LOCUS BC004257 3486 bp mRNA linear HUM 06-MAR-2007
DEFINITION Homo sapiens ret proto-oncogene, mRNA (cDNA clone MGC:10752
IMAGE:3160389), complete cds.
ACCESSION BC004257
VERSION BC004257.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3486)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3486)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (01-MAR-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 13 Row: e Column: 3
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 50593520.
FEATURES Location/Qualifiers
source 1..3486
/db_xref="H-InvDB:HIT000031824"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:10752 IMAGE:3160389"
/tissue_type="Brain, neuroblastoma"
/clone_lib="NIH_MGC_19"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..3486
/gene="RET"
/gene_synonym="CDHF12"
/gene_synonym="PTC"
/gene_synonym="RET-ELE1"
/gene_synonym="RET51"
/db_xref="GeneID:5979"
/db_xref="HGNC:HGNC:9967"
/db_xref="MIM:164761"
CDS 181..3399
/gene="RET"
/gene_synonym="CDHF12"
/gene_synonym="PTC"
/gene_synonym="RET-ELE1"
/gene_synonym="RET51"
/codon_start=1
/product="ret proto-oncogene"
/protein_id="AAH04257.1"
/db_xref="GeneID:5979"
/db_xref="HGNC:HGNC:9967"
/db_xref="MIM:164761"
/translation="MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQ
AAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLD
HSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSL
KPRELCFPETRPSFRIRENRPPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAP
DSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAPTFPAGV
DTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHW
PNETSVQANGSFVRATVHDYRLVLNRNLSISENRTMQLAVLVNDSDFQGPGAGVLLLH
FNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCS
TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSY
VAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCP
DGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPED
IQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQA
FPVSYSSSSARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVK
ATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDG
PLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAW
QISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIP
VKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMER
PDNCSEEMYCLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYD
DGLSEEETPLVDCNNAPLPRALPSTWIENKLYGRISHAFTRF"
BASE COUNT 691 a 1087 c 1037 g 671 t
ORIGIN
1 ccgaagcagg gcgcgcagca gcgctgagtg ccccggaacg tgcgtcgcgc ccccagtgtc
61 cgtcgcgtcc gccgcgcccc gggcggggat ggggcggcca gactgagcgc cgcacccgcc
121 atccagaccc gccggcccta gccgcagtcc ctccagccgt ggccccagcg cgcacgggcg
181 atggcgaagg cgacgtccgg tgccgcgggg ctgcgtctgc tgttgctgct gctgctgccg
241 ctgctaggca aagtggcatt gggcctctac ttctcgaggg atgcttactg ggagaagctg
301 tatgtggacc aggcggccgg cacgcccttg ctgtacgtcc atgccctgcg ggacgcccct
361 gaggaggtgc ccagcttccg cctgggccag catctctacg gcacgtaccg cacacggctg
421 catgagaaca actggatctg catccaggag gacaccggcc tcctctacct taaccggagc
481 ctggaccata gctcctggga gaagctcagt gtccgcaacc gcggctttcc cctgctcacc
541 gtctacctca aggtcttcct gtcacccaca tcccttcgtg agggcgagtg ccagtggcca
601 ggctgtgccc gcgtatactt ctccttcttc aacacctcct ttccagcctg cagctccctc
661 aagccccggg agctctgctt cccagagaca aggccctcct tccgcattcg ggagaaccga
