGNC:HGNC:382"
/db_xref="MIM:604707"
CDS 266..1216
/gene="AKR1B10"
/gene_synonym="AKR1B12"
/gene_synonym="ALDRLn"
/gene_synonym="ARL-1"
/gene_synonym="ARL1"
/gene_synonym="HIS"
/gene_synonym="HSI"
/gene_synonym="MGC14103"
/codon_start=1
/product="aldo-keto reductase family 1, member B10 (aldose
reductase)"
/protein_id="AAH08837.1"
/db_xref="GeneID:57016"
/db_xref="HGNC:HGNC:382"
/db_xref="MIM:604707"
/translation="MATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHID
CAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKL
SYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVS
NFSHFQIEKLLNKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDR
PWAKPEDPSLLEDPKIKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQV
FDFKLSDEEMATILSFNRNWRACNVLQSSHLEDYPFDAEY"
BASE COUNT 459 a 351 c 374 g 367 t
ORIGIN
1 cctgagctca ggagtttgag accagcctgt ctctactaac aatataaaaa ttagctggga
61 gtcacggtgg gcgcctgtaa tcccagctac tcgggaggct gaggcaggag aattgcttga
121 acccaggaga cagaggttgt agtgagctga gatcgcacca ctgcactcta gccttggcaa
181 cagtgcaaga ctgtctcaaa aacagcaaca gagagcagga cgtgagactt ctacctgctc
241 actcagaatc atttctgcac caaccatggc cacgtttgtg gagctcagta ccaaagccaa
301 gatgcccatt gtgggcctgg gcacttggaa gtctcctctt ggcaaagtga aagaagcagt
361 gaaggtggcc attgatgcag gatatcggca cattgactgt gcctatgtct atcagaatga
421 acatgaagtg ggggaagcca tccaagagaa gatccaagag aaggctgtga agcgggagga
481 cctgttcatc gtcagcaagt tgtggcccac tttctttgag agaccccttg tgaggaaagc
541 ctttgagaag accctcaagg acctgaagct gagctatctg gacgtctatc ttattcactg
601 gccacaggga ttcaagtctg gggatgacct tttccccaaa gatgataaag gtaatgccat
661 cggtggaaaa gcaacgttct tggatgcctg ggaggccatg gaggagctgg tggatgaggg
721 gctggtgaaa gcccttgggg tctccaattt cagccacttc cagatcgaga agctcttgaa
781 caaacctgga ctgaaatata aaccagtgac taaccaggtt gagtgtcacc catacctcac
841 acaggagaaa ctgatccagt actgccactc caagggcatc accgttacgg cctacagccc
901 cctgggctct ccggatagac cttgggccaa gccagaagac ccttccctgc tggaggatcc
961 caagattaag gagattgctg caaagcacaa aaaaaccgca gcccaggttc tgatccgttt
1021 ccatatccag aggaatgtga ttgtcatccc caagtctgtg acaccagcac gcattgttga
1081 gaacattcag gtctttgact ttaaattgag tgatgaggag atggcaacca tactcagctt
1141 caacagaaac tggagggcct gtaacgtgtt gcaatcctct catttggaag actatccctt
1201 cgatgcagaa tattgaggtt gaatctcctg gtgagattat acaggagatt ctctttcttc
1261 gctgaagtgt gactacctcc actcatgtcc cattttagcc aagcttattt aagatcacag
1321 tgaacttagt cctgttatag acgagaatcg aggtgctgtt ttagacattt atttctgtat
1381 gttcaactag gatcagaata tcacagaaaa gcatggcttg aataaggaaa tgacaatttt
1441 ttccacttat ctgatcagaa caaatgttta ttaagcatca gaaactctgc caacactgag
1501 gatgtaaaga tcaataaaaa aaataataat cataaaaaaa aaaaaaaaaa a
//