721 cccccaggca ccttccacca gttccgcctg ctgcctgtgc agttcttgtg ccccaacatc
781 agcgtggcct acaggctcct ggagggtgag ggtctgccct tccgctgcgc cccggacagc
841 ctggaggtga gcacgcgctg ggccctggac cgcgagcagc gggagaagta cgagctggtg
901 gccgtgtgca ccgtgcacgc cggcgcgcgc gaggaggtgg tgatggtgcc cttcccggtg
961 accgtgtacg acgaggacga ctcggcgccc accttccccg cgggcgtcga caccgccagc
1021 gccgtggtgg agttcaagcg gaaggaggac accgtggtgg ccacgctgcg tgtcttcgat
1081 gcagacgtgg tacctgcatc aggggagctg gtgaggcggt acacaagcac gctgctcccc
1141 ggggacacct gggcccagca gaccttccgg gtggaacact ggcccaacga gacctcggtc
1201 caggccaacg gcagcttcgt gcgggcgacc gtacatgact ataggctggt tctcaaccgg
1261 aacctctcca tctcggagaa ccgcaccatg cagctggcgg tgctggtcaa tgactcagac
1321 ttccagggcc caggagcggg cgtcctcttg ctccacttca acgtgtcggt gctgccggtc
1381 agcctgcacc tgcccagtac ctactccctc tccgtgagca ggagggctcg ccgatttgcc
1441 cagatcggga aagtctgtgt ggaaaactgc caggcattca gtggcatcaa cgtccagtac
1501 aagctgcatt cctctggtgc caactgcagc acgctagggg tggtcacctc agccgaggac
1561 acctcgggga tcctgtttgt gaatgacacc aaggccctgc ggcggcccaa gtgtgccgaa
1621 cttcactaca tggtggtggc caccgaccag cagacctcta ggcaggccca ggcccagctg
1681 cttgtaacag tggaggggtc atatgtggcc gaggaggcgg gctgccccct gtcctgtgca
1741 gtcagcaaga gacggctgga gtgtgaggag tgtggcggcc tgggctcccc aacaggcagg
1801 tgtgagtgga ggcaaggaga tggcaaaggg atcaccagga acttctccac ctgctctccc
1861 agcaccaaga cctgccccga cggccactgc gatgttgtgg agacccaaga catcaacatt
1921 tgccctcagg actgcctccg gggcagcatt gttgggggac acgagcctgg ggagccccgg
1981 gggattaaag ctggctatgg cacctgcaac tgcttccctg aggaggagaa gtgcttctgc
2041 gagcccgaag acatccagga tccactgtgc gacgagctgt gccgcacggt gatcgcagcc
2101 gctgtcctct tctccttcat cgtctcggtg ctgctgtctg ccttctgcat ccactgctac
2161 cacaagtttg cccacaagcc acccatctcc tcagctgaga tgaccttccg gaggcccgcc
2221 caggccttcc cggtcagcta ctcctcttcc agtgcccgcc ggccctcgct ggactccatg
2281 gagaaccagg tctccgtgga tgccttcaag atcctggagg atccaaagtg ggaattccct
2341 cggaagaact tggttcttgg aaaaactcta ggagaaggcg aatttggaaa agtggtcaag
2401 gcaacggcct tccatctgaa aggcagagca gggtacacca cggtggccgt gaagatgctg
2461 aaagagaacg cctccccgag tgagcttcga gacctgctgt cagagttcaa cgtcctgaag
2521 caggtcaacc acccacatgt catcaaattg tatggggcct gcagccagga tggcccgctc
2581 ctcctcatcg tggagtacgc caaatacggc tccctgcggg gcttcctccg cgagagccgc
2641 aaagtggggc ctggctacct gggcagtgga ggcagccgca actccagctc cctggaccac
2701 ccggatgagc gggccctcac catgggcgac ctcatctcat ttgcctggca gatctcacag
2761 gggatgcagt atctggccga gatgaagctc gttcatcggg acttggcagc cagaaacatc
2821 ctggtagctg aggggcggaa gatgaagatt tcggatttcg gcttgtcccg agatgtttat
2881 gaagaggatt cgtacgtgaa gaggagccag ggtcggattc cagttaaatg gatggcaatt
2941 gaatcccttt ttgatcatat ctacaccacg caaagtgatg tatggtcttt tggtgtcctg
3001 ctgtgggaga tcgtgaccct agggggaaac ccctatcctg ggattcctcc tgagcggctc
3061 ttcaaccttc tgaagaccgg ccaccggatg gagaggccag acaactgcag cgaggagatg
3121 tactgcctga tgctgcaatg ctggaagcag gagccggaca aaaggccggt gtttgcggac
3181 atcagcaaag acctggagaa gatgatggtt aagaggagag actacttgga ccttgcggcg
3241 tccactccat ctgactccct gatttatgac gacggcctct cagaggagga gacaccgctg
3301 gtggactgta ataatgcccc cctccctcga gccctccctt ccacatggat tgaaaacaaa
3361 ctctatggta gaatttccca tgcatttact agattctagc accgctgtcc cctctgcact
3421 atccttcctc tctgtgatgc tttttaaaaa tgtttctggt ctgaacaaaa aaaaaaaaaa
3481 aaaaaa
//